Understanding Cancer From A Systems Biology Point Of View

Understanding Cancer From A Systems Biology Point Of View Book PDF
✏Book Title : Understanding Cancer from a Systems Biology Point of View
✏Author : Irina Kareva
✏Publisher : Academic Press
✏Release Date : 2018-02-07
✏Pages : 118
✏ISBN : 9780128136744
✏Available Language : English, Spanish, And French

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✏Understanding Cancer from a Systems Biology Point of View Book Summary : Understanding Cancer from a Systems Biology Point of View: From Observation to Theory and Back starts with a basic question, why do we sometimes observe accelerated metastatic growth after resection of primary tumors? Next, it helps readers understand the systemic nature of cancer and how it affects treatment approaches and decisions. The book puts together aspects of cancer that many readers have most likely never combined, using unfamiliar, novel methods. It is a valuable resource for cancer researchers, cancer biologists, mathematicians and members of the biomedical field who are interested in applying systems biology methodologies for understanding and treating cancer. Explains the systemic nature of cancer and how it affects decisions on treatment Brings a variety of methods together, showing, in detail, the logical approach to finding answers to complex questions Discusses the theoretical underpinnings of cancer as a systemic disease, providing the reader with valuable information on applicable cases

A Practical Guide To Cancer Systems Biology Book PDF
✏Book Title : A Practical Guide To Cancer Systems Biology
✏Author : Juan Hsueh-fen
✏Publisher : World Scientific
✏Release Date : 2017-11-29
✏Pages : 152
✏ISBN : 9789813229167
✏Available Language : English, Spanish, And French

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✏A Practical Guide To Cancer Systems Biology Book Summary : Systems biology combines computational and experimental approaches to analyze complex biological systems and focuses on understanding functional activities from a systems-wide perspective. It provides an iterative process of experimental measurements, data analysis, and computational simulation to model biological behavior. This book provides explained protocols for high-throughput experiments and computational analysis procedures central to cancer systems biology research and education. Readers will learn how to generate and analyze high-throughput data, therapeutic target protein structure modeling and docking simulation for drug discovery. This is the first practical guide for students and scientists who wish to become systems biologists or utilize the approach for cancer research. Contents: Introduction to Cancer Systems Biology (Hsueh-Fen Juan and Hsuan-Cheng Huang)Transcriptome Analysis: Library Construction (Hsin-Yi Chang and Hsueh-Fen Juan)Quantitative Proteome: The Isobaric Tags for Relative and Absolute Quantitation (iTRAQ) (Yi-Hsuan Wu and Hsueh-Fen Juan)Phosphoproteome: Sample Preparation (Chia-Wei Hu and Hsueh-Fen Juan)Transcriptomic Data Analysis: RNA-Seq Analysis Using Galaxy (Chia-Lang Hsu and Chantal Hoi Yin Cheung)Proteomic Data Analysis: Functional Enrichment (Hsin-Yi Chang and Hsueh-Fen Juan)Phosphorylation Data Analysis (Chia-Lang Hsu and Wei-Hsuan Wang)Pathway and Network Analysis (Chen-Tsung Huang and Hsueh-Fen Juan)Dynamic Modeling (Yu-Chao Wang)Protein Structure Modeling (Chia-Hsien Lee and Hsueh-Fen Juan)Docking Simulation (Chia-Hsien Lee and Hsueh-Fen Juan) Readership: Graduate students and researchers entering the cancer systems biology field. Keywords: Systems Biology;Transcriptomics;Proteomics;Network Biology;Dynamic Modeling;Protein Structure Modeling;Docking Simulation;BioinformaticsReview: Key Features: Written by two active researchers in the fieldCovers both experimental and computational areas in cancer systems biologyStep-by-step instructions help beginners who are interested in creating biological data and analyzing the data by themselvesReaders will gain the skills to generate and analyze omics data and discover potential therapeutic targets and drug candidates

Cancer Systems Biology Book PDF
✏Book Title : Cancer Systems Biology
✏Author : Edwin Wang
✏Publisher : CRC Press
✏Release Date : 2010-05-04
✏Pages : 456
✏ISBN : 1439811865
✏Available Language : English, Spanish, And French

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✏Cancer Systems Biology Book Summary : The unprecedented amount of data produced with high-throughput experimentation forces biologists to employ mathematical representation and computation methods to glean meaningful information in systems-level biology. Applying this approach to the underlying molecular mechanisms of tumorigenesis, cancer researchers can uncover a series of new discov

Computational Systems Biology Approaches In Cancer Research Book PDF
✏Book Title : Computational Systems Biology Approaches in Cancer Research
✏Author : Inna Kuperstein
✏Publisher : CRC Press
✏Release Date : 2019-09-09
✏Pages : 167
✏ISBN : 9781000682922
✏Available Language : English, Spanish, And French

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✏Computational Systems Biology Approaches in Cancer Research Book Summary : Praise for Computational Systems BiologyApproaches in Cancer Research: "Complex concepts are written clearly and with informative illustrations and useful links. The book is enjoyable to read yet provides sufficient depth to serve as a valuable resource for both students and faculty." — Trey Ideker, Professor of Medicine, UC Xan Diego, School of Medicine "This volume is attractive because it addresses important and timely topics for research and teaching on computational methods in cancer research. It covers a broad variety of approaches, exposes recent innovations in computational methods, and provides acces to source code and to dedicated interactive web sites." — Yves Moreau, Department of Electrical Engineering, SysBioSys Centre for Computational Systems Biology, University of Leuven With the availability of massive amounts of data in biology, the need for advanced computational tools and techniques is becoming increasingly important and key in understanding biology in disease and healthy states. This book focuses on computational systems biology approaches, with a particular lens on tackling one of the most challenging diseases - cancer. The book provides an important reference and teaching material in the field of computational biology in general and cancer systems biology in particular. The book presents a list of modern approaches in systems biology with application to cancer research and beyond. It is structured in a didactic form such that the idea of each approach can easily be grasped from the short text and self-explanatory figures. The coverage of topics is diverse: from pathway resources, through methods for data analysis and single data analysis to drug response predictors, classifiers and image analysis using machine learning and artificial intelligence approaches. Features Up to date using a wide range of approaches Applicationexample in each chapter Online resources with useful applications’

Computational Systems Biology Of Cancer Book PDF
✏Book Title : Computational Systems Biology of Cancer
✏Author : Emmanuel Barillot
✏Publisher : CRC Press
✏Release Date : 2012-08-25
✏Pages : 461
✏ISBN : 9781439831441
✏Available Language : English, Spanish, And French

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✏Computational Systems Biology of Cancer Book Summary : The future of cancer research and the development of new therapeutic strategies rely on our ability to convert biological and clinical questions into mathematical models—integrating our knowledge of tumour progression mechanisms with the tsunami of information brought by high-throughput technologies such as microarrays and next-generation sequencing. Offering promising insights on how to defeat cancer, the emerging field of systems biology captures the complexity of biological phenomena using mathematical and computational tools. Novel Approaches to Fighting Cancer Drawn from the authors’ decade-long work in the cancer computational systems biology laboratory at Institut Curie (Paris, France), Computational Systems Biology of Cancer explains how to apply computational systems biology approaches to cancer research. The authors provide proven techniques and tools for cancer bioinformatics and systems biology research. Effectively Use Algorithmic Methods and Bioinformatics Tools in Real Biological Applications Suitable for readers in both the computational and life sciences, this self-contained guide assumes very limited background in biology, mathematics, and computer science. It explores how computational systems biology can help fight cancer in three essential aspects: Categorising tumours Finding new targets Designing improved and tailored therapeutic strategies Each chapter introduces a problem, presents applicable concepts and state-of-the-art methods, describes existing tools, illustrates applications using real cases, lists publically available data and software, and includes references to further reading. Some chapters also contain exercises. Figures from the text and scripts/data for reproducing a breast cancer data analysis are available at www.cancer-systems-biology.net.

Automated Reasoning For Systems Biology And Medicine Book PDF
✏Book Title : Automated Reasoning for Systems Biology and Medicine
✏Author : Pietro Liò
✏Publisher : Springer
✏Release Date : 2019-06-11
✏Pages : 474
✏ISBN : 9783030172978
✏Available Language : English, Spanish, And French

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✏Automated Reasoning for Systems Biology and Medicine Book Summary : This book presents outstanding contributions in an exciting, new and multidisciplinary research area: the application of formal, automated reasoning techniques to analyse complex models in systems biology and systems medicine. Automated reasoning is a field of computer science devoted to the development of algorithms that yield trustworthy answers, providing a basis of sound logical reasoning. For example, in the semiconductor industry formal verification is instrumental to ensuring that chip designs are free of defects (or “bugs”). Over the past 15 years, systems biology and systems medicine have been introduced in an attempt to understand the enormous complexity of life from a computational point of view. This has generated a wealth of new knowledge in the form of computational models, whose staggering complexity makes manual analysis methods infeasible. Sound, trusted, and automated means of analysing the models are thus required in order to be able to trust their conclusions. Above all, this is crucial to engineering safe biomedical devices and to reducing our reliance on wet-lab experiments and clinical trials, which will in turn produce lower economic and societal costs. Some examples of the questions addressed here include: Can we automatically adjust medications for patients with multiple chronic conditions? Can we verify that an artificial pancreas system delivers insulin in a way that ensures Type 1 diabetic patients never suffer from hyperglycaemia or hypoglycaemia? And lastly, can we predict what kind of mutations a cancer cell is likely to undergo? This book brings together leading researchers from a number of highly interdisciplinary areas, including: · Parameter inference from time series · Model selection · Network structure identification · Machine learning · Systems medicine · Hypothesis generation from experimental data · Systems biology, systems medicine, and digital pathology · Verification of biomedical devices “This book presents a comprehensive spectrum of model-focused analysis techniques for biological systems ...an essential resource for tracking the developments of a fast moving field that promises to revolutionize biology and medicine by the automated analysis of models and data.”Prof Luca Cardelli FRS, University of Oxford

📒Systems Biology Of Cancer ✍ Sam Thiagalingam

Systems Biology Of Cancer Book PDF
✏Book Title : Systems Biology of Cancer
✏Author : Sam Thiagalingam
✏Publisher : Cambridge University Press
✏Release Date : 2015-04-09
✏Pages : 548
✏ISBN : 9780521493390
✏Available Language : English, Spanish, And French

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✏Systems Biology of Cancer Book Summary : An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

Systems Biology Of Tumor Physiology Book PDF
✏Book Title : Systems Biology of Tumor Physiology
✏Author : David H. Nguyen
✏Publisher : Springer
✏Release Date : 2015-12-11
✏Pages : 56
✏ISBN : 9783319256016
✏Available Language : English, Spanish, And French

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✏Systems Biology of Tumor Physiology Book Summary : This exciting SpringerBrief presents evidence for new ideas that will challenge several theories of how cancer biology is understood. Cancer biology has undergone several intellectual revolutions in the past 50 years. A mutation-centric view of cancer has given way to the tumor microenvironment view. Reductionistic studies of one gene at a time have given way to systems biology approaches that analyze the whole genome (omics) at the same time. However, this text combines the complex levels studying cancer at the molecular biology level, endocrinology level, and transcriptomics level. What researchers are now realizing is that there is a need to combine omics with physiology concepts in order to better understand cancer and this book will give insight to the merging of these two fields in order to define how cancer is studied in the future.​

Systems Biology Book PDF
✏Book Title : Systems Biology
✏Author :
✏Publisher :
✏Release Date :
✏Pages :
✏ISBN : 9789814462907
✏Available Language : English, Spanish, And French

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✏Systems Biology Book Summary :

Unravelling Cancer Signaling Pathways A Multidisciplinary Approach Book PDF
✏Book Title : Unravelling Cancer Signaling Pathways A Multidisciplinary Approach
✏Author : Kakoli Bose
✏Publisher : Springer Nature
✏Release Date : 2019-11-25
✏Pages : 583
✏ISBN : 9789813298163
✏Available Language : English, Spanish, And French

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✏Unravelling Cancer Signaling Pathways A Multidisciplinary Approach Book Summary : Unravelling the intricate cell signalling networks and their significance in cancer poses major intellectual challenge. Keeping this in mind, the book aims at understanding the mechanism of action of different proteins and their complexes in the cancer signalling pathways. Hence, the proposed book that comprises 20 chapters provides a comprehensive introduction on cell signalling, its alterations in cancer, molecules that have been popular targets as well as the ones that are emerging as targets. In addition, it discusses different forms of therapy that are coming up for its treatment. Other than that, a major portion of the book is focused on studying different disciplines at the interface of biology and other areas of science that are being used to understand cancer biology in depth.

Systems Biology Of Tumor Microenvironment Book PDF
✏Book Title : Systems Biology of Tumor Microenvironment
✏Author : Katarzyna A. Rejniak
✏Publisher : Springer
✏Release Date : 2016-10-13
✏Pages : 249
✏ISBN : 9783319420233
✏Available Language : English, Spanish, And French

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✏Systems Biology of Tumor Microenvironment Book Summary : This edited volume discusses the complexity of tumor microenvironments during cancer development, progression and treatment. Each chapter presents a different mathematical model designed to investigate the interactions between tumor cells and the surrounding stroma and stromal cells. The topics covered in this book include the quantitative image analysis of a tumor microenvironment, the microenvironmental barriers in oxygen and drug delivery to tumors, the development of tumor microenvironmental niches and sanctuaries, intravenous transport of the circulating tumor cells, the role of the tumor microenvironment in chemotherapeutic interventions, the interactions between tumor cells, the extracellular matrix, the interstitial fluid, and the immune and stromal cells. Mathematical models discussed here embrace both continuous and agent-based approaches, as well as mathematical frameworks of solid mechanics, fluid dynamics and optimal control theory. The topics in each chapter will be of interest to a biological community wishing to apply the mathematical methods to interpret their experimental data, and to a biomathematical audience interested in exploring how mathematical models can be used to address complex questions in cancer biology.

📒Systems Biology ✍ P. Bringmann

Systems Biology Book PDF
✏Book Title : Systems Biology
✏Author : P. Bringmann
✏Publisher : Springer Science & Business Media
✏Release Date : 2007-05-26
✏Pages : 177
✏ISBN : 9783540313397
✏Available Language : English, Spanish, And French

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✏Systems Biology Book Summary : This volume features contributions from participants of an ESRF Workshop on "Systems Biology" held in Berkeley, USA, in November 2005. Significant progress has been made in developing technologies that enable systems interrogations at a molecular level. Recent successes and challenges of applying systems level measurements to the different steps of drug discovery and development in the pharmaceutical industry are summarized.

Modeling Evolution Of Heterogeneous Populations Book PDF
✏Book Title : Modeling Evolution of Heterogeneous Populations
✏Author : Irina Kareva
✏Publisher : Academic Press
✏Release Date : 2019-10-16
✏Pages : 354
✏ISBN : 9780128144329
✏Available Language : English, Spanish, And French

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✏Modeling Evolution of Heterogeneous Populations Book Summary : Modeling Evolution of Heterogeneous Populations: Theory and Applications describes, develops and provides applications of a method that allows incorporating population heterogeneity into systems of ordinary and discrete differential equations without significantly increasing system dimensionality. The method additionally allows making use of results of bifurcation analysis performed on simplified homogeneous systems, thereby building on the existing body of tools and knowledge and expanding applicability and predictive power of many mathematical models. Introduces Hidden Keystone Variable (HKV) method, which allows modeling evolution of heterogenous populations, while reducing multi-dimensional selection systems to low-dimensional systems of differential equations Demonstrates that replicator dynamics is governed by the principle of maximal relative entropy that can be derived from the dynamics of selection systems instead of being postulated Discusses mechanisms behind models of both Darwinian and non-Darwinian selection Provides examples of applications to various fields, including cancer growth, global demography, population extinction, tragedy of the commons and resource sustainability, among others Helps inform differences in underlying mechanisms of population growth from experimental observations, taking one from experiment to theory and back

Handbook Of Research On Systems Biology Applications In Medicine Book PDF
✏Book Title : Handbook of Research on Systems Biology Applications in Medicine
✏Author : Daskalaki, Andriani
✏Publisher : IGI Global
✏Release Date : 2008-11-30
✏Pages : 982
✏ISBN : 9781605660776
✏Available Language : English, Spanish, And French

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✏Handbook of Research on Systems Biology Applications in Medicine Book Summary : "This book highlights the use of systems approaches including genomic, cellular, proteomic, metabolomic, bioinformatics, molecular, and biochemical, to address fundamental questions in complex diseases like cancer diabetes but also in ageing"--Provided by publisher.

Computational Systems Biology Book PDF
✏Book Title : Computational Systems Biology
✏Author : Andres Kriete
✏Publisher : Academic Press
✏Release Date : 2013-11-26
✏Pages : 548
✏ISBN : 9780124059382
✏Available Language : English, Spanish, And French

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✏Computational Systems Biology Book Summary : This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modeling. Logical information flow aids understanding of basic building blocks of life through disease phenotypes Evolved principles gives insight into underlying organizational principles of biological organizations, and systems processes, governing functions such as adaptation or response patterns Coverage of technical tools and systems helps researchers to understand and resolve specific systems biology problems using advanced computation Multi-scale modeling on disparate scales aids researchers understanding of dependencies and constraints of spatio-temporal relationships fundamental to biological organization and function.

📒Complexity ✍ Nam P. Suh

Complexity Book PDF
✏Book Title : Complexity
✏Author : Nam P. Suh
✏Publisher : Oxford University Press on Demand
✏Release Date : 2005
✏Pages : 300
✏ISBN : 9780195178760
✏Available Language : English, Spanish, And French

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✏Complexity Book Summary : Nam P. Suh focussed his axiomatic design theories on methods to understand and deal with complexity. Suh is a well-respected designer and researcher in the fields of manufacturing and composite materials. He is best known for his systems that aim to speed up and simplify the process of design for manufacturing. The 'axioms' in axiomatic design refer to a process to help engineers reduce design specifications down to their simplest components, so that the engineers can produce the simplest possible solution to a problem. Complexity, besides being a key area of burgeoning research in disciplines interested in complex systems and chaos theory (like computer science and physics), is a complicating factor in engineering design that many engineers find difficult to overcome. Suh's multidisciplinary exploration of complex systems is meant to eliminate much of the confusion and allow engineers to accommodate complexity within simple, elegant design solutions.

Issues In Life Sciences Molecular Biology 2011 Edition Book PDF
✏Book Title : Issues in Life Sciences Molecular Biology 2011 Edition
✏Author :
✏Publisher : ScholarlyEditions
✏Release Date : 2012-01-09
✏Pages : 3330
✏ISBN : 9781464963490
✏Available Language : English, Spanish, And French

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✏Issues in Life Sciences Molecular Biology 2011 Edition Book Summary : Issues in Life Sciences: Molecular Biology / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Life Sciences—Molecular Biology. The editors have built Issues in Life Sciences: Molecular Biology: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Life Sciences—Molecular Biology in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Life Sciences: Molecular Biology: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Philosophy Of Systems Biology Book PDF
✏Book Title : Philosophy of Systems Biology
✏Author : Sara Green
✏Publisher : Springer
✏Release Date : 2016-12-15
✏Pages : 265
✏ISBN : 9783319470009
✏Available Language : English, Spanish, And French

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✏Philosophy of Systems Biology Book Summary : The emergence of systems biology raises many fascinating questions: What does it mean to take a systems approach to problems in biology? To what extent is the use of mathematical and computational modelling changing the life sciences? How does the availability of big data influence research practices? What are the major challenges for biomedical research in the years to come? This book addresses such questions of relevance not only to philosophers and biologists but also to readers interested in the broader implications of systems biology for science and society. The book features reflections and original work by experts from across the disciplines including systems biologists, philosophers, and interdisciplinary scholars investigating the social and educational aspects of systems biology. In response to the same set of questions, the experts develop and defend their personal perspectives on the distinctive character of systems biology and the challenges that lie ahead. Readers are invited to engage with different views on the questions addressed, and may explore numerous themes relating to the philosophy of systems biology. This edited work will appeal to scholars and all levels, from undergraduates to researchers, and to those interested in a variety of scholarly approaches such as systems biology, mathematical and computational modelling, cell and molecular biology, genomics, systems theory, and of course, philosophy of biology.

Systems Biology In Toxicology And Environmental Health Book PDF
✏Book Title : Systems Biology in Toxicology and Environmental Health
✏Author : Rebecca Fry
✏Publisher : Academic Press
✏Release Date : 2015-06-11
✏Pages : 284
✏ISBN : 9780128015681
✏Available Language : English, Spanish, And French

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✏Systems Biology in Toxicology and Environmental Health Book Summary : Systems Biology in Toxicology and Environmental Health uses a systems biological perspective to detail the most recent findings that link environmental exposures to human disease, providing an overview of molecular pathways that are essential for cellular survival after exposure to environmental toxicants, recent findings on gene-environment interactions influencing environmental agent-induced diseases, and the development of computational methods to predict susceptibility to environmental agents. Introductory chapters on molecular and cellular biology, toxicology and computational biology are included as well as an assessment of systems-based tools used to evaluate environmental health risks. Further topics include research on environmental toxicants relevant to human health and disease, various high-throughput technologies and computational methods, along with descriptions of the biological pathways associated with disease and the developmental origins of disease as they relate to environmental contaminants. Systems Biology in Toxicology and Environmental Health is an essential reference for undergraduate students, graduate students, and researchers looking for an introduction in the use of systems biology approaches to assess environmental exposures and their impacts on human health. Provides the first reference of its kind, demonstrating the application of systems biology in environmental health and toxicology Includes introductions to the diverse fields of molecular and cellular biology, toxicology, and computational biology Presents a foundation that helps users understand the connections between the environment and health effects, and the biological mechanisms that link them

Fundamentals Of Systems Biology Book PDF
✏Book Title : Fundamentals of Systems Biology
✏Author : Markus W. Covert
✏Publisher : CRC Press
✏Release Date : 2017-10-19
✏Pages : 367
✏ISBN : 9781498728478
✏Available Language : English, Spanish, And French

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✏Fundamentals of Systems Biology Book Summary : For decades biology has focused on decoding cellular processes one gene at a time, but many of the most pressing biological questions, as well as diseases such as cancer and heart disease, are related to complex systems involving the interaction of hundreds, or even thousands, of gene products and other factors. How do we begin to understand this complexity? Fundamentals of Systems Biology: From Synthetic Circuits to Whole-cell Models introduces students to methods they can use to tackle complex systems head-on, carefully walking them through studies that comprise the foundation and frontier of systems biology. The first section of the book focuses on bringing students quickly up to speed with a variety of modeling methods in the context of a synthetic biological circuit. This innovative approach builds intuition about the strengths and weaknesses of each method and becomes critical in the book’s second half, where much more complicated network models are addressed—including transcriptional, signaling, metabolic, and even integrated multi-network models. The approach makes the work much more accessible to novices (undergraduates, medical students, and biologists new to mathematical modeling) while still having much to offer experienced modelers--whether their interests are microbes, organs, whole organisms, diseases, synthetic biology, or just about any field that investigates living systems.

Cancer Bioinformatics Book PDF
✏Book Title : Cancer Bioinformatics
✏Author : Ying Xu
✏Publisher : Springer
✏Release Date : 2014-08-30
✏Pages : 368
✏ISBN : 9781493913817
✏Available Language : English, Spanish, And French

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✏Cancer Bioinformatics Book Summary : This book provides a framework for computational researchers studying the basics of cancer through comparative analyses of omic data. It discusses how key cancer pathways can be analyzed and discovered to derive new insights into the disease and identifies diagnostic and prognostic markers for cancer. Chapters explain the basic cancer biology and how cancer develops, including the many potential survival routes. The examination of gene-expression patterns uncovers commonalities across multiple cancers and specific characteristics of individual cancer types. The authors also treat cancer as an evolving complex system, explore future case studies, and summarize the essential online data sources. Cancer Bioinformatics is designed for practitioners and researchers working in cancer research and bioinformatics. It is also suitable as a secondary textbook for advanced-level students studying computer science, biostatistics or biomedicine.

Systems Biology For Signaling Networks Book PDF
✏Book Title : Systems Biology for Signaling Networks
✏Author : Sangdun Choi
✏Publisher : Springer Science & Business Media
✏Release Date : 2010-08-09
✏Pages : 908
✏ISBN : 1441957979
✏Available Language : English, Spanish, And French

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✏Systems Biology for Signaling Networks Book Summary : System Biology encompasses the knowledge from diverse fields such as Molecular Biology, Immunology, Genetics, Computational Biology, Mathematical Biology, etc. not only to address key questions that are not answerable by individual fields alone, but also to help in our understanding of the complexities of biological systems. Whole genome expression studies have provided us the means of studying the expression of thousands of genes under a particular condition and this technique had been widely used to find out the role of key macromolecules that are involved in biological signaling pathways. However, making sense of the underlying complexity is only possible if we interconnect various signaling pathways into human and computer readable network maps. These maps can then be used to classify and study individual components involved in a particular phenomenon. Apart from transcriptomics, several individual gene studies have resulted in adding to our knowledge of key components that are involved in a signaling pathway. It therefore becomes imperative to take into account of these studies also, while constructing our network maps to highlight the interconnectedness of the entire signaling pathways and the role of that particular individual protein in the pathway. This collection of articles will contain a collection of pioneering work done by scientists working in regulatory signaling networks and the use of large scale gene expression and omics data. The distinctive features of this book would be: Act a single source of information to understand the various components of different signaling network (roadmap of biochemical pathways, the nature of a molecule of interest in a particular pathway, etc.), Serve as a platform to highlight the key findings in this highly volatile and evolving field, and Provide answers to various techniques both related to microarray and cell signaling to the readers.

📒Cancer Systems Biology ✍ Louise von Stechow

Cancer Systems Biology Book PDF
✏Book Title : Cancer Systems Biology
✏Author : Louise von Stechow
✏Publisher : Humana Press
✏Release Date : 2018-01-18
✏Pages : 402
✏ISBN : 1493974920
✏Available Language : English, Spanish, And French

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✏Cancer Systems Biology Book Summary : This book comprises protocols describing systems biology methodologies and computational tools, offering a variety of ways to analyze different types of high-throughput cancer data. Chapters give an overview over data types available in large-scale data repositories and state-of-the-art methods used in the field of cancer systems biology. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cancer Systems Biology : Methods and Protocols aims to ensure successful results in the further study of this vital field. The chapters "Identifying Genetic Dependencies in Cancer by Analyzing siRNA Screens in Tumor Cell Line Panels", "Perseus: A Bioinformatics Platform for Integrative Analysis of Proteomics Data in Cancer Research" and "Phosphoproteomics-based Profiling of Kinase Activities in Cancer Cells" are available open access under a CC BY 4.0 license via link.springer.com.

Cancer Systems Biology Bioinformatics And Medicine Book PDF
✏Book Title : Cancer Systems Biology Bioinformatics and Medicine
✏Author : Alfredo Cesario
✏Publisher : Springer Science & Business Media
✏Release Date : 2011-08-21
✏Pages : 484
✏ISBN : 9400715676
✏Available Language : English, Spanish, And French

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✏Cancer Systems Biology Bioinformatics and Medicine Book Summary : This teaching monograph on systems approaches to cancer research and clinical applications provides a unique synthesis, by world-class scientists and doctors, of laboratory, computational, and clinical methods, thereby establishing the foundations for major advances not possible with current methods. Specifically, the book: 1) Sets the stage by describing the basis of systems biology and bioinformatics approaches, and the clinical background of cancer in a systems context; 2) Summarizes the laboratory, clinical, data systems analysis and bioinformatics tools, along with infrastructure and resources required; 3) Demonstrates the application of these tools to cancer research; 4) Extends these tools and methods to clinical diagnosis, drug development and treatment applications; and 5) Finishes by exploring longer term perspectives and providing conclusions. This book reviews the state-of-the-art, and goes beyond into new applications. It is written and highly referenced as a textbook and practical guide aimed at students, academics, doctors, clinicians, industrialists and managers in cancer research and therapeutic applications. Ideally, it will set the stage for integration of available knowledge to optimize communication between basic and clinical researchers involved in the ultimate fight against cancer, whatever the field of specific interest, whatever the area of activity within translational research.

📒The Complexity Paradox ✍ Kenneth Mossman

The Complexity Paradox Book PDF
✏Book Title : The Complexity Paradox
✏Author : Kenneth Mossman
✏Publisher : Oxford University Press
✏Release Date : 2014-08-26
✏Pages : 240
✏ISBN : 9780199330362
✏Available Language : English, Spanish, And French

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✏The Complexity Paradox Book Summary : Living systems exhibit a fundamental contradiction: they are highly stable and reliable, yet they have the capacity to adapt to changing environmental conditions. This paradoxical behavior arises from the complexity of life--a high degree of order and cooperation that emerges from relatively simple interactions among cellular components. The Complexity Paradox proposes inventive, interdisciplinary approaches to maintaining health and managing and preventing disease by considering the totality of human biology, from the cellular level on up to entire populations of individuals. From the perspective of complexity, which acknowledges that there are limits to what we can know, Kenneth L. Mossman opens the door to understanding essential life processes in new and extraordinary ways. By tying together evolution, functional dynamics, and investigations into how the body processes energy and uses genetic information, Mossman's analysis expresses a unified theory of biology that fills a critical niche for future research in biology, medicine, and public health.

📒Systems Biology ✍ Aleš Prokop

Systems Biology Book PDF
✏Book Title : Systems Biology
✏Author : Aleš Prokop
✏Publisher : Springer Science & Business Media
✏Release Date : 2013-08-28
✏Pages : 553
✏ISBN : 9789400768031
✏Available Language : English, Spanish, And French

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✏Systems Biology Book Summary : Growth in the pharmaceutical market has slowed down – almost to a standstill. One reason is that governments and other payers are cutting costs in a faltering world economy. But a more fundamental problem is the failure of major companies to discover, develop and market new drugs. Major drugs losing patent protection or being withdrawn from the market are simply not being replaced by new therapies – the pharmaceutical market model is no longer functioning effectively and most pharmaceutical companies are failing to produce the innovation needed for success. This multi-authored new book looks at a vital strategy which can bring innovation to a market in need of new ideas and new products: Systems Biology (SB). Modeling is a significant task of systems biology. SB aims to develop and use efficient algorithms, data structures, visualization and communication tools to orchestrate the integration of large quantities of biological data with the goal of computer modeling. It involves the use of computer simulations of biological systems, such as the networks of metabolites comprise signal transduction pathways and gene regulatory networks to both analyze and visualize the complex connections of these cellular processes. SB involves a series of operational protocols used for performing research, namely a cycle composed of theoretical, analytic or computational modeling to propose specific testable hypotheses about a biological system, experimental validation, and then using the newly acquired quantitative description of cells or cell processes to refine the computational model or theory.

Systems Biology Of Apoptosis Book PDF
✏Book Title : Systems Biology of Apoptosis
✏Author : Inna N. Lavrik
✏Publisher : Springer Science & Business Media
✏Release Date : 2012-09-13
✏Pages : 204
✏ISBN : 9781461440093
✏Available Language : English, Spanish, And French

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✏Systems Biology of Apoptosis Book Summary : Systems Biology of Apoptosis summarizes all current achievements in this emerging field. Apoptosis is a process common to all multicellular organisms. Apoptosis leads to the elimination of cells via a complex but highly defined cellular programme. Defects in the regulation of apoptosis result in serious diseases such as cancer, autoimmunity, AIDS and neurodegeneration. Recently, a substantial step forward in understanding the complex apoptotic pathways has been made by utilising systems biology approaches. Systems biology combines rigorous mathematical modelling with experimental approaches in a closed loop cycle for advancing our knowledge about complex biological processes. In this book, the editor describes the contemporary systems biology studies devoted to apoptotic signaling and focuses on the question how systems biology helps to understand life/death decisions made in the cell and to develop new approaches to rational treatment strategies.

📒Handbook Of Systems Biology ✍ Marian Walhout

Handbook Of Systems Biology Book PDF
✏Book Title : Handbook of Systems Biology
✏Author : Marian Walhout
✏Publisher : Academic Press
✏Release Date : 2012-12-31
✏Pages : 552
✏ISBN : 9780123859457
✏Available Language : English, Spanish, And French

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✏Handbook of Systems Biology Book Summary : This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Chapters organized around broader themes of Organelles and Organisms, Systems Properties of Biological Processes, Cellular Networks, and Systems Biology and Disease discuss the development of concepts, the current applications, and the future prospects. Emphasis is placed on concepts and insights into the multi-disciplinary nature of the field as well as the importance of systems biology in human biological research. Technology, being an extremely important aspect of scientific progress overall, and in the creation of new fields in particular, is discussed in 'boxes' within each chapter to relate to appropriate topics. 2013 Honorable Mention for Single Volume Reference in Science from the Association of American Publishers' PROSE Awards Emphasizes the interdisciplinary nature of systems biology with contributions from leaders in a variety of disciplines Includes the latest research developments in human and animal models to assist with translational research Presents biological and computational aspects of the science side-by-side to facilitate collaboration between computational and biological researchers

An Omics Perspective On Cancer Research Book PDF
✏Book Title : An Omics Perspective on Cancer Research
✏Author : William C.S. Cho
✏Publisher : Springer Science & Business Media
✏Release Date : 2010-04-07
✏Pages : 269
✏ISBN : 9048126754
✏Available Language : English, Spanish, And French

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✏An Omics Perspective on Cancer Research Book Summary : Omics is an emerging and exciting area in the field of science and medicine. Numerous promising developments have been elucidated using omics (including genomics, transcriptomics, epigenomics, proteomics, metabolomics, interactomics, cytomics and bioinformatics) in cancer research. The development of high-throughput technologies that permit the solution of deciphering cancer from higher dimensionality will provide a knowledge base which changes the face of cancer understanding and therapeutics. This is the first book to provide such a comprehensive coverage of a rapidly evolving area written by leading experts in the field of omics. It complies and details cutting-edge cancer research that covers the broad advances in the field and its application from cancer-associated gene discovery to drug target validation. It also highlights the potential of using integration approach for cancer research. This unique and timely book provides a thorough overview of developing omics, which will appeal to anyone involved in cancer research. It will be a useful reference book for graduate students of different subjects (medicine, biology, engineering, etc) and senior scientists interested in the fascinating area of advanced technologies in cancer research. Readership: This is a precious book for all types of readers – cancer researchers, oncologists, pathologists, biologists, clinical chemists, pharmacologists, pharmaceutical specialists, biostatisticians, and bioinformaticists who want to expand their knowledge in cancer research.

📒The Molecular Biology Of Cancer ✍ Stella Pelengaris

The Molecular Biology Of Cancer Book PDF
✏Book Title : The Molecular Biology of Cancer
✏Author : Stella Pelengaris
✏Publisher : John Wiley & Sons
✏Release Date : 2009-03-12
✏Pages : 544
✏ISBN : 9781444309089
✏Available Language : English, Spanish, And French

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✏The Molecular Biology of Cancer Book Summary : This comprehensive text provides a detailed overview of the molecular mechanisms underpinning the development of cancer and its treatment. Written by an international panel of researchers, specialists and practitioners in the field, the text discusses all aspects of cancer biology from the causes, development and diagnosis through to the treatment of cancer. Written by an international panel of researchers, specialists and practitioners in the field Covers both traditional areas of study and areas of controversy and emerging importance, highlighting future directions for research Features up-to-date coverage of recent studies and discoveries, as well as a solid grounding in the key concepts in the field Each chapter includes key points, chapter summaries, text boxes, and topical references for added comprehension and review Supported by a dedicated website at www.blackwellpublishing.com/pelengaris An excellent text for upper-level courses in the biology of cancer, for medical students and qualified practitioners preparing for higher exams, and for researchers and teachers in the field