Tumor Vascularization

• Author : Domenico Ribatti,Francesco Pezzella
• Publisher : Academic Press
• Release : 07 January 2020

Tumor Vascularization discusses the different types of growth of tumor blood vessels and their implications on research and healthcare. The book is divided into three parts: the first one, General Mechanisms, discusses different vessel growth mechanisms, such as sprouting angiogenesis, non-angiogenesis dependent growth, intussusceptive microvascular growth, vascular co-option and vasculogenic mimicry. The second and third parts, entitled Clinical Implications and Therapeutic Implications are dedicated to translating recent findings in this field to patient treatment and healthcare. This book is a

• Author : Domenico Ribatti,Francesco Pezzella
• Publisher : Academic Press
• Release : 21 January 2020

Tumor Vascularization discusses the different types of growth of tumor blood vessels and their implications on research and healthcare. The book is divided into three parts: the first one, General Mechanisms, discusses different vessel growth mechanisms, such as sprouting angiogenesis, non-angiogenesis dependent growth, intussusceptive microvascular growth, vascular co-option and vasculogenic mimicry. The second and third parts, entitled Clinical Implications and Therapeutic Implications are dedicated to translating recent findings in this field to patient treatment and healthcare. This book is a

• Author : Anonim
• Publisher : Unknown
• Release : 25 March 2023

Tumors must manipulate the host vasculature to provide a blood supply adequate for their proliferation. Although tumors may arise as avascular masses. there is increasing evidence that some tumors begin to proliferate by coopting the host vasculature. By analyzing cell proliferation kinetics of endothelial cells (EC) and PC3 prostate cancer cells, we provide evidence that EC proliferation could not account for rapid tumor growth. Although PC3mm2 expressing green fluorescent protein (GFP) failed to grow in the ears, in an

• Author : Domenico Ribatti
• Publisher : Springer Science & Business Media
• Release : 16 December 2008

In 1971, J. Folkman published in the “New England Journal of Medicine” a hypothesis that tumor growth is angiogenesis-dependent. Folkman introduced the concept that tumors probably secrete diffusible molecules that could stimulate the growth of new blood vessels toward the tumor and that the resulting tumor neovascularization could conceivably be prevented or interrupted by angiogenesis inhibitors. Solid and haematological tumors consist of an avascular and a subsequent vascular phase. Assuming that this depends on the release of angiogenic factors, acquisition of

• Author : Mikhail G. Kolonin
• Publisher : Springer Science & Business Media
• Release : 17 July 2013

Recent studies have shown that cells from adipose tissue are capable of trafficking to tumors, thus enabling paracrine action of adipokines from within the tumor microenvironment. Increased tumor vascularization, immune system suppression and direct effects on malignant cell survival and proliferation have been investigated as mechanisms regulated by adipokines. The goal of this book is to discuss data pointing to the role of adipose tissue in cancer and to dissect individual mechanisms through which adipose tissue excess or restriction could

• Author : Jung-Hyun Kim
• Publisher : Unknown
• Release : 25 March 2023

• Author : Józef Dulak,Alicja Józkowicz,Agnieszka Łoboda
• Publisher : Springer Science & Business Media
• Release : 10 February 2014

The book presents the overview of the current knowledge in some fields of vascular biology, addressing cellular and molecular aspects of blood-vessel formation and their role in health and disease. The major factors involved in the formation of blood vessels are presented by scientists actively involved in this area of research. Special emphasis is put on the presentation of various molecular mechanisms not addressed in similar works to date. The book is divided into three parts. The first part describes

• Author : Enrico Mihich
• Publisher : Springer Science & Business Media
• Release : 11 November 2013

The series of volumes entitled Biological Responses in Cancer provides information on approaches through which the interaction between neoplas tic and normal cells may be modified. Topics discussed in various volumes include immunological and host defense systems, control mechanisms of cell and population growth, cell differentiation, and cell transformation. This volume is specifically concerned with various aspects of cell interactions and regulation within heterogeneous tumor cell populations, and their role in tumor progression and metastasis. Knowledge in this area is

• Author : Enrico Mihich,Carlo Croce
• Publisher : Springer Science & Business Media
• Release : 29 June 2013

The Ninth Annual Pezcoller Symposium entitled "The Biology of Tumors" was held in Rovereto, Italy, June 4-7, 1997. It focused on the genetic mechanisms underlying het erogeneity of tumor cell populations and tumor cell differentiation, on interactions be tween tumor cells and cells of host defenses, and the mechanisms of angiogenesis. With presentations at the cutting edge of progress and stimulating discussions, this symposium addressed issues related to phenomena concerned with cell regulation and cell interactions as determined by activated genes

• Author : Anonim
• Publisher : Unknown
• Release : 25 March 2023

Tumor growth, progression, and metastasis are dependent on the ability of the tumor to recruit a blood supply. It is currently believed that tumors become vascularized by a process referred to as angiogenesis. We propose that a second process of blood vessel formation, vasculogenesis, a process not currently associated with tumor vascularization, is operative in breast cancer. Although it is well established that all new blood vessels are formed by either angiogenesis or vasculogenesis, it is believed that only angiogenesis,

• Author : Christian Stock,Luis A. Pardo
• Publisher : Springer Nature
• Release : 26 May 2022

This second book of the three-volume collection "Ion Transport in Tumor Biology" helps readers gain comprehensive knowledge of the pathophysiology of cancer. The authors highlight that ion transport proteins, channels and transporters - collectively referred to as the transportome - are significantly involved in the development and progression of cancer. Nearly 90% of malignant tumor diseases originate from epithelial cells, the function of which, for the most part, is based on the transportome. This volume focuses on molecular principles by showing

• Author : Domenico Ribatti
• Publisher : Springer Science & Business Media
• Release : 28 January 2010

The chick embryo chorioallantoic membrane (CAM) is an extraembryonic membrane which serves as a gas exchange surface and its function is supported by a dense capillary network. Because of its extensive vascularization and easy accessibility, the CAM has been broadly used to study the morpho-functional aspects of the angiogenesis process in vivo and to investigate the efficacy and mechanisms of action of pro-angiogenic and anti-angiogenic natural and synthetic molecules. The CAM is a suitable site for transplanting tissues, which can

• Author : E. Löhr,R. Ackerman,D. Bachmann,A. Baert,H. Behrendt,D. Beyer,W. Bischoff,E. Boijsen,H.C. Dominick,V. Fiedler,W.A. Fuchs,M. Georgi,U. Goerttler,M. Goldberg,R. Günther,W. Havers,R. Heckmann,H. Holfeld,L. Jeanmart,J.V. Kaude,L.D. Leder,M. Marberger,G. Marchal,P. Mellin,A. Moss,O. Olsson,M. Osteaux,H.J. Richter,E. Scherer,C. Stambolis,M.W. Strötges,B. Swart,Guido Wilms
• Publisher : Springer Science & Business Media
• Release : 06 December 2012

The present volume constitutes an attempt to compile contem porary features of diagnosis and treatment of renal and adrenal tumors. A thorough survey of the field is ensured by the authors' considerable scientific experience. Tumors of the kidneys and the adrenal glands are being diagnosed and treated by physicians of different medical disciplines. For both types of tumor, the pathologic cellular substrate is of crucial importance in diagnosis and therapy. In recent years significant diagnostic advances have been made, ranging

• Author : M.A. Hayat
• Publisher : Springer Science & Business Media
• Release : 03 April 2011

Advantages and limitations of biomarkers in gliomagenesis are described. Molecular subtypes of gliomas are detailed. The role played by TP53 gene mutation in the deadliest brain tumor, glioblastoma multiforme, is pointed out. The role of mutations of IDH1 and IDH2, and isocitrate dehydrogenases in malignant gliomas are presented. Metabolic differences in different regions of the glioma tumor are clarified. Various types of imaging modalities, including PET and SPECT, to diagnose gliomas in general and glioblastoma in particular in patients are

• Author : Anonim
• Publisher : ScholarlyEditions
• Release : 09 January 2012

Issues in Gynecology, Obstetrics, Fertility, and Pregnancy Research: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Gynecology, Obstetrics, Fertility, and Pregnancy Research. The editors have built Issues in Gynecology, Obstetrics, Fertility, and Pregnancy Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Gynecology, Obstetrics, Fertility, and Pregnancy Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and