Tumor Microenvironment Regulation of Tumor Expansion

• Author : Domenico Ribatti
• Publisher : Academic Press
• Release : 04 April 2021

Tumor Microenvironment Regulation of Tumor Expansion is a practical guide to understand and perform research on tumor microenvironments, and to support related clinical decisions. Tumor progression is linked to an imbalance between positive and negative regulators, and mainly depends on the release of specific growth factors by inflammatory or neoplastic cells. Inflammatory infiltrate contributes to tumor progression and the metastatic process, and there are many reports of associations between tumor inflammatory infiltrate, progression, and prognosis. Understanding different contexts of organs

• Author : Timothy Chao
• Publisher : Unknown
• Release : 07 June 2023

The cytokine milieu in the tumor microenvironment plays a key role in modulating the immune response either in favor of or against tumorigenesis. For many tumors, this complex network of cytokine and immune interactions represent a formidable means of escape from immune surveillance. These cytokine networks are particularly important in pancreatic ductal adenocarcinoma (PDA), where a prominent infiltration of immunosuppressive immune populations could be found. Myeloid-derived suppressor cells (MDSCs) have previously been shown to be potent suppressors of anti-tumor immunity

• Author : Alexander Birbrair
• Publisher : Springer Nature
• Release : 08 February 2020

Revealing essential roles of the tumor microenvironment in cancer progression, this book focuses on the role of hematopoietic components of the tumor microenvironment. Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include neutrophils, basophils, T helper cells, cytotoxic lymphocytes, fibrocytes, and myeloid-derived suppressor cells, and more. Taken alongside its companion volumes, these books update us on what we know about various aspects of the tumor microenvironment as

• Author : Yanyan Tang,Shiv K. Gupta,Zong Sheng Guo
• Publisher : Frontiers Media SA
• Release : 14 September 2022

• Author : Yao Zhou
• Publisher : Unknown
• Release : 07 June 2023

Tumor angiogenesis is a hallmark of cancer, and plays a critical role in tumor growth, expansion, and metastasis. Both physiological and pathological angiogenesis is assumed to be regulated by the balance between pro and anti-angiogenic factors. One of the best characterized and most potent pro-angiogenic regulators is vascular endothelial growth factor, or VEGF. Calcineurin signaling is an important mediator of VEGF signaling in endothelial cells. Negative regulation of calcineurin by increased expression of its endogenous inhibitor, Down Syndrome Candidate Region-1 (

• Author : Paul D. Rennert
• Publisher : Springer
• Release : 30 May 2016

Cancer care is undergoing a radical transformation as novel technologies are directed toward new treatments and personalized medicine. The most dramatic advances in the treatment of cancer have come from therapeutics that augment the immune response to tumors. The immune checkpoint inhibitors are the best-known and most highly advanced examples of Immune Therapeutics targeting tumor cells and include approved antibody drugs directed at the cell surface proteins CTLA4 and PD-1. These are now considered foundational treatments for several solid tumor

• Author : Michal Amit Rahat,Bernhard Hemmerlein,Vijaya Iragavarapu-Charyulu
• Publisher : Frontiers E-books
• Release : 03 November 2014

Angiogenesis is the physiological process where new blood vessels grow from existing ones, in order to replenish tissues suffering from inadequate blood supply. Perhaps the most studied angiogenic process occurs in solid tumors whose growing mass and expanding cells create a constant demand for additional supply of oxygen and nutrients for survival. However, other physiological and clinical conditions, such as wound healing, ischemic events, autoimmune and age-related diseases also involve angiogenesis. Angiogenesis is a well-structured process that begins when oxygen

• Author : Cesar Alexander Corzo
• Publisher : Unknown
• Release : 07 June 2023

ABSTRACT: Myeloid-derived suppressor cells (MDSC) are a major component of the immune suppressive network that develops during cancer. MDSC down-regulate immune surveillance and antitumor immunity and facilitate tumor growth. The ability of MDSC to suppress T cell responses has been documented; however the mechanisms regulating this suppression remain to be understood. This work proposes a biological dichotomy of MDSC regulated by the tumor microenvironment. In peripheral lymphoid organs MDSC cause T-cell non-responsiveness that is antigen-specific. These MDSC have increased expression

• Author : Youcef M. Rustum
• Publisher : MDPI
• Release : 26 March 2019

Gene cloning and sequence has provided the opportunity to identify and characterize the functional role of biomarkers expressed in and on tumor cells and the surrounding microenvironment. Molecular and immunologic heterogeneity of cells in the tumor microenvironment contributes to instability, enhanced angiogenesis, and drug resistance of the tumor cell. Since tumor cells are the ultimate therapeutic targets for drugs and therapy development, the tumor microenvironment that regulates the growth and the delivery of effective drug concentrations to tumor cells is

• Author : Marlies Cortés Hinojosa
• Publisher : Unknown
• Release : 07 June 2023

ZEB1 is a transcription factor whose expression in cancer cells promotes tumor initiation and progression. In this study, we for the first time characterized Zeb1 and study its function in macrophages under either homeostasis or activation conditions as well as in a murine cancer model. We found that macrophages deficient for Zeb1 showed aberrant characteristics in phenotype and functions, under physiological and pathological conditions. Here we clarified a functional role of Zeb1 on macrophages playing a role in macrophage phagocytosis,

• Author : Anonim
• Publisher : Unknown
• Release : 07 June 2023

Epidemiological and experimental evidence supports the concept that chronic inflammation promotes and enhances cancerous growth through several key mechanisms, although these processes are not well understood. Several important mechanisms by which inflammation may initiate and support malignant progression have been previously described, such as the induction of DNA damage, the promotion of angiogenesis and new vasculature, and the production of growth and survival factors. The purpose of this study is to identify a novel mechanism by which chronic inflammation may

• Author : Salem Chouaib,James Lorens
• Publisher : Frontiers Media SA
• Release : 02 July 2020

• Author : Alexander Birbrair
• Publisher : Springer Nature
• Release : 06 February 2020

Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on how different signaling pathways are important in the tumor microenvironment. Multiple signaling pathways are covered, including S1P, neuregulin, Notch, erythropoietin, Rho-ROCK, mTOR, and more. Taken alongside its companion volumes, these books update us on what we know about various aspects of the tumor microenvironment as well as future directions. Tumor Microenvironment: Signaling Pathways – Part A is essential reading

• Author : Ying-Ju Cecilia Sung,宋穎如
• Publisher : Open Dissertation Press
• Release : 27 January 2017

This dissertation, "Reuglation of T Helper 17 by Bacteria: an Approach for the Treatment of Hepatocellular Carcinoma" by Ying-ju, Cecilia, Sung, 宋穎如, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above

• Author : David Naor
• Publisher : Frontiers Media SA
• Release : 18 July 2016

The biological outcome of Hyaluronan (also hyaluronic acid, abbreviated HA) interaction with its CD44 or RHAMM receptors recently attracted much attention within the scientific community owing to a Nature article by Tian X et al. (Nature 2013; 499:346-9). The article described a life span exceeding 30 years in naked mole rats, whereas the maximal lifespan of mice, to which the naked mole rat is related, is only 4 years. This observation is accompanied by the finding that the naked mole rat, in contrast