Toxicogenomics Based Cellular Models

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  • Author : Jos Kleinjans
  • Publisher : Academic Press
  • Pages : 362 pages
  • ISBN : 0123978718
  • Rating : /5 from reviews
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Download or Read online Toxicogenomics Based Cellular Models full in PDF, ePub and kindle. this book written by Jos Kleinjans and published by Academic Press which was released on 02 January 2014 with total page 362 pages. We cannot guarantee that Toxicogenomics Based Cellular Models book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Toxicogenomics-Based Cellular Models is a unique and valuable reference for all academic and professional researchers employing toxicogenomic methods with respect to animal testing for chemical safety. This resource offers cutting-edge information on the application of toxicogenomics to developing alternatives to current animal toxicity tests. By illustrating the development of toxicogenomics-based cellular models for critical endpoints of toxicity and providing real-world examples for validation and data analysis, this book provides an assessment of the current state of the field, as well as opportunities and challenges for the future. Written by renowned international toxicological experts, this book explores ‘omics technology for developing new assays for toxicity testing and safety assessment and provides the reader with a focused examination of alternative means to animal testing. Describes the state-of-the-art in developing toxicogenomics-based cellular models for chemical-induced carcinogenicity, immunotoxicity, developmental toxicity, neurotoxicity and reproduction toxicity Illustrates how to validate toxicogenomics-based alternative test models and provides an outlook to societal and economic implementation of these novel assays Includes an overview of current testing methods and risk assessment frameworks Provides a real-world assessment by articulating the current development and challenges in toxicogenomics while suggesting ways to move this field forward

Toxicogenomics Based Cellular Models

Toxicogenomics Based Cellular Models
  • Author : Jos Kleinjans
  • Publisher : Academic Press
  • Release : 02 January 2014
GET THIS BOOK Toxicogenomics Based Cellular Models

Toxicogenomics-Based Cellular Models is a unique and valuable reference for all academic and professional researchers employing toxicogenomic methods with respect to animal testing for chemical safety. This resource offers cutting-edge information on the application of toxicogenomics to developing alternatives to current animal toxicity tests. By illustrating the development of toxicogenomics-based cellular models for critical endpoints of toxicity and providing real-world examples for validation and data analysis, this book provides an assessment of the current state of the field, as well

Information Resources in Toxicology

Information Resources in Toxicology
  • Author : Steve Gilbert,Asish Mohapatra,Sol Bobst,Antoinette Hayes,Sara T. Humes
  • Publisher : Academic Press
  • Release : 16 May 2020
GET THIS BOOK Information Resources in Toxicology

This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. Both volumes represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. The editors and authors are among the leaders of the profession sharing their cumulative wisdom in toxicology’s subdisciplines. This edition keeps pace with the digital world

Big Data in Predictive Toxicology

Big Data in Predictive Toxicology
  • Author : Andrea-Nicole Richarz,Daniel Neagu
  • Publisher : Royal Society of Chemistry
  • Release : 10 December 2019
GET THIS BOOK Big Data in Predictive Toxicology

The rate at which toxicological data is generated is continually becoming more rapid and the volume of data generated is growing dramatically. This is due in part to advances in software solutions and cheminformatics approaches which increase the availability of open data from chemical, biological and toxicological and high throughput screening resources. However, the amplified pace and capacity of data generation achieved by these novel techniques presents challenges for organising and analysing data output. Big Data in Predictive Toxicology discusses

Integrative Toxicogenomics Analytical Strategies to Amalgamate Exposure Effects with Genomic Sciences

Integrative Toxicogenomics  Analytical Strategies to Amalgamate Exposure Effects with Genomic Sciences
  • Author : Pierre R. Bushel,Weida Tong
  • Publisher : Frontiers Media SA
  • Release : 09 April 2019
GET THIS BOOK Integrative Toxicogenomics Analytical Strategies to Amalgamate Exposure Effects with Genomic Sciences

Toxicogenomics combines the use of toxicology and genomic sciences to elucidate chemical, toxic and environmental stressor effects on biological systems. Integrative toxicogenomics requires innovation in bioinformatics, statistics and systems toxicology and typically a combination of the utility of two of more of these disciplines to better understand molecular mechanisms involved in toxic responses. This Frontiers in Toxicogenomics Research Topic eBook focuses on integrative toxicogenomics more so at the late stage (analyzing each data set separately and then merging the results )

Advances in Molecular Toxicology

Advances in Molecular Toxicology
  • Author : James C. Fishbein,Jacqueline M. Heilman
  • Publisher : Academic Press
  • Release : 21 September 2018
GET THIS BOOK Advances in Molecular Toxicology

Advances in Molecular Toxicology, Volume Twelve, features the latest advances in the subspecialties of the broad area of molecular toxicology. This series details the study of the molecular basis of toxicology by which a vast array of agents encountered in the human environment, and produced by the human body, manifest themselves as toxins. The work not only documents these examples, but also covers the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The

Translating Diverse Environmental Data into Reliable Information

Translating Diverse Environmental Data into Reliable Information
  • Author : Daniel Vallero
  • Publisher : Academic Press
  • Release : 15 September 2017
GET THIS BOOK Translating Diverse Environmental Data into Reliable Information

Translating Diverse Environmental Data into Reliable Information: How to Coordinate Evidence from Different Sources is a resource for building environmental knowledge, particularly in the era of Big Data. Environmental scientists, engineers, educators and students will find it essential to determine data needs, assess their quality, and efficiently manage their findings. Decision makers can explore new open access databases and tools, especially portals and dashboards. The book demonstrates how environmental knowledgebases are and can be built to meet the needs of

Risk Assessment for Human Metal Exposures

Risk Assessment for Human Metal Exposures
  • Author : Gunnar F. Nordberg,Bruce A. Fowler
  • Publisher : Academic Press
  • Release : 21 August 2018
GET THIS BOOK Risk Assessment for Human Metal Exposures

Risk Assessment for Human Metal Exposures: Mode of Action and Kinetic Approaches examines the current principles of risk assessment in human metal exposures, with a focus on Mode of Action(MOA), Toxicokinetic and Toxicodynamic (TKTD) considerations, and computer models. Derived from the highly respected Handbook on the Toxicology of Metals, Fourth Edition (2014), the book summarizes principles and methods and provides examples of how MOA –TKTD can be used. In addition, it presents tactics on how information generated by such methods

Toxicoepigenetics

Toxicoepigenetics
  • Author : Shaun D. McCullough,Dana Dolinoy
  • Publisher : Academic Press
  • Release : 02 November 2018
GET THIS BOOK Toxicoepigenetics

Toxicoepigenetics: Core Principles and Applications examines the core aspects of epigenetics, including chromatin biology, DNA methylation, and non-coding RNA, as well as fundamental techniques and considerations for studying each of these mechanisms of epigenetic regulation. Although its integration into the field of toxicology is in its infancy, epigenetics have taken center stage in the study of diseases such as cancer, diabetes, and neurodegeneration. Increasing the presence of epigenetics in toxicological research allows for a more in-depth understanding of important aspects

Emerging Bioinformatic Tools in Toxicogenomics

Emerging Bioinformatic Tools in Toxicogenomics
  • Author : Danyel Jennen,Paul Jennings
  • Publisher : Frontiers Media SA
  • Release : 27 February 2020
GET THIS BOOK Emerging Bioinformatic Tools in Toxicogenomics

Toxicogenomics was established as a merger of toxicology with genomics approaches and methodologies more than 15 years ago, and considered of major value for studying toxic mechanisms-of-action in greater depth and for classification of toxic agents for predicting adverse human health risks. While the original focus was on technological validation of in particular microarray-based whole genome expression analysis (transcriptomics), mainly through cross-comparing different platforms for data generation (MAQC-I), it was soon appreciated that actually the wide variety of data analysis approaches

Applications of Toxicogenomics in Safety Evaluation and Risk Assessment

Applications of Toxicogenomics in Safety Evaluation and Risk Assessment
  • Author : Darrell R. Boverhof,B. Bhaskar Gollapudi
  • Publisher : John Wiley & Sons
  • Release : 11 October 2011
GET THIS BOOK Applications of Toxicogenomics in Safety Evaluation and Risk Assessment

This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process – including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics

The History of Alternative Test Methods in Toxicology

The History of Alternative Test Methods in Toxicology
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 20 October 2018
GET THIS BOOK The History of Alternative Test Methods in Toxicology

The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement,Reduction, Refinement) concept expounded by William Russell and

Comprehensive Toxicology

Comprehensive Toxicology
  • Author : Anonim
  • Publisher : Elsevier
  • Release : 01 June 2010
GET THIS BOOK Comprehensive Toxicology

An explosive increase in the knowledge of the effects of chemical and physical agents on biological systems has led to an increased understanding of normal cellular functions and the consequences of their perturbations. The 14-volume Second Edition of Comprehensive Toxicology has been revised and updated to reflect new advances in toxicology research, including content by some of the leading researchers in the field. It remains the premier resource for toxicologists in academia, medicine, and corporations. Comprehensive Toxicology Second Edition provides

Pluripotent Stem Cell Biology

Pluripotent Stem Cell Biology
  • Author : Craig Atwood,Sivan Vadakkadath Meethal
  • Publisher : BoD – Books on Demand
  • Release : 02 July 2014
GET THIS BOOK Pluripotent Stem Cell Biology

Pluripotent stem cells have the potential to revolutionize treatment options for a range of diseases and conditions. This book presents recent advances in our understanding of the biological mechanisms of stem cell self-renewal, reprograming and regeneration. Also covered are novel methodological advances in the culture, purification and use of stem cells, as well as the ethical and moral dilemmas of embryo donation and adoption. These advances will shape the utilization of stem cells for future basic and applied applications.

Toxicology and Risk Assessment

Toxicology and Risk Assessment
  • Author : Helmut Greim,Robert Snyder
  • Publisher : John Wiley & Sons
  • Release : 10 August 2018
GET THIS BOOK Toxicology and Risk Assessment

Provides a complete understanding of how our bodies respond to toxicants, and the principles used to assess the health risks of specific exposure scenarios Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition reflects recent advances in science and technology, and provides the scientific background and methodological issues to enable the reader to understand the basic principles in toxicology and to evaluate the health risks of specific exposure scenarios. Completely updated with the latest information, this book offers a concise

Toxicogenomics

Toxicogenomics
  • Author : Saura C. Sahu
  • Publisher : John Wiley & Sons
  • Release : 20 November 2008
GET THIS BOOK Toxicogenomics

Toxicogenomics is the integration of genomics to toxicology. This technology is a powerful tool for collecting information from a large number of biological samples simultaneously and thus it is very useful for large-scale screening of potential toxicants. Toxicogenomics: A Powerful Tool For Toxicity Assessment provides up-to-date state-of-the-art information presented by the recognized experts, and is therefore an authoritative source of current knowledge in this field of research. The potential link between toxicology, genetics and human diseases makes this book very