Thresholds of Genotoxic Carcinogens

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  • Author : Takehiko Nohmi
  • Publisher : Academic Press
  • Pages : 224 pages
  • ISBN : 0128018038
  • Rating : /5 from reviews
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Download or Read online Thresholds of Genotoxic Carcinogens full in PDF, ePub and kindle. this book written by Takehiko Nohmi and published by Academic Press which was released on 20 May 2016 with total page 224 pages. We cannot guarantee that Thresholds of Genotoxic Carcinogens book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation brings together current opinion and research activities from Japan, the US, and Europe on the subject of genotoxic thresholds. In regulation, it is an adage that genotoxic carcinogens have no thresholds for action, and that they impose cancer risk on humans even at very low levels. This policy is frequently called into question as humans possess a number of defense mechanisms including detoxication, DNA repair, and apoptosis, meaning there is a threshold at which these genotoxic carcinogens take action. The book examines these potential thresholds, describing the potential cancer risks of daily low-level exposure, the mechanisms involved (such as DNA repair, detoxication, translesion DNA synthesis), chemical and statistical methods of analysis, and the ways in which these may be utilized to inform policy. Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation is an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation. Unites an international team of experts to provide a balanced overview of the current opinion on thresholds of genotoxic carcinogens Provides all the information readers need to determine a safe threshold for potential genotoxic carcinogens Includes information on the mechanisms of genotoxic carcinogens and how these can inform regulation Serves as an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation

Thresholds of Genotoxic Carcinogens

Thresholds of Genotoxic Carcinogens
  • Author : Takehiko Nohmi,Shoji Fukushima
  • Publisher : Academic Press
  • Release : 20 May 2016
GET THIS BOOK Thresholds of Genotoxic Carcinogens

Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation brings together current opinion and research activities from Japan, the US, and Europe on the subject of genotoxic thresholds. In regulation, it is an adage that genotoxic carcinogens have no thresholds for action, and that they impose cancer risk on humans even at very low levels. This policy is frequently called into question as humans possess a number of defense mechanisms including detoxication, DNA repair, and apoptosis, meaning there is a threshold

The Cellular Response to the Genotoxic Insult

The Cellular Response to the Genotoxic Insult
  • Author : Helmut Greim,Richard Albertini
  • Publisher : Royal Society of Chemistry
  • Release : 09 November 2015
GET THIS BOOK The Cellular Response to the Genotoxic Insult

Genotoxic carcinogens can lead to DNA mutations with the potential to cause cancer. Typically, a series of mutation events are needed before malignancy occurs so a single, small exposure may not result in disease. Also, cells have an armoury of defence mechanisms which, to a degree, counter the effects of mutagens. Distinguishing the point at which exposure to a carcinogen increases mutation rates beyond the background level is challenging. In fact, there is now general agreement that, for genotoxic carcinogens,

Cancer Risk Assessment

Cancer Risk Assessment
  • Author : Ching-Hung Hsu,Todd Stedeford
  • Publisher : John Wiley & Sons
  • Release : 08 December 2010
GET THIS BOOK Cancer Risk Assessment

With a weight-of-the-evidence approach, cancer risk assessment indentifies hazards, determines dose-response relationships, and assesses exposure to characterize the true risk. This book focuses on the quantitative methods for conducting chemical cancer risk assessments for solvents, metals, mixtures, and nanoparticles. It links these to the basic toxicology and biology of cancer, along with the impacts on regulatory guidelines and standards. By providing insightful perspective, Cancer Risk Assessment helps researchers develop a discriminate eye when it comes to interpreting data accurately and

Toxicology and Ecotoxicology in Chemical Safety Assessment

Toxicology and Ecotoxicology in Chemical Safety Assessment
  • Author : Laura Robinson,Ian Thorn
  • Publisher : CRC PressI Llc
  • Release : 13 June 2021
GET THIS BOOK Toxicology and Ecotoxicology in Chemical Safety Assessment

The use of chemicals in any workplace in the developed world is governed by stringent health, safety and environmental legislation, and companies spend significant amounts of time and money assessing the risks associated with the handling and use of chemicals. In practice, those risk assessments are generally carried out by a range of competent people, be it the corporate safety manager, the R&D chemist or the manufacturing unit manager. This book will guide those personnel in the understanding, interpretation

Methods to Assess Adverse Effects of Pesticides on Non Target Organisms

Methods to Assess Adverse Effects of Pesticides on Non Target Organisms
  • Author : Scientific Group on Methodologies for the Safety Evaluation of Chemicals
  • Publisher : John Wiley & Son Limited
  • Release : 30 April 1992
GET THIS BOOK Methods to Assess Adverse Effects of Pesticides on Non Target Organisms

Introduction, general conclusions and recommendations. Methods to assess exposure to pesticides: data acquisition and monitoring techniques. Methods to assess toxic effects of pesticides in humans. Methods to assess toxic effects on ecosystems. Management technologies: integrated pest management. Methods to evaluate exposures to pesticides. Role of evaluative models to assess exposure to pesticides. Exposure assessment models: accuracy and validity. Assessment of acute toxicity of pesticides on humans. Assessment of chronic effects of pesticides on humans. Ecological effects of pesticides on non-target

Genetic Toxicology and Cancer Risk Assessment

Genetic Toxicology and Cancer Risk Assessment
  • Author : Wai Nang Choy
  • Publisher : CRC Press
  • Release : 31 August 2001
GET THIS BOOK Genetic Toxicology and Cancer Risk Assessment

Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation! This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard identification, dose-response relationships, exposure assessment, and current practices of risk characterization. Examines predictive values of mutagenicity tests, mechanisms of carcinogenesis, and conventional genotoxicity tests required by the International Conference on Harmonization and the Organization for Economic Cooperation and

Quality and Treatment of Drinking Water II

Quality and Treatment of Drinking Water II
  • Author : Jiri Hrubec
  • Publisher : Springer
  • Release : 18 March 1998
GET THIS BOOK Quality and Treatment of Drinking Water II

Drinking water quality is a vast and complex subject. In addition to the topics already addressed in Volume 5, part B of this Handbook in 1995, this new volume discusses in an authoritative way the current key issues of drinking water quality and its control: - Toxicity tests for assessing drinking water quality - Toxicological approaches for developing drinking water standards - Analysis of organic micropollutants - Algal toxins and human health - Quality changes due to application of ozone and chlorine