Third Generation EGFR Inhibitors

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  • Author : Harun M. Patel
  • Publisher : Elsevier
  • Pages : 208 pages
  • ISBN : 0081026625
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Third Generation EGFR Inhibitors

Download or Read online Third Generation EGFR Inhibitors full in PDF, ePub and kindle. this book written by Harun M. Patel and published by Elsevier which was released on 27 November 2018 with total page 208 pages. We cannot guarantee that Third Generation EGFR Inhibitors book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Third Generation EGFR Inhibitors: Overcoming EGFR Resistance and Toxicity Problems reviews current issues relating to the design of reversible and irreversible third generation EGFR inhibitors, highlighting the types of mutation responsible for resistance, and providing different chemical starting points for researchers to optimize and develop in designing the next generation of drugs. Beginning with an introduction to EGFR inhibitors and a review of inhibitors currently approved or in clinical trials, the book goes on to discuss current approaches in the development of both covalent irreversible and covalent reversible EGFR Inhibitors. In addition, mechanisms of resistance to third generation inhibitors, and discovery of fourth generation allosteric C797S inhibitors are explored before a discussion of potential future trends. This comprehensive coverage of the design and development of improved analogues to overcome the problems of resistance and toxicity associated with third generation EGFR inhibitors makes Third Generation EGFR Inhibitors a crucial resource for medicinal chemists, drug developers, and researchers investigating cancer therapeutics. Includes full synthetic schemes of all approved and in-trial third generation inhibitors Highlights the emergence of fourth generation EGFR inhibitors and the possibilities of them overcoming constraints of third generation compounds Provides a structural correlation of third and fourth generation EGFR inhibitors, reviewing both their design strategies and typical anticancer activity

Third Generation EGFR Inhibitors

Third Generation EGFR Inhibitors
  • Author : Harun M. Patel,Rahul Pawara,Sanjay J. Surana
  • Publisher : Elsevier
  • Release : 27 November 2018
GET THIS BOOK Third Generation EGFR Inhibitors

Third Generation EGFR Inhibitors: Overcoming EGFR Resistance and Toxicity Problems reviews current issues relating to the design of reversible and irreversible third generation EGFR inhibitors, highlighting the types of mutation responsible for resistance, and providing different chemical starting points for researchers to optimize and develop in designing the next generation of drugs. Beginning with an introduction to EGFR inhibitors and a review of inhibitors currently approved or in clinical trials, the book goes on to discuss current approaches in the

Third Generation EGFR Inhibitors

Third Generation EGFR Inhibitors
  • Author : Harun M. Patel,Rahul Pawara,S. J. Surana
  • Publisher : Elsevier
  • Release : 15 March 2019
GET THIS BOOK Third Generation EGFR Inhibitors

EGFR inhibitors are useful tools in cancer therapeutics, but resistance to the first generations have significantly increased, meaning a new generation of improved inhibitors are needed with better efficacy and lower toxicity. Third Generation EGFR Inhibitors: Overcoming EGFR Resistance and Toxicity Problems reviews current issues relating to the design of reversible and irreversible third generation EGFR inhibitors, highlighting the types of mutation responsible for resistance, and providing different chemical starting points for researchers to optimize and develop in designing the

Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC

Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC
  • Author : Anthony Faber
  • Publisher : Academic Press
  • Release : 15 March 2021
GET THIS BOOK Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC

Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC, Volume 17 presents updated information on how EGFR mutant lung cancers evolve to evade EGFR inhibitors, clinical strategies that identify these mechanisms, and how to implement newer therapeutic strategies to combat resistance and improve patient survival. As resistance to EGFR inhibitors is often through re-activation of MEK/ERK and PI3K pathways, or through loss of cell death responses, there is much overlap with resistance to targeted therapies in other paradigms, such

Frontiers in Anti Cancer Drug Discovery Volume 11

Frontiers in Anti Cancer Drug Discovery  Volume 11
  • Author : Atta-ur-Rahman ,Muhammad Iqbal Choudhary
  • Publisher : Bentham Science Publishers
  • Release : 01 September 2020
GET THIS BOOK Frontiers in Anti Cancer Drug Discovery Volume 11

Frontiers in Anti-Cancer Drug Discovery is a book series devoted to publishing the latest advances in anti-cancer drug design and discovery. In each volume, eminent scientists contribute reviews relevant to all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The book series should prove to be of interest to all pharmaceutical scientists involved in research in anti-cancer drug design and discovery. The

A Beginner s Guide to Targeted Cancer Treatments

A Beginner s Guide to Targeted Cancer Treatments
  • Author : Elaine Vickers
  • Publisher : John Wiley & Sons
  • Release : 08 May 2018
GET THIS BOOK A Beginner s Guide to Targeted Cancer Treatments

The accessible guide to the principles behind new, more targeted drug treatments for cancer Written for anyone who encounters cancer patients, cancer data or cancer terminology, but have no more than a passing knowledge of cell biology. A Beginner's Guide to Targeted Cancer Treatments provides an understanding of how cancer works and the many new treatments available. Using over 100 original illustrations, this accessible handbook covers the biology and mechanisms behind a huge range of targeted drug treatments, including many new

Clinical Applications of Circulating Tumor DNA Analysis

Clinical Applications of Circulating Tumor DNA Analysis
  • Author : Jacob John Chabon
  • Publisher : Unknown
  • Release : 28 July 2021
GET THIS BOOK Clinical Applications of Circulating Tumor DNA Analysis

Circulating tumor DNA (ctDNA) represents an exquisitely specific biomarker due to the fact that tumors harbor somatic mutations that are not present in other cell-types in the body. We begin with a review of the existing methodologies and applications of ctDNA, highlighting studies that illustrate the diverse clinical utility of ctDNA. Next we focus on a method for ctDNA detection developed by our lab called Cancer Personalized Profiling by Deep Sequencing (CAPP-Seq). CAPP-Seq is a targeted next-generation sequencing approach for

Chemoinformatics Approaches to Structure and Ligand Based Drug Design

Chemoinformatics Approaches to Structure  and Ligand Based Drug Design
  • Author : Adriano D. Andricopulo,Leonardo L. G. Ferreira
  • Publisher : Frontiers Media SA
  • Release : 05 February 2019
GET THIS BOOK Chemoinformatics Approaches to Structure and Ligand Based Drug Design

Chemoinformatics is paramount to current drug discovery. Structure- and ligand-based drug design strategies have been used to uncover hidden patterns in large amounts of data, and to disclose the molecular aspects underlying ligand-receptor interactions. This Research Topic aims to share with a broad audience the most recent trends in the use of chemoinformatics in drug design. To that end, experts in all areas of drug discovery have made their knowledge available through a series of articles that report state-of-the-art approaches.

Targeted Therapies for Lung Cancer

Targeted Therapies for Lung Cancer
  • Author : Ravi Salgia
  • Publisher : Springer
  • Release : 26 June 2019
GET THIS BOOK Targeted Therapies for Lung Cancer

This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient’s

AACR 2016 Abstracts 1 2696

AACR 2016  Abstracts 1 2696
  • Author : American Association for Cancer Research (AACR)
  • Publisher : CTI Meeting Technology
  • Release : 28 March 2016
GET THIS BOOK AACR 2016 Abstracts 1 2696

The AACR Annual Meeting is a must-attend event for cancer researchers and the broader cancer community. This year's theme, "Delivering Cures Through Cancer Science," reinforces the inextricable link between research and advances in patient care. The theme will be evident throughout the meeting as the latest, most exciting discoveries are presented in every area of cancer research. There will be a number of presentations that include exciting new data from cutting-edge clinical trials as well as companion presentations that spotlight

Molecular Targeted Therapy of Lung Cancer

Molecular Targeted Therapy of Lung Cancer
  • Author : Yuichi Takiguchi
  • Publisher : Springer
  • Release : 24 January 2017
GET THIS BOOK Molecular Targeted Therapy of Lung Cancer

This book discusses the latest molecular targeted therapy of lung cancer including its evaluation and future directions. It clearly illustrates the initial dramatic effectiveness of molecular targeted therapy, recurrence of the disease, overcoming the wide variety of resistance mechanisms using new-generation molecular targeted agents and potential novel approaches. It also outlines the increasing necessity for new diagnostic technology and strategies for managing different adverse effects and novel methods for evaluating effectiveness and safety. Edited and authored by opinion leaders, Molecular

Kinase Drug Discovery

Kinase Drug Discovery
  • Author : Richard A. Ward,Frederick W. Goldberg
  • Publisher : Royal Society of Chemistry
  • Release : 10 October 2018
GET THIS BOOK Kinase Drug Discovery

Kinase inhibition remains an area of significant interest, and growing importance, across academia and the pharmaceutical industry. There are now many marketed drugs that target kinases and a significant number of compounds are currently in various stages of clinical development. This book is a forward-looking analysis of a number of key areas for kinase inhibition in the coming years.

Next Generation Kinase Inhibitors

Next Generation Kinase Inhibitors
  • Author : Paul Shapiro
  • Publisher : Springer Nature
  • Release : 14 July 2020
GET THIS BOOK Next Generation Kinase Inhibitors

Protein kinases are fascinating enzymes that maintain the proper function of nearly every task performed by the cells of the human body. By extracting a phosphate from the energy molecule ATP and linking it to another protein, protein kinases alter the structure and ultimate function of other proteins. In this way, protein kinases help monitor the extracellular environment and integrate signaling cues that, for the most part, are beneficial for human health and survival. However, protein kinases are often dysregulated