Therapeutic Antibody Engineering

Therapeutic Antibody Engineering Book PDF
✏Book Title : Therapeutic Antibody Engineering
✏Author : William R Strohl
✏Publisher : Elsevier
✏Release Date : 2012-10-16
✏Pages : 696
✏ISBN : 9781908818096
✏Available Language : English, Spanish, And French

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✏Therapeutic Antibody Engineering Book Summary : The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that various genetic engineering approaches will have on future candidates. Chapters in the first part of the book provide an introduction to monoclonal antibodies, their discovery and development and the fundamental technologies used in their production. Following chapters cover a number of specific issues relating to different aspects of antibody engineering, including variable chain engineering, targets and mechanisms of action, classes of antibody and the use of antibody fragments, among many other topics. The last part of the book examines development issues, the interaction of human IgGs with non-human systems, and cell line development, before a conclusion looking at future issues affecting the field of therapeutic antibody engineering. Goes beyond the standard engineering issues covered by most books and delves into structure-function relationships Integration of knowledge across all areas of antibody engineering, development, and marketing Discusses how current and future genetic engineering of cell lines will pave the way for much higher productivity

📒Antibody Engineering ✍ Thomas Böldicke

Antibody Engineering Book PDF
✏Book Title : Antibody Engineering
✏Author : Thomas Böldicke
✏Publisher : BoD – Books on Demand
✏Release Date : 2018-02-21
✏Pages : 312
✏ISBN : 9789535138259
✏Available Language : English, Spanish, And French

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✏Antibody Engineering Book Summary : Antibody Engineering comprises in vitro selection and modification of human antibodies including humanization of mouse antibodies for therapy, diagnosis, and research. This book comprises an overview about the generation of antibody diversity and essential techniques in antibody engineering: construction of immune, naive and synthetic libraries, all available in vitro display methods, humanization by chain shuffling, affinity maturation techniques, de novo synthesis of antibody genes, colony assays for library screening, construction of scFvs from hybridomas, and purification of monoclonal antibodies by exclusion chromatography. In addition, other topics that are discussed in this book are application and mechanism of single domain antibodies, structural diversity of antibodies, immune-mediated skin reactions induced by TNF-alpha recombinant antibodies, and bioinformatic approaches to select pathogen-derived peptide sequences for antibody targets.

Handbook Of Therapeutic Antibodies Book PDF
✏Book Title : Handbook of Therapeutic Antibodies
✏Author : Stefan Dübel
✏Publisher : John Wiley & Sons
✏Release Date : 2014-12-03
✏Pages : 2544
✏ISBN : 9783527329373
✏Available Language : English, Spanish, And French

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✏Handbook of Therapeutic Antibodies Book Summary : Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content. Volume I covers selection and engineering strategies for new antibodies, while the second volume look at novel therapeutic concepts and antibodies in clinical trial phases, as well as their potential. Volume III features detailed and specific information about each antibody currently approved for therapeutic purposes, including the clinical data. Beyond providing current knowledge, the authors discuss emerging technologies, future developments, and intellectual property issues, such that this handbook meets the needs of academic researchers, decision makers in industry and healthcare professionals in the clinic.

Antibody Fc Engineering Towards Better Therapeutics Book PDF
✏Book Title : Antibody Fc Engineering Towards Better Therapeutics
✏Author : Tianlei Ying
✏Publisher : Frontiers Media SA
✏Release Date : 2018-12-21
✏Pages :
✏ISBN : 9782889456789
✏Available Language : English, Spanish, And French

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✏Antibody Fc Engineering Towards Better Therapeutics Book Summary :

Diagnostic And Therapeutic Antibodies Book PDF
✏Book Title : Diagnostic and Therapeutic Antibodies
✏Author : Andrew J. T. George
✏Publisher : Springer Science & Business Media
✏Release Date : 2000
✏Pages : 477
✏ISBN : 9781592590766
✏Available Language : English, Spanish, And French

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✏Diagnostic and Therapeutic Antibodies Book Summary : Soon after the first description of monoclonal antibodies in 1976, there was enormous interest in the clinical application of antibodies, especially in the context of cancer. Antibodies appeared to offer the "magic bullet" that would allow the specific destruction of neoplastic cells. H- ever, many years' effort resulted in very few cases of successful immu- therapy with antibodies. As a result there was a major backlash against antibody therapy, and the field lost a considerable amount of popularity. Fashion, in science as well as in other things, tends to be cyclical. Antibody-based therapy is once again attracting scientists and clinicians. There are several reasons for the renewed optimism; certainly the expe- ence of the last two decades has provided a wealth of information about problems associated with antibody therapy, and possible solutions to these problems. Recombinant antibody engineering has rejuvenated the field, allowing both the modification of antibodies to improve their in vivo pr- erties and the isolation of novel antibody molecules by such techniques as phage display. The results of recent clinical trials have demonstrated unequivocally the benefit of antibody therapy in a number of settings, and, finally, more careful consideration has been taken of the types of disease best treated using this approach.

Applications And Engineering Of Monoclonal Antibodies Book PDF
✏Book Title : Applications And Engineering Of Monoclonal Antibodies
✏Author : David J. King
✏Publisher : CRC Press
✏Release Date : 1998-11-27
✏Pages : 249
✏ISBN : 0748404228
✏Available Language : English, Spanish, And French

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✏Applications And Engineering Of Monoclonal Antibodies Book Summary : A valuable resource for researchers and workers in the fields of both pharmaceuticals and biotechnology as well as undergraduates in biochemistry, applied biology, biomedical sciences and pharmacy, this book compares established techniques of antibody production with the new. Antibody structure and the implications of antibody engineering are fully discussed, and a case study approach illustrates how antibodies are finding increasing use in the diagnosis and treatment of disease. The volume ends with commercial expression, purification and large-scale manufacture of antibodies and their future potential, particularly as therapeutic agents.

New Horizons In Therapeutic Antibody Discovery Book PDF
✏Book Title : New Horizons in Therapeutic Antibody Discovery
✏Author :
✏Publisher :
✏Release Date : 2015
✏Pages :
✏ISBN : OCLC:1052010546
✏Available Language : English, Spanish, And French

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✏New Horizons in Therapeutic Antibody Discovery Book Summary : Antibody drugs have become an increasingly significant component of the therapeutic landscape. Their success has been driven by some of their unique properties, in particular their very high specificity and selectivity, in contrast to the off-target liabilities of small molecules (SMs). Antibodies can bring additional functionality to the table with their ability to interact with the immune system, and this can be further manipulated with advances in antibody engineering. This review summarizes what antibody therapeutics have achieved to date and what opportunities and challenges lie ahead. The target landscape for large molecules (LMs) versus SMs and some of the challenges for antibody drug development are discussed. Effective penetration of membrane barriers and intracellular targeting is one challenge, particularly across the highly resistant blood-brain barrier. The expanding pipeline of antibody-drug conjugates offers the potential to combine SM and LM modalities in a variety of creative ways, and antibodies also offer exciting potential to build bi- and multispecific molecules. The ability to pursue more challenging targets can also be further exploited but highlights the need for earlier screening in functional cell-based assays. I discuss how this might be addressed given the practical constraints imposed by high-throughput screening sample type and process differences in antibody primary screening.

📒Antibodies ✍ G. Subramanian

Antibodies Book PDF
✏Book Title : Antibodies
✏Author : G. Subramanian
✏Publisher : Springer Science & Business Media
✏Release Date : 2013-03-07
✏Pages : 314
✏ISBN : 9781441988751
✏Available Language : English, Spanish, And French

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✏Antibodies Book Summary : If the antibody industry is to achieve its full potential in the next decade, the individual technical potentials must be exploited, the limitations must be addressed, and lessons learned must be applied both to current purification methods and to the new technologies that continue to emerge. This book presents an overview of the current advances applied in the manufacture of monoclonal antibody including: -concepts in development of manufacturing strategies, -importance of antibody fragments, -application of chromatography method development, -quality control, -effect of expression on antibody properties, -virus removal and safety, -pharmacokinetics, -regulatory aspects.

📒Antibody Engineering ✍ Patrick Chames

Antibody Engineering Book PDF
✏Book Title : Antibody Engineering
✏Author : Patrick Chames
✏Publisher : Humana Press
✏Release Date : 2016-08-23
✏Pages : 734
✏ISBN : 1493959441
✏Available Language : English, Spanish, And French

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✏Antibody Engineering Book Summary : More than ever, antibodies are being recognized as a major drug modality in a variety of diseases, including cancer, autoimmune diseases, infectious diseases, or even neurodegenerative disorders. Over 30 therapeutic antibodies have been approved and novel molecules are entering clinical trials at an average rate of 50 per year and that is predicted to continue well into the future. Notwithstanding the many achievements already made in the field, there is still a lot of room for improvements for these molecules in terms of activity, and a plethora of approaches have been attempted to optimize these molecules. Antibody Engineering: Methods and Protocols, Second Edition was compiled to give complete and easy access to a variety of antibody engineering techniques, starting from the creation of antibody repertoires and efficient ways to select binders from these repertoires, to their production in various hosts, their detailed characterization using various well established techniques, and to the modification and optimization of these lead molecules in terms of binding activity, specificity, size, shape, and more. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Antibody Engineering: Methods and Protocols, Second Edition serves as an invaluable resource for both experts and those new to the field, and most of all as a source of inspiration for the creation of the antibodies of tomorrow.

Introduction To Antibody Engineering Book PDF
✏Book Title : Introduction to Antibody Engineering
✏Author : Florian Rüker
✏Publisher : Springer Nature
✏Release Date : 2021-01-04
✏Pages : 388
✏ISBN : 9783030546304
✏Available Language : English, Spanish, And French

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✏Introduction to Antibody Engineering Book Summary : This highly readable textbook serves as a concise and engaging primer to the emerging field of antibody engineering and its various applications. It introduces readers to the basic science and molecular structure of antibodies, and explores how to characterize and engineer them. Readers will find an overview of the latest methods in antibody identification, improvement and biochemical engineering. Furthermore, alternative antibody formats and bispecific antibodies are discussed. The book’s content is based on lectures for the specializations “Protein Engineering” and “Medical Biotechnology” within the Master’s curriculum in “Biotechnology.” The lectures have been held at the University of Natural Resources and Life Sciences, Vienna, in cooperation with the Medical University of Vienna, since 2012 and are continuously adapted to reflect the latest developments in the field. The book addresses Master’s and PhD students in biotechnology, molecular biology and immunology, and all those who are interested in antibody engineering.

Biosimilars Of Monoclonal Antibodies Book PDF
✏Book Title : Biosimilars of Monoclonal Antibodies
✏Author : Cheng Liu
✏Publisher : John Wiley & Sons
✏Release Date : 2016-12-09
✏Pages : 704
✏ISBN : 9781118940624
✏Available Language : English, Spanish, And French

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✏Biosimilars of Monoclonal Antibodies Book Summary : Addressing a significant need by describing the science and process involved to develop biosimilars of monoclonal antibody (mAb) drugs, this book covers all aspects of biosimilar development: preclinical, clinical, regulatory, manufacturing. • Guides readers through the complex landscape involved with developing biosimilar versions of monoclonal antibody (mAb) drugs • Features flow charts, tables, and figures that clearly illustrate processes and makes the book comprehensible and accessible • Includes a review of FDA-approved mAb drugs as a quick reference to facts and useful information • Examines new technologies and strategies for improving biosimilar mAbs

📒Antibody Engineering ✍ Roland Kontermann

Antibody Engineering Book PDF
✏Book Title : Antibody Engineering
✏Author : Roland Kontermann
✏Publisher : Springer Science & Business Media
✏Release Date : 2001
✏Pages : 790
✏ISBN : 3540413545
✏Available Language : English, Spanish, And French

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✏Antibody Engineering Book Summary : Biological chemistry is a major frontier of inorganic chemistry. Three special volumes devoted to Metal Sites in Proteins and Models address the questions: How unusual ('entatic') are metal sites in metalloproteins and metalloenzymes compared to those in small coordination complexes? And if they are special, how do polypeptide chains and co-factors control this? The chapters deal with iron, with metal centres acting as Lewis acids, metals in phosphate enzymes, with vanadium, and with the wide variety of transition metal ions which act as redox centres. They illustrate in particular how the combined armoury of genetics and structure determination at the molecular level are providing unprecedented new tools for molecular engineering.

Development Of Antibody Based Therapeutics Book PDF
✏Book Title : Development of Antibody Based Therapeutics
✏Author : Mohammad A. Tabrizi
✏Publisher : Springer Science & Business Media
✏Release Date : 2012-04-24
✏Pages : 426
✏ISBN : 9781441959553
✏Available Language : English, Spanish, And French

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✏Development of Antibody Based Therapeutics Book Summary : Translational strategies for development of antibody-based therapeutics should allow understanding of the relationship between the ‘unit dose’ and ‘unit effect’ with respect to both beneficial and deleterious effects from early stages of development. The flow of information from later to earlier stages of development should provide opportunities to facilitate selection of more effective novel and next-generation drug candidates. Selection and evaluation of relevant biomarkers in early preclinical development in "relevant" animal models should allow for identifying potential risks to humans and establishing safe First-In-Human (FIH) dosing strategies. Hence, integration of knowledge with respect to target antigen properties such as antigen distribution, expression profile, kinetic properties, target pharmacology, antigen isoforms and pharmacological redundancy in health and disease, as well as antibody design criteria, such as antibody isotype, affinity, PK/PD and safety is a critical necessity for the design of effective translational strategies. Additionally, these factors will further offer critical differentiating characteristics for next-generation antibodies, and novel technologies prove instrumental in generation of biosuperior antibody candidates for market entry. This book will examine many important considerations necessary for the design of effective translational strategies during the development of antibody-based therapeutics.

📒Antibody Engineering ✍ Roland E. Kontermann

Antibody Engineering Book PDF
✏Book Title : Antibody Engineering
✏Author : Roland E. Kontermann
✏Publisher : Springer Science & Business Media
✏Release Date : 2010-03-10
✏Pages : 788
✏ISBN : 3642011446
✏Available Language : English, Spanish, And French

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✏Antibody Engineering Book Summary : Antibodies are indispensable tools for research, diagnosis, and therapy. Recombinant approaches allow the modification and improvement of nearly all antibody properties, such as affinity, valency, specificity, stability, serum half-life, effector functions, and immunogenicity. "Antibody Engineering" provides a comprehensive toolbox covering the well-established basics but also many exciting new techniques. The protocols reflect the latest "hands on" knowledge of key laboratories in this still fast-moving field. Newcomers will benefit from the proven step-by-step protocols, which include helpful practical advice; experienced antibody engineers will appreciate the new ideas and approaches. The book is an invaluable resource for all those engaged in antibody research and development.

📒Bispecific Antibodies ✍ Roland E. Kontermann

Bispecific Antibodies Book PDF
✏Book Title : Bispecific Antibodies
✏Author : Roland E. Kontermann
✏Publisher : Springer Science & Business Media
✏Release Date : 2011-07-21
✏Pages : 373
✏ISBN : 3642209106
✏Available Language : English, Spanish, And French

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✏Bispecific Antibodies Book Summary : The concept of using bispecific antibodies for cancer therapy by retargeting immune effector cells was developed several years ago. Initial clinical studies were rather disappointing mainly due to low efficacy, severe side effects and the immunogenicity of the bispecific antibodies. The progress in antibody engineering finally led to the generation of new classes of bispecific antibodies lacking these obstacles. In addition, new applications were established, such as pre-targeting strategies in radioimmunotherapy and dual targeting approaches in order to improve binding, selectivity and efficacy. In this book, the different ways of generating bispecific antibodies are described, with emphasis on recombinant formats. The various applications of bispecific antibodies, e.g. in cellular cancer immunotherapy, radioimmunotherapy and pretargeting strategies are covered, and emerging applications such as dual targeting strategies, which involve the simultaneous inhibition of two targets, are addressed.

Handbook Of Therapeutic Antibodies Book PDF
✏Book Title : Handbook of Therapeutic Antibodies
✏Author : Stefan Dübel
✏Publisher : John Wiley & Sons
✏Release Date : 2014-12-03
✏Pages : 2544
✏ISBN : 9783527329373
✏Available Language : English, Spanish, And French

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✏Handbook of Therapeutic Antibodies Book Summary : Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content. Volume I covers selection and engineering strategies for new antibodies, while the second volume look at novel therapeutic concepts and antibodies in clinical trial phases, as well as their potential. Volume III features detailed and specific information about each antibody currently approved for therapeutic purposes, including the clinical data. Beyond providing current knowledge, the authors discuss emerging technologies, future developments, and intellectual property issues, such that this handbook meets the needs of academic researchers, decision makers in industry and healthcare professionals in the clinic.

📒Therapeutic Antibodies ✍ Yuti Chernajovsky

Therapeutic Antibodies Book PDF
✏Book Title : Therapeutic Antibodies
✏Author : Yuti Chernajovsky
✏Publisher : Springer Science & Business Media
✏Release Date : 2007-12-11
✏Pages : 380
✏ISBN : 3540732594
✏Available Language : English, Spanish, And French

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✏Therapeutic Antibodies Book Summary : This essential work, edited by two researchers at London’s famous Queen Mary’s medical school targets one of the most important areas in medical development today. These days, antibody therapeutics are the treatment of choice for several autoimmune and oncological conditions. They are, indeed, becoming the molecules of choice for further combination therapies and cell engineering. In this timely work, a slew of expert in the field of drug development summarize all the current developments and clinical successes.

Therapeutic Monoclonal Antibodies Book PDF
✏Book Title : Therapeutic Monoclonal Antibodies
✏Author : Zhiqiang An
✏Publisher : John Wiley & Sons
✏Release Date : 2011-09-20
✏Pages : 896
✏ISBN : 9781118210260
✏Available Language : English, Spanish, And French

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✏Therapeutic Monoclonal Antibodies Book Summary : 70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies. First book to address the discovery and development of antibody therapeutics in their entirety. Most chapters contain experimental data to illustrate the principles described in them. Authors provide detailed methodologies that readers can take away with them and use in their own laboratories.

Handbook Of Therapeutic Antibodies Book PDF
✏Book Title : Handbook of Therapeutic Antibodies
✏Author : Stefan Dübel
✏Publisher : John Wiley & Sons
✏Release Date : 2014-12-03
✏Pages : 2544
✏ISBN : 9783527329373
✏Available Language : English, Spanish, And French

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✏Handbook of Therapeutic Antibodies Book Summary : Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content. Volume I covers selection and engineering strategies for new antibodies, while the second volume look at novel therapeutic concepts and antibodies in clinical trial phases, as well as their potential. Volume III features detailed and specific information about each antibody currently approved for therapeutic purposes, including the clinical data. Beyond providing current knowledge, the authors discuss emerging technologies, future developments, and intellectual property issues, such that this handbook meets the needs of academic researchers, decision makers in industry and healthcare professionals in the clinic.

Handbook Of Therapeutic Antibodies Book PDF
✏Book Title : Handbook of Therapeutic Antibodies
✏Author : Stefan Dübel
✏Publisher : John Wiley & Sons
✏Release Date : 2014-12-03
✏Pages : 2544
✏ISBN : 9783527329373
✏Available Language : English, Spanish, And French

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✏Handbook of Therapeutic Antibodies Book Summary : Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content. Volume I covers selection and engineering strategies for new antibodies, while the second volume look at novel therapeutic concepts and antibodies in clinical trial phases, as well as their potential. Volume III features detailed and specific information about each antibody currently approved for therapeutic purposes, including the clinical data. Beyond providing current knowledge, the authors discuss emerging technologies, future developments, and intellectual property issues, such that this handbook meets the needs of academic researchers, decision makers in industry and healthcare professionals in the clinic.

📒Antibody Engineering ✍ Benny K. C. Lo

Antibody Engineering Book PDF
✏Book Title : Antibody Engineering
✏Author : Benny K. C. Lo
✏Publisher : Springer Science & Business Media
✏Release Date : 2004
✏Pages : 561
✏ISBN : 9781592596669
✏Available Language : English, Spanish, And French

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✏Antibody Engineering Book Summary : A core collection of diverse cutting-edge techniques for the generation, expression, optimization, and characterization of recombinant antibodies. Readily reproducible protocols for lead generation range from the cloning of human immunoglobulin genes to the selection and generation of human recombinant antibodies by humanization approaches, molecular display technologies and transgenic animals. Procedures are also described on restructuring antibody leads into monovalent, multivalent, and bispecific binding fragments for a wide variety of in vivo applications. State-of-the-art technologies are described for the characterization of antigen-binding affinity and specificity with novel applications in radioimmunotargeting, cancer immunotherapy, drug abuse, and proteomics. Use cutting-edge techniques for generating and optimizing recombinant antibodies Generate antibodies by humanization, molecular display technologies and transgenic mice Perform epitope mapping with mass spectrometry, bioinformatics, and array technologies Learn about novel applications in cancer, drug addiction, and proteomics Express recombinant antibodies in bacterial, yeast, insect, mammalian and plant systems.

📒Interleukin Twelve ✍ Luciano Adorini

Interleukin Twelve Book PDF
✏Book Title : Interleukin Twelve
✏Author : Luciano Adorini
✏Publisher : Karger Publishers
✏Release Date : 1997
✏Pages : 203
✏ISBN : 3805563566
✏Available Language : English, Spanish, And French

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✏Interleukin Twelve Book Summary : The contributions collected in this volume represent the most recent findings, reviewed by leading scientists in the field, on several different aspects of IL-12 biology. The opening chapter analyzes the molecular regulation of IL-12 production and its immunomodulatory activities. This is followed by three contributions describing the structure of the IL-12 receptor and its role in determining the early events in the differentiation of T cell subsets. The modulation of IL-12 activities by other cytokines such as TGF-Beta, IFN-Gamma and IL-4 is also addressed. IL-12 is a key cytokine that controls infectious diseases and its role in leishmania, candida, and protozoal infections is specifically examined. In addition, IL-12 provides a new tool to explore the regulatory role of the immune system in the control of tumor development and a potential new drug which is already being tested in clinical trials. Finally, the role of IL-12 in Th1-mediated autoimmune diseases and the potential for immunotherapy based on IL-12 targeting is discussed. Collectively, these contributions give a detailed account of the present knowledge on critical aspects of IL-12. The well-edited and stimulating material offered in this volume will be of interest to all immunologists, in particular to those interested in the different facets of the Th1/Th2 dichotomy.

📒Antibody Engineering ✍ Roland E. Kontermann

Antibody Engineering Book PDF
✏Book Title : Antibody Engineering
✏Author : Roland E. Kontermann
✏Publisher : Springer Science & Business Media
✏Release Date : 2010-03-10
✏Pages : 589
✏ISBN : 3642011470
✏Available Language : English, Spanish, And French

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✏Antibody Engineering Book Summary : Antibodies are indispensable tools for research, diagnosis, and therapy. Recombinant approaches allow the modification and improvement of nearly all antibody properties, such as affinity, valency, specificity, stability, serum half-life, effector functions, and immunogenicity. "Antibody Engineering" provides a comprehensive toolbox covering the well-established basics but also many exciting new techniques. The protocols reflect the latest "hands on" knowledge of key laboratories in this still fast-moving field. Newcomers will benefit from the proven step-by-step protocols, which include helpful practical advice; experienced antibody engineers will appreciate the new ideas and approaches. The book is an invaluable resource for all those engaged in antibody research and development.

Antibody Expression And Production Book PDF
✏Book Title : Antibody Expression and Production
✏Author : Mohamed Al-Rubeai
✏Publisher : Springer Science & Business Media
✏Release Date : 2011-05-16
✏Pages : 346
✏ISBN : 940071257X
✏Available Language : English, Spanish, And French

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✏Antibody Expression and Production Book Summary : Engineered antibodies currently represent over 30% of biopharmaceuticals in clinical trials and their total worldwide sales continue to increase significantly. The importance of antibody applications is reflected in their increasing clinical and industrial applications as well as in the progression of established and emerging production strategies. This volume provides detailed coverage of the generation, optimization, characterization, production and applications of antibody. It provides the necessary theoretical background and description of methods for the expression of antibody in microbial and animal cell cultures and in transgenic animals and plants. There is a strong focus on those issues related to the production of intrabodies, bispecific antibody and antibody fragments and also to novel applications in cancer immunotherapy.

📒Proteins ✍ Gary Walsh

Proteins Book PDF
✏Book Title : Proteins
✏Author : Gary Walsh
✏Publisher : John Wiley & Sons
✏Release Date : 2002
✏Pages : 547
✏ISBN : 0471899070
✏Available Language : English, Spanish, And French

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✏Proteins Book Summary : Protein Biotechnology and Biochemistry is a complete and definitive source of information for all those interested in the area, providing a broad overview of the various medical, diagnostic and industrial uses of proteins. It covers basic biochemical principles as well as providing a comprehensive survey of products currently available or under development. * The new edition has been thoroughly updated with new material. * The key difference is that this new edition will include more "pure" biochemistry. * There are two completely new chapters: Protein Structure - an overview and Novel Proteins from Novel Sources. Chapter 2, Protein Structure, an overview and chapter 3, Protein Purification & Characterisation, make up approximately 30% of the book. These chapters concentrate on the basic biochemical principles of proteins and will lay the foundations for the rest of the book. The remaining chapters focus on protein biotechnology and have been rearranged, updated and expanded.

Protein Therapeutics 2 Volume Set Book PDF
✏Book Title : Protein Therapeutics 2 Volume Set
✏Author : Tristan Vaughan
✏Publisher : John Wiley & Sons
✏Release Date : 2017-12-04
✏Pages : 768
✏ISBN : 9783527340866
✏Available Language : English, Spanish, And French

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✏Protein Therapeutics 2 Volume Set Book Summary : In this practice-oriented handbook, professionals from some of the largest biopharmaceutical companies and top academic researchers address the key concepts and challenges in the development of protein pharmaceuticals for medicinal chemists and other professionals working in drug development. Following an introduction tracing the rapid development of the protein therapeutics market over the last decade, all currently used therapeutic protein scaffolds are surveyed, from human and non-human antibodies to antibody mimetics, bispecific antibodies and antibody-drug conjugates. This ready reference then goes on to review other key aspects such as pharmacokinetics, safety and immunogenicity, manufacture, formulation and delivery. The handbook then takes a look at current key clinical applications for protein therapeutics, from respiratory and inflammation to oncology and immune-oncology, infectious diseases and rescue therapy. Finally, several exciting prospects for the future of protein therapeutics are highlighted and discussed.

📒Monoclonal Antibodies ✍ Steven Shire

Monoclonal Antibodies Book PDF
✏Book Title : Monoclonal Antibodies
✏Author : Steven Shire
✏Publisher : Woodhead Publishing
✏Release Date : 2015-04-24
✏Pages : 224
✏ISBN : 9780081002971
✏Available Language : English, Spanish, And French

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✏Monoclonal Antibodies Book Summary : Monoclonal antibodies (MAbs) are currently the major class of protein bio therapeutic being developed by biotechnology and pharmaceutical companies. Monoclonal Antibodies discusses the challenges and issues revolving around development of a monoclonal antibody produced by recombinant DNA technology into a therapeutic agent.This book covers downstream processing which includes design of processes to manufacture the formulation, formulation design, fill and finish into closure systems and routes of administration. The characterization of the final drug product is covered where the use of biophysical methods combined with genetic engineering is used to understand the solution properties of the formulation. The latter has become very important since many indications such as arthritis and asthma require the development of formulations for subcutaneous delivery (SC). The development of formulations for IV delivery is also important and comes with a different set of challenges. The challenges and strategies that can overcome these limitations are discussed in this book, starting with an introduction to these issues, followed by chapters detailing strategies to deal with them. Subsequent chapters explore the processing and storage of mAbs, development of delivery device technologies and conclude with a chapter on the future of mAbs in therapeutic remedies. Discusses the challenges to develop MAbs for intravenous (IV) and subcutaneous delivery (SC) Presents strategies to meet the challenges in development of MAbs for SC and IV administration Discusses the use of biophysical analytical tools coupled with MAb engineering to understand what governs MAb properties at high concentration

Molecular Biology And Biotechnology Book PDF
✏Book Title : Molecular Biology and Biotechnology
✏Author : John M. Walker
✏Publisher : Royal Society of Chemistry
✏Release Date : 2009-01-01
✏Pages : 604
✏ISBN : 9780854041251
✏Available Language : English, Spanish, And French

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✏Molecular Biology and Biotechnology Book Summary : This popular textbook has been revised and updated to provide a comprehensive overview and to reflect the latest developments in this rapidly developing area. Continuing with the broad base style of both current molecular and traditional biotechnology, chapters have been updated to reflect current interest and include new areas such as stem cell technology and important areas in drug discovery such as IP and patents. By presenting information in an easily assimilated form, this book makes an ideal undergraduate text for students of biology and chemistry, as well as to postgraduates.

📒The Antibody Molecule ✍ Anthony R. Rees

The Antibody Molecule Book PDF
✏Book Title : The Antibody Molecule
✏Author : Anthony R. Rees
✏Publisher : OUP Oxford
✏Release Date : 2014-10-30
✏Pages : 384
✏ISBN : 9780191016165
✏Available Language : English, Spanish, And French

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✏The Antibody Molecule Book Summary : The Antibody Molecule follows the extraordinary journey of the medics and scientists who shaped the course of medical advances in the field of immunology. One of the oldest of the medical sciences, immunology has a history that has seen chemists, physicists and biologists alike seeking to unravel the most complex system in the human body outside the brain. This book charts its intriguing history, from the genetic basis of antibody diversity, through the understanding of the mechanism by which the immune system's first line of defence works, to breakthroughs in crystallography and the exploitation of immunoglobulins as therapeutic platforms to treat cancer, inflammation and allergy. Tracing the developments in immunology in chronological order, Professor Anthony R. Rees presents the historical contexts of the periods in rich detail, bringing them to life with quotes and illustrations. This fascinating book examines the literature of the time, turning points, and controversies. A must read for immunologists and life scientists, as well as historians of science and medicine.

📒Monoclonal Antibodies ✍ J. R. Birch

Monoclonal Antibodies Book PDF
✏Book Title : Monoclonal Antibodies
✏Author : J. R. Birch
✏Publisher : Wiley-Liss
✏Release Date : 1995-03-02
✏Pages : 344
✏ISBN : UOM:39015034262322
✏Available Language : English, Spanish, And French

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✏Monoclonal Antibodies Book Summary : General introduction. Applications. Genetic manipulation and expression of antibodies. Modification of antibodies by chemical methods. The production of monoclonal antibodies. Blosafety considerations. Antibody patents.