The Paracellular Channel

• Author : Jianghui Hou
• Publisher : Academic Press
• Release : 08 June 2018

The Paracellular Channel: Biology, Physiology and Disease serves as the first volume to offer a cohesive and unifying picture of the critical functions of paracellular channels (tight junctions) in different tissues. This new class of ion channel utilizes a completely different mechanism to create ion passage pathways across the cell junction. This volume outlines common principles that govern the organization and regulation of these diverse cellular structures, describes the methodology of study, and highlights the pathophysiologic consequence of abnormal structure

• Author : Anonim
• Publisher : Unknown
• Release : 21 May 2022

• Author : Jianghui Hou
• Publisher : Academic Press
• Release : 24 April 2020

A Laboratory Guide to the Tight Junction offers broad coverage of the unique methods required to investigate its characteristics. The methods are described in detail, including its biochemical and biophysical principles, step-by-step process, data analysis, troubleshooting, and optimization. The coverage includes various cell, tissue, and animal models. Chapter 1 provides the foundations of cell biology of tight junction. Chapter 2 covers the Biochemical approaches for paracellular channels and is followed by chapter 3 providing the Biophysical approaches. Chapter 4 describes and discusses Histological approaches

• Author : Armin Kargol
• Publisher : Morgan & Claypool Publishers
• Release : 13 December 2019

All living matter is comprised of cells, small compartments isolated from the environment by a cell membrane and filled with concentrated solutions of various organic and inorganic compounds. Some organisms are single-cell, where all life functions are performed by that cell. Others have groups of cells, or organs, specializing in one particular function. The survival of the entire organism depends on all of its cells and organs fulfilling their roles. While the cells are studied by different sciences, they are

• Author : František Baluška,Dieter Volkmann,Peter W. Barlow
• Publisher : Springer Science & Business Media
• Release : 10 August 2007

he biological sciences are dominated by the idea that cells are the functionally autonomous, physically separated, discrete units of life. TThis concept was propounded in the 19th century by discoveries of the cellular structuring of both plants and animals. Moreover, the ap parent autonomy of unicellular eukaryotes, as well as the cellular basis of the mammalian brain (an organ whose anatomy for a long while defied attempts to validate the idea of the cellular nature of its neurons), seemed to

• Author : Stevo Najman
• Publisher : BoD – Books on Demand
• Release : 25 April 2012

A numerous internationally renowned authors in the pages of this book present the views of the fields of cell biology and their own research results or review of current knowledge. Chapters are divided into five sections that are dedicated to cell structures and functions, genetic material, regulatory mechanisms, cellular biomedicine and new methods in cell biology. Multidisciplinary and often quite versatile approach by many authors have imposed restrictions of this classification, so it is certain that many chapters could belong

• Author : Kwang W. Jeon
• Publisher : Elsevier
• Release : 20 February 2006

International Review of Cytology presents current advances and comprehensive reviews in cell biology – both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Articles in this volume address new insights into fatty acid modulation of pancreatic beta cell function; drosophila RNA binding proteins; plasticity of pelvic autonomic ganglia and urogenital innervation; vomeronasal vs. olifactory epithelium: cellular basis for human vomeronasal perception; and tight junctions.

• Author : Anonim
• Publisher : Academic Press
• Release : 23 October 2019

Drug Delivery Systems examines the current state of the field within pharmaceutical science and concisely explains the history of drug delivery systems, including key developments. The book translates the physicochemical properties of drugs into drug delivery systems administered via various routes, such as oral, parenteral, transdermal and inhalational. Regulatory and product development topics are also explored. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of drug delivery

• Author : Alan S. L. Yu,Glenn M. Chertow,Valerie Luyckx,Philip A. Marsden,Karl Skorecki,Maarten W. Taal
• Publisher : Elsevier Health Sciences
• Release : 25 October 2015

Overcome the toughest clinical challenges in nephrology with Brenner & Rector’s The Kidney -- the most well-known nephrology resource in the world. A diverse team of more than 200 international contributors brings you the latest knowledge and best practices on every front in nephrology worldwide. From basic science and pathophysiology to clinical best practices, Brenner & Rector’s The Kidney is your go-to resource for any stage of your career. Review of the basic science that underpins clinical nephrology, comprehensive selection of

• Author : Michael Fromm,Jörg-Dieter Schulzke
• Publisher : Wiley-Blackwell
• Release : 19 June 2012

Tight junctions between epithelial and endothelial cells form selective barriers and paracellular channels and regulate paracellular transport of solutes, immune cells, and drugs. More specifically, tight junctions consist of proteins that laterally interconnect neighboring cells of epithelia and endothelia. Certain proteins seal the tight junction, so that a nearly impermeable barrier develops, whereas others form channels that allow for permeation between the cells. Recent investigations have focused on tight junction proteins, belonging to the claudin family (claudins-1 to -27 in

• Author : Fredric Coe,Elaine M Worcester,James E Lingeman,Andrew P Evan
• Publisher : Jaypee Brothers Medical Publishers
• Release : 30 September 2019

This book is the new edition of this comprehensive guide to the medical and surgical management of kidney stones. Divided into three main sections, the text begins with discussion on the basic formation of kidney stones, followed by mineral metabolism and diseases that lead to the formation of stones, with the final section describing surgical management techniques. The second edition has been thoroughly revised and expanded with new topics including imaging methods, non invasive surgical techniques, and management in special

• Author : Anonim
• Publisher : Academic Press
• Release : 04 May 1999

Sodium reabsorbing epithelia play a major role in whole-body sodium homeostasis. Some examples of sodium regulating tissues include kidney, colon, lung, and sweat ducts. Sodium transport across these membranes is a two-step process: entry through an amiloride-sensitive sodium channel and exit via the ouabain-sensitive sodium/potassium ATPase. The sodium entry channels are the rate-limiting determinant for transport and are regulated by several different hormones. The sodium channels also play a significant role in a number of disease states, like hypertension,

• Author : Phillip D. Smith,Richard S. Blumberg,Thomas T. MacDonald,Society for Mucosal Immunology
• Publisher : Garland Science
• Release : 21 April 2020

This respected graduate-level textbook provides comprehensive and accessible coverage of the basic and clinical aspects of the mucosal immune system, addressing the major components of the mucosal barrier ̶ gastrointestinal, upper and lower respiratory, ocular, and genitourinary mucosal immune systems ̶ in a highly user-friendly style. The editors of and contributors to the book, all internationally-recognized leaders, present the current principles, concepts, and basic processes involved in mucosal immunology, mucosal diseases, and host defense at mucosal surfaces. Topics discussed include the development

• Author : David Proud
• Publisher : John Wiley & Sons
• Release : 30 April 2008

"This is essential reading for everyone who would like to update their knowledge of the pulmonary epithelium. It offers a comparison between laboratory animal models and human lungs, highlighting the differences and the similarities between the two, which will be particularly useful to researchers." –Doody's, April 2009 The past two decades have seen extraordinary advances in our understanding of the role of the pulmonary epithelium in airway health and disease. Our understanding of epithelial biology has expanded exponentially in the past

• Author : Michael Fromm,Susanne M. Krug
• Publisher : MDPI
• Release : 20 November 2020

For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ—mainly the two families of claudins and TAMPs—several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the