The Orexin Hypocretin System

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  • Author : Seiji Nishino
  • Publisher : Springer Science & Business Media
  • Pages : 416 pages
  • ISBN : 1592599508
  • Rating : /5 from reviews
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Download or Read online The Orexin Hypocretin System full in PDF, ePub and kindle. this book written by Seiji Nishino and published by Springer Science & Business Media which was released on 22 November 2007 with total page 416 pages. We cannot guarantee that The Orexin Hypocretin System book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Impairment of orexin/hypocretin signaling causes narcolepsy-cataplexy in animals and humans. Most human narcolepsy-cataplexy cases are associated with orexin/hypocretin ligand deficiency, which can be detected clinically using cerebrospinal orexin/hypocretin measures and may lead to future treatments with orexin/hypocretin replacement therapy. In The Orexin/Hypocretin System: Physiology and Pathophysiology, leading researchers and clinicians review these exciting developments to set the stage for further research on the loss of orexin/hypocretin neurons in humans, regulation of sleep and wakefulness by the orexin/hypocretin system, and the role of the orexin/hypocretin system in many other physiological processes, including feeding, autonomic regulation, and neuroendocrine regulation. Topics of interest include an assessment of the functions and the physiology of orexin/hypocretin, its pathophysiology in human narcolepsy-cataplexy, and possible pharmacological treatments. The authors also introduce several experimental methods for orexin/hypocretin research, and, using multidisciplinary approaches, explain their uses and limitations. Authoritative and state-of-the-art, The Orexin/Hypocretin System: Physiology and Pathophysiology will aid scientists in the search for novel bioactive peptides and their receptors, as well as novel physiological insights and opportunities for the clinical treatment of not only narcolepsy, but also a broad range of diseases associated with endocrine, feeding, and body weight regulation.

The Orexin Hypocretin System

The Orexin Hypocretin System
  • Author : Seiji Nishino,Takeshi Sakurai
  • Publisher : Springer Science & Business Media
  • Release : 22 November 2007
GET THIS BOOK The Orexin Hypocretin System

Impairment of orexin/hypocretin signaling causes narcolepsy-cataplexy in animals and humans. Most human narcolepsy-cataplexy cases are associated with orexin/hypocretin ligand deficiency, which can be detected clinically using cerebrospinal orexin/hypocretin measures and may lead to future treatments with orexin/hypocretin replacement therapy. In The Orexin/Hypocretin System: Physiology and Pathophysiology, leading researchers and clinicians review these exciting developments to set the stage for further research on the loss of orexin/hypocretin neurons in humans, regulation of sleep and wakefulness

The Orexin Hypocretin System

The Orexin Hypocretin System
  • Author : Jim R. Fadel,Joshua A. Burk
  • Publisher : Academic Press
  • Release : 03 January 2019
GET THIS BOOK The Orexin Hypocretin System

The Orexins/Hypocretins System: Functional Roles and Therapeutic Potential summarizes research on both the physiological functioning of orexins, their impact on homeostatic processes, and related disorders. The book encompasses the effects on appetite, sleep, substance abuse, cognition, and anxiety. Additionally, it examines new therapeutic approaches utilizing orexins, including utilization of orexin receptors for drug development. It is essential reading for neuroscience researchers interested in brain-behavior relationships, as well as psychiatrists, endocrinologists and pharmacologists. Provides an overview of new research on

The Orexin hypocretin System

The Orexin hypocretin System
  • Author : Anantha Shekhar
  • Publisher : Elsevier
  • Release : 03 December 2021
GET THIS BOOK The Orexin hypocretin System

"In The Orexin/Hypocretin System: Physiology and Pathophysiology, leading researchers and clinicians set the stage for further research on the loss of orexin/hypocretin neurons in humans, regulation of sleep and wakefulness by the orexin/hypocretin system, and the role of the orexin/hypocretin system in many other physiological processes, including feeding, autonomic regulation, and neuroendocrine regulation. Topics of interest include an assessment of the functions and the physiology of orexin/hypocretin, its pathophysiology in human narcolepsy-cataplexy, and possible pharmacological

Behavioral Neuroscience of Orexin Hypocretin

Behavioral Neuroscience of Orexin Hypocretin
  • Author : Andrew J Lawrence,Luis de Lecea
  • Publisher : Springer
  • Release : 29 May 2017
GET THIS BOOK Behavioral Neuroscience of Orexin Hypocretin

This issue of Current Topics in Behavioral Neuroscience focuses on the neuropeptide orexin (hypocretin) and brings together scientists from around the world who will provide a timely discussion of how this peptide regulates behavior. This is a fast-moving field, and with the incorporation of novel technologies, new breakthroughs are likely to continue. For example, the use of optogenetic approaches has enabled the identification of the role of orexin-containing neurons in arousal states, critical for higher order functioning. From a clinical

Insomnia and beyond Exploring the therapeutic potential of orexin receptor antagonists

Insomnia and beyond   Exploring the therapeutic potential of orexin receptor antagonists
  • Author : Michel Alexander Steiner,Christopher J Winrow
  • Publisher : Frontiers E-books
  • Release : 11 November 2014
GET THIS BOOK Insomnia and beyond Exploring the therapeutic potential of orexin receptor antagonists

Orexin/hypocretin neuropeptides, produced by a few thousand neurons in the lateral hypothalamus, are of critical importance for the control of vigilance and arousal of vertebrates, from fish to amphibians, birds and mammals. Two orexin peptides, called orexin-A and orexin-B, exist in mammals. They bind with different affinities to two distinct, widely distributed, excitatory G-protein- coupled receptors, orexin receptor type 1 and type 2 (OXR-1/2). The discovery of an OXR mutation causing canine narcolepsy, the narcolepsy-like phenotype of orexin peptide knockout mice,

Sleep and Movement Disorders

Sleep and Movement Disorders
  • Author : Sudhansu Chokroverty,Richard P. Allen,Arthur S. Walters,Pasquale Montagna
  • Publisher : Oxford University Press
  • Release : 01 April 2012
GET THIS BOOK Sleep and Movement Disorders

Sleep and Movement Disorders is the second edition of a successful book that was the first of its kind. Since its publication in 2002, significant progress has been made in our understanding of motor control in sleep and the relationship between sleep and movement disorders. Each editor is an authority on the subject and has assembled expert specialists for their chapter authors. The topic is very timely, the latest edition of the International classification of sleep disorders (ICSD-2, 2005) included a separate

The Orexin System Basic Science and Role in Sleep Pathology

The Orexin System  Basic Science and Role in Sleep Pathology
  • Author : M.A. Steiner,M. Yanagisawa,M. Clozel
  • Publisher : Karger Medical and Scientific Publishers
  • Release : 28 May 2021
GET THIS BOOK The Orexin System Basic Science and Role in Sleep Pathology

The orexin system, discovered in 1998, has emerged as a crucial player in regulating the sleep and wake balance inside our brain. This discovery has sparked a burst of novel and dynamic research on the physiology and pathology of sleep. The Orexin System: Basic Science and Role in Sleep Pathology honors this research and the authors share their ideas and perspectives on the novel developments within the field. The book examines the intricate role of the orexin system in regulating sleep

Hypocretins

Hypocretins
  • Author : Luis De Lecea,J. Gregor Sutcliffe
  • Publisher : Springer Science & Business Media
  • Release : 25 April 2007
GET THIS BOOK Hypocretins

The first report that rapid eye movements occur in sleep in humans was published in 1953. The research journey from this point to the realization that sleep consists of two entirely independent states of being (eventually labeled REM sleep and non-REM sleep) was convoluted, but by 1960 the fundamental duality of sleep was well established including the description of REM sleep in cats associated with “wide awake” EEG patterns and EMG suppression. The first report linking REM sleep to a pathology occurred

Issues in Brain and Cognition Research 2013 Edition

Issues in Brain and Cognition Research  2013 Edition
  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release : 01 May 2013
GET THIS BOOK Issues in Brain and Cognition Research 2013 Edition

Issues in Brain and Cognition Research / 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Cerebral Blood Flow and Metabolism. The editors have built Issues in Brain and Cognition Research: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cerebral Blood Flow and Metabolism in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in

The Science of Sleep

The Science of Sleep
  • Author : Wallace B. Mendelson
  • Publisher : University of Chicago Press
  • Release : 06 October 2017
GET THIS BOOK The Science of Sleep

From Ivy: We are sleeping less and less: statistics show that insomnia has reached pandemic proportions, and costs healthcare providers billions. Most of us spend a third of our lives asleep--our bodies insist on sleep; without it, we die. But why we sleep still remains relatively mysterious. The Science of Sleep explains the elements of the sleep state and explores the various sleep disorders and how their available treatments work. By offering an accessible account of sleep science, the book

The Human Nervous System

The Human Nervous System
  • Author : Juergen K. Mai,George Paxinos
  • Publisher : Academic Press
  • Release : 13 December 2011
GET THIS BOOK The Human Nervous System

The previous two editions of the Human Nervous System have been the standard reference for the anatomy of the central and peripheral nervous system of the human. The work has attracted nearly 2,000 citations, demonstrating that it has a major influence in the field of neuroscience. The 3e is a complete and updated revision, with new chapters covering genes and anatomy, gene expression studies, and glia cells. The book continues to be an excellent companion to the Atlas of the Human