The Orexin Hypocretin System

Orexin Hypocretin System Book PDF
✏Book Title : Orexin Hypocretin System
✏Author :
✏Publisher : Elsevier
✏Release Date : 2012-11-27
✏Pages : 208
✏ISBN : 9780444594907
✏Available Language : English, Spanish, And French

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✏Orexin Hypocretin System Book Summary : Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research. Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered. All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist. Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

The Orexin Hypocretin System Book PDF
✏Book Title : The Orexin Hypocretin System
✏Author : Seiji Nishino
✏Publisher : Springer Science & Business Media
✏Release Date : 2007-11-22
✏Pages : 416
✏ISBN : 9781592599509
✏Available Language : English, Spanish, And French

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✏The Orexin Hypocretin System Book Summary : Impairment of orexin/hypocretin signaling causes narcolepsy-cataplexy in animals and humans. Most human narcolepsy-cataplexy cases are associated with orexin/hypocretin ligand deficiency, which can be detected clinically using cerebrospinal orexin/hypocretin measures and may lead to future treatments with orexin/hypocretin replacement therapy. In The Orexin/Hypocretin System: Physiology and Pathophysiology, leading researchers and clinicians review these exciting developments to set the stage for further research on the loss of orexin/hypocretin neurons in humans, regulation of sleep and wakefulness by the orexin/hypocretin system, and the role of the orexin/hypocretin system in many other physiological processes, including feeding, autonomic regulation, and neuroendocrine regulation. Topics of interest include an assessment of the functions and the physiology of orexin/hypocretin, its pathophysiology in human narcolepsy-cataplexy, and possible pharmacological treatments. The authors also introduce several experimental methods for orexin/hypocretin research, and, using multidisciplinary approaches, explain their uses and limitations. Authoritative and state-of-the-art, The Orexin/Hypocretin System: Physiology and Pathophysiology will aid scientists in the search for novel bioactive peptides and their receptors, as well as novel physiological insights and opportunities for the clinical treatment of not only narcolepsy, but also a broad range of diseases associated with endocrine, feeding, and body weight regulation.

The Orexin Hypocretin System Book PDF
✏Book Title : The Orexin Hypocretin System
✏Author : Jim R. Fadel
✏Publisher : Academic Press
✏Release Date : 2019-01-03
✏Pages : 188
✏ISBN : 9780128137529
✏Available Language : English, Spanish, And French

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✏The Orexin Hypocretin System Book Summary : The Orexins/Hypocretins System: Functional Roles and Therapeutic Potential summarizes research on both the physiological functioning of orexins, their impact on homeostatic processes, and related disorders. The book encompasses the effects on appetite, sleep, substance abuse, cognition, and anxiety. Additionally, it examines new therapeutic approaches utilizing orexins, including utilization of orexin receptors for drug development. It is essential reading for neuroscience researchers interested in brain-behavior relationships, as well as psychiatrists, endocrinologists and pharmacologists. Provides an overview of new research on orexins/hypocretins Includes an overview of intracellular signaling and orexin physiology Discusses the effects on arousal, appetite, cognition, addiction and anxiety Examines orexin based therapies and their potential use in disorders Explores orexin receptors for drug development

The Orexin Hypocretin System Book PDF
✏Book Title : The Orexin Hypocretin System
✏Author : Jim R. Fadel
✏Publisher : Academic Press
✏Release Date : 2019-01-30
✏Pages : 190
✏ISBN : 0128137517
✏Available Language : English, Spanish, And French

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✏The Orexin Hypocretin System Book Summary : The Orexins/Hypocretins System: Functional Roles and Therapeutic Potential summarizes research on both the physiological functioning of orexins, their impact on homeostatic processes, and related disorders. The book encompasses the effects on appetite, sleep, substance abuse, cognition, and anxiety. Additionally, it examines new therapeutic approaches utilizing orexins, including utilization of orexin receptors for drug development. It is essential reading for neuroscience researchers interested in brain-behavior relationships, as well as psychiatrists, endocrinologists and pharmacologists. Provides an overview of new research on orexins/hypocretins Includes an overview of intracellular signaling and orexin physiology Discusses the effects on arousal, appetite, cognition, addiction and anxiety Examines orexin based therapies and their potential use in disorders Explores orexin receptors for drug development

Insomnia And Beyond Exploring The Therapeutic Potential Of Orexin Receptor Antagonists Book PDF
✏Book Title : Insomnia and beyond Exploring the therapeutic potential of orexin receptor antagonists
✏Author : Michel Alexander Steiner
✏Publisher : Frontiers E-books
✏Release Date : 2014-11-11
✏Pages :
✏ISBN : 9782889193301
✏Available Language : English, Spanish, And French

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✏Insomnia and beyond Exploring the therapeutic potential of orexin receptor antagonists Book Summary : Orexin/hypocretin neuropeptides, produced by a few thousand neurons in the lateral hypothalamus, are of critical importance for the control of vigilance and arousal of vertebrates, from fish to amphibians, birds and mammals. Two orexin peptides, called orexin-A and orexin-B, exist in mammals. They bind with different affinities to two distinct, widely distributed, excitatory G-protein- coupled receptors, orexin receptor type 1 and type 2 (OXR-1/2). The discovery of an OXR mutation causing canine narcolepsy, the narcolepsy-like phenotype of orexin peptide knockout mice, and the orexin neuron loss associated with human narcoleptic patients laid the foundation for the discovery of small molecule OXR antagonists as novel treatments for sleep disorders. Proof of concept studies from Glaxo Smith Kline, Actelion Pharmaceuticals Ltd. and Merck have now consistently demonstrated the efficacy of dual OXR antagonists (DORAs) in promoting sleep in rodents, dogs, non-human primates and humans. Some of these antagonists have completed late stage clinical testing in primary insomnia. Orexin drug discovery programs have also been initiated by other large pharmaceutical companies including Hoffmann La Roche, Novartis, Eli Lilly and Johnson & Johnson. Orexins are increasingly recognized for orchestrating the activity of the organism’s arousal system with appetite, reward and stress processing pathways. Therefore, in addition to models of insomnia, pharmacological effects of DORAs have begun to be investigated in rodent models of addiction, depression and anxiety. The first clinical trials in diabetic neuropathy, migraine and depression have been initiated with Merck’s MK-6096 (www.clinicaltrials.gov). Whereas the pharmacology of DORAs is established for their effects on wakefulness, pharmacological effects of selective OXR-1 or OXR-2 antagonists (SORAs) have remained less clear. From an evolutionary point of view, the OXR-2 was expressed first in most vertebrate lineages, whereas the OXR-1 is believed to result from a gene duplication event, when mammals emerged. Yet, both receptors do not have redundant function. Their brain expression pattern, their intracellular signaling, as well as their affinity for orexin-A and orexin-B differs. During the past decade most preclinical research on selective OXR-1 antagonism was performed with SB-334867. Only in recent years, other selective OXR-1 and OXR-2 antagonists with optimized selectivity profiles and pharmacokinetic properties have been discovered, and phenotypes of OXR-1 and OXR-2 knockout mice were described. The present Research Topic (referred to in the Editorial as “special topics issue”) comprises submissions of original research manuscripts as well as reviews, directed towards the neuropharmacology of OXR antagonists. The submissions are preclinical papers dealing with dual and/or selective OXR antagonists that shed light on the differential contribution of endogenous orexin signaling through both OXRs for cellular, physiological and behavioral processes. Some manuscripts also report on convergence or divergence of DORA vs. SORA effects with phenotypes expressed by OXR-1 or OXR-2 knockout animals. Ultimately these findings may help further define the potential of DORAs and SORAs in particular therapeutic areas in insomnia and beyond insomnia.

Involvement Of The Hypocretin Orexin System In The Addictive Properties Of Nicotine Book PDF
✏Book Title : Involvement of the Hypocretin orexin System in the Addictive Properties of Nicotine
✏Author : Ainhoa Plaza-Zabala
✏Publisher :
✏Release Date : 2012
✏Pages : 347
✏ISBN : OCLC:1120382877
✏Available Language : English, Spanish, And French

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✏Involvement of the Hypocretin orexin System in the Addictive Properties of Nicotine Book Summary : Hypocretin-1 and hypocretin-2, also known as orexin-A and orexin-B, are 2 neuropeptides that are exclusively expressed by a small subset of neurons of the lateral hypothalamic area. Despite their restricted expression pattern, hypocretin-containing axons project widely throughout the brain and exert their physiological functions acting on 2 G protein coupled receptors, hypocretin/orexin receptor-1 and hypocretin/orexin receptor-2. Initially, the hypocretin system was related to the regulation of sleep/wake cycles and feeding behavior. Nevertheless, a growing body of evidence has accumulated over the last decade indicating a role for these neuropeptides in drug addiction. In the present thesis, we have evaluated the involvement of hypocretin transmission in the addictive properties of nicotine, the main psychoactive component that sustains tobacco addiction, by using behavioral and biochemical approaches. Our results indicate that hypocretin peptides, mainly through their actions upon hypocretin receptor-1, influence the severity of nicotine withdrawal and modulate the relapse to nicotine-seeking after prolonged periods of abstinence. Given the importance of withdrawal and relapse on the pathophysiology of nicotine addiction, we propose hypocretin receptor-1 as a promising therapeutic target for the development of novel smoking cessation therapies.

📒Orexin And Sleep ✍ Takeshi Sakurai

Orexin And Sleep Book PDF
✏Book Title : Orexin and Sleep
✏Author : Takeshi Sakurai
✏Publisher : Springer
✏Release Date : 2015-09-22
✏Pages : 410
✏ISBN : 9783319230788
✏Available Language : English, Spanish, And French

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✏Orexin and Sleep Book Summary : This volume is intended for neuropharmacologists, psychopharmacologists, pharmacologists, pharmacists, sleep researchers, translational neuroscience researchers, and other basic researchers and clinical scientists interested in an interdisciplinary approach to sleep medicine. The level of the book is aiming at CNS researchers, drug development scientists, basic and clinical sleep researchers, as well as senior medical students and fellows in psychiatry and neurology. Orexin and Sleep provides a unique resource, giving a comprehensive and highly readable summary of the basic concepts in orexin biology and pharmacology along with clinical applications in sleep medicine in general, and narcolepsy in particular.

📒Hypocretins ✍ Luis De Lecea

Hypocretins Book PDF
✏Book Title : Hypocretins
✏Author : Luis De Lecea
✏Publisher : Springer Science & Business Media
✏Release Date : 2007-04-25
✏Pages : 441
✏ISBN : 9780387254463
✏Available Language : English, Spanish, And French

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✏Hypocretins Book Summary : The first report that rapid eye movements occur in sleep in humans was published in 1953. The research journey from this point to the realization that sleep consists of two entirely independent states of being (eventually labeled REM sleep and non-REM sleep) was convoluted, but by 1960 the fundamental duality of sleep was well established including the description of REM sleep in cats associated with “wide awake” EEG patterns and EMG suppression. The first report linking REM sleep to a pathology occurred in 1961 and a clear association of sleep onset REM periods, cataplexy, hypnagogic hallucinations and sleep paralysis was fully established by 1966. When a naïve individual happens to observe a full-blown cataplexy attack, it is both dramatic and unnerving. Usually the observer assumes that the loss of muscle tone represents syncope or seizure. In order to educate health professionals and the general public, Christian Guilleminault and I made movies of full-blown cataplectic episodes (not an easy task). We showed these movies of cataplexy attacks to a number of professional audiences, and were eventually rewarded with the report of a similar abrupt loss of muscle tone in a dog. We were able to bring the dog to Stanford University and with this as the trigger, we were able to develop the Stanford Canine Narcolepsy Colony. Breeding studies revealed the genetic determinants of canine narcolepsy, an autosomal recessive gene we termed canarc1. Emmanuel Mignot took over the colony in 1986 and began sequencing DNA, finally isolating canarc1 in 1999.

Interactions Of The Orexin Hypocretin Neurones And The Histaminergic System Book PDF
✏Book Title : Interactions of the Orexin hypocretin Neurones and the Histaminergic System
✏Author :
✏Publisher :
✏Release Date : 2014
✏Pages :
✏ISBN : OCLC:1051373414
✏Available Language : English, Spanish, And French

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✏Interactions of the Orexin hypocretin Neurones and the Histaminergic System Book Summary : Abstract Histaminergic and orexin/hypocretin systems are components in the brain wake‐promoting system. Both are affected in the sleep disorder narcolepsy, but the role of histamine in narcolepsy is unclear. The histaminergic neurones are activated by the orexin/hypocretin system in rodents, and the development of the orexin/hypocretin neurones is bidirectionally regulated by the histaminergic system in zebrafish. This review summarizes the current knowledge of the interactions of these two systems in normal and pathological conditions in humans and different animal models.

Sleep Hormones Book PDF
✏Book Title : Sleep Hormones
✏Author :
✏Publisher : Academic Press
✏Release Date : 2012-05-25
✏Pages : 464
✏ISBN : 9780123948397
✏Available Language : English, Spanish, And French

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✏Sleep Hormones Book Summary : First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. This volume focuses on sleep hormones. Contributions from leading authorities Informs and updates on all the latest developments in the field

Advances In Limbic System Research And Application 2013 Edition Book PDF
✏Book Title : Advances in Limbic System Research and Application 2013 Edition
✏Author :
✏Publisher : ScholarlyEditions
✏Release Date : 2013-06-21
✏Pages : 107
✏ISBN : 9781481670913
✏Available Language : English, Spanish, And French

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✏Advances in Limbic System Research and Application 2013 Edition Book Summary : Advances in Limbic System Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about ZZZAdditional Research. The editors have built Advances in Limbic System Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Limbic System Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Encyclopedia Of Behavioral Neuroscience Book PDF
✏Book Title : Encyclopedia of Behavioral Neuroscience
✏Author :
✏Publisher : Elsevier
✏Release Date : 2010-06-03
✏Pages : 1816
✏ISBN : 9780080453965
✏Available Language : English, Spanish, And French

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✏Encyclopedia of Behavioral Neuroscience Book Summary : Behavioral Neuroscientists study the behavior of animals and humans and the neurobiological and physiological processes that control it. Behavior is the ultimate function of the nervous system, and the study of it is very multidisciplinary. Disorders of behavior in humans touch millions of people’s lives significantly, and it is of paramount importance to understand pathological conditions such as addictions, anxiety, depression, schizophrenia, autism among others, in order to be able to develop new treatment possibilities. Encyclopedia of Behavioral Neuroscience is the first and only multi-volume reference to comprehensively cover the foundation knowledge in the field. This three volume work is edited by world renowned behavioral neuroscientists George F. Koob, The Scripps Research Institute, Michel Le Moal, Université Bordeaux, and Richard F. Thompson, University of Southern California and written by a premier selection of the leading scientists in their respective fields. Each section is edited by a specialist in the relevant area. The important research in all areas of Behavioral Neuroscience is covered in a total of 210 chapters on topics ranging from neuroethology and learning and memory, to behavioral disorders and psychiatric diseases. The only comprehensive Encyclopedia of Behavioral Neuroscience on the market Addresses all recent advances in the field Written and edited by an international group of leading researchers, truly representative of the behavioral neuroscience community Includes many entries on the advances in our knowledge of the neurobiological basis of complex behavioral, psychiatric, and neurological disorders Richly illustrated in full color Extensively cross referenced to serve as the go-to reference for students and researchers alike The online version features full searching, navigation, and linking functionality An essential resource for libraries serving neuroscientists, psychologists, neuropharmacologists, and psychiatrists

📒Sleep Disorders Medicine E Book ✍ Sudhansu Chokroverty

Sleep Disorders Medicine E Book Book PDF
✏Book Title : Sleep Disorders Medicine E Book
✏Author : Sudhansu Chokroverty
✏Publisher : Elsevier Health Sciences
✏Release Date : 2009-09-09
✏Pages : 750
✏ISBN : 9780702039089
✏Available Language : English, Spanish, And French

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✏Sleep Disorders Medicine E Book Book Summary : Dr. Sudhansu Chokroverty—a world-recognized expert in sleep medicine—presents the third edition of Sleep Disorders Medicine for the latest developments in this rapidly expanding specialty, with coverage of neuroscience and clinical application. In addition to summarizing basic science and important technological aspects of diagnosis and treatment, this edition presents new chapters—on sleep and memory consolidation, neuroimaging, and more—in a color layout that makes it easy to access the latest advances in the field. The text’s manageable size and logical, multi-disciplinary approach make it the right choice for newcomers and experienced clinicians alike. Covers all aspects of sleep medicine in a practical, logical format divided into three sections: the basic science of sleep physiology, neuroanatomy, and biochemistry; the technical methods of recording; and a clinical approach to patients with sleep complaints. Represents the breadth of knowledge across disciplines through the contributions of 50 prominent names in the field of sleep medicine. Provides a multidisciplinary approach to the diagnosis and management of sleep disorders with coverage of related fields such as pulmonology, otolaryngology, and psychiatry. Includes a Glossary of Terms adapted from the American Sleep Disorders Association for quick reference to the sleep terminology used throughout the text. Demonstrates how recent basic science advances affect clinical medicine through new chapters on Sleep Deprivation and Sleepiness; Sleep and Memory Consolidation; Neuroimaging in Sleep and Sleep Disorders; Nutrition and Sleep; Nature and Treatment of Insomnia; Evolution of Sleep from Birth through Adolescence; Sleep-Disordered Breathing in Children and Women’s Sleep. Improves on the clarity and consistency of the text with a new, completely redrawn art program, including full-color illustrations in the clinical section that enhances diagnostic material.

Biology Of Sleep An Issue Of Sleep Medicine Clinics E Book Book PDF
✏Book Title : Biology of Sleep An Issue of Sleep Medicine Clinics E Book
✏Author : Teofilo Lee-Chiong, Jr
✏Publisher : Elsevier Health Sciences
✏Release Date : 2012-10-01
✏Pages : 240
✏ISBN : 9781455747313
✏Available Language : English, Spanish, And French

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✏Biology of Sleep An Issue of Sleep Medicine Clinics E Book Book Summary : This issue of Sleep Medicine Clinics, Guest Edited by Teofilo Lee-Chiong MD, will focus on Biology of Sleep, with article topics including: Neurology of Sleep; Normal Sleep and Circadian Rhythms: Neurobiologic Mechanisms Underlying Sleep and Wakefulness; Physiology of Sleep Disordered Breathing; Evaluation of the Patient Who Has Sleep Complaints: A Case-Based Method Using the Sleep Process Matrix; Sleep States,Memory Processing, and Dreams; Neurobiologic Mechanisms in Chronic Insomnia; Sleep Behavior and Sleep Regulation from Infancy through Adolescence: Normative Aspects; Biological Timekeeping; Neurologic Basis of Sleep Breathing Disorders; Genetics of Sleep Timing, Duration, and Homeostasis in Humans; Sleep in Normal Aging; Modulation of Endocrine Function by Sleep-Wake Homeostasis and Circadian Rhythmicity; Cardiac Activity and Sympathovagal Balance During Sleep; Sleep and Cytokines; Neuropharmacology of Sleep and Wakefulness; Staging Sleep; Respiratory Physiology During Sleep; and Cyclic Alternating Pattern (CAP), Sleep Disordered Breathing, and Automatic Analysis.

The Brain And Host Defense Book PDF
✏Book Title : The Brain and Host Defense
✏Author :
✏Publisher : Elsevier
✏Release Date : 2009-12-24
✏Pages : 358
✏ISBN : 0444535454
✏Available Language : English, Spanish, And French

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✏The Brain and Host Defense Book Summary : It is now well recognized that the brain, and especially the hypothalamus, plays an important role in the regulation of immune reactions and inflammation. This book aims to review our current state of knowledge of this important field. Key historical findings are presented, and the reciprocal interactions between the brain and the immune system are examined. Particular emphasis is placed on inflammation, a critical host defense reaction that serves as an effector response for both the adaptive and innate immune systems. Mechanisms implicated in brain defense, as well as in more general host defense, are discussed. The regulatory influences of the brain on inflammatory responses are included with particular reference to the role of the hypothalamus, which is also the main director the hormonal regulation of immune/inflammatory. Gender-related differences in immune responsiveness, circadian modulator of immune responses, and evidence that behavioral conditioning (e.g. reward) of immune responses is possible are used as examples to reinforce the notion that the neuroendocrine system exerts a fundamental and complex regulatory influence on the immune system. * Presents timely issues such as immunological aspects of the blood-brain-barrier and the role of inflammatory mediators in the evolution of strokes and degenerative diseases * Includes analysis of the role of the brain in the adaptive responses to disease * Evaluates the argument that further knowledge of the influence of the brain on the immune system will provide new insights to the pathophysiology infectious and autoimmune diseases

Genetics And Sleep An Issue Of Sleep Medicine Clinics E Book Book PDF
✏Book Title : Genetics and Sleep An Issue of Sleep Medicine Clinics E Book
✏Author : Allan Pack
✏Publisher : Elsevier Health Sciences
✏Release Date : 2011-07-22
✏Pages : 144
✏ISBN : 9781455712007
✏Available Language : English, Spanish, And French

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✏Genetics and Sleep An Issue of Sleep Medicine Clinics E Book Book Summary : This issue describes in detail the most current thinking on the way genes affect and determine sleep patterns, behaviors, disorders and needs. Sleep researchers continue to study genetic markers that may someday lead to a personalized approach to treatment of sleep disorders. The genetics of restless legs syndrome, narcolepsy, circadian rhythm disorders, obstructive sleep apnea, parasomnias, and insomnia are discussed. A solid understanding of the role genetics and molecular biology play in sleep will aid clinicians in diagnosing and treating these disorders, as well as advising their patients.

Sleep In Childhood Neurological Disorders Book PDF
✏Book Title : Sleep in Childhood Neurological Disorders
✏Author : Suresh Kotagal, MD
✏Publisher : Demos Medical Publishing
✏Release Date : 2011-01-27
✏Pages : 362
✏ISBN : 9781935281559
✏Available Language : English, Spanish, And French

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✏Sleep in Childhood Neurological Disorders Book Summary : Sleep in Childhood Neurological Disorders addresses the myriad sleep-wake issues associated with neurological disturbances from the newborn period through adolescence. The editors and contributing authors are internationally recognized authorities who cover everything from sleep and ADHD, headaches, restless leg syndrome, parasomnias, hypersomnias, autism, brain tumors, epilepsy, traumatic brain injury, and other primary disorders to sleep co-morbidities, assessment, testing, interventions, pharmacology and more. The first book devoted to the growing field of pediatric neurosomnology, Sleep in Childhood Neurological Disorders is an invaluable text for clinicians looking for current information and practical guidance to successfully manage their pediatric sleep patients. Sleep in Childhood Neurological Disorders features Dedicated focus on neurologically-based sleep disorders in children Diagnostic tables, key points, clinical pearls, and treatment algorithms throughout to enhance clinical utility Directions for "Future Research" in each chapter highlight promising studies and new therapies Broad-based coverage of the full range of common sleep disorders and co-morbidities

📒Therapy In Sleep Medicine E Book ✍ Teri J. Barkoukis

Therapy In Sleep Medicine E Book Book PDF
✏Book Title : Therapy in Sleep Medicine E Book
✏Author : Teri J. Barkoukis
✏Publisher : Elsevier Health Sciences
✏Release Date : 2011-10-31
✏Pages : 816
✏ISBN : 9781455723300
✏Available Language : English, Spanish, And French

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✏Therapy in Sleep Medicine E Book Book Summary : Therapy in Sleep Medicine, by Drs. Teri J. Barkoukis, Jean K. Matheson, Richard Ferber, and Karl Doghrami, provides the clinically focused coverage you need for rapid diagnosis and effective treatment of sleep disorders. A multidisciplinary team of leading authorities presents the latest on sleep breathing disorders (including obstructive sleep apnea), neuropharmacology, parasomnias, neurologic disorders affecting sleep, sleep therapy for women, sleep therapy in geriatric patients, controversies, and future trends in therapy in a highly illustrated, easy-to-follow format. Diagnose and treat patients effectively with complete coverage of the full range of sleep disorders. Find diagnostic and treatment information quickly and easily thanks to a highly illustrated, easy-to-read format that highlights key details. Stay current on discussions of hot topics, including sleep breathing disorders (including obstructive sleep apnea), neuropharmacology, parasomnias, neurologic disorders affecting sleep, sleep therapy for women, sleep therapy in geriatric patients, controversies, and future trends in therapy. Tap into the expertise of a multidisciplinary team of leading authorities for well-rounded, trusted guidance.

Principles And Practice Of Sleep Medicine E Book Book PDF
✏Book Title : Principles and Practice of Sleep Medicine E Book
✏Author : Meir H. Kryger
✏Publisher : Elsevier Health Sciences
✏Release Date : 2010-11-01
✏Pages : 1766
✏ISBN : 9781437727739
✏Available Language : English, Spanish, And French

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✏Principles and Practice of Sleep Medicine E Book Book Summary : Principles and Practice of Sleep Medicine, 5th Edition, by Meir H. Kryger, MD, FRCPC, Thomas Roth, PhD, and William C. Dement, MD, PhD, delivers the comprehensive, dependable guidance you need to effectively diagnose and manage even the most challenging sleep disorders. Updates to genetics and circadian rhythms, occupational health, sleep in older people, memory and sleep, physical examination of the patient, comorbid insomnias, and much more keep you current on the newest areas of the field. A greater emphasis on evidence-based approaches helps you make the most well-informed clinical decisions. And, a new more user-friendly, full-color format, both in print and online, lets you find the answers you need more quickly and easily. Whether you are preparing for the new sleep medicine fellowship examination, or simply want to offer your patients today's best care, this is the one resource to use! Make optimal use of the newest scientific discoveries and clinical approaches that are advancing the diagnosis and management of sleep disorders.

Equine Internal Medicine E Book Book PDF
✏Book Title : Equine Internal Medicine E Book
✏Author : Stephen M. Reed
✏Publisher : Elsevier Health Sciences
✏Release Date : 2009-12-10
✏Pages : 1488
✏ISBN : 9781437708851
✏Available Language : English, Spanish, And French

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✏Equine Internal Medicine E Book Book Summary : Develop an essential understanding of the principles of equine disease with this one-of-a-kind, problem-based resource! Extensively revised and updated with contributions from an international team of experts, Equine Internal Medicine, 3rd Edition reflects the latest clinical research in equine medicine and focuses on the basic pathophysiologic mechanisms that underlie the development of various equine diseases to help you confidently diagnose, treat, and manage patient conditions. Problem-based approach outlines how to apply the latest clinical evidence directly to the conditions you’ll encounter in practice. Pathophysiology is emphasized throughout, providing a sound basis for discussions of the diagnosis, treatment, and prognosis that follow. Body systems chapters begin with a thorough discussion of the diagnostic method appropriate to the system, including physical examination, clinical pathology, radiography, endoscopy, and ultrasonography. Flow charts, diagrams, and algorithms clarify complex material. Extensive content updates help you improve patient care with up-to-date research and clinical evidence across the full spectrum of equine practice, including: New sections on biofilm ahesins, resistance to phagocytosis, and host substrate utilization New information on changes in body weight Recent findings on fibrocoxib and diclofenac Expanded and reorganized coverage of critical care New material on inborn errors of metabolism and acquired myopathies Detailed treatment information on various disorders of the reproductive tract A new section on toxicoses causing signs related to liver disease or dysfunction Bound-in companion DVD includes more than 120 high-quality video clips that guide you through procedures related to the cardiovascular and neurologic systems.

Hypersomnia An Issue Of Sleep Medicine Clinics E Book Book PDF
✏Book Title : Hypersomnia An Issue of Sleep Medicine Clinics E Book
✏Author : Alon Y. Avidan
✏Publisher : Elsevier Health Sciences
✏Release Date : 2012-06-11
✏Pages : 241
✏ISBN : 9781455744374
✏Available Language : English, Spanish, And French

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✏Hypersomnia An Issue of Sleep Medicine Clinics E Book Book Summary : Excessive Sleepiness, or hypersomnia, is one of the most common sleep complaints. In this issue, Dr. Alon Avidan of UCLA brings together a set of articles that offer a completely updated overview of hypersomnia, from neurophysiology of sleepiness and wakefulness to quality of life issues and public health. The main focus of the issue is the diagnosis and treatment of hypersomnia, including objective and subjective measurement of sleepness, biomarkers of sleepiness, narcolepsy, and hypersomnia in medical, neurological and psyhchiatric comorbidities. Excessive sleepiness among specific patient populations (children, elderly) and periodic hypersomnia are discussed. Pharmacotherapy of hypersomnia is given special attention, as are behavioural treatments.

G Protein Activation And Acetylcholine Release Stimulated By Hypocretin In The Rat Pons Book PDF
✏Book Title : G Protein Activation and Acetylcholine Release Stimulated by Hypocretin in the Rat Pons
✏Author : René Bernard
✏Publisher :
✏Release Date : 2005
✏Pages :
✏ISBN : UOM:39015061026558
✏Available Language : English, Spanish, And French

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✏G Protein Activation and Acetylcholine Release Stimulated by Hypocretin in the Rat Pons Book Summary :

📒Clinical Sleep Disorders ✍ Paul R. Carney

Clinical Sleep Disorders Book PDF
✏Book Title : Clinical Sleep Disorders
✏Author : Paul R. Carney
✏Publisher : Lippincott Williams & Wilkins
✏Release Date : 2012-01-19
✏Pages : 544
✏ISBN : 9781451153958
✏Available Language : English, Spanish, And French

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✏Clinical Sleep Disorders Book Summary : This clinically focused, practical reference is a complete guide to diagnosing and treating sleep disorders. It is written by and for the wide variety of clinicians who encounter sleep disorders, including neurologists, pediatric neurologists, pulmonologists, pediatric pulmonologists, neuropsychologists, psychiatrists, and sleep laboratory technicians. Chapters follow a standardized template and include bulleted lists, tables, and clinical pearls. New chapters in this edition cover dreams, interpretation of the polysomnography report, pediatric surgical management of obstructive sleep apnea, and sleep scoring for both adults and pediatric patients. Also included is an overview chapter on comprehensive sleep medicine. Other highlights include updates on narcolepsy, parasomnias, and insomnia.

Sleep Disorders An Issue Of Neurologic Clinics E Book Book PDF
✏Book Title : Sleep Disorders An Issue of Neurologic Clinics E Book
✏Author : Bradley Vaughn
✏Publisher : Elsevier Health Sciences
✏Release Date : 2012-11-15
✏Pages : 240
✏ISBN : 9781455747757
✏Available Language : English, Spanish, And French

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✏Sleep Disorders An Issue of Neurologic Clinics E Book Book Summary : Sleep disorders are a widely recognized consequence of many neurological pathologies. This issue of Neurologic Clinics features the following articles: Sleep Physiology; Sleep Assessment Tools for the Neurologist; Fitting Sleep into Neurological Practice; Insomnia; Parasomnias and look-alikes; Sleep Apnea: Obstructive and central; Restless Legs syndrome; Circadian Rhythm; Pediatric Sleep Disorders; Dementia; Stroke; Epilepsy; CNS Immunological and Infectious; Movement Disorders; Neuromuscular ; Headache; Traumatic Brain Injury; and Psychiatry in Sleep.

Handbook Of Biologically Active Peptides Book PDF
✏Book Title : Handbook of Biologically Active Peptides
✏Author : Abba Kastin
✏Publisher : Academic Press
✏Release Date : 2013-01-26
✏Pages : 2032
✏ISBN : 9780123850966
✏Available Language : English, Spanish, And French

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✏Handbook of Biologically Active Peptides Book Summary : Handbook of Biologically Active Peptides, Second Edition, is the definitive, indispensable reference for peptide researchers, biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and endocrinologists. Its chapters are designed to be a source for workers in the field and enable researchers working in a specific area to examine related areas outside their expertise. Peptides play a crucial role in many physiological processes, including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The second edition of Handbook of Biologically Active Peptides presents this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. Presents all aspects of biologically active peptides in one resource Features more than 20 sections spanning plant, bacterial, fungal, venom, and invertebrate peptides to general peptides Includes immunological, inflammatory, cancer, vaccine, and neurotrophic peptides Discusses peptide precursors, mRNA distribution, processing, and receptors, not just pathophysiological implications

Functional Neuroanatomy Text And Atlas 2nd Edition Book PDF
✏Book Title : Functional Neuroanatomy Text and Atlas 2nd Edition
✏Author : Adel K. Afifi
✏Publisher : McGraw Hill Professional
✏Release Date : 2005-02-18
✏Pages : 494
✏ISBN : 0071408126
✏Available Language : English, Spanish, And French

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✏Functional Neuroanatomy Text and Atlas 2nd Edition Book Summary : Superbly illustrated, this core textbook reinforces an understanding of basic neuroanatomical structures by emphasizing their clinical significance in neurologic disease. Features over 400 illustrations, cross-sectional atlas views of the brain and brain stem, MRI images in three planes, and key concepts. (Midwest).

Lishman S Organic Psychiatry Book PDF
✏Book Title : Lishman s Organic Psychiatry
✏Author : Anthony David
✏Publisher : John Wiley & Sons
✏Release Date : 2011-08-24
✏Pages : 948
✏ISBN : 9781444356816
✏Available Language : English, Spanish, And French

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✏Lishman s Organic Psychiatry Book Summary :

Principles Of Drug Therapy In Neurology Book PDF
✏Book Title : Principles of Drug Therapy in Neurology
✏Author : Michael V. Johnston
✏Publisher : Oxford University Press
✏Release Date : 2008-05
✏Pages : 558
✏ISBN : UOM:39015076178212
✏Available Language : English, Spanish, And French

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✏Principles of Drug Therapy in Neurology Book Summary : Since the first edition of this book was published in 1992, the number of pharmacological therapies available for treating neurological disorders has grown exponentialy. This new edition brings the book fully up-to-date, and features PET scans to illustrate brain action, and new chapters on practical therapeutics and clinical trials.

The Journal Of Neuroscience Book PDF
✏Book Title : The Journal of Neuroscience
✏Author :
✏Publisher :
✏Release Date : 2009
✏Pages :
✏ISBN : NWU:35558005745217
✏Available Language : English, Spanish, And French

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Anatomy And Function Of Orexin Containing Neurons In Day And Night Active Animals Book PDF
✏Book Title : Anatomy and Function of Orexin containing Neurons in Day and Night active Animals
✏Author : Joshua Patrick Nixon
✏Publisher :
✏Release Date : 2005
✏Pages : 334
✏ISBN : MSU:31293027364185
✏Available Language : English, Spanish, And French

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✏Anatomy and Function of Orexin containing Neurons in Day and Night active Animals Book Summary :