The Molecular and Cellular Basis of Neurodegenerative Diseases

• Author : Michael S. Wolfe
• Publisher : Academic Press
• Release : 29 March 2018

The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative

• Author : Anonim
• Publisher : Unknown
• Release : 21 June 1995

• Author : Thomas Müller
• Publisher : MDPI
• Release : 14 October 2019

The focus on dopamine-sensitive motor symptoms, in association with the improvement of motor complications in the heterogeneous disease entity Parkinson's disease, has led to a certain standstill in research.This Special Issue provides new concepts and new ideas on the pathogenesis, genetics, and clinical maintenance of Parkinson's disease and related disorders. Not only new experimental findings, but also clinical outcomes, case series, and research on alternative, non-pharmacological therapies are included.The objective is to bridge the currently increasing

• Author : LinFang Wang,Honglei Wang,Margaret S. Ho
• Publisher : Biota Publishing
• Release : 18 March 2019

Glia, the non-neuronal cells in the nervous systems, are both passive and active participants in diverse arrays of neuronal function. The diversity of glial cells in various animal species appears to be correlated with the complexity of brains. In the animal Drosophila melanogaster, glia are similarly categorized to their mammalian counterparts in morphology and function. Surface glia cover the outermost surface of the brain and function as a blood-brain-barrier to protect the nervous system. Cortex glia, similar to mammalian astrocytes,

• Author : Christian Behl
• Publisher : Springer Science & Business Media
• Release : 28 June 2011

It is well known that estrogen is "somehow” a protective hormone for various age-related disorders. This book provides a solid knowledge of estrogen’s neuroprotective activities in the brain with a special emphasis on neurodegenerative disorders such as Alzheimer’s Disease. The focus is (1) to describe the biochemical, molecular, and cellular basis of the protective activity of estrogen and (2) to transfer this knowledge into the hospitals by discussing preventive and therapeutic approaches such as estrogen replacement therapy for post-menopausal women.

• Author : Patrick A. Lewis,Jennifer E. Spillane
• Publisher : Academic Press
• Release : 16 November 2018

The Molecular and Clinical Pathology of Neurodegenerative Disease brings together in one volume our current understanding of the molecular basis of neurodegeneration in humans, targeted at neuroscientists and graduate students in neuroscience, and the biomedical and biological sciences. Bringing together up-to-date molecular biology data with clinical evidence, this book sheds a light on common molecular mechanisms that underlie many different neurodegenerative diseases and addresses the molecular pathologies in each. The combined research and clinical background of the authors provides a

• Author : Patrik Verstreken
• Publisher : Academic Press
• Release : 19 December 2016

Parkinson’s Disease: Molecular Mechanisms Underlying Pathology explores the molecular pathways at the basis of the cellular defects connected to Parkinson’s disease, the second most common neurodegenerative disease, and the most common movement disorder. This book presents the latest research on the pathways and mechanisms that have been discovered to play a role in Parkinson's pathology. This focus on mechanisms rather than individual genes allows the contributors to elaborate on overlapping and joint functions of different causative genes. Readers

• Author : Serge Duckett,Jack C. De La Torre
• Publisher : Unknown
• Release : 21 June 2021

This book is a concise and practical compendium of neuropathological information for all professionals whose responsibility it is to make diagnoses, care, and help elderly humans afflicted with neurological and/or psychiatric disorders. The term neuropathology includes a multitude of disciplines including pathology, histology, genetics, immunology, biochemistry, radiology, etc. This disciplinary approach is reflected in this book. This new edition has been completely revised and brought up to date from the 20th to the 21st century. Basic neuroscientists were invited

• Author : Anonim
• Publisher : Unknown
• Release : 21 June 1994

• Author : Michael.S Wolfe
• Publisher : Academic Press
• Release : 01 November 2019

Molecular Biology of Neurodegenerative Diseases: Visions for the Future, Volume 168 in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide variety of research topics. The series includes in-depth knowledge on the molecular biological aspects of organismal physiology, with this release including chapters on Alzheimer's disease, Prion-like propagation of alpha-synuclein, What - if anything - can we learn about neurodegenerative diseases from yeast?, Mitochondrial rejuvenation and replacement as a

• Author : Daniel Offen
• Publisher : Unknown
• Release : 01 January 2007

Neurodegenerative disorders are characterized by progressive atrophy and dysfunction of anatomically or physiologically related neurologic systems. There are several common features of neurodegenerative disorders. They are mostly chronic, progressive and start due to the death of specific neuronal populations in the central nerve system (CNS). The distinct clinical phenotypes are generally linked to neuronal loss and often associated with aging. These disorders might share common pathogenetic mechanisms such as intracytoplasmic or intranuclear inclusions in neurons or glia which are linked

• Author : Valentina L. Brashers
• Publisher : Mosby
• Release : 21 June 2021

This practice-focused review guide and workbook covers 27 of the most commonly encountered health problems to outline the connections between pathophysiology, assessment, diagnosis, and management, with an emphasis on the clinical use of pathophysiologic concepts. Each chapter includes case studies to illustrate the application of pathophysiology principles to clinical situations with questions relating to patient history, physical examination findings, lab and diagnostic studies, therapies, and follow-up care. Each question is designed to promote clinical reasoning and a deeper understanding through application

• Author : European Commission. Directorate General for Research
• Publisher : Office for Official Publications of the European Communities
• Release : 21 June 2021

The Biomedical and Health Research Programme 'BIOMED2' was in operation for four years between 1994-98 with a budget of 360 million ECU. The purpose of the programme was to support the competitiveness of the European scientific research base by participating in cost-sharing research in four key areas: pharmaceuticals, biomedical technology, brain research and human genome research. The overall objective was to promote general health improvements and the transfer of medical research results into medical practice. This publication seeks to assess

• Author : Anonim
• Publisher : Unknown
• Release : 21 June 2021

• Author : Scott T. Brady,George J. Siegel
• Publisher : Academic Press
• Release : 21 June 2021

Includes bibliographical references and index.