The Human Mitochondrial Genome

📒The Human Mitochondrial Genome ✍ Giuseppe Gasparre

The Human Mitochondrial Genome Book PDF
✏Book Title : The Human Mitochondrial Genome
✏Author : Giuseppe Gasparre
✏Publisher : Academic Press
✏Release Date : 2020-07-23
✏Pages : 596
✏ISBN : 9780128226421
✏Available Language : English, Spanish, And French

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✏The Human Mitochondrial Genome Book Summary : The Human Mitochondrial Genome: From Basic Biology to Disease offers a comprehensive, up-to-date examination of human mitochondrial genomics, connecting basic research to translational medicine across a range of disease types. Here, international experts discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, segregation, and heredity. Furthermore, mtDNA evolution and exploitation, mutations, methods, and models for functional studies of mtDNA are dealt with. Disease discussion is accompanied by approaches for treatment strategies, with disease areas discussed including cancer, neurodegenerative, age-related, mtDNA depletion, deletion, and point mutation diseases. Nucleosides supplementation, mitoTALENs, and mitoZNF nucleases are among the therapeutic approaches examined in-depth. With increasing funding for mtDNA studies, many clinicians and clinician scientists are turning their attention to mtDNA disease association. This book provides the tools and background knowledge required to perform new, impactful research in this exciting space, from distinguishing a haplogroup-defining variant or disease-related mutation to exploring emerging therapeutic pathways. Fully examines recent advances and technological innovations in the field, enabling new mtDNA studies, variant and mutation identification, pathogenic assessment, and therapies Disease discussion accompanied by diagnostic and therapeutic strategies currently implemented clinically Outlines and discusses essential research protocols and perspectives for young scientists to pick up Features an international team of authoritative contributors from basic biologists to clinician-scientists

Human Mitochondrial Dna And The Evolution Of Homo Sapiens Book PDF
✏Book Title : Human Mitochondrial DNA and the Evolution of Homo sapiens
✏Author : Hans-Jürgen Bandelt
✏Publisher : Springer Science & Business Media
✏Release Date : 2006-09-05
✏Pages : 271
✏ISBN : 9783540317890
✏Available Language : English, Spanish, And French

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✏Human Mitochondrial DNA and the Evolution of Homo sapiens Book Summary : Mitochondrial DNA is one of the most closely explored genetic systems, because it can tell us so much about the human past. This book takes a unique perspective, presenting the disparate strands that must be tied together to exploit this system. From molecular biology to anthropology, statistics to ancient DNA, this first volume of three presents a comprehensive global picture and a critical appraisal of human mitochondrial DNA variation.

The Evolution Of Human Mitochondrial Dna Book PDF
✏Book Title : The Evolution of Human Mitochondrial DNA
✏Author : Rebecca Louise Cann
✏Publisher :
✏Release Date : 1982
✏Pages : 650
✏ISBN : UCAL:C2935263
✏Available Language : English, Spanish, And French

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✏The Evolution of Human Mitochondrial DNA Book Summary :

High Throughput Analysis Of The Human Mitochondrial Genome Reveals Its Dynamics Function And Signals Of Selection In Cancer Book PDF
✏Book Title : High throughput Analysis of the Human Mitochondrial Genome Reveals Its Dynamics Function and Signals of Selection in Cancer
✏Author : Sneha Grandhi
✏Publisher :
✏Release Date : 2018
✏Pages :
✏ISBN : OCLC:1083218398
✏Available Language : English, Spanish, And French

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✏High throughput Analysis of the Human Mitochondrial Genome Reveals Its Dynamics Function and Signals of Selection in Cancer Book Summary : Known as the energy powerhouses of the cell, mitochondria carry their own genomes, and encode for key cellular respiration proteins. Carrying multiple copies per cell, a given mitochondrial DNA (mtDNA) variant can be present at varying proportions, termed heteroplasmy. MtDNA is acquired exclusively through maternal inheritance and becomes stochastically replicated and segregated into dividing mitochondria over an organism's lifespan. An individual's constellation of mtDNA variants and their respective heteroplasmy levels can therefore change in response to selective pressures in somatic cells and/or selection that takes place during germline transmission. MtDNA aberrations are associated with many disorders, including cancer. Although mitochondrial genomes accumulate elevated mutation rates in cancer cells, the origin and functional impact of these mutations remain controversial. Here, we queried whole-genome sequencing data from 1,916 patients across 24 cancer types to characterize patterns of mtDNA mutations and elucidate the selective constraints driving their fate. We also tracked changes in per-cell abundances of mtDNA mutations from normal to tumor cells in the same patient. Tumor mitochondrial genomes show distinct mutational patterns and are disproportionately enriched for protein-altering changes. Moreover, protein-altering mtDNA variants that are initially present at low frequencies in normal cells preferentially expand in the altered tumor environment, suggesting selective advantage. Renal chromophobe and thyroid cancers show strong signals of positive selection with higher proportions and per-cell abundances of truncating mtDNA variants. Dramatic tumor- and tissue-specific variations in selective pressures suggest that cancer cells with advantageous levels of damaged mitochondrial genomes will selectively proliferate to facilitate the tumorigenic process.We also cataloged mitochondrial sequence variants and gene expression across 927 cancer cell lines from the Cancer Cell Line Encyclopedia (CCLE). We used this data to create a novel computational method called DoReMi (Donor, Recipient Mitochondrial DNA matching). DoReMi scores candidate mtDNA donor and recipient cell lines for cybridization experiments, which help identify the role of mtDNA variants in-vitro under a controlled nuclear genetic background. This tool allows researchers to design optimized cybrid experiments for querying the role of mutations in their mitochondrial-encoded gene of interest. Researchers may also apply DoReMi to study their own cell lines of interest.

Mitomap Book PDF
✏Book Title : MITOMAP
✏Author :
✏Publisher :
✏Release Date : 2001
✏Pages :
✏ISBN : OCLC:299638771
✏Available Language : English, Spanish, And French

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✏MITOMAP Book Summary :

Human Mitochondrial Dna Evolution In Papua New Guinea Book PDF
✏Book Title : Human Mitochondrial DNA Evolution in Papua New Guinea
✏Author : Mark Allen Stoneking
✏Publisher :
✏Release Date : 1988
✏Pages : 648
✏ISBN : UCSD:31822003098803
✏Available Language : English, Spanish, And French

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✏Human Mitochondrial DNA Evolution in Papua New Guinea Book Summary :

📒Human Mitochondrial Genetics ✍ Source: Wikipedia

Human Mitochondrial Genetics Book PDF
✏Book Title : Human Mitochondrial Genetics
✏Author : Source: Wikipedia
✏Publisher : Books LLC, Wiki Series
✏Release Date : 2011-08
✏Pages : 54
✏ISBN : 1233134302
✏Available Language : English, Spanish, And French

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✏Human Mitochondrial Genetics Book Summary : Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Pages: 53. Chapters: Human mtDNA haplogroups, Mitochondrial Eve, Genetic history of indigenous peoples of the Americas, Human mitochondrial molecular clock, Haplogroup M, Macro-haplogroup L, Haplogroup N, Haplogroup U, Haplogroup N1a, Haplogroup R, Haplogroup X, Haplogroup L2, Haplogroup H, Haplogroup T, Haplogroup L3, Haplogroup L0, Haplogroup K, Haplogroup J, Human mitochondrial DNA haplogroup, Haplogroup H5, Haplogroup M30, Haplogroup K1a1b1a, Haplogroup L1, Haplogroup I, Haplogroup E, Haplogroup B, Haplogroup D, Haplogroup A, Haplogroup HV, Haplogroup Y, Haplogroup V, Haplogroup R0, Haplogroup L5, Haplogroup W, Haplogroup G, Haplogroup C, Haplogroup L6, Haplogroup F, Haplogroup Q, Haplogroup IWX, Haplogroup L4, Cambridge Reference Sequence, Haplogroup Z, Haplogroup P, Haplogroup CZ, Haplogroup L4a, Haplogroup JT, Haplogroup S, Haplogroup pre-JT, Haplogroup UK, Haplogroup O mtdna. Excerpt: Genetic history of indigenous peoples of the Americas primarily focus on Human Y-chromosome DNA haplogroups and Human mitochondrial DNA haplogroups. Autosomal "atDNA" markers are also used, but differ from mtDNA or Y-DNA in that they overlap significantly. The genetic pattern indicates Indigenous Amerindians experienced two very distinctive genetic episodes; first with the initial peopling of the Americas, and secondly with European colonization of the Americas. The former is the determinant factor for the number of gene lineages, zygosity mutations and founding haplotypes present in today's Indigenous Amerindian populations. Human settlement of the New World occurred in stages from the Bering sea coast line, with an initial layover on Beringia for the small founding population. The micro-satellite diversity and distributions of the Y lineage specific to South America indicates that certain Amerindian populations have been isolated since the initia...

Investigation Of Human Mitochondrial Dna Abnormality In Colon Cancer Book PDF
✏Book Title : Investigation of Human Mitochondrial DNA Abnormality in Colon Cancer
✏Author : Mansoureh Akouchekian
✏Publisher : Cuvillier Verlag
✏Release Date : 2008
✏Pages : 80
✏ISBN : 9783867277594
✏Available Language : English, Spanish, And French

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✏Investigation of Human Mitochondrial DNA Abnormality in Colon Cancer Book Summary :

Whole Genome Sequence Analysis Of Human Mitochondrial Dna Using Microarray Technology Book PDF
✏Book Title : Whole Genome Sequence Analysis of Human Mitochondrial DNA Using Microarray Technology
✏Author : Vivian Edesan Reyes
✏Publisher :
✏Release Date : 2008
✏Pages : 166
✏ISBN : UCAL:X78842
✏Available Language : English, Spanish, And French

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✏Whole Genome Sequence Analysis of Human Mitochondrial DNA Using Microarray Technology Book Summary :

Mitochondrial Dna Mitochondria Disease And Stem Cells Book PDF
✏Book Title : Mitochondrial DNA Mitochondria Disease and Stem Cells
✏Author : Justin C. St. John
✏Publisher : Springer Science & Business Media
✏Release Date : 2012-09-26
✏Pages : 190
✏ISBN : 9781627031011
✏Available Language : English, Spanish, And French

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✏Mitochondrial DNA Mitochondria Disease and Stem Cells Book Summary : This volume investigates how the mitochondrial genome is transmitted, segregated, and inherited. It starts by describing mtDNA mutations and deletions and how these impact on the offspring’s well-being. It progresses to discuss how mutations to the mtDNA-nuclear-encoded transcription, replication and translational factors lead to mtDNA-depletion syndromes and how these affect cellular function and lead to the pathology of human mitochondrial disease. It also highlights the importance of the mitochondrial assembly factors and how mutations to these can lead to mitochondrial disease. The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process. It then discusses how diseases like cancer are initiated and regulated by mutations to mitochondrial DNA and dysfunctional mitochondria. Finally, it draws on assisted reproductive technologies to discuss how some of these approaches might be adapted to prevent the transmission of mutant and deleted mtDNA from one generation to the next.

High Yield Cell And Molecular Biology Book PDF
✏Book Title : High yield Cell and Molecular Biology
✏Author : Ronald W. Dudek
✏Publisher : Lippincott Williams & Wilkins
✏Release Date : 2007
✏Pages : 254
✏ISBN : 078176887X
✏Available Language : English, Spanish, And French

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✏High yield Cell and Molecular Biology Book Summary : This completely revised and updated review book consolidates the most important clinical issues that medical students need to know to be prepared for questions on USMLE Step 1. The book reviews key cell biology concepts needed to study molecular biology, and reviews the key concepts of molecular biology necessary for clinical medical practice, Flow charts provide a clear overview of molecular biology techniques and how they are applied in medicine. A chapter on understanding the research literature provides a solid background in molecular biology protocol so that students can understand the purpose and thinking behind published research articles.

Identification Of Transcriptional Regulatory Elements In Human Mitochondrial Dna Book PDF
✏Book Title : Identification of Transcriptional Regulatory Elements in Human Mitochondrial DNA
✏Author : James Newman Topper
✏Publisher :
✏Release Date : 1991
✏Pages : 412
✏ISBN : STANFORD:36105025716072
✏Available Language : English, Spanish, And French

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✏Identification of Transcriptional Regulatory Elements in Human Mitochondrial DNA Book Summary :

Molecular Mechanisms Of Initiation Of Mitochondrial Dna Replication Book PDF
✏Book Title : Molecular Mechanisms of Initiation of Mitochondrial DNA Replication
✏Author : Baoji Xu
✏Publisher :
✏Release Date : 1995
✏Pages : 426
✏ISBN : STANFORD:36105009727335
✏Available Language : English, Spanish, And French

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✏Molecular Mechanisms of Initiation of Mitochondrial DNA Replication Book Summary :

Modular Architecture And Dynamic Oligomeric Structure Of The Human Mitochondrial Replicative Dna Helicase Book PDF
✏Book Title : Modular Architecture and Dynamic Oligomeric Structure of the Human Mitochondrial Replicative DNA Helicase
✏Author : Tawn Denise Ziebarth
✏Publisher :
✏Release Date : 2006
✏Pages : 160
✏ISBN : MSU:31293028456469
✏Available Language : English, Spanish, And French

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✏Modular Architecture and Dynamic Oligomeric Structure of the Human Mitochondrial Replicative DNA Helicase Book Summary :

Control Region Sequences From African Populations And The Evolution Of Human Mitochondrial Dna Book PDF
✏Book Title : Control Region Sequences from African Populations and the Evolution of Human Mitochondrial DNA
✏Author : Linda Ann Vigilant
✏Publisher :
✏Release Date : 1990
✏Pages : 420
✏ISBN : UCAL:C3364689
✏Available Language : English, Spanish, And French

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✏Control Region Sequences from African Populations and the Evolution of Human Mitochondrial DNA Book Summary :

Mitochondria And Their Role In Cardiovascular Disease Book PDF
✏Book Title : Mitochondria and Their Role in Cardiovascular Disease
✏Author : José Marín-García
✏Publisher : Springer Science & Business Media
✏Release Date : 2012-11-19
✏Pages : 500
✏ISBN : 9781461445999
✏Available Language : English, Spanish, And French

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✏Mitochondria and Their Role in Cardiovascular Disease Book Summary : Over the past two decades, due to dramatic advances in molecular and cell biology, biochemistry, and genetics, our view on mitochondria as a relatively static cellular powerhouse has changed radically. We now know that these organelles play a critical role in the normal and in the damaged heart. Written by Dr. José Marín-García, Director of the Molecular Cardiology and Neuromuscular Institute, Mitochondria and Their Role in Cardiovascular Disease brings readers up- to-date on the many significant advances in the field of mitochondrial cardiovascular medicine. The book begins with a general introduction to mitochondria, followed by laboratory methods to study the structure and function of the organelle, regulation of replication and biogenesis, and the mechanisms and functional consequences of mitophagia and mitochondrial dynamics. Subsequent chapters deal with mitochondrial oxidative stress and the role that the organelle plays in cell signaling and cell death. Discussions will be undertaken on the biochemistry of mitochondrial cell signaling, including the nature of the proteins engaged in these processes, many of them only recently discovered. Later chapters examine the role of mitochondria and mitochondrial abnormalities in cardiovascular diseases, including their diagnosis, therapeutic options currently available, animal models of mitochondrial disease, and new frontiers in mitochondria cardiovascular medicine, including areas of research that are relatively new or developing, such as proteomics, next generation sequencing, and systems biology.

📒Ancient Dna Typing ✍ Susanne Hummel

Ancient Dna Typing Book PDF
✏Book Title : Ancient DNA Typing
✏Author : Susanne Hummel
✏Publisher : Springer Science & Business Media
✏Release Date : 2013-03-09
✏Pages : 298
✏ISBN : 9783662050507
✏Available Language : English, Spanish, And French

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✏Ancient DNA Typing Book Summary : This is the definitive source of information on techniques for the identification and sequencing of old DNA (pieces) and their use in biological and medical research and application. Application of aDNA techniques are useful tools for investigations reaching from evolutionary studies to law enforcement approaches. What brings them together is the interest in specific methods of handling aDNA, i.e. elaborated PCR and sequencing techniques and the interpretation of the results. This books serves as an ideal guideline for it demonstrates how problem-solving strategies can be applied in various areas.

📒Forensic Biology ✍ Richard Li

Forensic Biology Book PDF
✏Book Title : Forensic Biology
✏Author : Richard Li
✏Publisher : CRC Press
✏Release Date : 2008-04-24
✏Pages : 448
✏ISBN : 9781420043440
✏Available Language : English, Spanish, And French

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✏Forensic Biology Book Summary : Designed as an accessible introduction to basic scientific principles and their application in professional practice, Forensic Biology provides a concise overview of the field. Focusing solely on the science behind the forensic analysis of biological evidence, this book highlights the principles, methods, and techniques used in forensic serologic and forensic DNA analysis. Divided into two areas, the first addresses the identification of biological fluids including blood, semen, and saliva. Chapters instruct on the identification techniques involved in presumptive and confirmatory tests. The second area covers the individualization of biological evidence using forensic DNA techniques. The book demonstrates extraction methods, quantization methods, DNA profiling analysis, and interpretation of results. Each technique introduced in this text is preceded by a brief background of its development and the basic principles that support the technique and its applications. All methods are discussed in detail and accompanied by schematic illustrations where appropriate. Each chapter presents study questions, and references. Instructors have access to a CD containing PowerPoint lecture slides. Emphasizing the fundamentals of basic science and its application to forensic biology, this book provides a solid scientific grounding and familiarity with not just the principles of biological and biochemical processes that occur in forensic analysis, but also the language and vocabulary of forensic biology. The explanations are accessible and straightforward, and informative to facilitate effective learning.

Cytology And Cell Physiology Supplement 17 Book PDF
✏Book Title : Cytology and Cell Physiology Supplement 17
✏Author : Geoffrey H. Bourne
✏Publisher : Elsevier
✏Release Date : 1987-12-12
✏Pages : 864
✏ISBN : 0123643783
✏Available Language : English, Spanish, And French

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✏Cytology and Cell Physiology Supplement 17 Book Summary : International Review of Cytology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

📒Mitochondrial Disorders In Neurology ✍ Anthony H.V. Schapira

Mitochondrial Disorders In Neurology Book PDF
✏Book Title : Mitochondrial Disorders in Neurology
✏Author : Anthony H.V. Schapira
✏Publisher : Butterworth-Heinemann
✏Release Date : 2013-10-22
✏Pages : 264
✏ISBN : 9781483193694
✏Available Language : English, Spanish, And French

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✏Mitochondrial Disorders in Neurology Book Summary : Mitochondrial Disorders in Neurology provides an overview of mitochondrial diseases. This book discusses the effects of mitochondrial dysfunction based on the relevant biochemistry and molecular genetics. The abnormal muscle and mitochondrial morphology in a variety of clinical presentations from isolated ophthalmoplegia to severe encephalopathy are also elaborated. This text likewise deliberates Leber's hereditary optic neuropathy, neurodegenerative disorders, and respiratory chain defects. Other topics covered include mitochondrial DNA and the genetics of mitochondrial disease; cytochrome oxidase deficiency; use of tissue culture in the diagnosis of mitochondrial disease; and advances in mitochondrial genetics. This publication is a good source for clinicians and students concerned with the defective mitochondrial function.

Organization And Expression Of The Mouse L Cell Mitochondrial Dna Genome Book PDF
✏Book Title : Organization and Expression of the Mouse L Cell Mitochondrial DNA Genome
✏Author : Richard Alfred Van Etten
✏Publisher :
✏Release Date : 1984
✏Pages : 282
✏ISBN : STANFORD:36105025694303
✏Available Language : English, Spanish, And French

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✏Organization and Expression of the Mouse L Cell Mitochondrial DNA Genome Book Summary :

Mitochondrial Function And Biogenesis Book PDF
✏Book Title : Mitochondrial Function and Biogenesis
✏Author : Carla Koehler
✏Publisher : Springer Science & Business Media
✏Release Date : 2004-05-13
✏Pages : 333
✏ISBN : 3540214895
✏Available Language : English, Spanish, And French

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✏Mitochondrial Function and Biogenesis Book Summary : This book provides the first modern and truly comprehensive coverage of the biochemistry, genetics, and pathology of mitochondria in different organisms. It particularly focuses on the recent advances in our understanding of basic mitochondrial research to the consequences of dysfunction at the molecular level. (Cover)

Reproductive Genomics In Domestic Animals Book PDF
✏Book Title : Reproductive Genomics in Domestic Animals
✏Author : Zhihua Jiang
✏Publisher : John Wiley & Sons
✏Release Date : 2011-06-17
✏Pages : 480
✏ISBN : 9780470961827
✏Available Language : English, Spanish, And French

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✏Reproductive Genomics in Domestic Animals Book Summary : Reproductive Genomics in Domestic Animals is a thorough examination of genomics in the livestock industry, encompassing genome sciences, genome biotechnology, and reproduction. Recent developments in molecular genetics and genomics have enabled scientists to identify and characterize genes contributing to the complexity of reproduction in domestic animals, allowing scientists to improve reproductive traits. Providing the livestock industry with essential tools for enhancing reproductive efficiency, Reproductive Genomics in Domestic Animals surveys the current status of reproductive genomes and looks to the future direction of research.

Oxidative Phosphorylation In Health And Disease Book PDF
✏Book Title : Oxidative Phosphorylation in Health and Disease
✏Author : Jan A.M. Smeitink
✏Publisher : Springer Science & Business Media
✏Release Date : 2004-11-02
✏Pages : 205
✏ISBN : 0306482320
✏Available Language : English, Spanish, And French

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✏Oxidative Phosphorylation in Health and Disease Book Summary : Mitochondrial diseases are often hard to diagnose. From the time they were first researched without animal models, patients of mitochondrial diseases were of equal interest to both clinical and basic scientists. With the new research done, this book includes updates on the normal structure, function, and molecular biology of the mitochondrial respiratory chain, information on traditional diagnostical methodologies, and an overview of the diagnostic promise of new technologies. The hypermetabolism of Luft disease, although only seen twice, is also studied. There are critical reviews of symptoms and signs associated with syndromes, as well as updates on the genetic defects of either the mitochondrial or the nuclear genome responsible for many disorders.

📒Biochemistry Of Aging ✍ Amin Elsersawi

Biochemistry Of Aging Book PDF
✏Book Title : Biochemistry of Aging
✏Author : Amin Elsersawi
✏Publisher : AuthorHouse
✏Release Date : 2010
✏Pages : 340
✏ISBN : 9781449073800
✏Available Language : English, Spanish, And French

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✏Biochemistry of Aging Book Summary : This book offers a good introduction to the biology and chemistry of aging. It emphasizes on cellular aging, and covers different areas and theories which deal with the mechanism of aging.

📒Intracellular Calcium ✍ Anthony K. Campbell

Intracellular Calcium Book PDF
✏Book Title : Intracellular Calcium
✏Author : Anthony K. Campbell
✏Publisher : John Wiley & Sons
✏Release Date : 2014-10-16
✏Pages : 848
✏ISBN : 9781118675533
✏Available Language : English, Spanish, And French

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✏Intracellular Calcium Book Summary : Thousands of imaginative scientists, over more than a century,have revealed the fascinating story of intracellular calcium,through a pathway of ingenious invention and discovery. Intracellular Calcium, the definitive book on this topic,reveals: The pathway of discovery and invention of intracellular calciumover more than 100 years. The evidence for intracellular calcium as a universal switch inall animal, plant, fungal and microbial cells How the components required for calcium signalling are namedand classified. The ingenious technology, which has been developed to studyintracellular calcium. How calcium is regulated inside cells and how it works totrigger an event. The role of intracellular calcium in disease, cell injury andcell death. How many drugs work through the calcium signalling system. How intracellular calcium is involved in the action of manynatural toxins. How the intracellular calcium signalling system has evolvedover 4000 million years, showing why it was crucial to the originof life. A key principle presented throughout the book is the molecularvariation upon which the intracellular calcium signalling systemdepends. This variation occurs within the same cell type andbetween cells with different functions, providing the invisiblematrix upon which Darwin and Wallace’s Natural Selectiondepends. Featuring more than 100 figures, including detailed chemicalstructures as well as pictures of key pioneers in the field, abibliography of more than 1500 references, as well asdetailed subject and organism indices, this definitive workprovides a unique source of scholarship for teachers andresearchers in the biomedical sciences and beyond.

Methods Of Cancer Diagnosis Therapy And Prognosis Book PDF
✏Book Title : Methods of Cancer Diagnosis Therapy and Prognosis
✏Author : M. A. Hayat
✏Publisher : Springer Science & Business Media
✏Release Date : 2008-11-21
✏Pages : 602
✏ISBN : 9781402084423
✏Available Language : English, Spanish, And French

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✏Methods of Cancer Diagnosis Therapy and Prognosis Book Summary : Cancer is the leading cause of death, in the number of older cancer patients is after cardiovascular diseases, in the expected. Approximately, 77% of all types United States. A total of ? 1,399,790 new of cancers are diagnosed in persons of 55 cancer cases and ? 564,830 deaths were years and older. It was estimated that o- reported in the year 2006 in the country. third of the 559,650 cancer deaths in 2007 Approximately, one in every two men and in the United States were related to ov- one in every three women in the country weight or obesity, physical inactivity, and will have some type of cancer during nutrition, and thus could also be prevented their lifetime. Healthcare costs exceed (Am. Cancer Society, 2007). However, 1. 7 trillion dollars per year in the United in developed countries, including United States, which is ? 15% of the country’s States, the average person of 65 years can gross domestic product. expect to live another 15 years in a fairly Tobacco use is the most serious prevent- good health. Persons of 75 or 85 years old able cause of cancer. Tobacco use causes have an average expectancy of 10 and 6 cancer of the lung, throat, mouth, pancreas, years, respectively. urinary bladder, stomach, liver, kidney, and During the last three decades, intensive other types. Passive smoking causes lung clinical research has resulted in reduced cancer.

Oxidative Stress And Neurodegenerative Disorders Book PDF
✏Book Title : Oxidative Stress and Neurodegenerative Disorders
✏Author : G. Ali Qureshi
✏Publisher : Elsevier
✏Release Date : 2007-03-22
✏Pages : 794
✏ISBN : 0080489494
✏Available Language : English, Spanish, And French

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✏Oxidative Stress and Neurodegenerative Disorders Book Summary : Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders. * Contains the latest information on the subject of neurodegenerative disorders * Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems

Analysis Of Polimorphisms And Heteroplasmy In Mitochondrial Dna For Human Idintification Book PDF
✏Book Title : Analysis of Polimorphisms and Heteroplasmy in Mitochondrial DNA for Human Idintification
✏Author : Cassandra Danelle Calloway
✏Publisher :
✏Release Date : 2009
✏Pages : 514
✏ISBN : UCAL:C3528054
✏Available Language : English, Spanish, And French

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✏Analysis of Polimorphisms and Heteroplasmy in Mitochondrial DNA for Human Idintification Book Summary :

📒Mitochondrial Dna ✍ William C. Copeland

Mitochondrial Dna Book PDF
✏Book Title : Mitochondrial DNA
✏Author : William C. Copeland
✏Publisher : Springer Science & Business Media
✏Release Date : 2002
✏Pages : 414
✏ISBN : 9781592592845
✏Available Language : English, Spanish, And French

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✏Mitochondrial DNA Book Summary : Mutations within mitochondrial DNA (mtDNA) and the nuclear genes involved in the maintenance of mitochondrial DNA have been linked to a wide range of human diseases, including several of the most common diseases of aging. In Mitochondrial DNA: Methods and Protocols internationally recognized authorities describe in great detail the methods they have perfected to analyze mtDNA and the proteins involved in its maintenance. The analytical techniques cover the purification of mtDNA from a variety of sources and the analysis of DNA for both deletions, point mutations, and damage, for replication intermediates, and for following the fate of mtDNA outside of the mitochondria. Additional analytical methods are presented for analyzing the proteins and enzymes that maintain mtDNA. Each readily reproducible protocol includes step-by-step instructions, tips on avoiding pitfalls and extending the method to other situation, and introductory material explaining the theory behind the process. Comprehensive and timely, Mitochondrial DNA: Methods and Protocols offers both basic and clinical researchers proven cutting-edge methods for analyzing the role mtDNA plays in the aging process, apoptosis, and possibly some cancers, and for investigating the cause of mitochondrial dysfunction and disease.