The Human Mitochondrial Genome

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  • Author : Giuseppe Gasparre
  • Publisher : Academic Press
  • Pages : 596 pages
  • ISBN : 0128196564
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>The Human Mitochondrial Genome

Download or Read online The Human Mitochondrial Genome full in PDF, ePub and kindle. this book written by Giuseppe Gasparre and published by Academic Press which was released on 19 August 2020 with total page 596 pages. We cannot guarantee that The Human Mitochondrial Genome book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. The Human Mitochondrial Genome: From Basic Biology to Disease offers a comprehensive, up-to-date examination of human mitochondrial genomics, connecting basic research to translational medicine across a range of disease types. Here, international experts discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, segregation, and heredity. Furthermore, mtDNA evolution and exploitation, mutations, methods, and models for functional studies of mtDNA are dealt with. Disease discussion is accompanied by approaches for treatment strategies, with disease areas discussed including cancer, neurodegenerative, age-related, mtDNA depletion, deletion, and point mutation diseases. Nucleosides supplementation, mitoTALENs, and mitoZNF nucleases are among the therapeutic approaches examined in-depth. With increasing funding for mtDNA studies, many clinicians and clinician scientists are turning their attention to mtDNA disease association. This book provides the tools and background knowledge required to perform new, impactful research in this exciting space, from distinguishing a haplogroup-defining variant or disease-related mutation to exploring emerging therapeutic pathways. Fully examines recent advances and technological innovations in the field, enabling new mtDNA studies, variant and mutation identification, pathogenic assessment, and therapies Disease discussion accompanied by diagnostic and therapeutic strategies currently implemented clinically Outlines and discusses essential research protocols and perspectives for young scientists to pick up Features an international team of authoritative contributors from basic biologists to clinician-scientists

The Human Mitochondrial Genome

The Human Mitochondrial Genome
  • Author : Giuseppe Gasparre,Anna Maria Porcelli
  • Publisher : Academic Press
  • Release : 19 August 2020
GET THIS BOOK The Human Mitochondrial Genome

The Human Mitochondrial Genome: From Basic Biology to Disease offers a comprehensive, up-to-date examination of human mitochondrial genomics, connecting basic research to translational medicine across a range of disease types. Here, international experts discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, segregation, and heredity. Furthermore, mtDNA evolution and exploitation, mutations, methods, and models for functional studies of mtDNA are dealt with. Disease discussion is accompanied by approaches for treatment strategies, with disease areas discussed including

High throughput Analysis of the Human Mitochondrial Genome Reveals Its Dynamics Function and Signals of Selection in Cancer

High throughput Analysis of the Human Mitochondrial Genome Reveals Its Dynamics  Function  and Signals of Selection in Cancer
  • Author : Sneha Grandhi
  • Publisher : Unknown
  • Release : 09 December 2021
GET THIS BOOK High throughput Analysis of the Human Mitochondrial Genome Reveals Its Dynamics Function and Signals of Selection in Cancer

Known as the energy powerhouses of the cell, mitochondria carry their own genomes, and encode for key cellular respiration proteins. Carrying multiple copies per cell, a given mitochondrial DNA (mtDNA) variant can be present at varying proportions, termed heteroplasmy. MtDNA is acquired exclusively through maternal inheritance and becomes stochastically replicated and segregated into dividing mitochondria over an organism's lifespan. An individual's constellation of mtDNA variants and their respective heteroplasmy levels can therefore change in response to selective pressures in somatic

MITOMAP

MITOMAP
  • Author : Anonim
  • Publisher : Unknown
  • Release : 09 December 1997
GET THIS BOOK MITOMAP

MITOMAP uses the mtDNA sequence as the unifying element for bringing together information on mitochondrial genome structure and function, pathogenic mutations, and their clinical characteristics, population associated variation, and gene-gene interactions.

Human Mitochondrial DNA and the Evolution of Homo sapiens

Human Mitochondrial DNA and the Evolution of Homo sapiens
  • Author : Hans-Jürgen Bandelt,Martin Richards,Vincent Macaulay
  • Publisher : Springer Science & Business Media
  • Release : 05 September 2006
GET THIS BOOK Human Mitochondrial DNA and the Evolution of Homo sapiens

Mitochondrial DNA is one of the most closely explored genetic systems, because it can tell us so much about the human past. This book takes a unique perspective, presenting the disparate strands that must be tied together to exploit this system. From molecular biology to anthropology, statistics to ancient DNA, this first volume of three presents a comprehensive global picture and a critical appraisal of human mitochondrial DNA variation.

Detection of Sequence Variation in the HVII Region of the Human Mitochondrial Genome in 689 Individuals Using Immobilized Sequence Specific Oligonucleotide Probes

Detection of Sequence Variation in the HVII Region of the Human Mitochondrial Genome in 689 Individuals Using Immobilized Sequence Specific Oligonucleotide Probes
  • Author : R. Reynolds,K. Walker,J. Varlaro,M. Alavaren,E. Clark,H. Erlich
  • Publisher : Unknown
  • Release : 09 December 2021
GET THIS BOOK Detection of Sequence Variation in the HVII Region of the Human Mitochondrial Genome in 689 Individuals Using Immobilized Sequence Specific Oligonucleotide Probes

We have developed a rapid, immobilized probe-based assay for the detection of sequence variation in the hyper-variable segment II (HVII) of the mitochondrial DNA (mtDNA) control region. Using a panel of 17 sequence-specific oligonucleotide (SSO) probes immobilized on nylon membrane strips, we typed 689 individuals from four population groups. The genetic diversity value for each population was calculated from the frequency data, and the frequencies of distinct "mitotypes" in each group were determined. We performed DNA sequence analysis of 129 samples to characterize

Regulation of Human Mitochondrial Gene Expression

Regulation of Human Mitochondrial Gene Expression
  • Author : Maria Isabel Guadalupe Lopez Sanchez
  • Publisher : Unknown
  • Release : 09 December 2021
GET THIS BOOK Regulation of Human Mitochondrial Gene Expression

Human mitochondrial DNA is a distinct, compact genetic system that encodes proteins crucial for energy metabolism in the cell. Due to its reduced size and relatively simple organisation, all the regulatory factors directing the expression of the mitochondrial genome are encoded by nuclear DNA. It is evident that mitochondrial gene expression is regulated at different levels, which is reflected by the numerous diseases associated with mutations in both nuclear and mitochondrial DNA-encoded mitochondrial proteins. Research focusing on the identification and

Mitochondrial DNA Mitochondria Disease and Stem Cells

Mitochondrial DNA  Mitochondria  Disease and Stem Cells
  • Author : Justin C. St. John
  • Publisher : Springer Science & Business Media
  • Release : 27 September 2012
GET THIS BOOK Mitochondrial DNA Mitochondria Disease and Stem Cells

This volume investigates how the mitochondrial genome is transmitted, segregated, and inherited. It starts by describing mtDNA mutations and deletions and how these impact on the offspring’s well-being. It progresses to discuss how mutations to the mtDNA-nuclear-encoded transcription, replication and translational factors lead to mtDNA-depletion syndromes and how these affect cellular function and lead to the pathology of human mitochondrial disease. It also highlights the importance of the mitochondrial assembly factors and how mutations to these can lead to