The Human Microbiome In Early Life

The Human Microbiome In Early Life Book PDF
✏Book Title : The Human Microbiome in Early Life
✏Author : Omry Koren
✏Publisher : Academic Press
✏Release Date : 2020-09-25
✏Pages : 326
✏ISBN : 9780128180983
✏Available Language : English, Spanish, And French

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✏The Human Microbiome in Early Life Book Summary : The Human Microbiome in Early Life: Implications to Health and Disease presents recent research advances that have highlighted the significance of early life, possibly beginning before birth, in the establishment of both the microbiome and its role in health and disease. The book reviews current knowledge on the origins of the human microbiota in early life, presents exposures which may disturb normal microbial colonization, and covers their implications to the risk of disease. Finally, emerging means to modify the early human microbiome to improve health are discussed. Examines the timeline of the human microbiome, from before conception to infancy, with an emphasis on clinical implications Evaluates the effort to understand not only the composition but also the origin of the microbiome Proves the emerging means to modify the human microbiome and particularly ‘the first 1000 days of life’ improve human health and prevent disease Generates resources to facilitate characterization of the human microbiota to further our understanding of how the microbiome impacts human health and disease

Microbiota In Health And Disease From Pregnancy To Childhood Book PDF
✏Book Title : Microbiota in health and disease from pregnancy to childhood
✏Author : Pamela D. Browne
✏Publisher : Wageningen Academic Publishers
✏Release Date : 2017-07-20
✏Pages : 344
✏ISBN : 9789086868391
✏Available Language : English, Spanish, And French

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✏Microbiota in health and disease from pregnancy to childhood Book Summary : This book offers a state-of-the-art overview of the vital relationship between human microbiota and infant and child health. Renowned clinical-experimental experts in this field discuss the development of microbiota during early life and review the environmental inputs that affect the developing infant’s gut microbiota, such as early diet and (postnatal) medical interventions. They further describe the interplay between gut microbiota and functional systems of the body, from the immune system to the central nervous system. The book discusses a range of infant and childhood diseases that are associated with microbial changes or dysbiosis, such as gastrointestinal disorders, allergic diseases, autoimmune disorders and respiratory disorders. Additionally mechanisms by which microbial dysbiosis may influence behaviour in infants are discussed. Other topics include the use of current tools in molecular microbiology for microbiota-related research and clinical practice. In the management of particular paediatric disorders, the potential of microbial manipulation with pre- and probiotics during infancy and childhood is increasingly being investigated. This book presents the evidence supporting their use in practice and reviews safety aspects. Microbiota in health and disease: from pregnancy to childhood has the ambition to provide the reader with an overview of the most recent and stunning advances in the field of infant and child microbiota and their role in health, disease and prevention. As such, it is an excellent resource for health care professionals, students and researchers in the field of life sciences.

The Human Microbiota And Microbiome Book PDF
✏Book Title : The Human Microbiota and Microbiome
✏Author : Julian R Marchesi
✏Publisher : CABI
✏Release Date : 2014-05-14
✏Pages : 208
✏ISBN : 9781780640495
✏Available Language : English, Spanish, And French

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✏The Human Microbiota and Microbiome Book Summary : Thousands of different microbial species colonize the human body, and are essential for our survival. This book presents a review of the current understanding of human microbiomes, the functions that they bring to the host, how we can model them, their role in health and disease and the methods used to explore them. Current research into areas such as the long-term effect of antibiotics makes this a subject of considerable interest. This title is essential reading for researchers and students of microbiology.

📒Microbiota ✍ Takashi Matsumoto

Microbiota Book PDF
✏Book Title : Microbiota
✏Author : Takashi Matsumoto
✏Publisher :
✏Release Date : 2018-12-14
✏Pages : 132
✏ISBN : 1910190934
✏Available Language : English, Spanish, And French

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✏Microbiota Book Summary : Essential reading for everyone working with human microbiota, probiotics and prebiotics.

Human Microbiota In Health And Disease Book PDF
✏Book Title : Human Microbiota in Health and Disease
✏Author : Bryan Tungland
✏Publisher : Academic Press
✏Release Date : 2018-05-25
✏Pages : 680
✏ISBN : 9780128146507
✏Available Language : English, Spanish, And French

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✏Human Microbiota in Health and Disease Book Summary : Human Gut Microbiota in Health and Disease: From Pathogenesis to Therapy is a comprehensive discussion on all the aspects associated with the early colonization of gut microbiota, its development and maintenance, and its symbiotic relationship with the host in promoting health. Chapters illustrate the complex mechanisms and metabolic signaling pathways related to how the gut microbiota maintain proper regulation of glucose, lipid and energy homeostasis and immune response, all while mediating inflammatory processes involved in the etiology of many chronic disease conditions. With today's common use of pharmaceutical medicine in treating symptoms and frequent overuse of antibiotics in chronic disease within mainstream medical practice, our understanding of the etiological mechanisms of dysbiosis-induced chronic disease and natural approaches to prevention and potential cures for these diseases is of vital importance to overall human health. Details the complex relationship between human microbiota in the gut, oral cavity and skin as well as their colonization, development and impact of factors that influence the relationship Illustrates the mechanisms associated with dysbiosis-associated inflammation and its role in the onset and progression in chronic disease Provides the primary mechanisms and comprehensive scientific evidence for the use of dietary modification and pro- and prebiotics in preventing chronic disease

Pets As Sentinels Forecasters And Promoters Of Human Health Book PDF
✏Book Title : Pets as Sentinels Forecasters and Promoters of Human Health
✏Author : M. Ramiro Pastorinho
✏Publisher : Springer Nature
✏Release Date : 2019-11-30
✏Pages : 375
✏ISBN : 9783030307349
✏Available Language : English, Spanish, And French

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✏Pets as Sentinels Forecasters and Promoters of Human Health Book Summary : This book provides an up-to-date overview of the current knowledge and research concerning domestic pets as sentinels, forecasters and promoters of human health. Written by leading specialists in the fields of medicine, veterinary, environment, analytical chemistry, sociology and behavioral science, this volume provides a comprehensive understanding of the capabilities of pets in what regards to human health. The first seven chapters are devoted to the use of pets as sentinels for their human companions, in terms of exposure to different classes of environmental chemicals. The following five chapters address the use of pets as models for human diseases and promoters of human health. The final two chapters highlight the psycho-social and psychophysiological aspects of human-animal interactions. The book offers an integrated approach to the One Health concept, providing, in a truly holistic manner, tools to assess the equilibrium between the environment, men and animals. This exercise will highlight and reshape our position towards the planet that despite being “a microscopic dot on a microscopic dot lost in the unimaginable infinity of the Universe” is still our own. At the end of the day, pets will always be there to help us.

Asthma In Early Childhood An Issue Of Immunology And Allergy Clinics Of North America E Book Book PDF
✏Book Title : Asthma in Early Childhood An Issue of Immunology and Allergy Clinics of North America E Book
✏Author : Theresa Guilbert
✏Publisher : Elsevier Health Sciences
✏Release Date : 2019-04-15
✏Pages :
✏ISBN : 9780323677882
✏Available Language : English, Spanish, And French

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✏Asthma in Early Childhood An Issue of Immunology and Allergy Clinics of North America E Book Book Summary : This issue of Immunology and Allergy Clinics is devoted to Asthma in Childhood and is Guest Edited by Drs. Leonard Bacharier and Theresa Guilbert. Articles in this outstanding issue include: Inception and Natural History of Pediatric Asthma; Recent Diagnosis Techniques in Pediatric Asthma; Management / co-morbidities for Preschool-aged Children with Asthma; Management/ co-morbidities for School-aged Children with Asthma; Effects of the Environment on Disease Activity; New Advances of Self-Management/Adherence Monitoring and Management in Pediatric Asthma; Severe Asthma in Early Childhood; Inner-city Asthma in Early Childhood; Personalized Medicine and Pediatric Asthma; Prevention in Pediatric Asthma; Asthma in the Schools; and New Directions in Pediatric Asthma.

Patterns And Processes Of Community Assembly In The Human Microbiome Book PDF
✏Book Title : Patterns and Processes of Community Assembly in the Human Microbiome
✏Author : Daniel David Sprockett
✏Publisher :
✏Release Date : 2019
✏Pages :
✏ISBN : OCLC:1111199517
✏Available Language : English, Spanish, And French

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✏Patterns and Processes of Community Assembly in the Human Microbiome Book Summary : The following dissertation presents an overview of host-associated microbial community assembly, focusing on the question: How do you acquire your microbiome, and what determines how it develops and matures over time? Chapter 1 highlights selected concepts in the fields of ecology, microbiology, and immunology that provide context to the subsequent chapters of this dissertation. Chapter 2 provides a conceptual overview of how the timing and order of colonization can impact assembly of the microbiome in early life -- as a phenomenon known as priority effects. I also highlight the importance of both maternal and non-maternal sources of infant-colonizing microbes, and examine factors that may alter assembly patterns, including regional or cultural differences in infant care associated behaviors (ICABs). Chapter 3 details the process of community assembly in a large cohort of indigenous Bolivians called the Tsimane people. I applied a neutral model of community assembly and estimated the relative importance of stochastic dispersal during assembly. I then further used this model to place Tsimane infants in a global context through a comparative analysis with two other large infant populations from Bangladesh and Finland. Finally, I identified microbes that are changing in response to large-scale societal changes experienced by the Tsimane, including increased market access, and speculated on the consequences that these shifts may have on traditional modes of infant colonization. Chapter 4 identifies heritable features of the oral microbiome and oral metabolome using saliva samples collected from the TwinsUK cohort. I report that the saliva of monozygotic twin pairs harbor more similar microbial communities and metabolites, on average, than do dizygotic twins, which is consistent with the hypothesis that there is an affect of host genetics on the oral microbiome and metabolome. I also identified a wide range of heritable bacterial taxa and metabolites present in human saliva using two different statistical approaches for quantifying heritability, Falconer's Heritability (H2) and the A.C.E. model of heritability. A network analysis of the microbial co-occurrence patterns revealed that the majority of species interactions in adult saliva were positive, and that there is also a positive correlation between the heritably of a microbe and the number of positive ecological interactions it participates in with other microbes. Finally, I observed that the three most abundant and prevalent Absconditabacteriales (SR1) ASVs had linear correlations and strong positive associations with Prevotella shahii and Alloprevotella, suggesting that these bacterial taxa may be candidate symbiotic partners of Absconditabacteriales, a highly heritable and prevalent clade in the Candidate Phyla Radiation. Chapter 5 characterizes the effects of dual antibiotic administration of metronidazole and azithromycin versus the standard of care, metronidazole alone, in a randomized controlled trial using a large, multinational cohort of children with Crohn's Disease. We report variable effects of the dual vs. single antibiotics on the gut microbiome, and somewhat limited associations with disease remission or treatment outcome. However, we did observe that the microbiome configurations from patients who went into remission were significantly different between the antibiotic treatment regimens, suggesting that there is no single "remission compatible" microbiome, a finding which should inform the design of future clinical studies. Chapter 6 summarizes what I've learned through the course of this work, and highlights some areas that I think are deserving of more attention in the coming years.

Early Life Exposures And Their Impact On Gut Microbiota Assembly Book PDF
✏Book Title : Early life Exposures and Their Impact on Gut Microbiota Assembly
✏Author : Kameron Sugino
✏Publisher :
✏Release Date : 2020
✏Pages : 174
✏ISBN : 9798641900407
✏Available Language : English, Spanish, And French

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✏Early life Exposures and Their Impact on Gut Microbiota Assembly Book Summary : Background: Obesity is a global epidemic and is responsible for increasing burdens on public health. Factors like diet and lifestyle have been investigated as modifiable factors that can help prevent the development of obesity, but another possible mediator of obesity development is the gut microbiome. The gut contains a diverse community of microbes that influences several physiological functions in humans and animals. There have been many studies investigating this association between obesity and the microbiota in adults, however, few studies have been done on the establishment of the infant gut microbiota in the context of its association with maternal pre-pregnancy body mass index (BMI), breastfeeding and delivery mode. Hypothesis: We expect maternal pre-pregnancy BMI will be associated with altered microbiota composition of women and their children. However, in children, this association will have less of an effect on the gut microbiota than exposure to human milk in the diet.Methods: Fecal samples and participant information were collected from a subset of dyads enrolled in two related prospective cohorts (ARCHGUT and BABYGUT) in Michigan. Sequencing the V4 region of the 16S gene was used to analyze fecal bacterial samples collected from mothers in their third trimester and infants at 1, 6, 12 and 24 months of age. The microbiota data was analyzed using alpha and beta diversity metrics, negative binomial regression to compare taxa abundances between groups and LonGP, a microbiota analysis tool for longitudinal data sets. Results: We found that fecal bacterial communities from overweight women had lower microbiota diversity than communities from normal weight or obese women and beta diversity of overweight women differed from those of normal and obese women at the genus and phylum levels. Infant alpha diversity at 1 month of age differed in membership (Sorensen index) by maternal pre-pregnancy BMI category and also differed by delivery mode and breastfeeding exclusivity. At 6 months of age, fewer infants born to women with pre-pregnancy obesity were breastfeeding compared to infants born to non-obese women (35.7% and 81.8%, respectively). Maternal pre-pregnancy BMI and human milk exposure were both significantly associated with alpha and beta diversity of the infant microbiota in univariate analyses. However, in multivariate analyses, human milk exposure accounted for 20% of variation in alpha diversity, but pre-pregnancy BMI was not significantly associated with microbiota diversity. The infant diet at six months was the major determinant of alpha and beta diversity of the infant. In our longitudinal analysis of the infant fecal microbiota from 1 month to 2 years of age, we found that age and participant explained most of the changes in abundance in our dataset. In the top 10 most abundant taxa, human milk exposure and antibiotic exposure at the time of sampling were the only variables important besides age and ID, specifically for Lachnospiraceae unclassified and Bacteroides abundances. Lachnospiraceae abundance was much higher as infants aged, in infants receiving 30.Conclusion: Here, we found several associations between the infant gut microbiota and infant exposures during the first two years of life. Exploring the relationship between gut health and early infant exposures could help develop potential preventative treatments for many gut-linked chronic diseases such as obesity.

Human Gut Microbiota Onset And Shaping Through Life Stages And Perturbations Book PDF
✏Book Title : Human gut microbiota onset and shaping through life stages and perturbations
✏Author : Lorenza Putignani
✏Publisher : Frontiers E-books
✏Release Date :
✏Pages :
✏ISBN : 9782889190874
✏Available Language : English, Spanish, And French

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✏Human gut microbiota onset and shaping through life stages and perturbations Book Summary :

📒The Long And Short Term Dynamics Of The Human Gut Microbiome ✍ Thilini Nilusha Jayasinghe Maddegoda Vidanelage

The Long And Short Term Dynamics Of The Human Gut Microbiome Book PDF
✏Book Title : The Long and Short Term Dynamics of the Human Gut Microbiome
✏Author : Thilini Nilusha Jayasinghe Maddegoda Vidanelage
✏Publisher :
✏Release Date : 2018
✏Pages : 222
✏ISBN : OCLC:1102649645
✏Available Language : English, Spanish, And French

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✏The Long and Short Term Dynamics of the Human Gut Microbiome Book Summary : The microbiome is closely linked to human health and disease. Research has shown that the microbiome changes throughout life but studies looking at: how early life events influence the differences in the microbial composition in mid-childhood; how the microbiome changes over a long period of time; and whether microbiome transplantation can shift imbalance in the human microbiome are limited. Thus, here I explore short and long-term fluctuations in the human gut microbiome that are associated with early life-events, ageing, and an intervention. Firstly, I hypothesise that adverse early life events in preterm children change the microbial composition, functions and metabolic products of the gut microbiome in midchildhood. My results identified different active microbial species as classifiers of the preterm condition together with functional changes, altered profiles of plasma and faecal amino acids, faecal volatiles and faecal calprotectin levels. I speculate that the pretermspecific changes observed in the active gut microbiome were established in early infancy and are associated with on-going low-grade gut inflammation. Secondly, characterisation of the gut microbial composition of artist Billy Apple® from stool contaminated toilet tissues collected in 1970 and 2016 showed that the microbial composition in 2016 represents 45% of the microbial species in 1970. Moreover, components of Apple‟s microbiome were associated with the allele frequency at seven single nucleotide polymorphisms in his genome confirming that genetics contribute to the selection and maintenance of the microbiome over the artist‟s lifetime. Thirdly, I studied the short- and medium-term effects of lean donor faecal microbiota transplantation on the gut microbiota composition in a group of female adolescents with severe obesity. My results showed that the faecal microbiome transplantation is capable of shifting the recipient microbiota successfully at 6 weeks, postfaecal microbiota transplantation. The engrafted microbiota remained unchanged for half of a year in spite of subtle dietary and environmental changes.

📒Microbial Ecology ✍ Larry L. Barton

Microbial Ecology Book PDF
✏Book Title : Microbial Ecology
✏Author : Larry L. Barton
✏Publisher : John Wiley & Sons
✏Release Date : 2011-10-14
✏Pages : 440
✏ISBN : 9781118015834
✏Available Language : English, Spanish, And French

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✏Microbial Ecology Book Summary : This book covers the ecological activities of microbes in the biosphere with an emphasis on microbial interactions within their environments and communities In thirteen concise and timely chapters, Microbial Ecology presents a broad overview of this rapidly growing field, explaining the basic principles in an easy-to-follow manner. Using an integrative approach, it comprehensively covers traditional issues in ecology as well as cutting-edge content at the intersection of ecology, microbiology, environmental science and engineering, and molecular biology. Examining the microbial characteristics that enable microbes to grow in different environments, the book provides insights into relevant methodologies for characterization of microorganisms in the environment. The authors draw upon their extensive experience in teaching microbiology to address the latest hot-button topics in the field, such as: Ecology of microorganisms in natural and engineered environments Advances in molecular-based understanding of microbial phylogeny and interactions Microbially driven biogeochemical processes and interactions among microbial populations and communities Microbial activities in extreme or unusual environments Ecological studies pertaining to animal, plant, and insect microbiology Microbial processes and interactions associated with environmental pollution Designed for use in teaching, Microbial Ecology offers numerous special features to aid both students and instructors, including: Information boxes that highlight key microbial ecology issues "Microbial Spotlights" that focus on how prominent microbial ecologists became interested in microbial ecology Examples that illustrate the role of bacterial interaction with humans Exercises to promote critical thinking Selected reading lists Chapter summaries and review questions for class discussion Various microbial interactions and community structures are presented through examples and illustrations. Also included are mini case studies that address activities of microorganisms in specific environments, as well as a glossary and key words. All these features make this an ideal textbook for graduate or upper-level undergraduate students in biology, microbiology, ecology, or environmental science. It also serves as a highly useful reference for scientists and environmental professionals. PowerPoint slides of figures from the book are available for download at: ftp://ftp.wiley.com/public/sci_tech_med/microbial_ecology

📒Missing Microbes ✍ Martin J. Blaser, MD

Missing Microbes Book PDF
✏Book Title : Missing Microbes
✏Author : Martin J. Blaser, MD
✏Publisher : Henry Holt and Company
✏Release Date : 2014-04-08
✏Pages : 288
✏ISBN : 9780805098112
✏Available Language : English, Spanish, And French

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✏Missing Microbes Book Summary : A critically important and startling look at the harmful effects of overusing antibiotics, from the field's leading expert Tracing one scientist's journey toward understanding the crucial importance of the microbiome, this revolutionary book will take readers to the forefront of trail-blazing research while revealing the damage that overuse of antibiotics is doing to our health: contributing to the rise of obesity, asthma, diabetes, and certain forms of cancer. In Missing Microbes, Dr. Martin Blaser invites us into the wilds of the human microbiome where for hundreds of thousands of years bacterial and human cells have existed in a peaceful symbiosis that is responsible for the health and equilibrium of our body. Now, this invisible eden is being irrevocably damaged by some of our most revered medical advances—antibiotics—threatening the extinction of our irreplaceable microbes with terrible health consequences. Taking us into both the lab and deep into the fields where these troubling effects can be witnessed firsthand, Blaser not only provides cutting edge evidence for the adverse effects of antibiotics, he tells us what we can do to avoid even more catastrophic health problems in the future.

Welcome To The Microbiome Book PDF
✏Book Title : Welcome to the Microbiome
✏Author : Rob DeSalle
✏Publisher : Yale University Press
✏Release Date : 2015-11-10
✏Pages : 264
✏ISBN : 9780300216325
✏Available Language : English, Spanish, And French

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✏Welcome to the Microbiome Book Summary : Suddenly, research findings require a paradigm shift in our view of the microbial world. The Human Microbiome Project at the National Institutes of Health is well under way, and unprecedented scientific technology now allows the censusing of trillions of microbes inside and on our bodies as well as in the places where we live, work, and play. This intriguing, up-to-the-minute book for scientists and nonscientists alike explains what researchers are discovering about the microbe world and what the implications are for modern science and medicine. Rob DeSalle and Susan Perkins illuminate the long, intertwined evolution of humans and microbes. They discuss how novel DNA sequencing has shed entirely new light on the complexity of microbe-human interactions, and they examine the potential benefits to human health: amazing possibilities for pinpoint treatment of infections and other illnesses without upsetting the vital balance of an individual microbiome. This book has been inspired by an exhibition, The Secret World Inside You: The Microbiome, at the American Museum of Natural History, which will open in New York in early November 2015 and run until August 2016. It will then travel to other museums in the United States and abroad.

📒Follow Your Gut ✍ Rob Knight

Follow Your Gut Book PDF
✏Book Title : Follow Your Gut
✏Author : Rob Knight
✏Publisher : Simon and Schuster
✏Release Date : 2015-04-07
✏Pages : 128
✏ISBN : 9781476784755
✏Available Language : English, Spanish, And French

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✏Follow Your Gut Book Summary : Allergies, asthma, obesity, acne: these are just a few of the conditions that may be caused—and someday cured—by the microscopic life inside us. The key is to understand how this groundbreaking science influences your health, mood, and more. In just the last few years, scientists have shown how the microscopic life within our bodies— particularly within our intestines—has an astonishing impact on our lives. Your health, mood, sleep patterns, eating preferences—even your likelihood of getting bitten by mosquitoes—can be traced in part to the tiny creatures that live on and inside of us. In Follow Your Gut, pioneering scientist Rob Knight pairs with award-winning science journalist Brendan Buhler to explain—with good humor and easy-to-grasp examples—why these new findings matter to everyone. They lead a detailed tour of the previously unseen world inside our bodies, calling out the diseases and conditions believed to be most directly impacted by them. With a practical eye toward deeper knowledge and better decisions, they also explore the known effects of antibiotics, probiotics, diet choice and even birth method on our children’s lifelong health. Ultimately, this pioneering book explains how to learn about your own microbiome and take steps toward understanding and improving your health, using the latest research as a guide.

📒Let Them Eat Dirt ✍ B. Brett Finlay

Let Them Eat Dirt Book PDF
✏Book Title : Let Them Eat Dirt
✏Author : B. Brett Finlay
✏Publisher : Algonquin Books
✏Release Date : 2016-09-20
✏Pages : 304
✏ISBN : 9781616206710
✏Available Language : English, Spanish, And French

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✏Let Them Eat Dirt Book Summary : “A must-read . . . Takes you inside a child’s gut and shows you how to give kids the best immune start early in life.” —William Sears, MD, coauthor of The Baby Book Like the culture-changing Last Child in the Woods, here is the first parenting book to apply the latest cutting-edge scientific research about the human microbiome to the way we raise our children. In the two hundred years since we discovered that microbes cause infectious diseases, we’ve battled to keep them at bay. But a recent explosion of scientific knowledge has led to undeniable evidence that early exposure to these organisms is beneficial to a child’s well-being. Our modern lifestyle, with its emphasis on hyper-cleanliness, is taking a toll on children’s lifelong health. In this engaging and important book, microbiologists Brett Finlay and Marie-Claire Arrieta explain how the trillions of microbes that live in and on our bodies influence childhood development; why an imbalance of those microbes can lead to obesity, diabetes, and asthma, among other chronic conditions; and what parents can do--from conception on--to positively affect their own behaviors and those of their children. They describe how natural childbirth, breastfeeding, and solid foods influence children’s microbiota. They also offer practical advice on matters such as whether to sterilize food implements for babies, the use of antibiotics, the safety of vaccines, and why having pets is a good idea. Forward-thinking and revelatory, Let Them Eat Dirt is an essential book in helping us to nurture stronger, more resilient, happy, and healthy kids.

The Microbiome In Early Life Self Completion And Microbiota Protection As Health Priorities Book PDF
✏Book Title : The Microbiome in Early Life Self Completion and Microbiota Protection as Health Priorities
✏Author :
✏Publisher :
✏Release Date : 2014
✏Pages :
✏ISBN : OCLC:1051368865
✏Available Language : English, Spanish, And French

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✏The Microbiome in Early Life Self Completion and Microbiota Protection as Health Priorities Book Summary : Abstract This minireview considers the benefits of refocusing attention away from treating the patient as a mammalian human to managing the complete patient: a majority microbial superorganism. Under the "completed self" model for formation of the human‐microbial superorganism, the single, most pivotal sign in distinguishing a life course of health versus that filled with disease is self‐completion (i.e., seeding of the minority mammalian human by the majority microbial portion of the symbiont). From a disease prevention perspective, microbial seeding at birth and subsequent nurturing of the microbiota are significant steps to reduce the risk of both noncommunicable diseases (e.g., type 1 diabetes) and certain infectious diseases. Management of the microbiome during pregnancy, birth, and shortly thereafter appears to be the most significant critical window for healthy superorganism formation. However, the bolus for microbiota seeding at birth and the nurturing process are subject to environmental influences and disruption, such as exposure to toxic chemicals and drugs, infections, and other physical and psychological stressors. Additionally, childhood and adult corrective measures, such as fecal transplantation and administration of prebiotics and probiotics, while potentially useful, may have limitations that are yet to be fully defined. This minireview considers (1) basic features of management of the microbiome to facilitate self‐completion, (2) protection of the microbiota from environmental hazards, and (3) the benefits of using a superorganism focus for health management beginning with pregnancy and extending throughout childhood and adult life.

📒The Skinny Gut Diet ✍ Brenda Watson, C.N.C.

The Skinny Gut Diet Book PDF
✏Book Title : The Skinny Gut Diet
✏Author : Brenda Watson, C.N.C.
✏Publisher : Harmony
✏Release Date : 2014-10-07
✏Pages : 304
✏ISBN : 9780553417951
✏Available Language : English, Spanish, And French

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✏The Skinny Gut Diet Book Summary : The secret to permanent weight loss revealed. The real reason diets fail has nothing to do with calories and everything to do with the balance of bacteria in your gut. A simple guide to show you how to finally achieve your ideal weight. The 100 trillion bacteria that live in your digestive tract—which make up 90 percent of the cells in your body—are the real reason you gain or lose weight. When those microbes are out of balance, chronic health conditions can occur, including irritable bowel syndrome, fatigue, and obesity. By balancing the good and bad bacteria, you can finally achieve your ideal weight—for good. In The Skinny Gut Diet, New York Times bestselling author, public television icon, certified nutritional consultant, and digestive health expert Brenda Watson offers an insightful perspective on the little-known connection between weight gain and an underlying imbalance of bacteria in the gut, or what she calls the “gut factor”—the overlooked root cause of weight gain. Drawing upon the latest scientific research, Brenda illuminates the inner workings of the digestive system and provides instructions for achieving a healthy bacterial ecosystem that spurs weight loss by enabling the body to absorb fewer calories from food, experience reduced cravings, and store less fat. The premise is simple: curtail sugar consumption (and its surprising sources) and eat more healthy fats, living foods, and protein to balance the gut bacteria. The result? A skinny gut. The Skinny Gut Diet centers around an easy-to-follow diet plan. A 14-day eating plan, dozens of delicious recipes and sage advice help you achieve—and maintain—digestive balance and sustained weight loss. With inspiring real-life stories of ten individuals who transformed their health on the Skinny Gut Diet, Brenda empowers you to become your own health advocate so that you can finally shed unwanted pounds and enjoy optimal health and vitality.

Nutritional Care Of Preterm Infants Book PDF
✏Book Title : Nutritional Care of Preterm Infants
✏Author : B. Koletzko
✏Publisher : Karger Medical and Scientific Publishers
✏Release Date : 2014-04-15
✏Pages : 326
✏ISBN : 9783318026412
✏Available Language : English, Spanish, And French

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✏Nutritional Care of Preterm Infants Book Summary : Improved conditions of care for premature infants have led to markedly increased survival rates over the last few decades, particularly in very low and extremely low birth weight infants. Nutritional measures play a central role in the long-term outcome, health and quality of life of these premature infants. In this publication, leading experts from all 5 continents present the most recent evidence and critical analyses of nutrient requirements and the practice of nutritional care (with the focus on very low birth weight infants) to provide guidance for clinical application. After the introductory chapters, covering nutritional needs and research evidence in a more general manner, topics such as amino acids and proteins, lipids, microminerals and vitamins, parenteral and enteral nutrition as well as approaches to various disease conditions are addressed. Due to its focus on critical appraisals and recommendations, this book is of interest not only for the researcher who wants to keep up to date, but also for the clinician faced with premature infants in his practice.

The Personalized Medicine Revolution Book PDF
✏Book Title : The Personalized Medicine Revolution
✏Author : Pieter Cullis
✏Publisher : Greystone Books
✏Release Date : 2015-02-10
✏Pages : 176
✏ISBN : 9781771640398
✏Available Language : English, Spanish, And French

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✏The Personalized Medicine Revolution Book Summary : Every one of us is unique. With recent advances in technology, we now know that that statement is more true that ever: we are each individuals, right down to a molecular level — a one-of-a-kind combination of genes, proteins, and metabolism. So why does healthcare still take a one-size-fits-all approach? The same methods are used on everyone to diagnose illness, and the same drugs are used to treat it — despite the fact that those methods and treatments are not effective for everyone and are even harmful for some. Shouldn’t our medicine be tailored to our differences? The Personalized Medicine Revolution explores recent advances in genomics, the study of the human genome — as well as its cousins proteomics, metabolomics, microbiomics, and the like — and explains how technology is even now changing the way medicine is delivered. Along the way, it takes the reader through the five critical healthcare areas that will be transformed most radically by personalized medicine — prediction, prevention, diagnosis, treatment, and monitoring — and examines the practical and ethical issues involved. Finally, it details how readers can use personalized medicine to take charge of their own health and build a stronger and safer medical system.

Microbial Ecology In States Of Health And Disease Book PDF
✏Book Title : Microbial Ecology in States of Health and Disease
✏Author : Institute of Medicine
✏Publisher : National Academies Press
✏Release Date : 2014-02-18
✏Pages : 548
✏ISBN : 9780309290654
✏Available Language : English, Spanish, And French

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✏Microbial Ecology in States of Health and Disease Book Summary : Individually and collectively, resident microbes play important roles in host health and survival. Shaping and shaped by their host environments, these microorganisms form intricate communities that are in a state of dynamic equilibrium. This ecologic and dynamic view of host-microbe interactions is rapidly redefining our view of health and disease. It is now accepted that the vast majority of microbes are, for the most part, not intrinsically harmful, but rather become established as persistent, co-adapted colonists in equilibrium with their environment, providing useful goods and services to their hosts while deriving benefits from these host associations. Disruption of such alliances may have consequences for host health, and investigations in a wide variety of organisms have begun to illuminate the complex and dynamic network of interaction - across the spectrum of hosts, microbes, and environmental niches - that influence the formation, function, and stability of host-associated microbial communities. Microbial Ecology in States of Health and Disease is the summary of a workshop convened by the Institute of Medicine's Forum on Microbial Threats in March 2013 to explore the scientific and therapeutic implications of microbial ecology in states of health and disease. Participants explored host-microbe interactions in humans, animals, and plants; emerging insights into how microbes may influence the development and maintenance of states of health and disease; the effects of environmental change(s) on the formation, function, and stability of microbial communities; and research challenges and opportunities for this emerging field of inquiry.

📒Epigenetics And Human Health ✍ Alexander Haslberger

Epigenetics And Human Health Book PDF
✏Book Title : Epigenetics and Human Health
✏Author : Alexander Haslberger
✏Publisher : John Wiley & Sons
✏Release Date : 2011-08-24
✏Pages : 316
✏ISBN : 9783527644759
✏Available Language : English, Spanish, And French

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✏Epigenetics and Human Health Book Summary : After first introducing the concept of epigenetics, this handbook and ready reference provides an overview of the main research on epigenetics. It adopts a multidisciplinary approach, involving molecular biology, molecular epidemiology and nutritional science, with a special focus of the book is on disease prevention and treatment. Of interest to all healthcare-related professionals as well as nutritionists, and the medical community focusing on disease prevention.

Genome Research Book PDF
✏Book Title : Genome Research
✏Author :
✏Publisher :
✏Release Date : 2008
✏Pages :
✏ISBN : UOM:39015072632998
✏Available Language : English, Spanish, And French

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✏Genome Research Book Summary :

Metabonomics And Gut Microbiota In Nutrition And Disease Book PDF
✏Book Title : Metabonomics and Gut Microbiota in Nutrition and Disease
✏Author : Sunil Kochhar
✏Publisher : Springer
✏Release Date : 2014-10-21
✏Pages : 375
✏ISBN : 9781447165392
✏Available Language : English, Spanish, And French

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✏Metabonomics and Gut Microbiota in Nutrition and Disease Book Summary : This book provides a comprehensive overview of metabonomics and gut microbiota research from molecular analysis to population-based global health considerations. The topics include the discussion of the applications in relation to metabonomics and gut microbiota in nutritional research, in health and disease and a review of future therapeutical, nutraceutical and clinical applications. It also examines the translatability of systems biology approaches into applied clinical research and to patient health and nutrition. The rise in multifactorial disorders, the lack of understanding of the molecular processes at play and the needs for disease prediction in asymptomatic conditions are some of the many questions that system biology approaches are well suited to address. Achieving this goal lies in our ability to model and understand the complex web of interactions between genetics, metabolism, environmental factors and gut microbiota. Being the most densely populated microbial ecosystem on earth, gut microbiota co-evolved as a key component of human biology, essentially extending the physiological definition of humans. Major advances in microbiome research have shown that the contribution of the intestinal microbiota to the overall health status of the host has been so far underestimated. Human host gut microbial interaction is one of the most significant human health considerations of the present day with relevance for both prevention of disease via microbiota-oriented environmental protection as well as strategies for new therapeutic approaches using microbiota as targets and/or biomarkers. In many aspects, humans are not a complete and fully healthy organism without their appropriate microbiological components. Increasingly, scientific evidence identifies gut microbiota as a key biological interface between human genetics and environmental conditions encompassing nutrition. Microbiota dysbiosis or variation in metabolic activity has been associated with metabolic deregulation (e.g. obesity, inflammatory bowel disease), disease risk factor (e.g. coronary heart disease) and even the aetiology of various pathologies (e.g. autism, cancer), although causal role into impaired metabolism still needs to be established. Metabonomics and Gut Microbiota in Nutrition and Disease serves as a handbook for postgraduate students, researchers in life sciences or health sciences, scientists in academic and industrial environments working in application areas as diverse as health, disease, nutrition, microbial research and human clinical medicine.

10 Human How Your Body S Microbes Hold The Key To Health And Happiness Book PDF
✏Book Title : 10 Human How Your Body s Microbes Hold the Key to Health and Happiness
✏Author : Alanna Collen
✏Publisher : HarperCollins UK
✏Release Date : 2015-04-23
✏Pages : 336
✏ISBN : 9780007584048
✏Available Language : English, Spanish, And French

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✏10 Human How Your Body s Microbes Hold the Key to Health and Happiness Book Summary : Obesity, autism, mental health problems, IBS, allergies, auto-immunity, cancer. Does the answer to the modern epidemic of ‘Western’ diseases lie in our gut?

Beneficial Microbes In Fermented And Functional Foods Book PDF
✏Book Title : Beneficial Microbes in Fermented and Functional Foods
✏Author : Ravishankar Rai V
✏Publisher : CRC Press
✏Release Date : 2014-12-17
✏Pages : 600
✏ISBN : 9781482206630
✏Available Language : English, Spanish, And French

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✏Beneficial Microbes in Fermented and Functional Foods Book Summary : In recent years, the potential health benefits of fermented and functional foods have made them increasingly popular among consumers. A complete overview of the physiology and functional aspects of microbes present in fermented foods and used as functional foods, Beneficial Microbes in Fermented and Functional Foods explores recent advances and pro

📒Biography Of Resistance ✍ Muhammad H. Zaman

Biography Of Resistance Book PDF
✏Book Title : Biography of Resistance
✏Author : Muhammad H. Zaman
✏Publisher : HarperCollins
✏Release Date : 2020-04-21
✏Pages : 320
✏ISBN : 9780062862983
✏Available Language : English, Spanish, And French

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✏Biography of Resistance Book Summary : Award-winning Boston University educator and researcher Muhammad H. Zaman provides a chilling look at the rise of antibiotic-resistant superbugs, explaining how we got here and what we must do to address this growing global health crisis. In September 2016, a woman in Nevada became the first known case in the U.S. of a person who died of an infection resistant to every antibiotic available. Her death is the worst nightmare of infectious disease doctors and public health professionals. While bacteria live within us and are essential for our health, some strains can kill us. As bacteria continue to mutate, becoming increasingly resistant to known antibiotics, we are likely to face a public health crisis of unimaginable proportions. “It will be like the great plague of the middle ages, the influenza pandemic of 1918, the AIDS crisis of the 1990s, and the Ebola epidemic of 2014 all combined into a single threat,” Muhammad H. Zaman warns. The Biography of Resistance is Zaman’s riveting and timely look at why and how microbes are becoming superbugs. It is a story of science and evolution that looks to history, culture, attitudes and our own individual choices and collective human behavior. Following the trail of resistant bacteria from previously uncontacted tribes in the Amazon to the isolated islands in the Arctic, from the urban slums of Karachi to the wilderness of the Australian outback, Zaman examines the myriad factors contributing to this unfolding health crisis—including war, greed, natural disasters, and germophobia—to the culprits driving it: pharmaceutical companies, farmers, industrialists, doctors, governments, and ordinary people, all whose choices are pushing us closer to catastrophe. Joining the ranks of acclaimed works like Microbe Hunters, The Emperor of All Maladies, and Spillover, A Biography of Resistance is a riveting and chilling tale from a natural storyteller on the front lines, and a clarion call to address the biggest public health threat of our time.

Year Book Of Neonatal And Perinatal Medicine 2011 E Book Book PDF
✏Book Title : Year Book of Neonatal and Perinatal Medicine 2011 E Book
✏Author : Avroy A. Fanaroff
✏Publisher : Elsevier Health Sciences
✏Release Date : 2011-09-01
✏Pages : 328
✏ISBN : 9780323087384
✏Available Language : English, Spanish, And French

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✏Year Book of Neonatal and Perinatal Medicine 2011 E Book Book Summary : The Year Book of Neonatal and Perinatal Medicine brings you abstracts of the articles that reported the year's breakthrough developments in neontatology and perinatology, carefully selected from more than 500 journals worldwide. Dr. Avroy Fanaroff, Emeritus Professor as Case Western Reserve University, is a key opinion leader who has been a driving force in the field for many years. He authors many commentaries himself and has assembled top experts to select the most important journal articles and write commentaries that evaluate the clinical importance of each article and discuss its application to patient care. There's no faster or easier way to stay informed! This annual covers all aspects of care from the fetus, postnatal growth, labor and delivery, infectious diseases, respiratory disorders, cardiovascular health, and gastrointestinal health to name a few. The Year Book of Neonatal and Perinatal Medicine publishes annually in November.

The Microbiome In Prenatal And Neonatal Life Book PDF
✏Book Title : The Microbiome in Prenatal and Neonatal Life
✏Author : Josef Neu
✏Publisher : Academic Press
✏Release Date : 2020-12-01
✏Pages : 250
✏ISBN : 9780128206096
✏Available Language : English, Spanish, And French

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✏The Microbiome in Prenatal and Neonatal Life Book Summary : The Microbiome in Prenatal and Neonatal Life clarifies that the microbiome in the maternal fetal unit and immediate changes that occur as new microbes are acquired postnatally play major roles in subsequent health and disease. Rapidly developing technologies for multi-omic analyses and systems biology are shifting paradigms in both scientific knowledge and clinical care with regard to this topic. In essence, we are changing the idea that newborns emerge from sterile environments. As such, in-utero colonization may have impacts on the development of immunity and metabolism that, with epigenetic modifications, will lead to diseases in later life. In addition, the microbial profile that develops during and after birth depends on mode of delivery, type of feeding (human milk versus formula), and various other environmental factors to which the newborn is exposed. Discusses the critical nonredundant timeframe in a newborn's life during which many factors drive immune and tissue maturation and influence the susceptibility to immune-mediated and other diseases in adult life Proves that the fetus and uterine membranes are exposed to not only microbes in close proximity but also to microbial products from metabolism of microbes in the mother Shows that since early life periods are a critical window for development, epigenetic and/or immunologic alterations may occur that can affect not only the infant during his/her lifetime but also subsequent generations Gives insight into factors that may affect the newborn microbiome and subsequent development

📒The Omics ✍ Giovanni Coppola

The Omics Book PDF
✏Book Title : The OMICs
✏Author : Giovanni Coppola
✏Publisher : Oxford University Press
✏Release Date : 2013-12-11
✏Pages : 272
✏ISBN : 9780199355006
✏Available Language : English, Spanish, And French

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✏The OMICs Book Summary : The OMICs: Applications in Neuroscience summarizes the state of the art in high-throughput approaches (collectively known as 'OMICs') in neurology and neuroscience, and is of interest to both neurologists tracking the progress of these methods towards clinical applications, and neuroscientists curious about the most recent advances in this ever-changing field. The explosion of high-throughput assays has introduced large datasets, computational servers, and bioinformatics approaches to neuroscience, and medicine in general. The book includes a rich survey of the most relevant OMICs applications and how they relate to neurology and neuroscience. The reader is given an overview of the method, a perspective on the current and future applications, and published examples illustrating practical uses.