The Detection Of Biomarkers

Developing Affimers For The Detection Of Biomarkers In Cancer Book PDF
✏Book Title : Developing Affimers for the Detection of Biomarkers in Cancer
✏Author : Danah A. A. A. Q. Al-Qallaf
✏Publisher :
✏Release Date : 2018
✏Pages :
✏ISBN : OCLC:1112386630
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Developing Affimers for the Detection of Biomarkers in Cancer Book Summary :

Early Detection Of Biomarkers For Disease Book PDF
✏Book Title : Early Detection of Biomarkers for Disease
✏Author : Richard Morgan
✏Publisher :
✏Release Date : 2014-03-01
✏Pages : 250
✏ISBN : 1849736138
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Early Detection of Biomarkers for Disease Book Summary : This volume presents the current knowledge on biomarkers for the early detection of disease, and the methodologies used for detecting these biomarkers, often present at very low concentrations in bodily fluids.

Biomarkers For The Detection Prognois And Evaluation Of Active Tuberculosis Book PDF
✏Book Title : Biomarkers for the Detection Prognois and Evaluation of Active Tuberculosis
✏Author :
✏Publisher :
✏Release Date : 2010
✏Pages :
✏ISBN : OCLC:1065638155
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Biomarkers for the Detection Prognois and Evaluation of Active Tuberculosis Book Summary : The global TS surveillance workshop aims to address the problems with current methods for the detection of TB, and tracking emergence of resistant strains. The purpose of the attached presentation is to review the current methods in the detection of pathogen biomarkers for TB and if that technology has promise for diagnosis of TB. A summary of three biomarkers and some data on their detection strategies is presented. Some of the work is from LANL work but much of it is derived from literature references on the subject.

In Vitro Biomarker Detection For Early Diagnosis Of Neurodegenerative Diseases Via The Ocular Fluid Book PDF
✏Book Title : In Vitro Biomarker Detection for Early Diagnosis of Neurodegenerative Diseases Via the Ocular Fluid
✏Author : Parisa Farajipour
✏Publisher :
✏Release Date : 2009
✏Pages : 87
✏ISBN : OCLC:781306528
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏In Vitro Biomarker Detection for Early Diagnosis of Neurodegenerative Diseases Via the Ocular Fluid Book Summary : "Non invasive early diagnosis of any disease is a crucial step in prevention, treatment and decreasing the mortality rate. The purpose of this study is in vitro screening of neurodegenerative disease biomarkers, employing polarimetric detection methodology via ocular fluid. According to Dr. Ansari 'eye can be considered, not only a window to the soul but a window to the body'2. The eye is easily accessed by light for in vitro imaging and screening of diseases. The unique biomarkers exist in the ocular fluid for large groups of diseases, which can determine the presence and the stage of the disease. For this research Amyloid, Vascular Endothelial Growth Factor and Glutamate biomarkers have been studied for in vitro detection of neurodegenerative diseases. The concentration elevation of any of these biomarkers may highlight the presence and progression rate of certain neurodegenerative diseases. The potential of in vitro spectral and power analysis of optical biomarkers, under two distinct geometries: a) Backscattered geometry; and b) Diffused reflectance geometry, to detect unique optical signatures has been investigated. The copolarized and crosspolarized contributions were achieved by spectrometer and power meter, and the corresponding Degree of Linear Polarization (DOLP) were calculated. Backscattering geometry detected light from the surface and subsurface of the tissue (epithelium), therefore it was anticipated to be highly polarized. Diffused reflectance geometry detected light from deeper structures therefore, light contributions were mostly unpolarized due to multiple scattering. The combination of the data collected utilizing both geometries may reveal more inclusive information, by not solely reaching the surface of the target, but also deeper depth of the target. Bot spectral and power analysis of various concentrations of each biomarker revealed a variation of the degree of linear polarization (DOLP) with increments in biomarker concentration. The coefficient of variation between multiple measurements were negligible and there was a consistency between repetitions. The statistical analysis of power and spectral responses illustrated a significant difference in DOLP by varying biomarker concentration, which can be utilized for early diagnosis of neurodegenerative diseases."--Abstract.

📒Biomarkers In Drug Development ✍ Michael R. Bleavins

Biomarkers In Drug Development Book PDF
✏Book Title : Biomarkers in Drug Development
✏Author : Michael R. Bleavins
✏Publisher : John Wiley & Sons
✏Release Date : 2011-09-20
✏Pages : 784
✏ISBN : 9781118210420
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Biomarkers in Drug Development Book Summary : Discover how biomarkers can boost the success rate of drugdevelopment efforts As pharmaceutical companies struggle to improve the success rateand cost-effectiveness of the drug development process, biomarkershave emerged as a valuable tool. This book synthesizes and reviewsthe latest efforts to identify, develop, and integrate biomarkersas a key strategy in translational medicine and the drugdevelopment process. Filled with case studies, the bookdemonstrates how biomarkers can improve drug development timelines,lower costs, facilitate better compound selection, reducelate-stage attrition, and open the door to personalizedmedicine. Biomarkers in Drug Development is divided into eightparts: Part One offers an overview of biomarkers and their role in drugdevelopment. Part Two highlights important technologies to help researchersidentify new biomarkers. Part Three examines the characterization and validation processfor both drugs and diagnostics, and provides practical advice onappropriate statistical methods to ensure that biomarkers fulfilltheir intended purpose. Parts Four through Six examine the application of biomarkers indiscovery, preclinical safety assessment, clinical trials, andtranslational medicine. Part Seven focuses on lessons learned and the practical aspectsof implementing biomarkers in drug development programs. Part Eight explores future trends and issues, including dataintegration, personalized medicine, and ethical concerns. Each of the thirty-eight chapters was contributed by one or moreleading experts, including scientists from biotechnology andpharmaceutical firms, academia, and the U.S. Food and DrugAdministration. Their contributions offer pharmaceutical andclinical researchers the most up-to-date understanding of thestrategies used for and applications of biomarkers in drugdevelopment.

📒Cancer Biomarkers ✍ Institute of Medicine

Cancer Biomarkers Book PDF
✏Book Title : Cancer Biomarkers
✏Author : Institute of Medicine
✏Publisher : National Academies Press
✏Release Date : 2007-03-27
✏Pages : 250
✏ISBN : 0309133998
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Cancer Biomarkers Book Summary : Many cancer patients are diagnosed at a stage in which the cancer is too far advanced to be cured, and most cancer treatments are effective in only a minority of patients undergoing therapy. Thus, there is tremendous opportunity to improve the outcome for people with cancer by enhancing detection and treatment approaches. Biomarkers will be instrumental in making that transition. Advances in biotechnology and genomics have given scientists new hope that biomarkers can be used to improve cancer screening and detection, to improve the drug development process, and to enhance the effectiveness and safety of cancer care by allowing physicians to tailor treatment for individual patients—an approach known as personalized medicine. However, progress overall has been slow, despite considerable effort and investment, and there are still many challenges and obstacles to overcome before this paradigm shift in oncology can become a reality.

Biomarkers And Biosensors Book PDF
✏Book Title : Biomarkers and Biosensors
✏Author : Ajit Sadana
✏Publisher : Newnes
✏Release Date : 2014-12-08
✏Pages : 702
✏ISBN : 9780444537959
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Biomarkers and Biosensors Book Summary : Biomarkers and Biosensors offers thorough coverage of biomarker/biosensor interaction, current research trends, and future developments in applications of drug discovery. This book is useful to researchers in this field as well as clinicians interested in new developments in early detection and diagnosis of disease or the mode of operation of biomarkers. Biomarkers and Biosensors also emphasizes kinetics, and clearly delineates how this influences the biomarker market. Offers thorough coverage of the kinetics of biomarker interaction with the biosensor surface Provides evidence-based approach to evaluate effectiveness Provides pharmaceutical chemists the possibilities and methodology in assessing the effectiveness of new drugs Provides the information needed for the selection of the best biomarker for a specific application

Identification And Evaluation Of Biomarkers For The Detection Of Bladder Cancer Book PDF
✏Book Title : Identification and Evaluation of Biomarkers for the Detection of Bladder Cancer
✏Author : Hafsa Abbas
✏Publisher :
✏Release Date : 2014
✏Pages : 172
✏ISBN : OCLC:1181417944
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Identification and Evaluation of Biomarkers for the Detection of Bladder Cancer Book Summary :

Longitudinal Bank For Serum Plasma And Dna For Detection Of Biomarkers Book PDF
✏Book Title : Longitudinal Bank for Serum Plasma and DNA for Detection of Biomarkers
✏Author :
✏Publisher :
✏Release Date : 2007
✏Pages :
✏ISBN : OCLC:1065778679
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Longitudinal Bank for Serum Plasma and DNA for Detection of Biomarkers Book Summary : The discovery of genetic or biochemical markers to discriminate malignant cancers from normal or benign disease states, markers to stage cancer or monitor disease progression and markers that provide an early indication of an individual's response to chemotherapy have become a major research objectives of the oncology community over the past few years. The goal of the project is to create a patient speciment bank of serum, plasma, urine and tissues from approximately 1500 individuals. The collection of samples from individuals on a longitudinal basis provided proteomic and biochemical data to be correlated with clinical endpoints. This greatly enhanced our ability to identify biiomarkers for staging different cancers and to detect patient responsiveness to therapy at an early state in the treatment process.

📒Cancer Biomarkers ✍ S. Srivastava

Cancer Biomarkers Book PDF
✏Book Title : Cancer Biomarkers
✏Author : S. Srivastava
✏Publisher : IOS Press
✏Release Date : 2004
✏Pages : 94
✏ISBN : 1586034596
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Cancer Biomarkers Book Summary : This special book edition of the journal Disease Markers concentrates on molecular biomarkers in cancer research. The main subjects of this book are: Prognostic and predictive markers in cancer; Statistical considerations in combining biomarkers for disease classification; Blood and urine markers for ovarian cancer; Use of markers for the detection and treatment of lung cancer; The promise of biomarkers in colorectal cancer detection; Development tracks for cancer prevention markers; Molecular markers for early detection of cervical neoplasia and Markers of prostate cancer detection, diagnosis and prognosis. This book contains contributions by an international board of experts on the topic.

Rapid And Sensitive Biomarker Detection Using Molecular Imprinting Polymer Hydrogel And Surface Enhanced Raman Scattering Book PDF
✏Book Title : Rapid and Sensitive Biomarker Detection Using Molecular Imprinting Polymer Hydrogel and Surface enhanced Raman Scattering
✏Author :
✏Publisher :
✏Release Date : 2018
✏Pages :
✏ISBN : OCLC:1051426530
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Rapid and Sensitive Biomarker Detection Using Molecular Imprinting Polymer Hydrogel and Surface enhanced Raman Scattering Book Summary : Abstract : Biomarkers are important biochemical indicators, which could be used for identification, early diagnosis and monitoring of diseases during the course of treatment. However, biomarker diagnosis has some shortcomings such as requiring a large amount of samples, long test time and high cost, which seriously influences the correctness and timely treatment to patients. Here, a relatively fast and efficient plasmonic hot spot-localized surface imprinting of Ag spheres using biomarker template immobilization and hydrogel copolymerization is described. The technique takes a fine control of the imprinting process at the nanometre scale and provides a biosensor with high sensitivity. Proof of the opinion is established by detection of biomarker using surface-enhanced Raman scattering (SERS) spectroscopy. This work represents a valuable step towards SERS with biomarkers for cost-saving and time-saving diagnostic assay. It is expected that the new surface imprinted hydrogel plasmonic material can drive possibilities in advancing application of biomarkers in plasmonic biosensors.

Biomarkers In Cancer Screening And Early Detection Book PDF
✏Book Title : Biomarkers in Cancer Screening and Early Detection
✏Author : Sudhir Srivastava
✏Publisher : John Wiley & Sons
✏Release Date : 2017-06-07
✏Pages : 320
✏ISBN : 9781118468821
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Biomarkers in Cancer Screening and Early Detection Book Summary : Prepared by world leaders on this topic, Biomarkers in Cancer Screening and Early Detection offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers, from their discovery and development to their validation, clinical utility, and use in developing personalized cancer treatment. Offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers Provides immediately actionable information – and hopefully also inspiration – to move discovery and clinical application forward Offers vital knowledge to help develop personalized cancer treatment for individual patients with specific cancers

Lipid Biomarkers And The Detection Of Ancient Mycobacterial Disease Book PDF
✏Book Title : Lipid Biomarkers and the Detection of Ancient Mycobacterial Disease
✏Author : Janet Elaine Redman
✏Publisher :
✏Release Date : 2008
✏Pages :
✏ISBN : OCLC:1065294385
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Lipid Biomarkers and the Detection of Ancient Mycobacterial Disease Book Summary :

Urine Proteomics In Kidney Disease Biomarker Discovery Book PDF
✏Book Title : Urine Proteomics in Kidney Disease Biomarker Discovery
✏Author : Youhe Gao
✏Publisher : Springer
✏Release Date : 2014-10-29
✏Pages : 203
✏ISBN : 9789401795234
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Urine Proteomics in Kidney Disease Biomarker Discovery Book Summary : This book systematically summarizes the ideas and technologies used in urine proteome analysis. It argues that change is the core of biomarker definition since the body uses its homeostatic mechanisms to correct changes in the blood. This means that urine is probably a better source of biomarkers than blood. A roadmap to the urinary biomarker era is proposed, and researchers are reminded of the potential opportunities and risks in their study design. Kidney diseases are emphasized as they produce the most significant changes in urine. This book tries to show researchers and graduate students, who are in or entering the field, "all things considered" rather than "the current affair".

Immunosensing For Detection Of Protein Biomarkers Book PDF
✏Book Title : Immunosensing for Detection of Protein Biomarkers
✏Author : Huangxian Ju
✏Publisher : Elsevier
✏Release Date : 2017-05-18
✏Pages : 304
✏ISBN : 9780081020005
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Immunosensing for Detection of Protein Biomarkers Book Summary : Immunosensing for Detection of Protein Biomarkers not only introduces the principles, methods, and classification of immunoassay, but also presents the latest achievements in areas such as electrochemical immunosensors, nanoprobe-based immunoassay, chemiluminescence immunoassay, electrochemiluminescent immunoassay, multianalyte immunoassay, optical imaging for immunoassay, signal amplification for immunoassay, and so on. In recent years, immunosensing and immunoassay methods have attracted considerable interest due to their applications in different fields, particularly clinical diagnosis. Although a large number of academic papers in immunosensing and immunoassay have been published in different journals recently, it is still a difficult and time-consuming task for researchers, especially those new to the area, to understand the principles, methods, and research progress of immunosensing. Based on the research experience of the authors and their research groups, this book offers readers with new research ideas to develop immunosensing methodology. As a monograph, it offers deeper and more complete coverage than review papers, which only report certain aspects of progress. Grounded in the research experience of Professor Ju’s research group, the book focuses on immunosensing for detection of protein biomarkers, summarizing understanding, research, and practice on immunosensing methodology in detection of protein biomarkers. Presents the latest research and thinking on immunosensing for detection of protein biomarkers Offers current techniques, and looks to the development of new methodologies Offers the latest developments in various aspects of immunosensing, including electrochemiluminescent immunoassay, multianalyte immunoassay, optical imaging immunoassay, and signal amplification immunoassay Offers readers new ideas to research and develop immunosensing methodologies for the future

📒Cancer Biomarkers In Body Fluids ✍ Gabriel D. Dakubo

Cancer Biomarkers In Body Fluids Book PDF
✏Book Title : Cancer Biomarkers in Body Fluids
✏Author : Gabriel D. Dakubo
✏Publisher : Springer
✏Release Date : 2016-11-23
✏Pages : 509
✏ISBN : 9783319483603
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Cancer Biomarkers in Body Fluids Book Summary : This book examines in depth the evidence, clinical applications and potential cancer signatures in the circulation and discusses alterations in circulating cell-free nucleic acids, and circulating tumor DNA, as well as the epigenome, genome, transcriptome (coding and noncoding), proteome (both traditional serum proteins and proteomic profiles) and metabolome. Further, it highlights the clinical applications of circulating tumor cells for each cancer type and addresses the emerging importance of extracellular vesicular contents, including miRNA, oncogenes and drug resistant factors. As such, it offers a valuable reference guide for cancer researchers, oncologists, clinicians, surgeons, medical students, oncology nurses, diagnostic laboratories, and the pharmaceutical industry. /div

Electrochemical Detection Of Cancer Biomarkers Book PDF
✏Book Title : Electrochemical Detection of Cancer Biomarkers
✏Author : Gary Conrad Jensen
✏Publisher :
✏Release Date : 2011
✏Pages :
✏ISBN : OCLC:1196364493
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Electrochemical Detection of Cancer Biomarkers Book Summary : The detection of proteins with clinical and diagnostic value has become an important method for detecting and following the progression of cancers. Electrochemical detection of these biomarkers offers an inexpensive and highly sensitive detection scheme for cancer biomarkers with the potential for point-of-care diagnostics. Multi-enzyme carriers linked with an antibody can accomplish amplification of electrochemical protein detection, as a secondary antibody in sandwich immunoassay. A multi-enzyme-antibody-carbon nanotube prepared using functionalized multiwalled carbon nanotubes, anti-prostate specific antigen antibodies (anti-PSA), and horseradish peroxidase enzyme labels (HRP) was fully characterized. Analysis of the bioconjugate by electrochemistry, microscopy, and enzyme-catalyzed polymerization determined that the bioconjugate had âˆ1⁄482 HRPs and 30±15 anti-PSA per 100 nm length of carbon nanotube and allowed for amplification over single enzyme secondary antibodies. Gold nanoparticles were printed into an eight-electrode electrochemical array utilizing inkjet printing. The gold nanoparticle platform was used to build a sandwich immunoassay for the protein biomarker interleukin-6 (IL-6). The fabricated arrays allowed for the electrochemical detection of IL-6 with a detection limit of 20 pg mL-1 in undiluted calf serum and a linear range from 20–400 pg mL-1 . These inkjet-printed gold arrays hold promise for use in multiplexed arrays and point-of-care diagnostics.

Graphene Biosensors For Detection Of Biomarkers Related To Mental Health Conditions Book PDF
✏Book Title : Graphene Biosensors for Detection of Biomarkers Related to Mental Health Conditions
✏Author : Rhiannan Forsyth
✏Publisher :
✏Release Date : 2018
✏Pages : 580
✏ISBN : OCLC:1154977515
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Graphene Biosensors for Detection of Biomarkers Related to Mental Health Conditions Book Summary :

Preprocessing And Biomarker Detection Analysis For Biological Mass Spectrometry Data Book PDF
✏Book Title : Preprocessing and Biomarker Detection Analysis for Biological Mass Spectrometry Data
✏Author : Jingjing Ye
✏Publisher :
✏Release Date : 2007
✏Pages : 310
✏ISBN : UCAL:X76271
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Preprocessing and Biomarker Detection Analysis for Biological Mass Spectrometry Data Book Summary :

📒Cancer Biomarkers ✍ Debmalya Barh

Cancer Biomarkers Book PDF
✏Book Title : Cancer Biomarkers
✏Author : Debmalya Barh
✏Publisher : CRC Press
✏Release Date : 2014-01-30
✏Pages : 951
✏ISBN : 9781466584297
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Cancer Biomarkers Book Summary : Gleaning information from more than 100 experts in the field of cancer diagnosis, prognosis, and therapy worldwide, Cancer Biomarkers: Non-Invasive Early Diagnosis and Prognosis determines the significance of clinical validation approaches for several markers. This book examines the use of noninvasive or minimally invasive molecular cancer markers that are under development or currently in use. It deals with a majority of commonly prevalent cancers and can help anyone working in the health-care industry to recommend or develop early diagnostics, at-risk tests, and prognostic biomarkers for various cancers. It explores the practice of determining biomarkers by their characteristics and relative methodologies, and presents the most recent data as well as a number of current and upcoming early diagnostic noninvasive molecular markers for many common cancers. It also considers the sensitivity and specificity of markers, biomarker market, test providers, and patent information. Approximately 30-35 Cancer Specific Noninvasive Molecular Diagnostic Markers in a Single Volume The book details the general and technical aspects of noninvasive cancer markers. It covers imaging, cutting-edge molecular technologies for biomarker development, and noninvasive or minimally invasive sources of molecular markers, as well as quality control and ethical issues in cancer biomarker discovery. It also provides a detailed account of brain, head and neck, and oral cancer markers, and provides information on a number of gastrointestinal cancers, lung cancer, and mesothelioma markers. Emphasizes the Importance of Volatile Markers in Early Cancer Diagnosis Presents noninvasive early molecular markers in urological cancers Describes gynecological and endocrine cancer markers Details noninvasive markers of breast, ovarian, cervical, and thyroid cancers Addresses hematological malignancies Contains information on noninvasive molecular markers in myelodysplastic syndromes, acute myeloid leukemia, Hodgkin’s lymphoma, and multiple myeloma Provides comprehensive information on diagnostic and prognostic biomarkers in cutaneous melanoma This text considers molecular technologies for biomarker development, noninvasive or minimally invasive sources of molecular markers, and quality control and ethical issues in cancer biomarker discovery.

Ultrasensitive Arrays For Multiplexed Detection Of Oral Cancer Serum Biomarker Proteins In The Clinic Book PDF
✏Book Title : Ultrasensitive Arrays for Multiplexed Detection of Oral Cancer Serum Biomarker Proteins in the Clinic
✏Author : Ruchika Malhotra
✏Publisher :
✏Release Date : 2012
✏Pages :
✏ISBN : OCLC:1196371215
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Ultrasensitive Arrays for Multiplexed Detection of Oral Cancer Serum Biomarker Proteins in the Clinic Book Summary : The occurrence of cancer involves altered protein expression, known as biomarkers of disease. The serum levels of biomarker proteins are used as indicators to differentiate between diseased and healthy states, and to monitor disease progression. Sensitive measurement of proteins over-expressed in individuals with cancer holds excellent promise for early disease detection and personalized therapies. However, the required point-of-care measurement has yet to be broadly realized. Thus, there is an urgent need for simpler, faster and inexpensive detection of serum biomarkers with high sensitivity and accuracy. In this dissertation, new methodologies for ultrasensitive multiplexed detection of serum biomarker proteins for oral cancer, as well as other malignancies, utilizing different aspects of nanotechnology in conjunction with electrochemical detection have been developed and characterized. The first part of the approach addresses the study of interleukin-6 (IL-6) using single-walled carbon nanotube forests based electrochemical immunosensor on pyrolytic graphite (PG) electrodes. With two levels of multi-enzyme labeling in a sandwich immunoassay format, 25 fM human IL-6 in serum, and experimental samples, was reproducibly measured. The second part features 8-sensor microfluidic array equipped with four specific capture antibodies to detect ultralow levels of interleukin-6 (IL-6), interleukin-8 (IL-8), vascular endothelial growth factor (VEGF) and vascular endothelial growth factor C (VEGF-C) proteins, and these proteins when captured off-line using magnetic beads derivatized with 120,000 antibodies and 400,000 enzyme labels, greatly decreased non-specific binding and enhanced sensitivity. This approach provided unprecedented detection limits in low fg mL−1 range for all four biomarkers in calf serum, essentially used as a human serum surrogate. This oral cancer biomarker panel was validated by detecting proteins in sera of oral cancer patients and cancer-free controls. Receiver operating characteristic (ROC) analysis showed that a normalized combination of the levels of all 4 biomarkers enhanced the clinical discrimination of oral cancer from non-cancer conditions compared to single biomarkers, with 89% sensitivity and 98% specificity. The use of microfluidic immunoarrays for multiplexed detection of biomarker proteins offers distinct advantages. The capability and versatility of these methodologies for simultaneous, sensitive, accurate, low cost real-time monitoring of protein biomarkers with high clinical selectivity and sensitivity holds excellent promise for diagnosis and prognosis of cancer with potential for rationalizing treatment options. Also described in this dissertation is the development of electrochemical sensors for peanut allergen Ara h2 in serum, along with various analytical techniques to characterize the sensors to establish the primary reasons for high sensitivity and selectivity.

Cardiac Markers An Issue Of Clinics In Laboratory Medicine E Book Book PDF
✏Book Title : Cardiac Markers An Issue of Clinics in Laboratory Medicine E Book
✏Author : Kent Balanis Lewandrowski
✏Publisher : Elsevier Health Sciences
✏Release Date : 2014-02-15
✏Pages : 209
✏ISBN : 9780323287111
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Cardiac Markers An Issue of Clinics in Laboratory Medicine E Book Book Summary : Topics in this clinically focused publication devoted to Cardiac Markers include: Overview of cardiac markers in heart disease; Methodologies for measurement of cardiac markers; Natriuretic peptides in HF and ACS; Tropoinins and high sensitivity troponins; Point-of-care testing for cardiac markers; ST-2 and galectin 3 in patients with heart failure; Cardiac markers following heart surgery and percutaneous coronary intervention; Cholesterol, lipoproteins, high sensitivity CRP and other risk factors for atherosclerosis; Myocarditis and cardiac transplant and rejection; New molecular genetic tests in the diagnosis of heart disease; Biomarkers for cholesterol balance.

Ultra Sensitive And Multiplex Detection Of Clinical Biomarkers Using A Spri Based Sensor Book PDF
✏Book Title : Ultra sensitive and Multiplex Detection of Clinical Biomarkers Using a SPRi based Sensor
✏Author : Effat Zeidan
✏Publisher :
✏Release Date : 2016
✏Pages : 91
✏ISBN : OCLC:1107492797
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Ultra sensitive and Multiplex Detection of Clinical Biomarkers Using a SPRi based Sensor Book Summary : "Reliable and reproducible biomarker analysis is the main focus of current clinical diagnostic approaches being developed for the sensitive detection and quantification of biomarkers in bodily fluids. Currently used tools are being revised for better analytical performance that overcomes the drawbacks of inaccurate results. Surface plasmon resonance imaging is rising quickly as an affinity-based optical biosensor that demonstrates numerous improvements to the sensor surface design and sensitivity for label-free and real-time biomarker analysis. In this work, our goal is to develop a more sensitive analytical method for the enhanced detection of the human growth hormone (hGH) in serum, multiplex detection of disease biomarkers (KIM-1 and HMGB-1) simultaneously in buffer using a sandwich-amplification assay, and small molecule-progesterone sensing using a novel aptasensor. Our goals were met by ensuring a homogenous and specific immunosensor for detecting hGH at very low concentrations (>9.1 pg/mL), substituting random antibody attachment with a site directed immobilization to the sensor surface for multiplex detection of two disease biomarkers down to 5 pg/mL levels in buffer, and further increasing the sensitivity of progesterone biosensor by exploiting x-aptamer technology for highly selective detection of progesterone (> 1 nM) in buffer."--Abstract from author supplied metadata. [This abstract has been edited to remove characters that will not display in this system. Please see the PDF for the full abstract.]

📒Cancer Biomarkers ✍ Mahmoud H. Hamdan

Cancer Biomarkers Book PDF
✏Book Title : Cancer Biomarkers
✏Author : Mahmoud H. Hamdan
✏Publisher : John Wiley & Sons
✏Release Date : 2007-04-23
✏Pages : 408
✏ISBN : 9780470113110
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Cancer Biomarkers Book Summary : Tools, techniques, and progress in cancer biomarkers discovery The completion of a number of gene sequencing projects, recent advances in genomic and proteomic technologies, and the availability of powerful bioinformatics tools have led to promising new avenues and approaches in the search for cancer biomarkers. This book provides a comprehensive overview of current methodologies and technologies. It discusses biomarker discovery as a whole, rather than focusing on one specific marker or cancer. With information on both existing and potential biomarkers, Cancer Biomarkers: Analytical Techniques for Discovery: * Provides insights into the current technological platforms for biomarker discovery, including mass spectrometry combined with multidimensional chromatography, DIGE, and various chip technologies * Includes a detailed discussion of protein networks and protein phosphorylation in cancer * Details the use of imaging mass spectrometry, laser capture microdissection, serial analysis of gene expression, enzyme-linked immunosorbent assays, protein microarrays, antibody-based microarrays, and bioinformatics * Covers the emerging role of surface-enhanced laser desorption ionization (SELDI) and various tagging and labeling strategies * Discusses related regulatory and ethical issues With a wealth of information that can be applied to a broad spectrum of biomarker research projects, this is a core reference for biomarker researchers, scientists working in proteomics and bioinformatics, pharmaceutical scientists, oncologists, biochemists, biologists, and chemists.

Advances In Bionanotechnology Research And Application 2011 Edition Book PDF
✏Book Title : Advances in Bionanotechnology Research and Application 2011 Edition
✏Author :
✏Publisher : ScholarlyEditions
✏Release Date : 2012-01-09
✏Pages : 514
✏ISBN : 9781464921346
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Advances in Bionanotechnology Research and Application 2011 Edition Book Summary : Advances in Bionanotechnology Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Bionanotechnology. The editors have built Advances in Bionanotechnology Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Bionanotechnology in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Bionanotechnology Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

📒Biomarkers ✍ Vishal S. Vaidya

Biomarkers Book PDF
✏Book Title : Biomarkers
✏Author : Vishal S. Vaidya
✏Publisher : John Wiley & Sons
✏Release Date : 2010-10-28
✏Pages : 632
✏ISBN : 0470918551
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Biomarkers Book Summary : This book provides an introduction to the field of biomarkers, how they have been and can be used, and how different approaches can be used to identify, characterize, and monitor biomarkers. The book has chapters on topics including HIV, Cancer, Parkinson’s, vascular injury, environmental exposure. A following section discusses the technologies (diagnostics and assays) to detect biomarkers and authors have emphasized the preclinical and clinical manifestation of the injury/disease process.

📒Volatile Biomarkers ✍ Anton Amann

Volatile Biomarkers Book PDF
✏Book Title : Volatile Biomarkers
✏Author : Anton Amann
✏Publisher : Newnes
✏Release Date : 2013-03-27
✏Pages : 600
✏ISBN : 9780444626202
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Volatile Biomarkers Book Summary : Volatile organic compounds (VOCs) in exhaled breath, sweat or urine carry much information on the state of human health. The role of VOCs in clinical diagnosis and therapeutic monitoring is expected to become increasingly significant due to recent advances in the field. Volatile Biomarkers: Non-Invasive Diagnosis in Physiology and Medicine includes the latest discoveries and applications for VOCs from the world's foremost scientists and clinicians working in this emerging analytic area. Appeals to a multidisciplinary audience, including scientists, researchers, and clinicians with an interest in breath analysis Features the latest scientific research and technical breakthroughs in the diagnostic and therapeutic aspects of volatile organic compounds Includes case presentations documenting applications in multiple areas of human health and safety

Microfluidic And Electronic Detection Of Protein Biomarkers Book PDF
✏Book Title : Microfluidic and Electronic Detection of Protein Biomarkers
✏Author : Dan Wu (Ph.D.)
✏Publisher :
✏Release Date : 2020
✏Pages : 146
✏ISBN : OCLC:1196373798
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Microfluidic and Electronic Detection of Protein Biomarkers Book Summary : Proteins are essential components of our bodies and play critical roles in biological processes. Quantifying protein levels can help characterize these biological processes and detect malfunctions. Thus, protein testing is widely utilized in clinical diagnostics. The current workflow for protein testing involves the processing of patient samples that are collected at healthcare facilities. These samples are sent to centralized laboratories and analyzed using sophisticated instruments. As a result, it can take days to deliver results. However, to manage acute conditions such as sepsis, rapid results are desired to ensure timely diagnosis and treatment. In contrast, point-of-care testing has shown great promise for rapid results through the use of miniaturized and inexpensive devices in non-laboratory settings. While there have been many advances in this field, only a small number of proteins (e.g., cardiac biomarkers) are covered by point-of-care devices, due to the profound challenge of maintaining sensitivity while miniaturizing testing system and reducing assay time. In this thesis, this technical challenge was tackled to develop a point-of-care system for the measurement of interleukin-6, which can be used as a biomarker for sepsis or cytokine release syndrome. Inspired by the success of commercial glucose meters, an all-electrical system was developed, due to easy miniaturization and low cost of electronics. First, surface chemistries were developed to coat antibodies onto electrodes and successful surface modification was validated via various techniques. Non-Faradaic impedimetric, Faradaic impedimetric and chemiresistive label-free electrical biosensors were developed and examined. However, it was found that these biosensing platforms are susceptible to drifts due to the non-specific nature of the signal transduction. Then, building on the enzyme-linked immunosorbent assay (ELISA, the gold standard), a bead-based electronic ELISA was developed, where beads expedite the testing and electrical readout replaces the colorimetric readout in the gold standard ELISA. An integrated mathematical model was developed to comprehensively understand the assay and inform optimization. While providing comparable limit of detection with the gold standard ELISA (

Biochemical Biomarkers In Alzheimer S Disease Book PDF
✏Book Title : Biochemical biomarkers in Alzheimer s disease
✏Author : Samuel Barrack
✏Publisher : iMedPub
✏Release Date : 2013-10-20
✏Pages : 148
✏ISBN : 9781492274469
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Biochemical biomarkers in Alzheimer s disease Book Summary : In view of the growing prevalence of AD worldwide, there is an urgent need for the development of better diagnostic tools and more effective therapeutic interventions. Indeed, much work in this field has been done during last decades. As such, a major goal of current clinical research in AD is to improve early detection of disease and presymptomatic detection of neuronal dysfunction, concurrently with the development of better tools to assess disease progression in this group of disorders. All these putative correlates are commonly referred to as AD-related biomarkers. The ideal biomarker should be easy to quantify and measure, reproducible, not subject to wide variation in the general population and unaffected by co- morbid factors. For evaluation of therapies, a biomarker needs to change linearly with disease progression and closely correlate with established clinico-pathological parameters of the disease. There is growing evidence that the use of biomarkers will increase our ability to better indentify the underlying biology of AD, especially in its early stages. These biomarkers will improve the detection of the patients suitable for research studies and drug trials, and they will contribute to a better management of the disease in the clinical practice. Indeed, much work in this field has been done during last decades. The vast number of important applications, combined with the untamed diversity of already identified biomarkers, show that there is a pressing need to structure the research made on AD biomarkers into a solid, comprehensive and easy to use tool to de deployed in clinical settings. To date there are few publications compiling results on this topic. That is why when I was asked to address this task I accepted inmediately. I am happy to present you a bundle of the best articles published about biomarkers for Alzheimer’s disease in recent times.

Neuroimaging Biomarkers In Alzheimer S Disease Book PDF
✏Book Title : Neuroimaging biomarkers in Alzheimer s disease
✏Author : Samuel Barrack
✏Publisher : iMedPub
✏Release Date : 2013-10
✏Pages : 136
✏ISBN : 9781492274421
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Neuroimaging biomarkers in Alzheimer s disease Book Summary : In view of the growing prevalence of AD worldwide, there is an urgent need for the development of better diagnostic tools and more effective therapeutic interventions. Indeed, much work in this field has been done during last decades. As such, a major goal of current clinical research in AD is to improve early detection of disease and presymptomatic detection of neuronal dysfunction, concurrently with the development of better tools to assess disease progression in this group of disorders. All these putative correlates are commonly referred to as AD-related biomarkers. The ideal biomarker should be easy to quantify and measure, reproducible, not subject to wide variation in the general population and unaffected by co- morbid factors. For evaluation of therapies, a biomarker needs to change linearly with disease progression and closely correlate with established clinico-pathological parameters of the disease. There is growing evidence that the use of biomarkers will increase our ability to better indentify the underlying biology of AD, especially in its early stages. These biomarkers will improve the detection of the patients suitable for research studies and drug trials, and they will contribute to a better management of the disease in the clinical practice. Indeed, much work in this field has been done during last decades. The vast number of important applications, combined with the untamed diversity of already identified biomarkers, show that there is a pressing need to structure the research made on AD biomarkers into a solid, comprehensive and easy to use tool to de deployed in clinical settings. To date there are few publications compiling results on this topic. That is why when I was asked to address this task I accepted inmediately. I am happy to present you a bundle of the best articles published about biomarkers for Alzheimer’s disease in recent times.