The Brain And Host Defense

The Brain And Host Defense Book PDF
✏Book Title : The Brain and Host Defense
✏Author :
✏Publisher : Elsevier
✏Release Date : 2009-12-24
✏Pages : 358
✏ISBN : 0444535454
✏Available Language : English, Spanish, And French

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✏The Brain and Host Defense Book Summary : It is now well recognized that the brain, and especially the hypothalamus, plays an important role in the regulation of immune reactions and inflammation. This book aims to review our current state of knowledge of this important field. Key historical findings are presented, and the reciprocal interactions between the brain and the immune system are examined. Particular emphasis is placed on inflammation, a critical host defense reaction that serves as an effector response for both the adaptive and innate immune systems. Mechanisms implicated in brain defense, as well as in more general host defense, are discussed. The regulatory influences of the brain on inflammatory responses are included with particular reference to the role of the hypothalamus, which is also the main director the hormonal regulation of immune/inflammatory. Gender-related differences in immune responsiveness, circadian modulator of immune responses, and evidence that behavioral conditioning (e.g. reward) of immune responses is possible are used as examples to reinforce the notion that the neuroendocrine system exerts a fundamental and complex regulatory influence on the immune system. * Presents timely issues such as immunological aspects of the blood-brain-barrier and the role of inflammatory mediators in the evolution of strokes and degenerative diseases * Includes analysis of the role of the brain in the adaptive responses to disease * Evaluates the argument that further knowledge of the influence of the brain on the immune system will provide new insights to the pathophysiology infectious and autoimmune diseases

Neural And Neuroendocrine Mechanisms In Host Defense And Autoimmunity Book PDF
✏Book Title : Neural and Neuroendocrine Mechanisms in Host Defense and Autoimmunity
✏Author : C. Jane Welsh
✏Publisher : Springer Science & Business Media
✏Release Date : 2007-04-05
✏Pages : 280
✏ISBN : 9780387483344
✏Available Language : English, Spanish, And French

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✏Neural and Neuroendocrine Mechanisms in Host Defense and Autoimmunity Book Summary : This book provides a lucid summary of behavioral, neural and endocrine regulation of immune responses and of the effects of immune system activity on neural and endocrine functions and behavior. The underlying premise is that the brain and immune system represent a single, integrated system of defense. The discussion includes such topics and stress induced modulation of innate resistance and adaptive immunity in influenza viral infections.

Host Defense Mechanisms Against Human Cytomegalovirus Brain Infection Book PDF
✏Book Title : Host Defense Mechanisms Against Human Cytomegalovirus Brain Infection
✏Author : Maxim Chacko-Joseph Cheeran
✏Publisher :
✏Release Date : 2000
✏Pages : 504
✏ISBN : MINN:31951P007314471
✏Available Language : English, Spanish, And French

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✏Host Defense Mechanisms Against Human Cytomegalovirus Brain Infection Book Summary :

Host Defense Dysfunction In Trauma Shock And Sepsis Book PDF
✏Book Title : Host Defense Dysfunction in Trauma Shock and Sepsis
✏Author : Eugen Faist
✏Publisher : Springer Science & Business Media
✏Release Date : 2012-12-06
✏Pages : 1296
✏ISBN : 9783642774058
✏Available Language : English, Spanish, And French

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✏Host Defense Dysfunction in Trauma Shock and Sepsis Book Summary : This book presents a unique overview of all aspects of host defense alterations under stressful conditions. It is based on the most important contributions given at the "2nd International Congress on the Immune Consequences of Trauma, Shock, and Sepsis-Mechanisms and Therapeutic Approaches," which was held in Munich under the auspices of the most distinguished scientific societies involved in this field (Society of Critical Care Medicine, European Society of Intensive Care Medicine, Societe Internationale de Chirurgie, Surgical Infection Society, Surgical Infection Society Europe, European Society for Surgical Research, International Society for Burn Injury, American Association for the Surgery of Trauma, and National Institutes of Health). Since the first conference of this kind in 1988, new information from basic studies and clinical trials has provided exciting and novel insights into the immune dysfunctions accom panying trauma, shock, and sepsis. The volume is divided into 18 parts presenting the structural background of trauma-induced alterations of immune and imflammatory mechanisms as well as the currently discussed therapeutic interventions designed to restore or maintain normal host defenses following major injury. Introducing the general theme of the book is a summary of the essential keystones of trauma and sepsis-related immune deficits. Discussions of the progress in trauma care brought through better understanding of the cell biology of injury and of the major clinical factors that influence host defense integrity in operative medicine provide a setting for understanding the wide array of detailed information that is presented thereafter.

Host Defenses To Intracellular Pathogens Book PDF
✏Book Title : Host Defenses to Intracellular Pathogens
✏Author : Toby K. Eisenstein
✏Publisher : Springer Science & Business Media
✏Release Date : 2012-12-06
✏Pages : 538
✏ISBN : 9781468444810
✏Available Language : English, Spanish, And French

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✏Host Defenses to Intracellular Pathogens Book Summary : The subject matter of this volume was the basis for a confer ence held in Philadelphia in June, 1981, and is an important one in the contemporary area of how the host interacts with micro organisms. In conception, it grew out of a graduate course entitled, "The Infectious Process," which has been taught in the Department of Microbiology and Immunology at Temple University School of Medicine during the past twelve years. This course has explored the broad areas of mechanisms of microbial pathogenesis and host resistance by in-depth consideration of selected models of experimental infection and immunity, as well as the clinical literature. It is noteworthy that there is no adequate text for this material, as the subject matter naturally crosses a wide spectrum of traditional disciplinary lines, encompassing topics as diverse as the mechanisms of action of bacterial toxins, the role of complement and antibody in phagocytosis, and the importance of cross-reacting bacterial polysaccharide antigens in vaccine development. A major portion of the course has always considered "cellular immunity" as it applies to host defenses to intracellular pathogens. It is in this area that the necessity for amalgamation of information from different disciplines is most evident, for one must be intimately concerned with the interactions between the microbe and the phagocyte, both before and after specific immune recognition.

Lectin In Host Defense Against Microbial Infections Book PDF
✏Book Title : Lectin in Host Defense Against Microbial Infections
✏Author : Shie-Liang Hsieh
✏Publisher : Springer Nature
✏Release Date : 2020
✏Pages : 240
✏ISBN : 9789811515804
✏Available Language : English, Spanish, And French

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✏Lectin in Host Defense Against Microbial Infections Book Summary : This book systemically presents the latest research on lectins, covering all the major topics in the field, including the heterocomplex of lectins and Toll-like receptors, protective versus pathogenic functions in connection with microbial infections, and novel strategies for enhancing host immunity against infectious diseases caused by viruses, bacteria, and fungi. Lectins are a large group of glycan-binding proteins that recognize diverse glycan and non-glycan structures expressed on prokaryotic and eukaryotic cells, and are vital to cell-cell interactions, the attachment of microbes to host cells, and the recognition and activation of immune responses to exogenous and endogenous danger signals. The composition and structure of microbes are complex and include numerous 'pathogen-associated molecular patterns or 'damage-associated molecular patterns. As such, microbes interactions with immune cells activate multiple innate immunity receptors and produce distinct inflammatory reactions, which can be protective to contain microbial invasion, or pathogenic to cause tissue damage and shock syndrome in the host. The book shares lessons learned from state-of-the art research in this field, highlights the latest discoveries, and provides insightful discussions on lectin-mediated inflammatory reactions, while also outlining future research directions.

Natural Killer Cells And Host Defense Book PDF
✏Book Title : Natural Killer Cells and Host Defense
✏Author : Edwin W. Ades
✏Publisher : S Karger Ag
✏Release Date : 1989
✏Pages : 301
✏ISBN : UOM:39015014484714
✏Available Language : English, Spanish, And French

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✏Natural Killer Cells and Host Defense Book Summary :

Host Defense Mechanisms Against Cancer Book PDF
✏Book Title : Host Defense Mechanisms Against Cancer
✏Author : Tadao Aoki
✏Publisher : Elsevier Science & Technology
✏Release Date : 1986
✏Pages : 336
✏ISBN : UOM:39015013202208
✏Available Language : English, Spanish, And French

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✏Host Defense Mechanisms Against Cancer Book Summary :

📒Interleukin 1 In The Brain ✍ Nancy J. Rothwell

Interleukin 1 In The Brain Book PDF
✏Book Title : Interleukin 1 in the Brain
✏Author : Nancy J. Rothwell
✏Publisher : Elsevier
✏Release Date : 2013-10-22
✏Pages : 216
✏ISBN : 9781483287768
✏Available Language : English, Spanish, And French

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✏Interleukin 1 in the Brain Book Summary : Interest in interleukin-1 (IL-1) has increased dramatically over the last decade, but has been largely restricted to immunologists, cell biologists and those studying inflammation and cancer. However, it has recently been recognized that the brain directly controls or modulates many aspects of immune function, while molecules classically associated with the immune system, such as interleukin-1, are synthesised within the brain and act directly on the central nervous system to modify local and systemic functions. Thus, this topic is relatively new to neurobiologists, and this book is the first comprehensive description of current knowledge on interleukin-1 in the brain, including its location, synthesis and receptors, actions on behaviour, fever, metabolism, neuroendocrine function, electrical activity of the brain, nerve growth factor, and relationship to clinical indications. The book is organised into three sections. The first reviews the data available on the neural localisation of IL-1 and the nature of its central receptors. The main part of the book examines the different neural effects of IL-1 and the mechanisms which are involved in these actions, comparing IL-1 where possible to other inflammatory cytokines which also have neurotrophic effects. The final section evaluates the possible role of IL-1 in neural plasticity and neuronal degeneration.

Immune Mediated Antiviral Defense Against Polyomavirus Infection Of The Brain Book PDF
✏Book Title : Immune mediated Antiviral Defense Against Polyomavirus Infection of the Brain
✏Author : Taryn Mockus
✏Publisher :
✏Release Date : 2019
✏Pages :
✏ISBN : OCLC:1107166000
✏Available Language : English, Spanish, And French

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✏Immune mediated Antiviral Defense Against Polyomavirus Infection of the Brain Book Summary : Progressive multifocal leukoencephalopathy (PML) is an often-fatal demyelinating disease of the brain caused by JC polyomavirus (JCPyV) in immunocompromised individuals. Initially rare, PML has increased in prevalence with the rise of immunomodulatory therapies used for the treatment of autoimmune diseases, many of which impede the movement or function of immune cells. Despite increased incidence, PML pathogenesis remains poorly understood; the only treatment available for PML is to reconstitute the immune response, which can cause immune reconstitution inflammatory syndrome. Most studies of PML to date have utilized post mortem brains of PML patients or immunocompromised humanized mouse models, leaving many unresolved questions regarding the mechanisms of demyelination and the content and contribution of anti-polyomavirus (PyV) immunity. The aim of our work is to provide insight into PyV pathogenesis and defense in the brain using intracerebral (i.c.) infection of immunocompetent mice with mouse polyomavirus (MuPyV), a naturally occurring mouse pathogen, as a novel brain PyV infection model. To this end, we first investigated the contribution of CD4 T cells to the development of antiviral brain-resident CD8 T cells (bTRM). We found that CD4 T cells are required for MuPyV-specific CD8 bTRM development, as demonstrated by decreased expression of canonical tissue-resident memory surface markers, continued dependence on CD8 T cells in the circulation, and decreased ability to control reinfection in CD8 T cells that develop in the absence of CD4 T cells. Furthermore, acquired CD4 T cell deficiency, modeled by delaying systemic CD4 T cell depletion until after the infiltration of MuPyV-specific CD8 T cells into the brain, also impacted the differentiation of CD8 bTRM and decreased the ability of these cells to control reinfection. Together, these findings reveal an intimate association between CD4 T cells and homeostasis of functional CD8 bTRM to brain polyomavirus infection. In conjunction with investigating the nature of the adaptive immune response to MuPyV, we also documented the role of type I, II, and III interferons (IFNs) in anti-PyV defense in the brain. Previous work has shown that IFNs induce an antiviral state in the infected cell and modulate the immune response. We found that type I IFNs mediated viral control during acute brain infection, but no single IFN contributed substantially to PyV control during persistent MuPyV infection. However, mice deficient in signal transducer and activator of transcription 1 (STAT1), the common downstream effector of the IFN family, developed severe hydrocephalus, likely resulting from a loss of intrinsic viral control and a prolonged immune response consisting of inflammatory myeloid cells and polyfunctional CD8 T cells. These findings show that STAT1 is a critical component of the antiviral defense against MuPyV infection. Furthermore, we characterized the infection of brain resident cells and damage following MuPyV infection in the mouse brain. Histological and imaging analysis of MuPyV-infected mouse brains demonstrated histopathological abnormalities similar to those found in PML patients, such as demyelination and infection of glial cells, and a critical role of T cells in preventing PyV encephalitis. Together, our work documents the components of host defense against brain PyV infection and provides insight into the mechanisms of immunological control of PML progression and PyV infection in the brain. A better understanding of polyomavirus infection in the brain is necessary to alleviate the morbidity and mortality that result from polyomavirus-associated diseases.

Cytokines And Mental Health Book PDF
✏Book Title : Cytokines and Mental Health
✏Author : Ziad Kronfol
✏Publisher : Springer Science & Business Media
✏Release Date : 2003-01-31
✏Pages : 426
✏ISBN : 1402073534
✏Available Language : English, Spanish, And French

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✏Cytokines and Mental Health Book Summary : Cytokines and Mental Health explores the relationship between cytokines, neural circuitry and mental health. It is interdisciplinary and "translational", bringing together information that spans the spectrum from the molecular and cellular levels to the patient and the clinic. Content includes chapters that discuss cytokine pathways in the brain, the neurochemical and neuroendocrine effects of cytokines, and the behavioral effects of cytokines including sickness behavior. These chapters in basic research are followed by a more clinical section that discusses the role of cytokines in neuropsychiatric disorders such as major depression, schizophrenia and Alzheimer's disease. The book offers different things to different people. It should be of great interest to neuroscientists and immunologists working in the field of psychoneuroimmunology. It would also greatly benefit mental health professionals including psychiatrists, psychologists and clinicians of diverse background who are interested in mind-body medicine.

📒Leukocytes And Host Defense ✍ Diane M. Jacobs

Leukocytes And Host Defense Book PDF
✏Book Title : Leukocytes and Host Defense
✏Author : Diane M. Jacobs
✏Publisher :
✏Release Date : 1986
✏Pages : 495
✏ISBN : UOM:39015010675554
✏Available Language : English, Spanish, And French

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✏Leukocytes and Host Defense Book Summary :

Principles And Practice Of Sleep Medicine E Book Book PDF
✏Book Title : Principles and Practice of Sleep Medicine E Book
✏Author : Meir H. Kryger
✏Publisher : Elsevier Health Sciences
✏Release Date : 2010-11-01
✏Pages : 1766
✏ISBN : 9781437727739
✏Available Language : English, Spanish, And French

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✏Principles and Practice of Sleep Medicine E Book Book Summary : Principles and Practice of Sleep Medicine, 5th Edition, by Meir H. Kryger, MD, FRCPC, Thomas Roth, PhD, and William C. Dement, MD, PhD, delivers the comprehensive, dependable guidance you need to effectively diagnose and manage even the most challenging sleep disorders. Updates to genetics and circadian rhythms, occupational health, sleep in older people, memory and sleep, physical examination of the patient, comorbid insomnias, and much more keep you current on the newest areas of the field. A greater emphasis on evidence-based approaches helps you make the most well-informed clinical decisions. And, a new more user-friendly, full-color format, both in print and online, lets you find the answers you need more quickly and easily. Whether you are preparing for the new sleep medicine fellowship examination, or simply want to offer your patients today's best care, this is the one resource to use! Make optimal use of the newest scientific discoveries and clinical approaches that are advancing the diagnosis and management of sleep disorders.

Acute And Chronic Complications Of Diabetes An Issue Of Endocrinology And Metabolism Clinics E Book Book PDF
✏Book Title : Acute and Chronic Complications of Diabetes An Issue of Endocrinology and Metabolism Clinics E Book
✏Author : Leonid Poretsky
✏Publisher : Elsevier Health Sciences
✏Release Date : 2013-12-06
✏Pages : 22
✏ISBN : 9780323260954
✏Available Language : English, Spanish, And French

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✏Acute and Chronic Complications of Diabetes An Issue of Endocrinology and Metabolism Clinics E Book Book Summary : This issue of Endocrinology Clinics brings the reader up to date on the important advances in research surrounding acute diabetic complications. Guest edited by Leonid Poretsky and Eliana Liao, the topics covered include retinopathy, neuropathy, gastrointestinal complications, diabetic foot, dental complications, dermatologic complications, and more.

📒Glycerophospholipids In The Brain ✍ Akhlaq A. Farooqui

Glycerophospholipids In The Brain Book PDF
✏Book Title : Glycerophospholipids in the Brain
✏Author : Akhlaq A. Farooqui
✏Publisher : Springer Science & Business Media
✏Release Date : 2006-10-28
✏Pages : 394
✏ISBN : 9780387499314
✏Available Language : English, Spanish, And French

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✏Glycerophospholipids in the Brain Book Summary : This volume provides a comprehensive description of phospholipid metabolism in brain, activities of phospholipases A2, and their involvement in neurological disorders. The purpose of this book is to present readers with cutting edge information in a lively manner that is useful not only to student and teachers but also to researchers and physicians.

📒Cannabinoids And The Brain ✍ Attila Köfalvi

Cannabinoids And The Brain Book PDF
✏Book Title : Cannabinoids and the Brain
✏Author : Attila Köfalvi
✏Publisher : Springer Science & Business Media
✏Release Date : 2007-12-22
✏Pages : 583
✏ISBN : 0387743499
✏Available Language : English, Spanish, And French

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✏Cannabinoids and the Brain Book Summary : Endocannabinoids have tremendous therapeutic potential. This book introduces readers to our current understanding of the neurobiology of endocannabinoids and related systems, detailing their pathophysiological role and therapeutic potential. Authors, experienced clinical investigators, present and analyze results of recent clinical trials as well as the development of new therapeutic strategies and medicines.

Inflammation And Oxidative Stress In Neurological Disorders Book PDF
✏Book Title : Inflammation and Oxidative Stress in Neurological Disorders
✏Author : Akhlaq A. Farooqui
✏Publisher : Springer Science & Business Media
✏Release Date : 2014-01-27
✏Pages : 355
✏ISBN : 9783319041117
✏Available Language : English, Spanish, And French

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✏Inflammation and Oxidative Stress in Neurological Disorders Book Summary : Unless new discoveries are made in the prevention or treatment of stroke, Alzheimer's Disease and depression, the number of patients with these diseases is sure to increase dramatically by the year 2050. Thus, developing strategies to retard or delay the onset of stroke, AD and depression these neurological disorders is of critical important. The present monograph will provide current and comprehensive information on the relationship between neuroinflammation and oxidative stress in age-related neurological disorders at the molecular level. The information described in this monograph on lifestyle (diet and exercise), genes and age is intended to facilitate and promote new discoveries for the treatment of age-related neurological disorders.

Encyclopedia Of Behavioral Neuroscience Book PDF
✏Book Title : Encyclopedia of Behavioral Neuroscience
✏Author :
✏Publisher : Elsevier
✏Release Date : 2010-06-03
✏Pages : 1816
✏ISBN : 9780080453965
✏Available Language : English, Spanish, And French

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✏Encyclopedia of Behavioral Neuroscience Book Summary : Behavioral Neuroscientists study the behavior of animals and humans and the neurobiological and physiological processes that control it. Behavior is the ultimate function of the nervous system, and the study of it is very multidisciplinary. Disorders of behavior in humans touch millions of people’s lives significantly, and it is of paramount importance to understand pathological conditions such as addictions, anxiety, depression, schizophrenia, autism among others, in order to be able to develop new treatment possibilities. Encyclopedia of Behavioral Neuroscience is the first and only multi-volume reference to comprehensively cover the foundation knowledge in the field. This three volume work is edited by world renowned behavioral neuroscientists George F. Koob, The Scripps Research Institute, Michel Le Moal, Université Bordeaux, and Richard F. Thompson, University of Southern California and written by a premier selection of the leading scientists in their respective fields. Each section is edited by a specialist in the relevant area. The important research in all areas of Behavioral Neuroscience is covered in a total of 210 chapters on topics ranging from neuroethology and learning and memory, to behavioral disorders and psychiatric diseases. The only comprehensive Encyclopedia of Behavioral Neuroscience on the market Addresses all recent advances in the field Written and edited by an international group of leading researchers, truly representative of the behavioral neuroscience community Includes many entries on the advances in our knowledge of the neurobiological basis of complex behavioral, psychiatric, and neurological disorders Richly illustrated in full color Extensively cross referenced to serve as the go-to reference for students and researchers alike The online version features full searching, navigation, and linking functionality An essential resource for libraries serving neuroscientists, psychologists, neuropharmacologists, and psychiatrists

📒Brain Edema Xv ✍ Yoichi Katayama

Brain Edema Xv Book PDF
✏Book Title : Brain Edema XV
✏Author : Yoichi Katayama
✏Publisher : Springer Science & Business Media
✏Release Date : 2013-04-06
✏Pages : 335
✏ISBN : 9783709114346
✏Available Language : English, Spanish, And French

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✏Brain Edema XV Book Summary : More than 60 papers written by internationally recognized experts cover the broad spectrum of brain edema. The main topics treated are: ischemia & hemorrhage, trauma (experimental and clinical), cerebral hemorrhage, tumor, hydrocephlaus & intracranial pressure (ICP), neuromonitoring & neuroimaging, treatments, blood brain barrier, and miscellaneous.

📒Neuroimmunology Of Sleep ✍ S. R. Pandi-Perumal

Neuroimmunology Of Sleep Book PDF
✏Book Title : Neuroimmunology of Sleep
✏Author : S. R. Pandi-Perumal
✏Publisher : Springer Science & Business Media
✏Release Date : 2007-08-19
✏Pages : 362
✏ISBN : 9780387691466
✏Available Language : English, Spanish, And French

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✏Neuroimmunology of Sleep Book Summary : This timely work reflects the growing importance of research into the nature of sleep and its medical aspects. One of the first of its kind, this work on the neuroimmunology of sleep provides an introduction to the interplay between these two key and interlinked areas. Written both from a basic and a clinical perspective, the volume is an invaluable information resource for biomedical professionals and students of the human biology. Highly practical guide written from both a basic and clinical perspective.

Thomas Hematopoietic Cell Transplantation Book PDF
✏Book Title : Thomas Hematopoietic Cell Transplantation
✏Author : Frederick R. Appelbaum
✏Publisher : John Wiley & Sons
✏Release Date : 2011-09-26
✏Pages : 1752
✏ISBN : 9781444357455
✏Available Language : English, Spanish, And French

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✏Thomas Hematopoietic Cell Transplantation Book Summary : This outstanding reference source on bone marrow transplantation has become recognised as the bible in the field. This fourth edition has been fully revised to reflect latest developments, and now features over 500 illustrations, including a colour plate section. The need for this new edition cannot be overstated - more than 13,000 new cases per year of haematopoietic stem cell transplantation have been reported to the International Bone Marrow Transplant Registry The original editor, Donnall Thomas, was a pioneer in stem cell research and won the 1990 Nobel Prize for his discoveries concerning organ and cell transplantation in the treatment of human diseases. The book also now includes a fully searchable CD with PDFs of the entire content.

Netter S Infectious Diseases E Book Book PDF
✏Book Title : Netter s Infectious Diseases E Book
✏Author : Elaine C. Jong
✏Publisher : Elsevier Health Sciences
✏Release Date : 2011-09-09
✏Pages : 624
✏ISBN : 9781455712250
✏Available Language : English, Spanish, And French

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✏Netter s Infectious Diseases E Book Book Summary : Netter’s Infectious Diseases provides a comprehensive yet concise overview of current global infectious disease concerns. Elaine Jong and Dennis Stevens cover the basics of the field using beautiful Netter illustrations and accessible "need to know" information on major conditions and problems— including multi-drug-resistance, Staph infections, Chagas disease, and the flu. In print and online, it’s a great tool for quick review or for sharing with patients and staff. Review the basics of infectious disease through comprehensive coverage contained in a single volume reference. Apply "need to know" information from the uniformly concise text and instructive Netter paintings. View detailed Netter illustrations that provide a quick and memorable overview of microbiology, pathophysiology, and clinical presentation. Stay current on modern infectious disease concerns—such as multi-drug-resistant tuberculosis, Staph aureus, Chagas disease, and the flu—with new illustrations in the Netter tradition specifically created to address new topics. Access a companion website at www.netterreference.com featuring the complete searchable text, an Image Bank containing all of the book’s illustrations...downloadable for your personal use, plus 25 printable patient education brochures.

Igf And Nutrition In Health And Disease Book PDF
✏Book Title : IGF and Nutrition in Health and Disease
✏Author : M. Sue Houston
✏Publisher : Springer Science & Business Media
✏Release Date : 2004-08-04
✏Pages : 359
✏ISBN : 9781592597956
✏Available Language : English, Spanish, And French

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✏IGF and Nutrition in Health and Disease Book Summary : A benchmark review on how specific nutrients or adverse nutritional states impact the components of the IGF (Insulin-like Growth Factor) system and affect human health and disease. The authors describe the fundamentals of the IGF system, explain its basic mechanisms of action, illuminate its essential role in physical development across the life span, and highlight the link between normal and abnormal cellular growth resulting in tumor formation. They also fully examine the clinical aspects of nutrition and IGF, from pre- and postnatal development through old age, in the maintenance of normal metabolism, bone, and muscle health, and their role in pathological states. Special attention is given to critical illness, diabetes, gastrointestinal diseases, kidney failure, endocrine dysfunctions, cardiovascular disease, neurological disorders, and cancer, as well as to their potential for IGF therapy.

Molecular Markers Of Brain Tumor Cells Book PDF
✏Book Title : Molecular Markers of Brain Tumor Cells
✏Author : Bela Bodey
✏Publisher : Springer Science & Business Media
✏Release Date : 2004-09-14
✏Pages : 362
✏ISBN : 1402027818
✏Available Language : English, Spanish, And French

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✏Molecular Markers of Brain Tumor Cells Book Summary : I. MOLECULAR BIOLOGY OF TUMORS. 1. Brain Tumors 2. Immunophenotypic Characterization of Infiltrating Poly- and Mononuclear Cells in Childhood Brain Tumors II. ANTI-NEOPLASTIC BIOLOGICAL THERAPIES 3. Experimental Therapies in Brain Tumors 4. Biologic Anti-Neoplastic Therapies 5. The lymphokine activated killer (LAK) cell phenomenon 6. Angiogenesis Inhibition in Anti-Neoplastic Therapy 7. Antigen Presentation by Dendritic Cells and Their Significance in Anti-Neoplastic Immunotherapy 8. Genetically Engineered Antibodies for Direct Anti-Neoplastic Treatment and Systematic Delivery of Various Therapeutic Agents to Cancer Cells 9. Cancer-Testis Antigens: Promising Targets for Antigen Directed Anti-neoplastic Immunotherapy III. APPENDIX 10. Materials and Methods

Issues In Brain And Cognition Research 2011 Edition Book PDF
✏Book Title : Issues in Brain and Cognition Research 2011 Edition
✏Author :
✏Publisher : ScholarlyEditions
✏Release Date : 2012-01-09
✏Pages : 1456
✏ISBN : 9781464964480
✏Available Language : English, Spanish, And French

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✏Issues in Brain and Cognition Research 2011 Edition Book Summary : Issues in Brain and Cognition Research / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Brain and Cognition Research. The editors have built Issues in Brain and Cognition Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Brain and Cognition Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Brain and Cognition Research: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Brain Immune System Signal Molecules In Protection From Aerobic And Anaerobic Infections Book PDF
✏Book Title : Brain Immune System Signal Molecules in Protection from Aerobic and Anaerobic Infections
✏Author : Armen A. Galoyan
✏Publisher : Springer Science & Business Media
✏Release Date : 2012-06-06
✏Pages : 200
✏ISBN : 9781461436676
✏Available Language : English, Spanish, And French

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✏Brain Immune System Signal Molecules in Protection from Aerobic and Anaerobic Infections Book Summary : Proline-rich polypeptides - in particular (PRP-1) galarmin and its structural analogues – are, when isolated from the neurosecretory granules of neurohypophysis of humans and animals, a new type of hypothalamic peptides. They work against aerobic, anaerobic, gram-positive, and gram-negative microorganisms in vivo, and do not have etiotropic properties. They are unique and capable substitutes to antibiotics, and, moreover, may be effective against strains, such as MRSA, that develop resistance to antibiotics. Galarmin, a component of the brain neuroendocrine system produced by the neurosecretory cells of hypothalamus, possesses immunomodulative, neuroprotective, antioxidant, antitumorigenic and hematopoietic properties. Moreover, galarmin and its structural analogues are powerful anti-inflammatory compounds. In addition to presenting a full overview of the neuroimmune system, it emphasizes the antibacterial, neuroprotective, and neuroregenerative properties of proline-rich polypeptides. It investigates the mechanism of galarmin’s action during different infectious processes, where it targets such dangerous pathogens as Bacillus anthracis, Clostridium perfringens, Mycobacterium tuberculosis, and Methycillin resistant Staphylococcus aureus. This research is important from both a theoretical and a clinical point of view, creating new prospects for the modern pharmaceutical industry and neuroendocrine, neuroimmunological sciences. Dr. Galoyan is a pioneer of the specialized field of neuroimmunology. During his 45-year long career, he has discovered a neuroendocrine immune system of the brain and identified a new type of brain cytokines: proline-rich polypeptides. The most important of these, PRP-1 (galarmin) has been shown to possess antibacterial properties and protect from certain neurotoxins.

Chemokines And Chemokine Receptors In Brain Homeostasis Book PDF
✏Book Title : Chemokines and Chemokine Receptors in Brain Homeostasis
✏Author : Flavia Trettel
✏Publisher : Frontiers Media SA
✏Release Date : 2015-08-17
✏Pages :
✏ISBN : 9782889196166
✏Available Language : English, Spanish, And French

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✏Chemokines and Chemokine Receptors in Brain Homeostasis Book Summary : Virtually involved in all pathologies that present an inflammatory component, it is now evident that, in the central nervous system, chemokines and chemokine receptors possess pleiotropic properties beyond chemotaxis: costitutive brain expression of chemokines and their receptors on endothelial cells, but also on neurons and glia, suggests a role for such molecules in mediating homeostatic cross-talk between cells of the brain perenchyma. Cross-talk between neurons and glia is determinant to the establishment and maintenance of a brain enviroment that ensure normal function, and in particular glial cells are active players that respond to enviromental changes and act for the survival, growth, differentiation and repair of the nervous tissue: in this regard brain endogenous chemokines represent key molecules that play a role in brain development, neurogenesis, neurotransmission and neuroprotection. As important regulators of peripheral immune response, chemokines are molecules of the immune system that play a central role in coordinating communication between the nervous and the immune systems, in the context of infections and brain injury. Indeed, in phatological processes resulting from infections, brain trauma, ischemia and chronic neurodegenerative diseases, chemokines represent important neuroinflammatory mediators that drive leucocytes trafficking into the central nervous system, facilitating an immune response by targeting cells of the innate and adaptive immune system. The third edition of the international conference "Chemokines and Chemokine Receptors in the Nervous System", hold in Rome in October 2013, represented an exciting platform to promote discussion among researchers in different disciplines to understand the role of chemokines in brain homoestasis. This Frontiers Research Topic arises from this conference, and wants to be an opportunity to further discuss and highlight the importance of brain chemokines as key molecules that, not only grant the interplay between the immune and the nervous systems, but in addition drive modulatory functions on brain homeoastasis orchestrating neurons, microglia, and astrocytes communication.

Immunomodulators And Nonspecific Host Defence Mechanisms Against Microbial Infections Book PDF
✏Book Title : Immunomodulators and Nonspecific Host Defence Mechanisms Against Microbial Infections
✏Author : K. Noel Masihi
✏Publisher : Pergamon
✏Release Date : 1988
✏Pages : 462
✏ISBN : UOM:39015012553858
✏Available Language : English, Spanish, And French

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✏Immunomodulators and Nonspecific Host Defence Mechanisms Against Microbial Infections Book Summary :

📒Neuropathology Review ✍ Richard A. Prayson

Neuropathology Review Book PDF
✏Book Title : Neuropathology Review
✏Author : Richard A. Prayson
✏Publisher : Springer Science & Business Media
✏Release Date : 2007-12-26
✏Pages : 252
✏ISBN : 159745219X
✏Available Language : English, Spanish, And French

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✏Neuropathology Review Book Summary : The scope of neuropathology continues to expand and the ever-increasing amount of information to assimilate and master can be daunting. Neuropathology Review, Second Edition summarizes in simple outline form the essentials of neuropathology. It has been updated to reflect the newest information and ideas in this constantly changing field.

Macrophages Biology And Role In The Pathology Of Diseases Book PDF
✏Book Title : Macrophages Biology and Role in the Pathology of Diseases
✏Author : Subhra K. Biswas
✏Publisher : Springer
✏Release Date : 2014-11-12
✏Pages : 615
✏ISBN : 9781493913114
✏Available Language : English, Spanish, And French

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✏Macrophages Biology and Role in the Pathology of Diseases Book Summary : Macrophages are a key component of the innate immune system and play an integral role in host defense and homeostasis. On one hand, these cells contribute to host defence by triggering inflammation, displaying microbicidal/tumoricidal properties, regulating the activation of adaptive immunity and promoting resolution of inflammation. On the other hand, they contribute to essential trophic functions such as neural patterning, bone morphogenesis and ductal branching in mammary glands. Thus, macrophages are extremely versatile cells that can respond efficiently to tissue micro environmental cues by polarizing to distinct phenotypes, depending on the functions they need to perform. Indeed, functional diversity and plasticity are hallmarks of these cells. Macrophages may also play a detrimental role. An overwhelming body of literature has indicated their crucial role in pathogenesis. The list includes sepsis, cancer, metabolic syndrome, immunodeficiency, auto-immune disease-virtually impacting every major pathology that we know. These observations have suggested macrophages and their related molecules as potential targets in therapeutic applications. Available evidence proclaims macrophages as a key player in homeostasis, host defense and disease. Crucial developments in the past few years call for a re-evaluation and update of our understanding of macrophages. The present book is an endeavour that attempts provide state-of-the art knowledge of these cells in health and disease.