Targeting Cell Survival Pathways to Enhance Response to Chemotherapy

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  • Author : Anonim
  • Publisher : Academic Press
  • Pages : 308 pages
  • ISBN : 9780128137536
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Targeting Cell Survival Pathways to Enhance Response to Chemotherapy

Download or Read online Targeting Cell Survival Pathways to Enhance Response to Chemotherapy full in PDF, ePub and kindle. this book written by Anonim and published by Academic Press which was released on 17 April 2018 with total page 308 pages. We cannot guarantee that Targeting Cell Survival Pathways to Enhance Response to Chemotherapy book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Targeting Cell Survival Pathways to Enhance Response to Chemotherapy encompasses recently developed molecular targeting agents and approaches that suppress cell survival signaling. Cell survival signaling attenuates the effectiveness of conventional chemotherapy and numerous mechanisms have been described, and continue to be described, which contribute to cell survival in the face of chemotherapy treatment. Key pathways leading to chemoresistance emanate from growth factor receptors, PI3K, STAT3, anti-apoptotic Bcl-2 family members, autophagy, and the DNA damage response pathway. New advances have underscored the potential of targeting each of these cell survival mechanisms to improve responsiveness to chemotherapy. This book reviews these recent advances and provides a foundational background and hints of new opportunities for basic, translational, and clinical investigators focused on improving therapeutic responses to chemotherapy. Presents cutting-edge agents and approaches with proved success in different model systems that can be translated to a different type of cancer Brings updated information to be used to propose new clinical trials investigating innovative strategies for improving responses to chemotherapy Provides mechanistic details to help guide the design of laboratory studies associated with clinical trials

Targeting Cell Survival Pathways to Enhance Response to Chemotherapy

Targeting Cell Survival Pathways to Enhance Response to Chemotherapy
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 17 April 2018
GET THIS BOOK Targeting Cell Survival Pathways to Enhance Response to Chemotherapy

Targeting Cell Survival Pathways to Enhance Response to Chemotherapy encompasses recently developed molecular targeting agents and approaches that suppress cell survival signaling. Cell survival signaling attenuates the effectiveness of conventional chemotherapy and numerous mechanisms have been described, and continue to be described, which contribute to cell survival in the face of chemotherapy treatment. Key pathways leading to chemoresistance emanate from growth factor receptors, PI3K, STAT3, anti-apoptotic Bcl-2 family members, autophagy, and the DNA damage response pathway. New advances have

Targeting Cell Survival Pathways to Enhance Response to Chemotherapy

Targeting Cell Survival Pathways to Enhance Response to Chemotherapy
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 28 March 2018
GET THIS BOOK Targeting Cell Survival Pathways to Enhance Response to Chemotherapy

Targeting Cell Survival Pathways to Enhance Response to Chemotherapy encompasses recently developed molecular targeting agents and approaches that suppress cell survival signaling. Cell survival signaling attenuates the effectiveness of conventional chemotherapy and numerous mechanisms have been described, and continue to be described, which contribute to cell survival in the face of chemotherapy treatment. Key pathways leading to chemoresistance emanate from growth factor receptors, PI3K, STAT3, anti-apoptotic Bcl-2 family members, autophagy, and the DNA damage response pathway. New advances have

New Targeting in The Reversal of Resistant Glioblastomas

New Targeting in The Reversal of Resistant Glioblastomas
  • Author : Ali Syed Arbab
  • Publisher : Academic Press
  • Release : 18 March 2021
GET THIS BOOK New Targeting in The Reversal of Resistant Glioblastomas

New Targeting in The Reversal of Resistant Glioblastomas discusses alternative treatment strategies that not only target tumor cells but also target the tumor microenvironment, metabolic pathways and interaction of cytokines in tumor cells. The current treatment for primary and recurrent glioblastomas is failing because clinicians are not considering the effect of bone marrow derived cells to the development of resistance to clinically practiced therapies. This book helps readers rethink treatment strategies to successfully fight glioblastomas. It is a valuable resource

Characterization of Uracil DNA Glycosylase as a Therapeutic Target for Sensitization of Floxuridine in Cancer with P53 Mutation Or Deficiency

Characterization of Uracil DNA Glycosylase as a Therapeutic Target for Sensitization of Floxuridine in Cancer with P53 Mutation Or Deficiency
  • Author : Yan Yan
  • Publisher : Unknown
  • Release : 15 June 2021
GET THIS BOOK Characterization of Uracil DNA Glycosylase as a Therapeutic Target for Sensitization of Floxuridine in Cancer with P53 Mutation Or Deficiency

Cancer is a collection of genetic diseases which occur via a step-by-step mutagenic process whereby cancer cells gain a selective growth advantage over normal epithelial cells. Mutation in the TP53 tumor suppressor gene is one of the most frequent events in tumorigenesis, as p53 acts as a master regulator of numerous signaling pathways that drive tumor suppressive activities. In particular, mutant p53 proteins not only lose their tumor suppressor function but often endow cells with novel abilities that promote tumor

Dissecting the Molecular Mechanisms of Therapeutic Resistance in Cancer

Dissecting the Molecular Mechanisms of Therapeutic Resistance in Cancer
  • Author : Vibhuti Agrawal
  • Publisher : Unknown
  • Release : 15 June 2021
GET THIS BOOK Dissecting the Molecular Mechanisms of Therapeutic Resistance in Cancer

Therapeutic resistance continues to be a persistent challenge in medical oncology. In clinical settings, resistance can occur at the beginning of treatment, or may be acquired after an initial clinical response to the therapy. Several mechanisms of drug resistance have been described in cancer, including alterations in the drug transport and metabolism process, mutations in drug-target, activation of bypass signaling pathways, inhibition of cell-death pathways, and induction of an epithelial to mesenchymal transition (EMT) in response to cytotoxic or targeted

Improving the Therapeutic Ratio in Head and Neck Cancer

Improving the Therapeutic Ratio in Head and Neck Cancer
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 04 October 2019
GET THIS BOOK Improving the Therapeutic Ratio in Head and Neck Cancer

Improving the Therapeutic Ratio in Head and Neck Cancer provides a complete review of current approaches to modulating therapeutic sensitivity in head and neck cancer. It presents a broad background of current approaches and by highlighting the potential for clinical translational, introduces a roadmap for how to move promising preclinical findings into the clinic. The book discusses topics such as immunotherapy and molecularly targeted therapies in head and neck cancer, PI3k/mTOR pathway, autophagy inhibition to sensitize HNC to

Regulation of Radioadaptive Response by Mitochondrial Protein Influx in Normal and Cancer Cells

Regulation of Radioadaptive Response by Mitochondrial Protein Influx in Normal and Cancer Cells
  • Author : Demet Candas
  • Publisher : Unknown
  • Release : 15 June 2021
GET THIS BOOK Regulation of Radioadaptive Response by Mitochondrial Protein Influx in Normal and Cancer Cells

Chronic exposure of cells to ionizing radiation (IR) induces an adaptive response that results in enhanced tolerance to the subsequent cytotoxicity induced by IR. Radioadaptive resistance is a feature of both malignant and non-malignant cells. Accumulating evidence show an extensive communication between the mitochondria and cytoplasmic environment under oxidative stress, namely radiation insult, in both normal and cancer cells. Mitochondria are the major resource generating cellular fuel for the aerobic cells to maintain normal functions. Apart from this critical function

Therapeutic Oligonucleotides

Therapeutic Oligonucleotides
  • Author : Yoon S. Cho-Chung,Alan M. Gewirtz,Cy A. Stein
  • Publisher : Unknown
  • Release : 15 June 2021
GET THIS BOOK Therapeutic Oligonucleotides

Explores the potential for the development of therapeutic oligonucleotides into clinical medicines and their use as basic research tools, which is the proceedings of the 7th NIH Symposium on Therapeutic Oligonucleotides. This book focuses on antisense, RNAi, triple-helix, gene repair, DNA chips, and CpG immune modulatory oligonucleotides.