Target Validation In Drug Discovery

📒Target Discovery And Validation ✍ Alleyn T. Plowright

Target Discovery And Validation Book PDF
✏Book Title : Target Discovery and Validation
✏Author : Alleyn T. Plowright
✏Publisher : John Wiley & Sons
✏Release Date : 2019-12-31
✏Pages : 400
✏ISBN : 9783527345298
✏Available Language : English, Spanish, And French

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✏Target Discovery and Validation Book Summary : The modern drug developers? guide for making informed choices among the diverse target identification methods Target Discovery and Validation: Methods and Strategies for Drug Discovery offers a hands-on review of the modern technologies for drug target identification and validation. With contributions from noted industry and academic experts, the book addresses the most recent chemical, biological, and computational methods. Additionally, the book highlights techologies that are applicable to ?difficult? targets and drugs directed at multiple targets, including chemoproteomics, activity-based protein profiling, pathway mapping, genome-wide association studies, and array-based profiling. Throughout, the authors highlight a range of diverse approaches, and target validation studies reveal how these methods can support academic and drug discovery scientists in their target discovery and validation research. This resource: -Offers a guide to identifying and validating targets, a key enabling technology without which no new drug development is possible -Presents the information needed for choosing the appropriate assay method from the ever-growing range of available options -Provides practical examples from recent drug development projects, e. g. in kinase inhibitor profiling Written for medicinal chemists, pharmaceutical professionals, biochemists, biotechnology professionals, and pharmaceutical chemists, Target Discovery and Validation explores the current methods for the identification and validation of drug targets in one comrpehensive volume. It also includes numerous practical examples.

Target Validation In Drug Discovery Book PDF
✏Book Title : Target Validation in Drug Discovery
✏Author : Brian W. Metcalf
✏Publisher : Elsevier
✏Release Date : 2011-04-28
✏Pages : 296
✏ISBN : 0080465978
✏Available Language : English, Spanish, And French

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✏Target Validation in Drug Discovery Book Summary : This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book.

Target Identification And Validation In Drug Discovery Book PDF
✏Book Title : Target Identification and Validation in Drug Discovery
✏Author : Jurgen Moll
✏Publisher : Humana Press
✏Release Date : 2016-05-01
✏Pages : 388
✏ISBN : 1493962787
✏Available Language : English, Spanish, And French

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✏Target Identification and Validation in Drug Discovery Book Summary : This Methods in Molecular Biology book details current procedures for identifying and validating new drug targets. Includes methods and approaches covering biochemical, cell based, in vivo models and translational methods, as well as relevant case reports."

Target Identification And Validation In Drug Discovery Book PDF
✏Book Title : Target Identification and Validation in Drug Discovery
✏Author : Jürgen Moll
✏Publisher : Humana Press
✏Release Date : 2019-04-12
✏Pages : 318
✏ISBN : 1493991442
✏Available Language : English, Spanish, And French

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✏Target Identification and Validation in Drug Discovery Book Summary : This second edition book explores breakthrough technologies in the field of drug target identification and validation. The volume emphasizes particularly revolutionary technologies, such as CRISPR-related screening, “big data,” and in silico approaches, as well as in vivo applications of CRISPR and best uses of animal models in drug development. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Fully updated and authoritative, Target Identification and Validation in Drug Discovery: Methods and Protocols, Second Edition is an ideal guide for molecular and cellular biologists, pharmacologists, pathologists, bioinformaticians, clinical researchers, or investigators, as well as experts in other fields that need a quick overview of these state-of-the-art technologies.

Target Discovery And Validation Reviews And Protocols Book PDF
✏Book Title : Target Discovery and Validation Reviews and Protocols
✏Author : Mouldy Sioud
✏Publisher : Springer Science & Business Media
✏Release Date : 2007
✏Pages : 356
✏ISBN : 9781597452083
✏Available Language : English, Spanish, And French

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✏Target Discovery and Validation Reviews and Protocols Book Summary : Target Discovery and Validation Reviews and Protocols, Volumes 1 and 2 review the most progressive and current methods for drug target discovery and validation. These volumes explore how recent improvement in understanding the molecular mechanisms of human pathology is impacting drug target discovery in the laboratory and in real therapeutics, specifically for cancers and autoimmune disorders. Volume 1 focuses on novel and innovative techniques, and presents the most up-to-date protocols available for maximizing the likelihood of achieving target-selective inhibition in vivo while minimizing side effects. The profound impact of genomics, proteomics and bioinformatics on target discovery is explored, and specific attention is given to the role of transgenic and knockout animals in functional genomics and target validation. Cancer researchers will find tremendous value in the molecular classification of breast cancers and the review of protocols for tumor antigens and cancer vaccines. The methods and protocols collected here, all reviewed by leading scientists and clinicians, present the practical details necessary for translating the enormous discovery potential of the genome into real therapeutic products. Volume 2 collects all the practical details required for efficient translation of discovered targets into real pharmaceutical drugs. Specific targets in cancers and autoimmunity are described and the potential of using siRNAs, antisense oligonucleotides and RNA aptamers in patients is reviewed. This volume explores the tremendous impact of the application of genotyping and gene expression profiling on the future of healthcare, and presents cutting-edge protocols to aid in bringing agents against specific targets closer to application in the clinic. Collectively, these volumes provide a thorough review of the most cutting-edge methods available for each step in drug target identification, validation, and clinical application. For researchers, an understanding of available methods aids in the creation of innovative experiments in the laboratory, and the successful translation of target discovery to real therapeutics.

In Silico Technologies In Drug Target Identification And Validation Book PDF
✏Book Title : In Silico Technologies in Drug Target Identification and Validation
✏Author : Darryl Leon
✏Publisher : CRC Press
✏Release Date : 2006-06-13
✏Pages : 504
✏ISBN : 9781420015737
✏Available Language : English, Spanish, And French

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✏In Silico Technologies in Drug Target Identification and Validation Book Summary : The pharmaceutical industry relies on numerous well-designed experiments involving high-throughput techniques and in silico approaches to analyze potential drug targets. These in silico methods are often predictive, yielding faster and less expensive analyses than traditional in vivo or in vitro procedures. In Silico Technologies in Drug Target Identification and Validation addresses the challenge of testing a growing number of new potential targets and reviews currently available in silico approaches for identifying and validating these targets. The book emphasizes computational tools, public and commercial databases, mathematical methods, and software for interpreting complex experimental data. The book describes how these tools are used to visualize a target structure, identify binding sites, and predict behavior. World-renowned researchers cover many topics not typically found in most informatics books, including functional annotation, siRNA design, pathways, text mining, ontologies, systems biology, database management, data pipelining, and pharmacogenomics. Covering issues that range from prescreening target selection to genetic modeling and valuable data integration, In Silico Technologies in Drug Target Identification and Validation is a self-contained and practical guide to the various computational tools that can accelerate the identification and validation stages of drug target discovery and determine the biological functionality of potential targets more effectively. Daniel E. Levy, editor of the Drug Discovery Series, is the founder of DEL BioPharma, a consulting service for drug discovery programs. He also maintains a blog that explores organic chemistry.

Comprehensive Analysis Of Parasite Biology Book PDF
✏Book Title : Comprehensive Analysis of Parasite Biology
✏Author : Sylke M?ller
✏Publisher : John Wiley & Sons
✏Release Date : 2016-10-17
✏Pages : 576
✏ISBN : 9783527339044
✏Available Language : English, Spanish, And French

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✏Comprehensive Analysis of Parasite Biology Book Summary : Written and edited by experts in the field, this book brings together the current state of the art in phenotypic and rational, target-based approaches to drug discovery against pathogenic protozoa. The chapters focus particularly on virtual compounds and high throughput screening, natural products, computer-assisted drug design, structure-based drug design, mechanism of action identification, and pathway modelling. Furthermore, state-of the art "omics" technologies are described and currently studied enzymatic drug targets are discussed. Mathematical, systems biology-based approaches are introduced as new methodologies for dissecting complex aspects of pathogen survival mechanisms and for target identification. In addition, recently developed anti-parasitic agents targeting particular pathways, which serve as lead compounds for further drug development, are presented.

Platform Technologies In Drug Discovery And Validation Book PDF
✏Book Title : Platform Technologies in Drug Discovery and Validation
✏Author :
✏Publisher : Academic Press
✏Release Date : 2017-11-21
✏Pages : 690
✏ISBN : 9780128130704
✏Available Language : English, Spanish, And French

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✏Platform Technologies in Drug Discovery and Validation Book Summary : Platform Technologies in Drug Discovery and Validation, Volume 50, the latest release in the Annual Reports in Medicinal Chemistry series, provides timely and critical reviews of important topics in medicinal chemistry, with an emphasis on emerging topics in the biological sciences. Topics covered in this new volume include DELT, Oligos: ASO, siRNA, CRISPR, Micro-fluidic chemistry, High throughput screening, Kinase-centric computational drug development, Virtual Screening, Phenotypic screening, PROTACS, Chemical Biology, Fragment-based lead generation, Antibody-Drug Conjugates, Antibody-recruiting small molecules, Deuteration, and Peptides. Unique for its treatment of platform technologies for medicinal chemistry and target validation Provides a single, rich volume that summaries a broad spectrum of expertise relevant to the field Presents state-of-the-art summaries of platform technologies

Imaging In Drug Discovery And Early Clinical Trials Book PDF
✏Book Title : Imaging in Drug Discovery and Early Clinical Trials
✏Author : Markus Rudin
✏Publisher : Springer Science & Business Media
✏Release Date : 2006-07-11
✏Pages : 392
✏ISBN : 3764377801
✏Available Language : English, Spanish, And French

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✏Imaging in Drug Discovery and Early Clinical Trials Book Summary : This monograph examines the contribution of imaging modalities to the stages of drug discovery and development, from early target validation to their use in clinical development programs. Chapters are devoted to the description of the drug discovery process, to the various imaging modalities preclinically and clinically, to applications of imaging during the optimization of a lead compound, addressing issues such as bioavailability and efficacy, and during drug safety evaluation.

New Approaches To Drug Discovery Book PDF
✏Book Title : New Approaches to Drug Discovery
✏Author : Ulrich Nielsch
✏Publisher : Springer
✏Release Date : 2016-03-30
✏Pages : 341
✏ISBN : 9783319289144
✏Available Language : English, Spanish, And French

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✏New Approaches to Drug Discovery Book Summary : This volume gives an overview of state of the art technologies and future developments in the field of preclinical pharmaceutical research. A balanced mix of experts from academia and industry give insight in selected new developments in the drug discovery pathway. The topics cover the different parts of the drug discovery process, starting with new developments in the target identification and validation area. The lead generation part as a next step focuses on the requirements and technologies to identify new small molecules as lead compounds for further optimization; in a second section the technologies to identify biologics as leads are addressed. The final part focuses on the pharmacological models and technologies to characterize new compounds and the impact of biomarkers to facilitate the transfer of drug candidates into the development phase.

📒Deriving Drug Discovery Value From Large Scale Genetic Bioresources ✍ National Academies of Sciences, Engineering, and Medicine

Deriving Drug Discovery Value From Large Scale Genetic Bioresources Book PDF
✏Book Title : Deriving Drug Discovery Value from Large Scale Genetic Bioresources
✏Author : National Academies of Sciences, Engineering, and Medicine
✏Publisher : National Academies Press
✏Release Date : 2016-11-02
✏Pages : 114
✏ISBN : 9780309447812
✏Available Language : English, Spanish, And French

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✏Deriving Drug Discovery Value from Large Scale Genetic Bioresources Book Summary : The process of discovering and developing a new drug or therapy is extremely costly and time consuming, and recently, it has been estimated that the creation of a new medicine costs on average more than $2 billion and takes 10 years to reach patients. The challenges associated with bringing new medicines to market have led many pharmaceutical companies to seek out innovative methods for streamlining their drug discovery research. One way to increase the odds of success for compounds in the drug development pipeline is to adopt genetically guided strategies for drug discovery, and recognizing the potential benefits of collecting genetic and phenotypic information across specific populations, pharmaceutical companies have started collaborating with healthcare systems and private companies that have curated genetic bioresources, or large databases of genomic information. Large-scale cohort studies offer an effective way to collect and store information that can be used to assess geneâ€"environment interactions, identify new potential drug targets, understand the role of certain genetic variants in the drug response, and further elucidate the underlying mechanisms of disease onset and progression. To examine how genetic bioresources could be used to improve drug discovery and target validation, the National Academies of Sciences, Engineering, and Medicine hosted a workshop in March 2016. Participants at the workshop explored the current landscape of genomics-enabled drug discovery activities in industry, academia, and government; examined enabling partnerships and business models; and considered gaps and best practices for collecting population data for the purpose of improving the drug discovery process. This publication summarizes the presentations and discussions from the workshop.

In Vivo Models For Drug Discovery Book PDF
✏Book Title : In vivo Models for Drug Discovery
✏Author : José Miguel Vela
✏Publisher : John Wiley & Sons
✏Release Date : 2014-08-11
✏Pages : 594
✏ISBN : 9783527333288
✏Available Language : English, Spanish, And French

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✏In vivo Models for Drug Discovery Book Summary : This one-stop reference is the first to present the complete picture -- covering all relevant organisms, from single cells to mammals, as well as all major disease areas, including neurological disorders, cancer and infectious diseases. Addressing the needs of the pharmaceutical industry, this unique handbook adopts a broad perspective on the use of animals in the early part of the drug development process, including regulatory rules and limitations, as well as numerous examples from real-life drug development projects. After a general introduction to the topic, the expert contributors from research-driven pharmaceutical companies discuss the basic considerations of using animal models, including ethical issues. The main part of the book systematically surveys the most important disease areas for current drug development, from cardiovascular to endocrine disorders, and from infectious to neurological diseases. For each area, the availability of animal models for target validation, hit finding and lead profiling is reviewed, backed by numerous examples of both successes and failures among the use of animal models. The whole is rounded off with a discussion of perspectives and challenges. Key knowledge for drug researchers in industry as well as academia.

📒Real World Drug Discovery ✍ Robert M. Rydzewski

Real World Drug Discovery Book PDF
✏Book Title : Real World Drug Discovery
✏Author : Robert M. Rydzewski
✏Publisher : Elsevier
✏Release Date : 2010-07-07
✏Pages : 600
✏ISBN : 0080914888
✏Available Language : English, Spanish, And French

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✏Real World Drug Discovery Book Summary : Drug discovery increasingly requires a common understanding by researchers of the many and diverse factors that go into the making of new medicines. The scientist entering the field will immediately face important issues for which his education may not have prepared him: project teams, patent law, consultants, target product profiles, industry trends, Gantt charts, target validation, pharmacokinetics, proteomics, phenotype assays, biomarkers, and many other unfamiliar topics for which a basic understanding must somehow be obtained. Even the more experienced scientist can find it frustratingly difficult to get an overview of the many factors involved in modern drug discovery and often only after years of exploring does a whole and integrated picture emerge in the mind of the researcher. Real World Drug Discovery: A Chemist’s Guide to Biotech and Pharmaceutical Research presents this kind of map of the landscape of drug discovery. In a single, readable volume it outlines processes and explains essential concepts and terms for the recent science graduate wondering what to expect in pharma or biotech, the medicinal chemist seeking a broader and more timely understanding of the industry, or the contractor or collaborator whose understanding of the commercial drug discovery process could increase the value of his contribution to it. Interviews with well-known experts in many of the fields involved, giving insightful comments from authorities on many of the sub-disciplines important to cutting edge drug discovery. Helpful suggestions gleaned from years of experience in biotech and pharma, which represents a repository drug discovery "lore" not previously available in any book. "Periodic Table of Drugs" listing current top-selling drugs arranged by target and laid out so that structural similarities and differences are plain and clear. Extensive use of diagrams to illustrate concepts like biotech startup models, preteomic profiling for target identification, Gantt charts for project planning, etc.

Model Organisms In Drug Discovery Book PDF
✏Book Title : Model Organisms in Drug Discovery
✏Author : Pamela M. Carroll
✏Publisher : John Wiley & Sons
✏Release Date : 2004-04-21
✏Pages : 302
✏ISBN : 9780470871300
✏Available Language : English, Spanish, And French

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✏Model Organisms in Drug Discovery Book Summary : Fruit flies are "little people with wings" goes the saying in the scientific community, ever since the completion of the Human Genome Project and its revelations about the similarity amongst the genomes of different organisms. It is humbling that most signalling pathways which "define" humans are conserved in Drosophila, the common fruit fly. Feed a fruit fly caffeine and it has trouble falling asleep; feed it antihistamines and it cannot stay awake. A C. elegans worm placed on the antidepressant flouxetine has increased serotonin levels in its tiny brain. Yeast treated with chemotherapeutics stop their cell division. Removal of a single gene from a mouse or zebrafish can cause the animals to develop Alzheimer’s disease or heart disease. These organisms are utilized as surrogates to investigate the function and design of complex human biological systems. Advances in bioinformatics, proteomics, automation technologies and their application to model organism systems now occur on an industrial scale. The integration of model systems into the drug discovery process, the speed of the tools, and the in vivo validation data that these models can provide, will clearly help definition of disease biology and high-quality target validation. Enhanced target selection will lead to the more efficacious and less toxic therapeutic compounds of the future. Leading experts in the field provide detailed accounts of model organism research that have impacted on specific therapeutic areas and they examine state-of-the-art applications of model systems, describing real life applications and their possible impact in the future. This book will be of interest to geneticists, bioinformaticians, pharmacologists, molecular biologists and people working in the pharmaceutical industry, particularly genomics.

📒High Content Screening ✍ D. Lansing Taylor

High Content Screening Book PDF
✏Book Title : High Content Screening
✏Author : D. Lansing Taylor
✏Publisher : Springer Science & Business Media
✏Release Date : 2007
✏Pages : 444
✏ISBN : 9781597452175
✏Available Language : English, Spanish, And French

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✏High Content Screening Book Summary : This book assists both existing users of High Content Screening (HCS), as well as investigators considering the addition of a discovery-driven platform to their R&D activities. The chapters have been organized into sections that highlight the importance of integrating instrumentation, application software, reagents and informatics. In addition, there is a combination of pure review chapters on key topics and specific methods chapters.

📒Drug Discovery ✍ Jie Jack Li

Drug Discovery Book PDF
✏Book Title : Drug Discovery
✏Author : Jie Jack Li
✏Publisher : John Wiley & Sons
✏Release Date : 2013-04-03
✏Pages : 570
✏ISBN : 9781118354469
✏Available Language : English, Spanish, And French

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✏Drug Discovery Book Summary : Sets forth the history, state of the science, and future directions of drug discovery Edited by Jie Jack Li and Nobel laureate E. J. Corey, two leading pioneers in drug discovery and medicinal chemistry, this book synthesizes great moments in history, the current state of the science, and future directions of drug discovery into one expertly written and organized work. Exploring all major therapeutic areas, the book introduces readers to all facets and phases of drug discovery, including target selection, biological testing, drug metabolism, and computer-assisted drug design. Drug Discovery features chapters written by an international team of pharmaceutical and medicinal chemists. Contributions are based on a thorough review of the current literature as well as the authors' firsthand laboratory experience in drug discovery. The book begins with the history of drug discovery, describing groundbreaking moments in the field. Next, it covers such topics as: Target identification and validation Drug metabolism and pharmacokinetics Central nervous system drugs In vitro and in vivo assays Cardiovascular drugs Cancer drugs Each chapter features a case study, helping readers understand how science is put into practice throughout all phases of drug discovery. References at the end of each chapter serve as a gateway to groundbreaking original research studies and reviews in the field. Drug Discovery is ideal for newcomers to medicinal chemistry and drug discovery, providing a comprehensive overview of the field. Veterans in the field will also benefit from the perspectives of leading international experts in all aspects of drug discovery.

Drug Discovery And Development E Book Book PDF
✏Book Title : Drug Discovery and Development E Book
✏Author : Raymond G Hill
✏Publisher : Elsevier Health Sciences
✏Release Date : 2012-07-20
✏Pages : 368
✏ISBN : 9780702053160
✏Available Language : English, Spanish, And French

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✏Drug Discovery and Development E Book Book Summary : The modern pharmacopeia has enormous power to alleviate disease, and owes its existence almost entirely to the work of the pharmaceutical industry. This book provides an introduction to the way the industry goes about the discovery and development of new drugs. The first part gives a brief historical account from its origins in the mediaeval apothecaries’ trade, and discusses the changing understanding of what we mean by disease, and what therapy aims to achieve, as well as summarising case histories of the discovery and development of some important drugs. The second part focuses on the science and technology involved in the discovery process: the stages by which a promising new chemical entity is identified, from the starting point of a medical need and an idea for addressing it. A chapter on biopharmaceuticals, whose discovery and development tend to follow routes somewhat different from synthetic compounds, is included here, as well as accounts of patent issues that arise in the discovery phase, and a chapter on research management in this environment. The third section of the book deals with drug development: the work that has to be undertaken to turn the drug candidate that emerges from the discovery process into a product on the market. The definitive introduction to how a pharmaceutical company goes about its business of discovering and developing drugs. The second edition has a new editor: Professor Raymond Hill ● non-executive director of Addex Pharmaceuticals, Covagen and of Orexo AB ● Visiting Industrial Professor of Pharmacology in the University of Bristol ● Visiting Professor in the School of Medical and Health Sciences at the University of Surrey ● Visiting Professor in Physiology and Pharmacology at the University of Strathclyde ● President and Chair of the Council of the British Pharmacological Society ● member of the Nuffield Council on Bioethics and the Advisory Council on Misuse of Drugs. New to this edition: Completely rewritten chapter on The Role of Medicinal Chemistry in the Drug Discovery Process. New topic - DMPK Optimization Strategy in drug discovery. New chapter on Scaffolds: Small globular proteins as antibody substitutes. Totally updated chapters on Intellectual Property and Marketing 50 new illustrations in full colour Features Accessible, general guide to pharmaceutical research and development. Examines the interfaces between cost and social benefit, quality control and mass production, regulatory bodies, patent management, and all interdisciplinary intersections essential to effective drug development. Written by a strong team of scientists with long experience in the pharmaceutical industry. Solid overview of all the steps from lab bench to market in an easy-to-understand way which will be accessible to non-specialists. From customer reviews of the previous edition: ‘... it will have everything you need to know on this module. Deeply referenced and, thus, deeply reliable. Highly Commended in the medicine category of the BMA 2006 medical book competition Winner of the Royal Society of Medicine Library Prize for Medical Book of the Year

📒Reducing Drug Attrition ✍ James R. Empfield

Reducing Drug Attrition Book PDF
✏Book Title : Reducing Drug Attrition
✏Author : James R. Empfield
✏Publisher : Springer
✏Release Date : 2014-11-27
✏Pages : 162
✏ISBN : 9783662439142
✏Available Language : English, Spanish, And French

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✏Reducing Drug Attrition Book Summary : Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Target Discovery And Validation Book PDF
✏Book Title : Target Discovery and Validation
✏Author : Mouldy Sioud
✏Publisher : Springer Science & Business Media
✏Release Date : 2007
✏Pages : 384
✏ISBN : 9781597451659
✏Available Language : English, Spanish, And French

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✏Target Discovery and Validation Book Summary : Annotation These volumes review the most current methods for drug target discovery and validation. They explore how recent improvement in understanding the molecular mechanisms of human pathology is impacting drug target discovery in the laboratory and in real therapeutics, specifically for cancers and autoimmune disorders. This book provides a thorough review of the most cutting-edge methods available for each step in drug target identification, validation, and clinical application.

📒Handbook Of Drug Screening ✍ Ramakrishna Seethala

Handbook Of Drug Screening Book PDF
✏Book Title : Handbook of Drug Screening
✏Author : Ramakrishna Seethala
✏Publisher : CRC Press
✏Release Date : 2016-04-19
✏Pages : 504
✏ISBN : 9781420061697
✏Available Language : English, Spanish, And French

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✏Handbook of Drug Screening Book Summary : Building upon the foundation of basics discussed in the previous edition, the Second Edition provides a more in-depth look at the latest methods and technologies of advanced drug screening, an essential function of drug discovery. With extensively updated content and 21 new chapters, this text examines:quality and efficiency of drug target validati

Antiparasitic And Antibacterial Drug Discovery Book PDF
✏Book Title : Antiparasitic and Antibacterial Drug Discovery
✏Author : Paul M. Selzer
✏Publisher : John Wiley & Sons
✏Release Date : 2009-06-08
✏Pages : 489
✏ISBN : 9783527323272
✏Available Language : English, Spanish, And French

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✏Antiparasitic and Antibacterial Drug Discovery Book Summary : Mainly addressing parasitic diseases but also focusing on diseases caused by bacteria, this much-needed reference and handbook provides a unique insight into the approach adopted by commercial science towards infectious diseases, including the work of medicinal chemists. Many of the authors are scientists with hands-on experience of drug discovery units within the pharmaceutical industry. In addition, the text covers efforts towards drug development in infectious diseases from academic groups and non profit organizations.

Drug Discovery From Natural Products Book PDF
✏Book Title : Drug Discovery from Natural Products
✏Author : Olga Genilloud
✏Publisher : Royal Society of Chemistry
✏Release Date : 2012
✏Pages : 436
✏ISBN : 9781849733618
✏Available Language : English, Spanish, And French

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✏Drug Discovery from Natural Products Book Summary : An integrated review of the most recent trends in natural products drug discovery and key lead candidates that are outstanding for their chemistry and biology in novel drug development.

Chemoinformatics Approaches To Structure And Ligand Based Drug Design Book PDF
✏Book Title : Chemoinformatics Approaches to Structure and Ligand Based Drug Design
✏Author : Adriano D. Andricopulo
✏Publisher : Frontiers Media SA
✏Release Date : 2019-02-05
✏Pages :
✏ISBN : 9782889457441
✏Available Language : English, Spanish, And French

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✏Chemoinformatics Approaches to Structure and Ligand Based Drug Design Book Summary : Chemoinformatics is paramount to current drug discovery. Structure- and ligand-based drug design strategies have been used to uncover hidden patterns in large amounts of data, and to disclose the molecular aspects underlying ligand-receptor interactions. This Research Topic aims to share with a broad audience the most recent trends in the use of chemoinformatics in drug design. To that end, experts in all areas of drug discovery have made their knowledge available through a series of articles that report state-of-the-art approaches. Readers are provided with outstanding contributions focusing on a wide variety of topics which will be of great value to those interested in the many different and exciting facets of drug design.

📒Biotechnology Annual Review ✍ M. Raafat El-Gewely

Biotechnology Annual Review Book PDF
✏Book Title : Biotechnology Annual Review
✏Author : M. Raafat El-Gewely
✏Publisher : Elsevier
✏Release Date : 2005-09-12
✏Pages : 452
✏ISBN : 0444519521
✏Available Language : English, Spanish, And French

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✏Biotechnology Annual Review Book Summary : Biotechnology is a diverse, complex and rapidly evolving field. Students and experienced researchers alike face the challenges of staying on top of developments in their field of specialty and maintaining a broader overview of the field as a whole. Volumes containing competent reviews on a diverse range of topics in the field fulfill the dual role of broadening and updating biotechnologists' knowledge. The current volume is an excellent example of such a book. The topics covered range from classical issues in biotechnology - such as, vehicles for the production of biotechnology products and methods for their detection, separation and analysis - to topics that are focused on the role of biotechnology in the health sciences. The information presented in this book will therefore will be of great value to both experienced biotechnologists and biotechnologists in training.

📒Drug Discovery In Africa ✍ Kelly Chibale

Drug Discovery In Africa Book PDF
✏Book Title : Drug Discovery in Africa
✏Author : Kelly Chibale
✏Publisher : Springer Science & Business Media
✏Release Date : 2012-08-09
✏Pages : 440
✏ISBN : 9783642281754
✏Available Language : English, Spanish, And French

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✏Drug Discovery in Africa Book Summary : Drug discovery originating in Africa has the potential to provide significantly improved treatment of endemic diseases such as malaria, tuberculosis and HIV/AIDS. This book critically reviews the current status of drug discovery research and development in Africa, for diseases that are a major threat to the health of people living in Africa. Compiled by leading African and international experts, this book presents the science and strategies of modern drug discovery. It explores how the use of natural products and traditional medicines can benefit from conventional drug discovery approaches, and proposes solutions to current technological, infrastructural, human resources, and economic challenges, which are presented when attempting to engage in full-scale drug discovery. Topics addressed are varied; from African medicinal plants to marine bioprospecting, pharmacogenetics and the use of nanotechnology. This book brings together for the first time a collection of strategies and techniques that need to be considered when developing drugs in an African setting. It is an unprecedented and truly international effort, highlighting the remarkable effort made so far in the area of drug discovery research by African scientists, and scientists from other parts of the world working on African health problems.

📒Molecular Cancer Therapeutics ✍ George C. Prendergast

Molecular Cancer Therapeutics Book PDF
✏Book Title : Molecular Cancer Therapeutics
✏Author : George C. Prendergast
✏Publisher : John Wiley & Sons
✏Release Date : 2004-04-02
✏Pages : 351
✏ISBN : 0471432024
✏Available Language : English, Spanish, And French

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✏Molecular Cancer Therapeutics Book Summary : Molecular Cancer Therapeutics covers state-of-the-art strategies to identify and develop cancer drug target molecules and lead inhibitors for clinical testing. It provides a thorough treatment of drug target discovery, validation, and development. The introductory chapters provide an overview of pathways to discovery and development of molecular cancer therapeutics. Subsequent chapters progress from initial stages of drug target discovery to drug discovery, development, and testing in preclinical and clinical models. Topics include drug lead screening, drug-to-lead development, proof-of-concept studies, medicinal chemistry issues, intellectual property concerns, and clinical development. This invaluable reference promotes understanding of steps involved in developing drug leads for industrial partnering and development. It provides an overview of the strategies for discovery and validation of drug target molecules, and discusses cell- and molecule-based drug screening strategies, as well as mouse models for cancer. Coverage also includes how to refine drug leads for suitability in clinical testing, the special issues of clinical testing of molecular-targeted drugs, and intellectual property concerns.

📒High Content Screening ✍ Steven A. Haney

High Content Screening Book PDF
✏Book Title : High Content Screening
✏Author : Steven A. Haney
✏Publisher : John Wiley & Sons
✏Release Date : 2008-01-18
✏Pages : 424
✏ISBN : 0470229853
✏Available Language : English, Spanish, And French

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✏High Content Screening Book Summary : The authoritative reference on High Content Screening (HCS) in biological and pharmaceutical research, this guide covers: the basics of HCS: examples of HCS used in biological applications and early drug discovery, emphasizing oncology and neuroscience; the use of HCS across the drug development pipeline; and data management, data analysis, and systems biology, with guidelines for using large datasets. With an accompanying CD-ROM, this is the premier reference on HCS for researchers, lab managers, and graduate students.

The Handbook Of Medicinal Chemistry Book PDF
✏Book Title : The Handbook of Medicinal Chemistry
✏Author : Andrew Davis
✏Publisher : Royal Society of Chemistry
✏Release Date : 2014-12-09
✏Pages : 753
✏ISBN : 9781849736251
✏Available Language : English, Spanish, And French

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✏The Handbook of Medicinal Chemistry Book Summary : Developed to provide a comprehensive guide, the Handbook of Medicinal Chemistry has been revised and brought up to date to cover the past, present and future of the entire drug development process.

Animal And Translational Models For Cns Drug Discovery Reward Deficit Disorders Book PDF
✏Book Title : Animal and Translational Models for CNS Drug Discovery Reward Deficit Disorders
✏Author : Robert A. McArthur
✏Publisher : Academic Press
✏Release Date : 2009-02-24
✏Pages : 432
✏ISBN : 9780080920405
✏Available Language : English, Spanish, And French

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✏Animal and Translational Models for CNS Drug Discovery Reward Deficit Disorders Book Summary : Reward Deficit Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for reward deficit disorders such as alcohol dependence, nicotine dependence, heroin and cocaine addiction, obesity, and gambling and impulse control disorders. Reward Deficit Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. Reward Deficit Disorders also has a section dedicated to the specifics of the regulatory aspects to abuse liability testing. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This is the third volume in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, which is also available for purchase individually. Provides clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process Critical evaluation of animal and translational models improving transition from drug discovery and clinical development Emphasizes what results mean to the overall drug discovery process Explores issues in clinical trial design and conductance in each therapeutic area Neurological Disorders is available for purchase individually.

Frontiers In Drug Design And Discovery Book PDF
✏Book Title : Frontiers in Drug Design and Discovery
✏Author : Atta-ur- Rahman
✏Publisher : Bentham Science Publishers
✏Release Date : 2010-12-13
✏Pages : 360
✏ISBN : 9781608052004
✏Available Language : English, Spanish, And French

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✏Frontiers in Drug Design and Discovery Book Summary : "Frontiers in Drug Design and Discovery" is an Ebook series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery inclu