Structure and Function of the Extracellular Matrix

• Author : Bela Suki
• Publisher : Academic Press
• Release : 06 December 2021

Structure and Function of the Extracellular Matrix: A Multiscale Quantitative Approach introduces biomechanics and biophysics with applications to understand the biological function of the extracellular matrix in health and disease. A general multiscale approach is followed by investigating behavior from the scale of single molecules, through fibrils and fibers, to tissues of various organ systems. Through mathematical models and structural information, quantitative description of the extracellular matrix function is derived with tissue specific details. The book introduces the properties and

• Author : E.D. Hay
• Publisher : Springer Science & Business Media
• Release : 11 November 2013

In the ten-year interval since the first edition of this volume went to press, our knowledge of extracellular matrix (ECM) function and structure has enor mously increased. Extracellular matrix and cell-matrix interaction are now routine topics in the meetings and annual reviews sponsored by cell biology societies. Research in molecular biology has so advanced the number of known matrix molecules and the topic of gene structure and regulation that we won dered how best to incorporate the new material. For

• Author : Robert Mecham
• Publisher : Springer Science & Business Media
• Release : 16 February 2011

Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept

• Author : Richard Maynes
• Publisher : Elsevier
• Release : 02 December 2012

Structure and Function of Collagen Types is a collection of articles that reviews the different types of collagens (Type I to XI). Each article focuses on a particular type of collagen and written by leading investigators in the collagen field. The book begins with a review of the fibril forming collagens (types I, II, and III) and traces the early work on the structure of these collagens to our knowledge of the structure of the collagen genes. This chapter is

• Author : Anonim
• Publisher : BoD – Books on Demand
• Release : 27 October 2021

Understanding extracellular matrix (ECM) structure and function is important for developing biomedical applications that are as close to ‘native’ as possible. Written by pioneering scientists from all over the world, this book reports research and new developments in the field of collagen structure, function, and biomechanics and discusses the relevance of hyaluronic acid and its therapeutic uses. It gives readers a glimpse of what is current in this area and we hope it piques their interest in learning more about

• Author : Anonim
• Publisher : Academic Press
• Release : 02 December 2012

This book serves as a much-needed guide for new investigators in the field of glycobiology as well as researchers in other disciplines attempting to define the role of glycoconjugates in their biological systems. Cell Surface and Extracellular Glycoconjugates: Structure and Function describes the determination of structure and function of glycoconjugates that occur on the cell surface and in molecules involved in cell-matrix interactions. The broad scope of thebook covers basic background and technical information in this rapidly expanding field. The

• Author : Dena Wiltz
• Publisher : Unknown
• Release : 30 May 2023

Extracellular Matrix Organization, Structure, and Function.

• Author : Francesco Travascio
• Publisher : BoD – Books on Demand
• Release : 15 June 2016

The extracellular matrix (ECM) is an ensemble of non-cellular components present within all tissues and organs of the human body. The ECM provides structural support for scaffolding cellular constituents and biochemical and biomechanical support for those events leading to tissue morphogenesis, differentiation and homeostasis. Essential components of all ECMs are water, proteins and polysaccharides. However, their composition, architecture and bioactivity greatly vary from tissue to tissue in relation to the specific role the ECM is required to assume. This book

• Author : Peter D. Yurchenco
• Publisher : Academic Press
• Release : 22 October 2013

The complex and critical process of extracellular matrix (ECM) assembly is described in this book. Assembly may involve molecules interacting with molecules of the same matrix class, such as in collagen, or interactions between different ECM molecules, such as in basement membranes. The text shows how this is driven by structural information within the matrix monomer. This information will be of interest to cell, developmental, and molecular biologists, biochemists, biophysicists, and biomedical researchers involved in macromolecular assembly, biological macromolecules, and

• Author : A. H. Reddi
• Publisher : Unknown
• Release : 01 December 1985

• Author : Nikos Karamanos
• Publisher : Walter de Gruyter
• Release : 31 August 2012

Over the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell migration, adhesion and signaling. This comprehensive handbook of the extracellular matrix is organized into seven thematic sections, giving an overview of the current state of knowledge of matrix components (structure and function), their roles in health and disease (matrix pathobiology) as well as new concepts of pharmacological targeting.

• Author : Charles Streuli,Michael Grant
• Publisher : Springer Science & Business Media
• Release : 05 February 2008

It is now widely accepted that much of the dynamic function of cells and tissues is regulated from outside the cell by the extracellular matrix. In ad- tion to its conventional role in providing a scaffold for building tissues, the extracellular matrix acts as a directional highway for cellular movement and provides instructional information for promoting survival, proliferation, and differentiation. Indeed, the extracellular matrix is beginning to take a starring role in the choreography of cell and tissue function. The

• Author : John Mcdonald
• Publisher : Academic Press
• Release : 02 December 2012

Receptors for Extracellular Matrix covers the major receptor families and their potential biological functions. Composed of eight chapters, the book first discusses the structure and function of membrane-associated proteoglycans, focusing on two classes of integral membrane molecules: syndecan and CD44. It then examines the important area of mechanisms of signal transduction from integrin receptors that must mediate the effects of extracellular matrices and other ligands on cell behavior. Multidomain proteins of the extracellular matrix and their role in controlling cellular

• Author : Mark Anthony Hadley
• Publisher : Unknown
• Release : 30 May 1986

• Author : Mark A. Zern,Lola M. Reid
• Publisher : CRC Press
• Release : 01 April 1993

Describing state-of-the-art research techniques for clinicians and introducing important clinical perspectives for basic scientists, this reference examines some significant areas of investigation into the biology of the extracellular matrix and its implications in human pathophysiology.;Focusing on the liver and providing a broad survey of the latest information available, Extracellular Matrix: discusses a wide range of models and organ systems; presents pathophysiological studies emphasizing hepatic disease, particularly the development of fibrosis and cirrhosis; furnishes structure and function analyses of the