Strategies and Tactics in Organic Synthesis

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  • Author : Thomas Lindberg
  • Publisher : Academic Press
  • Pages : 552 pages
  • ISBN : 0080924301
  • Rating : /5 from reviews
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Download or Read online Strategies and Tactics in Organic Synthesis full in PDF, ePub and kindle. this book written by Thomas Lindberg and published by Academic Press which was released on 02 December 2012 with total page 552 pages. We cannot guarantee that Strategies and Tactics in Organic Synthesis book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Strategies and Tactics in Organic Synthesis, Volume 3 provides detailed accounts of interesting advances in the field of synthesis. This book discusses the tasks of multistep synthesis from finding the proper reagents, reaction, and conditions for individual steps to inventing new chemistry to fill gaps in existing synthetic methodology. Organized into 13 chapters, this volume begins with an overview of the development of redox glycosidation strategy through ester methylenation. This text then examines the development of computer-assisted molecular modeling with applications to a wide range of problems in biological and organic chemistry. Other chapters consider the medicinal significance of ginkgo tree, which has prompted systematic studies to correlate the claimed beneficial effects of its extracts to the active principles. This book discusses as well the biological potency of pentacyclic quassinoids. The final chapter deals with the economic synthesis of a penem antibacterial. This book is a valuable resource for chemists.

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Thomas Lindberg
  • Publisher : Academic Press
  • Release : 02 December 2012
GET THIS BOOK Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis, Volume 3 provides detailed accounts of interesting advances in the field of synthesis. This book discusses the tasks of multistep synthesis from finding the proper reagents, reaction, and conditions for individual steps to inventing new chemistry to fill gaps in existing synthetic methodology. Organized into 13 chapters, this volume begins with an overview of the development of redox glycosidation strategy through ester methylenation. This text then examines the development of computer-assisted molecular modeling with applications to

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Michael Harmata
  • Publisher : Academic Press
  • Release : 01 January 2008
GET THIS BOOK Strategies and Tactics in Organic Synthesis

This work provides a forum for investigators to discuss their approach to the science and art of organic. Rather than a simple presentation of data or a second-hand analysis, it provides stories which demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners.

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Michael Harmata
  • Publisher : Academic Press
  • Release : 29 June 2004
GET THIS BOOK Strategies and Tactics in Organic Synthesis

A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a second-hand analysis, we are given stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners. First hand accounts of each project tell of the excitement of conception, the

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Erik J. Sorensen,David A. Siler,Jeffrey D. Mighion
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 July 2013
GET THIS BOOK Strategies and Tactics in Organic Synthesis

This chapter defines risk-taking in organic synthesis as the deliberate pursuit of strategies that do not have near neighbors in the chemical literature. In these ventures into the unknown, chemical behavior can be difficult to predict. The literature of organic chemistry is replete with examples of powerful, bond-forming strategies that had little or no precedent when they were developed. This essay addresses some of those examples in an effort to demonstrate the merits of creative risk-taking in the planning and

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Michael F. Greaney,Lei Shi,Naim Nazef
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 July 2013
GET THIS BOOK Strategies and Tactics in Organic Synthesis

This chapter describes the synthesis of two related sesquiterpenes, anislactone A and merrilactone A. We initially accessed a tetracyclic oxetane in the merrilactone series using a Paternò–Büchi reaction but found the compound to be too underfunctionalized to advance further. We then developed an approach based on reductive epoxide ring opening, whereby a fully elaborated C-ring epoxy-cyclopentane, containing five stereocenters, could undergo reductive epoxide cleavage when treated with Ti(III). The resulting tertiary radical then participates in a 5-exo-dig

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Steven L. Castle,Bing Ma
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 July 2013
GET THIS BOOK Strategies and Tactics in Organic Synthesis

This account describes the total synthesis of the title compound, an antimitotic bicyclic peptide. A first-generation approach involving right-hand ring formation followed by left-hand ring annulation was unsuccessful but yielded several interesting observations. A revised strategy was devised in which left-hand ring synthesis would precede right-hand macrocycle construction. A suitably functionalized tryptophan derivative was prepared via phase transfer-catalyzed asymmetric alkylation and Larock heteroannulation. A Knoevenagel condensation–radical conjugate addition sequence fashioned the tryptophan–leucine cross-link, and macrolactamization furnished the left-hand

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Joseph D. Panarese,Stephen P. Waters
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 July 2013
GET THIS BOOK Strategies and Tactics in Organic Synthesis

In 2008, (+)-aspergillide C, a structurally novel marine metabolite bearing a 14-membered macrolactone around a 2,6-dihydropyran core, was isolated from a marine-derived fungus, Aspergillus ostianus. In a biological assay, (+)-aspergillide C displayed promising anticancer activity (LD50=2.0μg/ml) against mouse lymphocytic leukemia cells (L1210). Due to its notable biological activity and interesting architecture, we viewed aspergillide C as an attractive synthetic target. Moreover, the aspergillide scaffold could lend itself to diverse structural modifications in projected syntheses of biologically active congeners. In

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Michael Harmata
  • Publisher : Elsevier
  • Release : 09 August 2011
GET THIS BOOK Strategies and Tactics in Organic Synthesis

A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic. Rather than a simple presentation of data or a second-hand analysis, we are given stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners. First hand accounts of each project tell of the excitement of conception, the frustration

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Jenny B. Werness,Wei Zhang,Weiping Tang
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 July 2013
GET THIS BOOK Strategies and Tactics in Organic Synthesis

Addition of halogen and nucleophiles to conjugated 1,3-enynes in a 1,4-fashion produces a chiral allene and a stereogenic center. The diastereo- and enantioselectivity of this process are discussed in detail. The 1,4-bromoetherification of 1,3-enynes can be applied to the synthesis of various bromoallene-containing natural products. Our diastereo- and enantioselective total synthesis of kumausallene is described in this chapter. The synthesis features a cascade reaction involving palladium-catalyzed desymmetrization and a DMF-mediated diastereoselective 1,4-bromoetherification reaction.

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Michel Miesch,Tania Welsch,Vincent Rietsch,Laurence Miesch
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 July 2013
GET THIS BOOK Strategies and Tactics in Organic Synthesis

This chapter describes various syntheses of hamigeran B. Different methodologies were developed, and for our part, we achieved a formal synthesis of (±)-hamigeran B involving an intramolecular alkynylogous Mukaiyama aldol reaction promoted by dual Lewis acid activation as a key step. This unexpected reaction was discovered by treating a ketone with TBSOTf/NEt3 in order to obtain the corresponding silyl enol ether, which, in fact, evolves toward a new type of intramolecular aldol reaction. Fortunately, the study of the scope

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Gopal Sirasani,Rodrigo B. Andrade
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 July 2013
GET THIS BOOK Strategies and Tactics in Organic Synthesis

Described herein is an account of my laboratory’s entry into the magnificent field of complex alkaloid total synthesis, spanning the development of novel methods for quickly assembling polycyclic frameworks through the total synthesis of various members of the Strychnos alkaloids. A discussion of the prior art related to our approach to these alkaloids in addition to strategic decisions and reasoning made en route to targets akuammicine ( 1 ), strychnine ( 2 ), and leuconicines A ( 3 ) and B ( 4 ) is carefully detailed. Finally, we present the

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Masayuki Inoue,Daisuke Urabe
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 July 2013
GET THIS BOOK Strategies and Tactics in Organic Synthesis

In this chapter, we described the asymmetric total synthesis of merrilactone A and resolvin E2 based on the symmetry-driven strategy. The enantio- and diastereoselective transannular aldol reaction of the meso eight-membered diketone led to the efficient total syntheses of both enantiomers of merrilactone A, and the convergent assembly of the pseudo-enantiomeric fragments, prepared through the enantioselective solvolysis of the meso intermediate, resulted in total synthesis of resolvin E2. These syntheses demonstrate the power and generality of the symmetry-driven strategy for