Spinal Interneurons

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  • Author : Lyandysha Zholudeva
  • Publisher : Academic Press
  • Pages : 300 pages
  • ISBN : 9780128192603
  • Rating : /5 from reviews
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Download or Read online Spinal Interneurons full in PDF, ePub and kindle. this book written by Lyandysha Zholudeva and published by Academic Press which was released on 15 June 2021 with total page 300 pages. We cannot guarantee that Spinal Interneurons book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Spinal Interneurons: Plasticity after Spinal Cord Injury provides neuroscientists, clinicians and trainees a reference book exclusively concentrating on spinal interneurons and the techniques and experiments employed to identify and study these cells as part of normal, diseased and injured neural circuits. In addition, the book highlights the therapeutic potential of these cells by presenting relevant pre-clinical and clinical work that has been performed. The book's focus on the latest in therapeutic strategies for targeting spinal interneurons, considerations for the development and use of treatments, and how such treatments work make this a comprehensive source of information. Provides a comprehensive overview of the techniques used to identify, characterize and classify spinal interneurons and their role in neural circuits Presents an in-depth discussion of the therapeutic potential of spinal interneurons for SCI injury and/or disease Represents the first book to discuss spinal interneurons and translational research

Spinal Interneurons in Sensorimotor Integration

Spinal Interneurons in Sensorimotor Integration
  • Author : Ting Ting Liu
  • Publisher : Unknown
  • Release : 05 December 2021
GET THIS BOOK Spinal Interneurons in Sensorimotor Integration

Even though spinal cord research has expanded enormously during the past decades, we still lack a precise understanding of how spinal interneuron networks perfectly integrate sensory feedback with motor control, and how these neuron circuits give rise to specific functions. The present study thus has three basic aims: (1) to investigate propriospinal interneurons connecting rostral and caudal lumbar spinal cord in the rat; (2) to investigate input properties of identified spinal interneurons interposed in different pathways; (3) to investigate cholinergic terminals in the

Spinal Interneurons

Spinal Interneurons
  • Author : Lyandysha Zholudeva,Michael Lane
  • Publisher : Academic Press
  • Release : 15 June 2021
GET THIS BOOK Spinal Interneurons

Spinal Interneurons: Plasticity after Spinal Cord Injury provides neuroscientists, clinicians and trainees a reference book exclusively concentrating on spinal interneurons and the techniques and experiments employed to identify and study these cells as part of normal, diseased and injured neural circuits. In addition, the book highlights the therapeutic potential of these cells by presenting relevant pre-clinical and clinical work that has been performed. The book's focus on the latest in therapeutic strategies for targeting spinal interneurons, considerations for the development

Lumbar Spinal Interneuron Activity as it Relates to Rhythmic Motor Output in the Adult Spinal Air stepping Cat

Lumbar Spinal Interneuron Activity as it Relates to Rhythmic Motor Output in the Adult  Spinal  Air stepping Cat
  • Author : Chantal Marie McMahon
  • Publisher : Unknown
  • Release : 05 December 2021
GET THIS BOOK Lumbar Spinal Interneuron Activity as it Relates to Rhythmic Motor Output in the Adult Spinal Air stepping Cat

Interneurons of the lumbar spinal cord inherently maintain and modulate stepping. In order to advance therapeutic interventions for spinal cord injury, it is necessary to clearly understand both the localized locomotor spinal circuitry as well as the activation patterns within the spinal cord. In this study, the structural organization of interneurons regulating antagonistic motor pools and the neural activation patterns driving behavior were investigated. In-vivo extracellularly recorded neurons of the intermediate zone and ventral horn of the lumbar spinal cord

Lineage Tracing of Ipsilateral Ventral Spinal Interneurons Delineates a Sensorimotor Connectivity Map Based on Developmental Origin and Spatial Distribution

Lineage Tracing of Ipsilateral Ventral Spinal Interneurons Delineates a Sensorimotor Connectivity Map Based on Developmental Origin and Spatial Distribution
  • Author : Stefania Di Costanzo
  • Publisher : Unknown
  • Release : 05 December 2021
GET THIS BOOK Lineage Tracing of Ipsilateral Ventral Spinal Interneurons Delineates a Sensorimotor Connectivity Map Based on Developmental Origin and Spatial Distribution

Movement is a fundamental behavior that is generated and patterned by premotor neural networks that reside in the ventral spinal cord of vertebrates. Despite ongoing investigations in multiple animal models, including humans, non-human primates, cats and rodents, identifying the functional neuron cell types that shape various motor tasks has proved difficult. One of the key issues in the field is the criteria by which neuronal cell types are characterized and defined. This dissertation describes my work tackling this problem using

Deconstructing Spinal Interneurons One Cell Type at a Time

Deconstructing Spinal Interneurons  One Cell Type at a Time
  • Author : Mariano Ignacio Gabitto
  • Publisher : Unknown
  • Release : 05 December 2021
GET THIS BOOK Deconstructing Spinal Interneurons One Cell Type at a Time

By using our Sparse Bayesian approach, we showed that V1 interneurons, a major inhibitory population that controls motor output, fractionate into diverse subsets on the basis of the expression of nineteen transcription factors. Transcriptionally defined subsets exhibit highly structured spatial distributions with mediolateral and dorsoventral positional biases. These distinctions in settling position are largely predictive of patterns of input from sensory and motor neurons, arguing that settling position is a determinant of inhibitory microcircuit organization. Finally, we extensively validated inferred

The Neuroplastic and Therapeutic Potential of Interneurons in the Injured Spinal Cord

The Neuroplastic and Therapeutic Potential of Interneurons in the Injured Spinal Cord
  • Author : Lyandysha Viktorovna Zholudeva
  • Publisher : Unknown
  • Release : 05 December 2021
GET THIS BOOK The Neuroplastic and Therapeutic Potential of Interneurons in the Injured Spinal Cord

There is a growing appreciation for spontaneous anatomical and functional changes, or neuroplasticity, after spinal cord injury. One key element of neuroplasticity recently identified are spinal interneurons. The work presented in this thesis identifies a specific population of spinal interneurons that contribute to respiratory plasticity -- the excitatory, ipsilaterally projecting population of V2a SpINs -- after high cervical spinal cord injury (Aim 1). Building upon these results, we transplanted neural progenitor cells enriched with stem-cell derived V2a interneurons and

Autonomic Dysfunction After Spinal Cord Injury

Autonomic Dysfunction After Spinal Cord Injury
  • Author : Lynne C. Weaver,Canio Polosa
  • Publisher : Elsevier
  • Release : 11 October 2005
GET THIS BOOK Autonomic Dysfunction After Spinal Cord Injury

Autonomic dysfunction is a major and poorly understood consequence of spinal cord injury. It is a cause of very serious disability and requires much more research. It should be a focus of treatment strategies. This book will be of interest to anyone involved in research and treatment of spinal cord injury since it helps to explain the tremendously negative impact on the body caused by cord injury that is not as obvious as paralysis and loss of sensation. It contains

Motor Neurobiology of the Spinal Cord

Motor Neurobiology of the Spinal Cord
  • Author : Timothy C. Cope
  • Publisher : CRC Press
  • Release : 26 June 2001
GET THIS BOOK Motor Neurobiology of the Spinal Cord

Traumatic injuries of the spinal cord continue to be the most common cause of permanent paralysis in young adults in the United States. New information has emerged on the response of spinal neurons to injury of either the spinal cord or peripheral nerves demonstrating that dendrites of injured motoneurons take on characteristics of axons. These and other new developments have helped to promote an exciting new era in the study of spinal cord neurobiology. Motor Neurobiology of the Spinal Cord