Sirtuin Biology in Cancer and Metabolic Disease

Produk Detail:
  • Author : Kenneth Maiese
  • Publisher : Elsevier
  • Pages : 300 pages
  • ISBN : 0128224843
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Sirtuin Biology in Cancer and Metabolic Disease

Download or Read online Sirtuin Biology in Cancer and Metabolic Disease full in PDF, ePub and kindle. this book written by Kenneth Maiese and published by Elsevier which was released on 20 February 2021 with total page 300 pages. We cannot guarantee that Sirtuin Biology in Cancer and Metabolic Disease book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Sirtuin Biology in Cancer and Metabolic Disease: Cellular Pathways for Clinical Discovery offers a compelling and thought-provoking perspective for the examination of the intriguing biology of sirtuins that ties cancer and metabolic disease together and provides a critical platform for the development of sirtuin-based novel therapeutic strategies to effectively treat cancer and metabolic disorders with precision in order to minimize any potentially detrimental clinical outcomes. An exciting prospect for the development of innovative therapeutics for cancer and metabolic disorders involves sirtuins. Sirtuins are histone deacetylases that have an intricate role in the onset and development of cancer and metabolic disease. Implementing a translational medicine format, this innovative reference highlights the ability of sirtuins to oversee critical pathways that involve stem cell maintenance, cellular proliferation, metabolic homeostasis, apoptosis, and autophagy that can impact cellular dysfunction and unchecked cellular growth that can occur during cancer and metabolic disease. Each chapter offers an intuitive perspective of advances on the application of sirtuin pathways for cancer and metabolic disease that will be become a "go-to" resource for a broad audience of scientists, physicians, pharmaceutical industry experts, nutritionists, and students. Chapters are authored by internationally recognized experts who elucidate the intimate relationship between cancer and metabolic disease that intersects with sirtuin pathways Presents the basic and clinical role of sirtuins in regard to cancer and metabolic disease Summarizes the multidiscipline views and publications for this exciting field of sirtuins for the development of new clinical treatments for cancer and metabolic disease Provides a vital foundation for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings

Sirtuin Biology in Cancer and Metabolic Disease

Sirtuin Biology in Cancer and Metabolic Disease
  • Author : Kenneth Maiese
  • Publisher : Elsevier
  • Release : 20 February 2021
GET THIS BOOK Sirtuin Biology in Cancer and Metabolic Disease

Sirtuin Biology in Cancer and Metabolic Disease: Cellular Pathways for Clinical Discovery offers a compelling and thought-provoking perspective for the examination of the intriguing biology of sirtuins that ties cancer and metabolic disease together and provides a critical platform for the development of sirtuin-based novel therapeutic strategies to effectively treat cancer and metabolic disorders with precision in order to minimize any potentially detrimental clinical outcomes. An exciting prospect for the development of innovative therapeutics for cancer and metabolic disorders involves

Sirtuins

Sirtuins
  • Author : Riekelt H. Houtkooper
  • Publisher : Springer
  • Release : 05 July 2018
GET THIS BOOK Sirtuins

The sirtuin family of proteins (SIRT1-7) received a lot of attention in recent years as they serve as metabolic sensors that control not only metabolism, but also aging and lifespan regulation. As such, sirtuins are strong targets for the treatment of age-related metabolic diseases, including obesity, diabetes, and cancer. Indeed, many research groups as well as pharmaceutical companies discovered food components and/or drugs that target the sirtuins and provide significant health benefits. This book focuses on various aspects

Sirtuins in Biology and Disease

Sirtuins in Biology and Disease
  • Author : Tiago F. Outeiro,Aleksey G. Kazantsev
  • Publisher : Frontiers E-books
  • Release : 04 December 2021
GET THIS BOOK Sirtuins in Biology and Disease

Sirtuins comprise a family of NAD+-dependent enzymes that have been shown to impact longevity in a number of eukaryotic organisms. Sir2 (Silent Information Regulator 2) was the first sirtuin protein discovered. The discovery that Sir2 requires NAD+ for its activity suggested a link between Sir2 activity and the phenomenon of caloric restriction in prolonging longevity. This link was strengthened by the observation that lifespan extension by caloric restriction requires Sir2 protein. Under conditions of caloric restriction, NAD+ levels are high,

Introductory Review on Sirtuins in Biology Aging and Disease

Introductory Review on Sirtuins in Biology  Aging  and Disease
  • Author : Leonard Guarente,Raul Mostoslavsky,Aleksey Kazantsev
  • Publisher : Academic Press
  • Release : 20 April 2018
GET THIS BOOK Introductory Review on Sirtuins in Biology Aging and Disease

Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus,

Mechanism based Peptidic and Peptideomimetic Human Sirtuin Inhibitors

Mechanism based Peptidic and Peptideomimetic Human Sirtuin Inhibitors
  • Author : Brett Hirsch
  • Publisher : Unknown
  • Release : 04 December 2021
GET THIS BOOK Mechanism based Peptidic and Peptideomimetic Human Sirtuin Inhibitors

"Silent information regulator 2 (Sir2) enzymes or sirtuins are a family of intracellular protein deacetylases that can catalyze the [beta]-nicotinamide adenine dinucleotide ([beta]-NAD+)-dependent deacetylation of N[epsilon]-acetyl-lysine on protein substrates. These enzymes are evolutionarily conserved among all the three kingdoms of life, with the yeast Sir2 being the founding family member. In humans, seven sirtuins, SIRT1-7, have been identified. Protein acetylation/deacetylation plays a critical role in biological processes such as metabolism, gene transcription, neurodegeneration, apoptosis,

Sirtuin Biology in Medicine

Sirtuin Biology in Medicine
  • Author : Kenneth Maiese
  • Publisher : Academic Press
  • Release : 04 March 2021
GET THIS BOOK Sirtuin Biology in Medicine

Sirtuin Biology in Medicine: Targeting New Avenues of Care in Development, Aging, and Disease provides a fascinating and in-depth analysis of sirtuins in the body during normal physiology as well during disease highlighting the targeting of sirtuin-controlled pathways for the development of innovative, efficacious, and safe therapeutic strategies for multiple disorders in the body that ultimately can affect lifespan extension. Sirtuins are expressed throughout the body, have broad biological effects, and can significantly impact both cellular survival and longevity during

Sirtuins in Health and Disease

Sirtuins in Health and Disease
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 03 February 2018
GET THIS BOOK Sirtuins in Health and Disease

Sirtuins in Health and Disease, Volume 154 presents the reactions catalyzed by sirtuins in terms of their unique coenzyme NAD+-dependent catalytic mechanisms, the ways to elucidate these mechanisms, and the design of the inhibitory compounds against the sirtuin-catalyzed reactions as potential therapeutic agents for human diseases. Sections cover the concepts and chemical tools in sirtuin research, SIRT4 and SIRT7, the regulatory effects of NAD metabolic pathways on sirtuin activity, sirtuins as modifiers of Huntington’s Disease (HD) pathology, parasite sirtuins

Handbook of the Biology of Aging

Handbook of the Biology of Aging
  • Author : Nicolas Musi,Peter Hornsby
  • Publisher : Academic Press
  • Release : 19 January 2021
GET THIS BOOK Handbook of the Biology of Aging

Handbook of the Biology of Aging, Ninth Edition, provides a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology. The book focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and metabolomics methodologies applied to aging related problems. Sections cover longevity pathways and interventions that modulate aging, innovative tools that

Handbook of the Biology of Aging

Handbook of the Biology of Aging
  • Author : Edward J. Masoro,Steven N. Austad
  • Publisher : Academic Press
  • Release : 13 December 2010
GET THIS BOOK Handbook of the Biology of Aging

Handbook of the Biology of Aging, Seventh Edition, reviews and synthesizes recent findings and discoveries in the field. This volume is part of The Handbooks of Aging series, which also includes The Handbook of the Psychology of Aging and The Handbook of Aging and the Social Sciences. The book is organized into two parts. Part 1 covers basic aging processes. It covers concepts relevant to clinical research, such as muscle, adipose tissue, and stem cells. It discusses research on how dietary

Resveratrol State of the art Science And Health Applications Actionable Targets And Mechanisms Of Resveratrol

Resveratrol  State of the art Science And Health Applications   Actionable Targets And Mechanisms Of Resveratrol
  • Author : Joseph M Wu,Tze-chen Hsieh
  • Publisher : World Scientific
  • Release : 06 December 2018
GET THIS BOOK Resveratrol State of the art Science And Health Applications Actionable Targets And Mechanisms Of Resveratrol

Resveratrol is a structurally simple, grape-derived polyphenol with seemingly boundless biological activities. The Editors have assembled a group of renowned scientists who have illustrious careers and lifelong passions for studies of this compound. Each chapter covers topics using published and, at times, unpublished data to provide scholarly and comprehensive reviews and perspectives. Several areas with basic clinical and public health interests are highlighted. The book is intended to serve as a text and reference covering recent research findings and clinical

International Review of Cell and Molecular Biology

International Review of Cell and Molecular Biology
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 16 May 2017
GET THIS BOOK International Review of Cell and Molecular Biology

International Review of Cell and Molecular Biology, Volume 332 reviews current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and average cited half-life of nine years. This great resource ranks high amongst scientific journals dealing with cell biology. Publishes only invited review articles on selected

Sirtuins

Sirtuins
  • Author : Riekelt H. Houtkooper
  • Publisher : Springer
  • Release : 17 November 2016
GET THIS BOOK Sirtuins

The sirtuin family of proteins (SIRT1-7) received a lot of attention in recent years as they serve as metabolic sensors that control not only metabolism, but also aging and lifespan regulation. As such, sirtuins are strong targets for the treatment of age-related metabolic diseases, including obesity, diabetes, and cancer. Indeed, many research groups as well as pharmaceutical companies discovered food components and/or drugs that target the sirtuins and provide significant health benefits. This book focuses on various aspects

Role of Metabolism in Regulating Immune Cell Fate Decisions

Role of Metabolism in Regulating Immune Cell Fate Decisions
  • Author : Anna Ohradanova-Repic,Marianne Boes,Hannes Stockinger
  • Publisher : Frontiers Media SA
  • Release : 26 May 2020
GET THIS BOOK Role of Metabolism in Regulating Immune Cell Fate Decisions

We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.

Chemical and Synthetic Biology Approaches to Understand Cellular Functions Part C

Chemical and Synthetic Biology Approaches to Understand Cellular Functions   Part C
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 10 February 2020
GET THIS BOOK Chemical and Synthetic Biology Approaches to Understand Cellular Functions Part C

Chemical and Synthetic Biology Approaches to Understand Cellular Functions - Part C, Volume 633, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial. This release includes sections on Next generation probes for molecular imaging in cells, Competitive binding assay for biotin and biotin derivatives, based on avidin and biotin-4-fluorescein, Converting avidin to bind ligands other than biotin, especially steroids, Chemoenzymatic Labeling Strategy, Engineered Siderophores, Small molecules to inhibit bacterial population behavior, NMR tube