Sirtuin Biology In Cancer And Metabolic Disease

Sirtuin Biology In Cancer And Metabolic Disease Book PDF
✏Book Title : Sirtuin Biology in Cancer and Metabolic Disease
✏Author : Kenneth Maiese
✏Publisher : Elsevier
✏Release Date : 2021-03-01
✏Pages : 350
✏ISBN : 9780128224847
✏Available Language : English, Spanish, And French

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✏Sirtuin Biology in Cancer and Metabolic Disease Book Summary : Sirtuin Biology in Cancer and Metabolic Disease: Cellular Pathways for Clinical Discovery fills a significant void that provides a unique resource for elucidating the most recent research and advances on the biology of sirtuins, the application of these pathways upon cellular biology, and the translation of sirtuin pathways for the treatment of multiple disease entities. Scientists, physicians, students and pharmaceutical industry researchers from diverse backgrounds will use this reference as the “go-to resource for both the biology and medical applications that focus upon sirtuins. As sirtuins play an intricate role in the pathology, progression and treatment of several disease entities ranging from metabolic disease and diabetes, cancer, cardiovascular disease, immune system dysfunction, to reproductive dysfunction, and aging-related disorders, this book provides an ideal update on the topic. Details the basic and clinical role of sirtuins and their broad applicability for sirtuin biology to be targeted for multiple medical disease entities Elucidates the research and advances on the biology of sirtuins, the application of these pathways upon cellular biology, and the translation of sirtuin pathways for the treatment of multiple disease entities Summarizes the multi-discipline views and publications for this diverse topic, covering cell development, cancer and metabolism

Introductory Review On Sirtuins In Biology Aging And Disease Book PDF
✏Book Title : Introductory Review on Sirtuins in Biology Aging and Disease
✏Author : Leonard Guarente
✏Publisher : Academic Press
✏Release Date : 2018-04-20
✏Pages : 220
✏ISBN : 9780128135006
✏Available Language : English, Spanish, And French

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✏Introductory Review on Sirtuins in Biology Aging and Disease Book Summary : Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration. Covers both the general and specific aspects of sirtuin proteins and their role in biology, aging and disease Presents a top quality collection of leading experts who contribute on a wide range of sirtuin-related topics Ideal resource for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses

📒Sirtuin Biology In Medicine ✍ Kenneth Maiese, MD

Sirtuin Biology In Medicine Book PDF
✏Book Title : Sirtuin Biology in Medicine
✏Author : Kenneth Maiese, MD
✏Publisher : Academic Press
✏Release Date : 2019-06-15
✏Pages : 512
✏ISBN : 0128141182
✏Available Language : English, Spanish, And French

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✏Sirtuin Biology in Medicine Book Summary : Sirtuin Biology in Medicine: Targeting New Avenues of Care in Development, Aging, and Disease fills a significant void, providing a unique resource for elucidating the most recent research and advances on the biology of sirtuins, the application of these pathways upon cellular biology, and the translation of sirtuin pathways for the treatment of multiple disease entities. Scientists, physicians, students and pharmaceutical industry researchers from diverse backgrounds will find this book to be a go-to resource for both the biology and medical applications that focus on sirtuins. Elucidates the research and advances on the biology of sirtuins, the application of these pathways upon cellular biology, and the translation of sirtuin pathways for the treatment of multiple disease entities Summarizes the multidiscipline views and publications on this diverse topic, covering cell development, cardiovascular and pulmonary systems, neurodegenerative disorders, cancer and metabolism

📒Sirtuins ✍ Riekelt H. Houtkooper

Sirtuins Book PDF
✏Book Title : Sirtuins
✏Author : Riekelt H. Houtkooper
✏Publisher : Springer
✏Release Date : 2016-11-17
✏Pages : 288
✏ISBN : 9789402409628
✏Available Language : English, Spanish, And French

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✏Sirtuins Book Summary : The sirtuin family of proteins (SIRT1-7) received a lot of attention in recent years as they serve as metabolic sensors that control not only metabolism, but also aging and lifespan regulation. As such, sirtuins are strong targets for the treatment of age-related metabolic diseases, including obesity, diabetes, and cancer. Indeed, many research groups as well as pharmaceutical companies discovered food components and/or drugs that target the sirtuins and provide significant health benefits. This book focuses on various aspects of sirtuin biology, from basic biochemistry, via molecular function, to its role in (fighting) human disease.

Sirtuins In Biology And Disease Book PDF
✏Book Title : Sirtuins in Biology and Disease
✏Author : Tiago F. Outeiro
✏Publisher : Frontiers E-books
✏Release Date :
✏Pages :
✏ISBN : 2889191176
✏Available Language : English, Spanish, And French

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✏Sirtuins in Biology and Disease Book Summary : Sirtuins comprise a family of NAD+-dependent enzymes that have been shown to impact longevity in a number of eukaryotic organisms. Sir2 (Silent Information Regulator 2) was the first sirtuin protein discovered. The discovery that Sir2 requires NAD+ for its activity suggested a link between Sir2 activity and the phenomenon of caloric restriction in prolonging longevity. This link was strengthened by the observation that lifespan extension by caloric restriction requires Sir2 protein. Under conditions of caloric restriction, NAD+ levels are high, Sir2 is activated, and the rate of aging is decreased. These effects have been replicated in invertebrate organisms, where a close structural and functional homologue of Sir2 was found in C. elegans and Drosophila. The sirtuin-dependent effects on metabolism and ageing, observed in lower organisms, have ignited intensive investigation of their biological and therapeutic roles in mammals. There are seven known mammalian sirtuins, SIRTs 1-7, the most studied of which is SIRT1, a close structural and functional homologue of yeast Sir2. Enhancement of organismal longevity and other health-promoting effects of mammalian SIRT1 have frequently been attributed to the regulation of metabolism. A recognized molecular link between metabolism and aging stimulated a firestorm of investigations, aiming to combat metabolic and age-dependent human diseases. It has become clear, however, that the sirtuin family of proteins regulates a diverse repertoire of cellular functions in mammals. Mounting evidence implicating SIRT1 in important clinical indications, such as diabetes, cancer, cardiovascular dysfunction and neurodegenerative disease, suggest that modality as attractive therapeutic target. Subsequently, drug discovery and development, targeting sirtuin activation, has been intensified in the recent years. Despite rapid progress and accumulation of new data, the biological roles of other mammalian sirtuins have been less studied and remain poorly understood. There are several important questions that remain to be addressed. What are the functions of sirtuins in different cell types and tissues? Are all sirtuins involved in the regulation of metabolism and aging? What is the functional relationship between different sirtuins? What are the mechanisms of regulation of sirtuin activities? What is the role of sirtuins in disease and therapy? This issue aims to address these and other critical questions, relevant to Research Topic on sirtuin biology and therapeutics. To that end the issue solicits expert opinions of sirtuin research on structural biology, biochemistry, cell biology, animal genetics, pharmacology, medicinal chemistry and drug discovery, and on areas of investigation studying human conditions, like diabetes, cancer, cardio-vascular, and neutodegeneration. Of particular interest are the new methods and assays to study sirtuins in various organisms and developing sirtuin-based therapeutics. Furthermore, we propose to encourage contributors to discuss new concepts and paradigms, and to express their perspectives on the future development of the sirtuin research field. Altogether, we believe this issue provides a unique opportunity for comprehensive and diverse coverage of the topic, and will be of broad interest for the journal’s readership.

📒Chemical Epigenetics ✍ Antonello Mai

Chemical Epigenetics Book PDF
✏Book Title : Chemical Epigenetics
✏Author : Antonello Mai
✏Publisher : Springer Nature
✏Release Date : 2020-03-31
✏Pages : 567
✏ISBN : 9783030429829
✏Available Language : English, Spanish, And French

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✏Chemical Epigenetics Book Summary : This book presents an authoritative review of the most significant findings about all the epigenetic targets (writers, readers, and erasers) and their implication in physiology and pathology. The book also covers the design, synthesis and biological validation of epigenetic chemical modulators, which can be useful as novel chemotherapeutic agents. Particular attention is given to the chemical mechanisms of action of these molecules and to the drug discovery prose which allows their identification. This book will appeal to students who want to know the extensive progresses made by epigenetics (targets and modulators) in the last years from the beginning, and to specialized scientists who need an instrument to quickly search and check historical and/or updated notices about epigenetics.

Resveratrol State Of The Art Science And Health Applications Actionable Targets And Mechanisms Of Resveratrol Book PDF
✏Book Title : Resveratrol State of the art Science And Health Applications Actionable Targets And Mechanisms Of Resveratrol
✏Author : Wu Joseph M
✏Publisher : World Scientific
✏Release Date : 2018-12-06
✏Pages : 348
✏ISBN : 9789813270923
✏Available Language : English, Spanish, And French

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✏Resveratrol State of the art Science And Health Applications Actionable Targets And Mechanisms Of Resveratrol Book Summary : Resveratrol is a structurally simple, grape-derived polyphenol with seemingly boundless biological activities. The Editors have assembled a group of renowned scientists who have illustrious careers and lifelong passions for studies of this compound. Each chapter covers topics using published and, at times, unpublished data to provide scholarly and comprehensive reviews and perspectives. Several areas with basic clinical and public health interests are highlighted. The book is intended to serve as a text and reference covering recent research findings and clinical applications in the field.The content is presented in several parts: mechanistic leads provided by laboratory studies of resveratrol; cellular and molecular targets of resveratrol; modulation of disease states by resveratrol; virtual leads and drug discovery.

Sirt Family In Endocrinology Book PDF
✏Book Title : SIRT Family in Endocrinology
✏Author : Yang Yang
✏Publisher : Frontiers Media SA
✏Release Date : 2019-09-26
✏Pages : 212
✏ISBN : 9782889630219
✏Available Language : English, Spanish, And French

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✏SIRT Family in Endocrinology Book Summary :

Histone Deacetylases The Biology And Clinical Implication Book PDF
✏Book Title : Histone Deacetylases the Biology and Clinical Implication
✏Author : Tso-Pang Yao
✏Publisher : Springer Science & Business Media
✏Release Date : 2011-08-31
✏Pages : 260
✏ISBN : 3642216315
✏Available Language : English, Spanish, And French

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✏Histone Deacetylases the Biology and Clinical Implication Book Summary : The book highlights work from many different labs that taught us abnormal HDACs potentially contribute to the development or progression of many human diseases including immune dysfunctions, heart disease, cancer, memory impairment, aging, and metabolic disorders.

Sirtuins In Health And Disease Book PDF
✏Book Title : Sirtuins in Health and Disease
✏Author :
✏Publisher : Academic Press
✏Release Date : 2018-02-03
✏Pages : 186
✏ISBN : 9780128122624
✏Available Language : English, Spanish, And French

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✏Sirtuins in Health and Disease Book Summary : Sirtuins in Health and Disease, Volume 154 presents the reactions catalyzed by sirtuins in terms of their unique coenzyme NAD+-dependent catalytic mechanisms, the ways to elucidate these mechanisms, and the design of the inhibitory compounds against the sirtuin-catalyzed reactions as potential therapeutic agents for human diseases. Sections cover the concepts and chemical tools in sirtuin research, SIRT4 and SIRT7, the regulatory effects of NAD metabolic pathways on sirtuin activity, sirtuins as modifiers of Huntington’s Disease (HD) pathology, parasite sirtuins as targets for novel chemotherapeutic agents, targeting sirtuins – substrate specificity and inhibitor design, and chemical probes in sirtuin research. This book focuses on the outstanding issues in the sirtuin field and implications for future sirtuin research. Presents an excellent subject, excellent structural organization, and authoritative contributions from world-renowned scholars in the sirtuin field Provides the latest updates on sirtuins in health and disease

Epigenetics In Biology And Medicine Book PDF
✏Book Title : Epigenetics in Biology and Medicine
✏Author : Manel Esteller
✏Publisher : CRC Press
✏Release Date : 2008-09-17
✏Pages : 312
✏ISBN : 1420007076
✏Available Language : English, Spanish, And French

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✏Epigenetics in Biology and Medicine Book Summary : Anomalous epigenetic patterns touch many areas of study including biomedical, scientific, and industrial. With perspectives from international experts, this resource offers an all-inclusive overview of epigenetics, which bridge DNA information and function by regulating gene expression without modifying the DNA sequence itself. Epigenetics, in its

📒Molecular Biology Of Aging ✍ Leonard Guarente

Molecular Biology Of Aging Book PDF
✏Book Title : Molecular Biology of Aging
✏Author : Leonard Guarente
✏Publisher : CSHL Press
✏Release Date : 2008
✏Pages : 610
✏ISBN : 9780879698249
✏Available Language : English, Spanish, And French

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✏Molecular Biology of Aging Book Summary : This volume covers the major threads in the molecular genetics of aging, including genes that regulate aging, causes of aging, evolutionary theories of aging, and the relationship between diet and aging. Among specific topics covered are calorie restriction, mitochondria, sirtuins, telomeres, stem cells, and cancer.

📒Sensing In Nature ✍ Carlos López-Larrea

Sensing In Nature Book PDF
✏Book Title : Sensing in Nature
✏Author : Carlos López-Larrea
✏Publisher : Springer Science & Business Media
✏Release Date : 2012-03-07
✏Pages : 316
✏ISBN : 9781461417040
✏Available Language : English, Spanish, And French

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✏Sensing in Nature Book Summary : Biological systems are an emerging discipline that may provide integrative tools by assembling the hierarchy of interactions among genes, proteins and molecular networks involved in sensory systems. The aim of this volume is to provide a picture, as complete as possible, of the current state of knowledge of sensory systems in nature. The presentation in this book lies at the intersection of evolutionary biology, cell and molecular biology, physiology and genetics. Sensing in Nature is written by a distinguished panel of specialists and is intended to be read by biologists, students, scientific investigators and the medical community.

Structure Book PDF
✏Book Title : Structure
✏Author :
✏Publisher :
✏Release Date : 2007
✏Pages :
✏ISBN : UCLA:L0090696592
✏Available Language : English, Spanish, And French

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✏Structure Book Summary :

📒Clocks And Rhythms ✍ Cold Spring Harbor Laboratory

Clocks And Rhythms Book PDF
✏Book Title : Clocks and Rhythms
✏Author : Cold Spring Harbor Laboratory
✏Publisher : CSHL Press
✏Release Date : 2007
✏Pages : 674
✏ISBN : 9780879698232
✏Available Language : English, Spanish, And French

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✏Clocks and Rhythms Book Summary : Based on presentations by world–renowned investigators at the 72nd annual Cold Spring Harbor Symposium on Quantitative Biology, this volume reviews the latest advances in biological clocks and rhythms. Topics include genetic and cellular studies aimed at characterizing circadian mechanisms; systems approaches to understanding physiological, endocrine, and neural networks; and models used for studying mental and physical cycles. A variety of normal and abnormal chronobiological patterns are discussed, including sleep, aging, migration, hibernation, seasonality, depression, and arrhythmias.

Chemical Mechanisms Of Sir2 Protein Deacetylases Book PDF
✏Book Title : Chemical Mechanisms of Sir2 Protein Deacetylases
✏Author : Brian Christopher Smith
✏Publisher :
✏Release Date : 2008
✏Pages : 190
✏ISBN : WISC:89101821767
✏Available Language : English, Spanish, And French

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✏Chemical Mechanisms of Sir2 Protein Deacetylases Book Summary :

Genetic Engineering Biotechnology News Book PDF
✏Book Title : Genetic Engineering Biotechnology News
✏Author :
✏Publisher :
✏Release Date : 2008
✏Pages :
✏ISBN : STANFORD:36105123659547
✏Available Language : English, Spanish, And French

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✏Genetic Engineering Biotechnology News Book Summary :

Biochemistry And Cell Biology Book PDF
✏Book Title : Biochemistry and Cell Biology
✏Author :
✏Publisher :
✏Release Date : 2010
✏Pages :
✏ISBN : OSU:32435077100212
✏Available Language : English, Spanish, And French

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✏Biochemistry and Cell Biology Book Summary :

Advances In Nutrition And Cancer Book PDF
✏Book Title : Advances in Nutrition and Cancer
✏Author : Vincenzo Zappia
✏Publisher : Springer Science & Business Media
✏Release Date : 2013-10-10
✏Pages : 460
✏ISBN : 9783642380075
✏Available Language : English, Spanish, And French

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✏Advances in Nutrition and Cancer Book Summary : This book comprises proceedings from the Third International Conference on Advances in Nutrition and Cancer, held in Naples in May 2012. This highly multidisciplinary meeting analyzed “nutrition and cancer” from different perspectives and on the basis of distinct and up-to-date experimental approaches. Knowledge on the relation between lifestyle, diet, and cancer is explored in a number of contributions, and the role of dietary intervention in cancer patients is discussed. Issues of vital interest to the research community, such as epidemiological and experimental oncology (genetics, epigenetics, and the mechanisms of action of natural compounds in the diet), receive detailed consideration. A further key topic is the emerging molecular technologies (the “omics”) that can cast light on the interplay between nutrition and human malignancies. Chapters take the form of reviews that include sections presenting expert opinions.

Mitochondrial Signaling In Health And Disease Book PDF
✏Book Title : Mitochondrial Signaling in Health and Disease
✏Author : Sten Orrenius
✏Publisher : CRC Press
✏Release Date : 2012-06-20
✏Pages : 530
✏ISBN : 9781439880036
✏Available Language : English, Spanish, And French

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✏Mitochondrial Signaling in Health and Disease Book Summary : Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis. With contributions from an impressive cadre of internationally recognized scientists, the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include: Electron transport and energy production Mitochondrial biogenesis and dynamics Mitochondrial signaling Apoptosis and autophagy Pharmacology signaling Epigenetic signaling: mitochondrial methylation and acetylation reactions An essential resource for life and health scientists as well as pharmaceutical industry professionals, this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.

Hazzard S Geriatric Medicine And Gerontology 7e Book PDF
✏Book Title : Hazzard s Geriatric Medicine and Gerontology 7E
✏Author : Jeffrey B. Halter
✏Publisher : McGraw Hill Professional
✏Release Date : 2016-11-18
✏Pages : 2304
✏ISBN : 9780071833462
✏Available Language : English, Spanish, And French

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✏Hazzard s Geriatric Medicine and Gerontology 7E Book Summary : The gold-standard text on the diagnosis and treatment of disorders affecting the elderly – completely updated with a new full-color presentation A Doody's Core Title for 2017! The definitive treatise on the subject of geriatrics, this comprehensive text combines gerontology principles with clinical geriatrics, offering a uniquely holistic approach to this ever-expanding area of medicine. Written by some of the world’s most respected geriatricians, Hazzard’s Geriatric Medicine and Gerontology, Seventh Edition presents up-to-date, evidence-based information in a rich new full-color design. Unmatched as a textbook, this classic is also valuable to fellows in geriatric medicine. Hazzards’s Geriatric Medicine and Gerontology, Seventh Edition is logically divided into five parts: Principles of Gerontology, Principles of Geriatrics, Geriatric Syndromes, Principles of Palliative Medicine, and Organ Systems and Diseases. Within its pages, you will find balanced, authoritative coverage of every essential topic – from evaluation and management to nutrition and palliative medicine. Here’s why the Seventh Edition is the best edition ever: • NEW full-color design with hundreds of color photographs • NEW chapters: Quality of Care in Older Adults, Common Non-Pain Symptoms in Older Adults, Strategies of Effective Communication Around Advanced Illness, Palliative Medicine in the Continuum of Care Including Hospice, Coagulation Disorders, and Plasma Cell Disorders • MORE chapters on Palliative Medicine • NEW Learning Objectives and Key Points added to each chapter • MORE tables, drawings, and clinical algorithms • EVIDENCE-BASED through the use of the latest clinical practice guidelines , references to systemic reviews, and critically appraised topics • UPDATED to reflect the most current clinical breakthroughs and advances for managing older adults in various settings

Robbins Cotran Pathologic Basis Of Disease E Book Book PDF
✏Book Title : Robbins Cotran Pathologic Basis of Disease E Book
✏Author : Vinay Kumar
✏Publisher : Elsevier Health Sciences
✏Release Date : 2009-06-10
✏Pages : 1464
✏ISBN : 9781437720150
✏Available Language : English, Spanish, And French

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✏Robbins Cotran Pathologic Basis of Disease E Book Book Summary : One of the best-selling medical textbooks of all time, Robbins and Cotran Pathologic Basis of Disease is the one book that nearly all medical students purchase, and is also widely used by physicians worldwide. A "who's who" of pathology experts delivers the most dependable, current, and complete coverage of today's essential pathology knowledge. At the same time, masterful editing and a practical organization make mastering every concept remarkably easy. The result remains the ideal source for an optimal understanding of pathology. Offers the most authoritative and comprehensive, yet readable coverage available in any pathology textbook, making it ideal for USMLE or specialty board preparation as well as for course work. Delivers a state-of-the-art understanding of the pathologic basis of disease through completely updated coverage, including the latest cellular and molecular biology. Demonstrates every concept visually with over 1,600 full-color photomicrographs and conceptual diagrams - many revised for even better quality. Facilitates learning with an outstanding full-color, highly user-friendly design.

Robbins Cotran Pathologic Basis Of Disease E Book Book PDF
✏Book Title : Robbins Cotran Pathologic Basis of Disease E Book
✏Author : Vinay Kumar
✏Publisher : Elsevier Health Sciences
✏Release Date : 2009-06-10
✏Pages : 1464
✏ISBN : 9781437721829
✏Available Language : English, Spanish, And French

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✏Robbins Cotran Pathologic Basis of Disease E Book Book Summary : One of the best-selling medical textbooks of all time, Robbins and Cotran Pathologic Basis of Disease is the one book you likely purchased as a medical student that still provides answers now that you're in practice. The new PROFESSIONAL EDITION is the same "who's who" of pathology experts that delivers the most dependable, current, and complete coverage of today's essential pathology knowledge, now enhanced with PERKS DESIGNED SPECIALLY FOR YOU AS A PRACTITIONER. Masterful editing and a practical organization make learning or reinforcing every concept remarkably easy. The result remains the ideal source for an optimal understanding of pathology at its core. Offers the most authoritative and comprehensive, yet readable coverage available in any pathology textbook, making it ideal for USMLE or specialty board preparation as well as for course work

Biological Basis Of Alcohol Induced Cancer Book PDF
✏Book Title : Biological Basis of Alcohol Induced Cancer
✏Author : Vasilis Vasiliou
✏Publisher : Springer
✏Release Date : 2014-11-26
✏Pages : 436
✏ISBN : 9783319096148
✏Available Language : English, Spanish, And French

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✏Biological Basis of Alcohol Induced Cancer Book Summary : In the recent years, a significant amount of research has emerged connecting the link between alcohol and cancer. The field has rapidly advanced, especially since the complex connection between alcohol and cancer has several unique sub areas that are being investigated. This proceedings volume will contain chapters based upon the presentation of the 2nd International Conference on Alcohol and Cancer in Colorado, 2013. The various topics explore the affects of alcohol on: liver and breast cancer; cell signaling and cancer; stem cells; biomarkers and metabolomics; aerodigestive cancers; cancer and the immune system and more.

Endocrinology Adult And Pediatric E Book Book PDF
✏Book Title : Endocrinology Adult and Pediatric E Book
✏Author : J. Larry Jameson
✏Publisher : Elsevier Health Sciences
✏Release Date : 2015-02-25
✏Pages : 2700
✏ISBN : 9780323321952
✏Available Language : English, Spanish, And French

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✏Endocrinology Adult and Pediatric E Book Book Summary : Considered the definitive source in its field for over 35 years, Endocrinology: Adult and Pediatric, has been thoroughly updated to reflect today's recent advances in adult and pediatric endocrinology. Unique perspectives from a team of trusted, world-renowned experts ensure this medical reference book remains the most highly-regarded text in the field. Make the best clinical decisions with an enhanced emphasis on evidence-based practice and expert opinions on treatment strategies. Zero in on the most relevant and useful references with the aid of a more focused, concise bibliography. Locate information quickly, while still getting the complete coverage you expect. Expanded coverage for key topics such as pediatric endocrinology and obesity mechanisms and treatment, in addition to today's hot topics in endocrinology, including endocrine disruptors, bariatric surgery, androgen deficiency, genetic causes of obesity, endocrine rhythms, and the use of tyrosine kinase inhibitors in thyroid cancer. New content addressing the latest advances in testosterone and estrogen replacement, as well as the new causes of calcium and phosphate disorders, new molecular causes of endocrine cancers, new genetic causes of reproductive disorders, and more. Updated clinical guidelines for diabetes, lipid disorders, obesity management, osteoporosis, and more, as well as essential treatment updates for the medical management of acromegaly, Cushing's Disease, hypercalcemia, and diabetes mellitus. New Key Points provide snapshots of what to expect in each chapter, or serve as a refresher of what you just read. Consult this title on your favorite e-reader.

The Mitochondrion In Aging And Disease Book PDF
✏Book Title : The Mitochondrion in Aging and Disease
✏Author :
✏Publisher : Academic Press
✏Release Date : 2014-08-19
✏Pages : 290
✏ISBN : 9780123948403
✏Available Language : English, Spanish, And French

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✏The Mitochondrion in Aging and Disease Book Summary : Mitochondria, the "power plants" of eukaryotic cells, are best known for the generation of adenosine triphosphate (ATP), the universal cellular "energy currency" of the cell, and the synthesis of different essential components. Mitochondrial dysfunction is known to lead to various degenerative disorders, disease, and aging. The Mitochondrion in Aging and Disease works to unravel the processes leading to mitochondrial impairments and of pathways involved in mitochondrial quality control and their impact on health and aging will be addressed. Reviews current topics of interest Written by experts in the field

Brenner And Rector S The Kidney E Book Book PDF
✏Book Title : Brenner and Rector s The Kidney E Book
✏Author : Maarten W. Taal
✏Publisher : Elsevier Health Sciences
✏Release Date : 2011-11-01
✏Pages : 3064
✏ISBN : 9781455723041
✏Available Language : English, Spanish, And French

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✏Brenner and Rector s The Kidney E Book Book Summary : Overcome the toughest clinical challenges in nephrology with the new 9th edition of Brenner/Rector’s The Kidney! A brand-new editorial team of Drs. Maarten W. Taal, Glenn M. Chertow, Philip A. Marsden, Karl Skorecki, Alan S. L. Yu, and Barry M. Brenner,, together with a diverse list of international contributors bring you the latest knowledge and best practices on every front in nephrology worldwide. Brand-new sections on Global Considerations in Nephrology and Pediatric Nephrology, as well as new chapters on recent clinical trials, cardiovascular and renal risk prediction in chronic kidney disease, identification of genetic causes of kidney disease, and many others, keep you at the forefront of this rapidly growing, ever-changing specialty. Brenner/Rector remains the go-to resource for practicing and training nephrologists and internists who wish to master basic science, pathophysiology, and clinical best practices. Broaden your knowledge base with expert, dependable, comprehensive answers for every stage of your career from the most comprehensive, definitive clinical reference in the field! Prepare for certification or recertification with a review of the basic science that underpins clinical nephrology as well as a comprehensive selection of the most important bibliographical sources in nephrology. Visually grasp and better understand critical information with the aid of over 700 full-color high-quality photographs as well as carefully chosen figures, algorithms, and tables to illustrate essential concepts, nuances of clinical presentation and technique, and decision making. Get internationally diverse, trusted guidance and perspectives from a team of well-respected global contributors, all of whom are at the top and the cutting edge of your field. A new editorial team headed by Dr. Taal and hand-picked by Dr. Brenner ensures the ongoing adherence to previous standards of excellence. Access information quickly thanks to a new, reorganized format and supplemental figures, tables, additional references, and expanded discussions. Keep current with the rapid development of care and research worldwide. A new section, "Global Considerations", focuses on regions outside Europe and North America. Leading experts from Latin America, Africa, Near and Middle East, Indian Subcontinent, Far East, Oceania and Australia present their expert insights into specific conditions, as well as progress and challenges in the development of the specialty. Improve therapy and outcomes for children with renal disease. New to this edition, "Pediatric Nephrology" addresses renal pathologies that usually present in childhood and covers topics such as Maturation of Kidney Structure and Function; Fluid; Electrolyte and Acid-Base Disorders in Children; Diseases of the Kidney and Urinary Tract in Children; Dialysis in Children; and Kidney Transplantation in Children. Stay up to date with all the latest clinical information including recent clinical trials, genetic causes of kidney disease, and cardiovascular and renal risk prediction in chronic kidney disease.

📒The Cancer Chronicles ✍ George Johnson

The Cancer Chronicles Book PDF
✏Book Title : The Cancer Chronicles
✏Author : George Johnson
✏Publisher : Vintage
✏Release Date : 2013-08-27
✏Pages : 304
✏ISBN : 9780385349710
✏Available Language : English, Spanish, And French

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✏The Cancer Chronicles Book Summary : When the woman he loved was diagnosed with a metastatic cancer, science writer George Johnson embarked on a journey to learn everything he could about the disease and the people who dedicate their lives to understanding and combating it. What he discovered is a revolution under way—an explosion of new ideas about what cancer really is and where it comes from. In a provocative and intellectually vibrant exploration, he takes us on an adventure through the history and recent advances of cancer research that will challenge everything you thought you knew about the disease. Deftly excavating and illuminating decades of investigation and analysis, he reveals what we know and don’t know about cancer, showing why a cure remains such a slippery concept. We follow him as he combs through the realms of epidemiology, clinical trials, laboratory experiments, and scientific hypotheses—rooted in every discipline from evolutionary biology to game theory and physics. Cogently extracting fact from a towering canon of myth and hype, he describes tumors that evolve like alien creatures inside the body, paleo-oncologists who uncover petrified tumors clinging to the skeletons of dinosaurs and ancient human ancestors, and the surprising reversals in science’s comprehension of the causes of cancer, with the foods we eat and environmental toxins playing a lesser role. Perhaps most fascinating of all is how cancer borrows natural processes involved in the healing of a wound or the unfolding of a human embryo and turns them, jujitsu-like, against the body. Throughout his pursuit, Johnson clarifies the human experience of cancer with elegiac grace, bearing witness to the punishing gauntlet of consultations, surgeries, targeted therapies, and other treatments. He finds compassion, solace, and community among a vast network of patients and professionals committed to the fight and wrestles to comprehend the cruel randomness cancer metes out in his own family. For anyone whose life has been affected by cancer and has found themselves asking why?, this book provides a new understanding. In good company with the works of Atul Gawande, Siddhartha Mukherjee, and Abraham Verghese, The Cancer Chronicles is endlessly surprising and as radiant in its prose as it is authoritative in its eye-opening science.

Activation Of Sirt1 By An N Terminal Regulatory Domain Book PDF
✏Book Title : Activation of SIRT1 by an N terminal Regulatory Domain
✏Author : Fiorella Ghisays
✏Publisher :
✏Release Date : 2012
✏Pages : 197
✏ISBN : OCLC:856523245
✏Available Language : English, Spanish, And French

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✏Activation of SIRT1 by an N terminal Regulatory Domain Book Summary : The NAD+-dependent protein deacetylase SIRT1 regulates transcriptional responses and enzymatic functions involving energy metabolism, responses to stress, and aging and is thus a candidate drug target for the treatment of metabolic, inflammatory, and neurodegenerative diseases. However, the mechanism(s) controlling the activity of SIRT1 itself is poorly understood. SIRT1 overexpression or activation by small molecules has been shown to ameliorate disease phenotypes in both animal and cellular models of disease, making SIRT1 a high priority drug target. SIRT1 deacetylates many protein substrates including p53, HNF1- [alpha], PPAR-[gamma], FOXO, NF[kappa]B, and Ku 70. The mechanism for selecting protein substrates is enigmatic since there is no defined sequence motif surrounding the acetyl-lysine targeted for deacetylation, and a variety of peptide substrates are accommodated in vitro. My thesis project aimed to understand how SIRT1 achieves its biological specialization for specific protein targets and cellular activities; specifically, the role of SIRT1's unique N-terminal domain in selecting substrates and activating SIRT1 enzymatic activity. We have shown that the recombinant N-terminal (NTERM) domain (SIRT1 residues 1-221) trans-activates deacetylation activity, revealing an unprecedented mechanism for the regulation of SIRT1 activity. The NTERM domain physically interacts with endogenous SIRT1 and promotes its association with protein substrates including the p65 subunit of NF-[kappa]B. Two motifs within the NTERM domain contribute to activation of SIRT1-dependent activities, and one of these motifs is targeted by the negative regulator, Deleted in Breast Cancer 1 (DBC1). These novel bipartite motifs interact with each other, and thus may function in cis to enhance substrate binding or allosterically control SIRT1 enzymatic activity. Our results provide a new rationale for the selective pharmacological control of SIRT1-dependent activities.

American Journal Of Respiratory And Critical Care Medicine Book PDF
✏Book Title : American Journal of Respiratory and Critical Care Medicine
✏Author :
✏Publisher :
✏Release Date : 2008
✏Pages :
✏ISBN : NWU:35558005670308
✏Available Language : English, Spanish, And French

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✏American Journal of Respiratory and Critical Care Medicine Book Summary :