Side Reactions in Peptide Synthesis

Produk Detail:
  • Author : Yi Yang
  • Publisher : Academic Press
  • Pages : 376 pages
  • ISBN : 0128011815
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Side Reactions in Peptide Synthesis

Download or Read online Side Reactions in Peptide Synthesis full in PDF, ePub and kindle. this book written by Yi Yang and published by Academic Press which was released on 01 September 2015 with total page 376 pages. We cannot guarantee that Side Reactions in Peptide Synthesis book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Side Reactions in Peptide Synthesis, based on the author’s academic and industrial experience, and backed by a thorough review of the current literature, provides analysis of, and proposes solutions to, the most frequently encountered side reactions during peptide and peptidomimetic synthesis. This valuable handbook is ideal for research and process chemists working with peptide synthesis in diverse settings across academic, biotech, and pharmaceutical research and development. While peptide chemistry is increasingly prevalent, common side reactions and their causes are often poorly understood or anticipated, causing unnecessary waste of materials and delay. Each chapter discusses common side reactions through detailed chemical equations, proposed mechanisms (if any), theoretical background, and finally, a variety of possible solutions to avoid or alleviate the specified side reaction. Provides a systematic examination on how to troubleshoot and minimize the most frequent side reactions in peptide synthesis Gives chemists the background information and the practical tools they need to successfully troubleshoot and improve results Includes optimization-oriented analysis of side reactions in peptide synthesis for improved industrial process development in peptidyl API (active pharmaceutical ingredient) production Answers the growing, global need for improved, replicable processes to avoid impurities and maintain the integrity of the end product. Presents a thorough discussion of critical factors in peptide synthesis which are often neglected or underestimated by chemists Covers solid phase and solution phase methodologies, and provides abundant references for further exploration

Side Reactions in Peptide Synthesis

Side Reactions in Peptide Synthesis
  • Author : Yi Yang
  • Publisher : Academic Press
  • Release : 01 September 2015
GET THIS BOOK Side Reactions in Peptide Synthesis

Side Reactions in Peptide Synthesis, based on the author’s academic and industrial experience, and backed by a thorough review of the current literature, provides analysis of, and proposes solutions to, the most frequently encountered side reactions during peptide and peptidomimetic synthesis. This valuable handbook is ideal for research and process chemists working with peptide synthesis in diverse settings across academic, biotech, and pharmaceutical research and development. While peptide chemistry is increasingly prevalent, common side reactions and their causes are

Principles of Peptide Synthesis

Principles of Peptide Synthesis
  • Author : M. Bodanszky
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOK Principles of Peptide Synthesis

A look at the shelves of a major library awakens doubts in the author of this small volume about the importance of writing a new introduction to peptide synthesis. This rather narrow area of bio-organic chemistry already has received considerable attention. A whole series of books deals with the synthesis of peptides. Some of these are textbooks written to support lecture courses on peptide synthesis. Others try to help the beginner, otherwise well versed in organic chemistry, to embark on

Chemical Approaches to the Synthesis of Peptides and Proteins

Chemical Approaches to the Synthesis of Peptides and Proteins
  • Author : Paul Lloyd-Williams,Fernando Albericio,Ernest Giralt
  • Publisher : CRC Press
  • Release : 18 August 2020
GET THIS BOOK Chemical Approaches to the Synthesis of Peptides and Proteins

Organic chemists working on the synthesis of natural products have long found a special challenge in the preparation of peptides and proteins. However, more reliable, more efficient synthetic preparation methods have been developed in recent years. This reference evaluates the most important synthesis methods available today, and also considers methods that show promise for future applications. This text describes the state of the art in efficient synthetic methods for the synthesis of both natural and artificial large peptide and protein

Major Methods of Peptide Bond Formation

Major Methods of Peptide Bond Formation
  • Author : Erhard Gross,Johannes Meienhofer
  • Publisher : Elsevier
  • Release : 10 May 2014
GET THIS BOOK Major Methods of Peptide Bond Formation

The Peptides: Analysis, Synthesis, Biology, Volume 1: Major Methods of Peptide Bond Formation provides comprehensive and critical reviews of important developments in three major areas of peptide research—analysis, synthesis, and biology. This book discusses the nature of the peptide bond, coupling between amino acid residues, and catalysis of active ester reactions. The formation of hydrazides, reactions of carbodiimides with amines, and mixed carbonic anhydride method of peptide synthesis are also elaborated. This publication likewise covers the control of racemization during

The Peptides

The Peptides
  • Author : Eberhard Schröder,Klaus Lübke
  • Publisher : Elsevier
  • Release : 12 May 2014
GET THIS BOOK The Peptides

The Peptides, Volume I: Methods of Peptide Synthesis focuses on detailed description of protecting groups, individual amino acids, and coupling reactions. The publication first offers information on amino-protecting and carboxyl-protecting groups, including carboxyl protection by salt formation, esterification, and amide formation and acyl-type, alkyl-type, and urethane protecting groups. The text then examines the formation of the peptide bond and amino acids. Discussions focus on amino acids with the alcoholic hydroxyl group, sulfur amino acids, basic and acidic amino acids, synthesis

The World of Peptides

The World of Peptides
  • Author : Theodor Wieland,Miklos Bodanszky
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOK The World of Peptides

Almost two centuries ago proteins were recognized as the primary materials (proteios = primary) oflife, but the significance and wide role of peptides (from pepsis = digestion) in practically all life pro cesses has only become apparent in the last few decades. Biologi cally active peptides are now being discovered at rapid intervals in the brain and in other organs including the heart, in the skin of amphibians and many other tissues. Peptides and peptide-like compounds are found among toxins and antibiotics.

Aspects of the Merrifield Peptide Synthesis

Aspects of the Merrifield Peptide Synthesis
  • Author : C. Birr
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOK Aspects of the Merrifield Peptide Synthesis

This book was written in the context of the daily confrontation with problems in the utilization of polymeric supports for the synthesis of pep tides. Therefore, views and experiences which usually are not mentioned in scientific journals are collected in these pages. The author has deliberately discussed in detail the possible influence of the polymer phase on the varying reaction conditions in the Merrifield synthesis; this aspect is neglected in most publications dealing with peptide synthesis. However, in view of

Amino Acid and Peptide Synthesis

Amino Acid and Peptide Synthesis
  • Author : John Jones
  • Publisher : Oxford University Press, USA
  • Release : 05 December 1992
GET THIS BOOK Amino Acid and Peptide Synthesis

The principal methods for the synthesis of amino acids and peptides are outlined in this concise introduction. With its emphasis on chemical principles and strategies, the book should be of value to all undergraduate chemistry students.

Fmoc Solid Phase Peptide Synthesis

Fmoc Solid Phase Peptide Synthesis
  • Author : W. Chan,Peter White
  • Publisher : Oxford University Press
  • Release : 16 December 1999
GET THIS BOOK Fmoc Solid Phase Peptide Synthesis

In the years since the publication of Atherton and Sheppard's volume, the technique of Fmoc solid-phase peptide synthesis has matured considerably and is now the standard approach for the routine production of peptides. The basic problems at the time of publication of this earlier work have now for the most part, been solved. As a result, innovators in the field have focussed their efforts to develop methodologies and chemistry for the synthesis of more complex structures. The focus of this

Protection of Functional Groups in Peptide Synthesis

Protection of Functional Groups in Peptide Synthesis
  • Author : Erhard Gross,Johannes Meienhofer
  • Publisher : Elsevier
  • Release : 10 May 2014
GET THIS BOOK Protection of Functional Groups in Peptide Synthesis

The Peptides: Analysis, Synthesis, Biology, Volume 3: Protection of Functional Groups in Peptide Synthesis focuses on protection of functional groups in peptide synthesis. This book consists of seven chapters. Chapter 1 reviews the large variety of amine protecting groups. The protection of carboxyl groups is described in Chapter 2, while the chemistry of sulfhydryl group protection in peptide synthesis is discussed in Chapter 3. Chapter 4 covers the protection of the hydroxyl groups of serine, threonine, tyrosine, and other hydroxyl-containing amino acids. Differential protection and

Chemistry of Peptide Synthesis

Chemistry of Peptide Synthesis
  • Author : N. Leo Benoiton
  • Publisher : CRC Press
  • Release : 19 April 2016
GET THIS BOOK Chemistry of Peptide Synthesis

Chemistry of Peptide Synthesis is a complete overview of how peptides are synthesized and what techniques are likely to generate the most desirable reactions. Incorporating elements from the author's role of Career Investigator of the Medical Research Council of Canada and his extensive teaching career, the book emphasizes learning rather th

Solid Phase Synthesis

Solid Phase Synthesis
  • Author : Fernando Albericio
  • Publisher : CRC Press
  • Release : 28 April 2000
GET THIS BOOK Solid Phase Synthesis

This volume provides the information needed to synthesize peptides by solid-phase synthesis (SPS) - employing polymeric support (resins), anchoring linkages (handles), coupling reagents (activators), and protection schemes. It presents strategies for creating a wide variety of compounds for drug discovery and analyzes peptides, DNA, carbohydrates,

The Chemical Synthesis of Peptides

The Chemical Synthesis of Peptides
  • Author : John Jones,Lecturer in Organic Chemistry and Official Fellow and Tutor of Balliol College Dean John Jones
  • Publisher : Oxford University Press
  • Release : 05 December 1991
GET THIS BOOK The Chemical Synthesis of Peptides

Peptides have many roles in medicine, and their potential for future application is even greater. They are involved in the regulation of fertility, the control of pain, the stimulation of growth, cancer therapy, cardiovascular problems, connective tissue diseases, digestive disorders, mental illness, and infections by microbial or viral agents. The preparation of such compounds by manipulating biological systems (genetic engineering) is an increasingly sophisticated art, but each case requires developmental work, and the approach is at present almost powerless with

Synthetic Peptides

Synthetic Peptides
  • Author : Gregory A. Grant
  • Publisher : Oxford University Press on Demand
  • Release : 05 December 2021
GET THIS BOOK Synthetic Peptides

The first synthetic peptides were produces a century ago. In the ensuing period, they have developed as valuable research tools that are readily available to all researchers. However, since most reasearchers do not make their own peptides, they are often unfamiliar with not only the synthetic chemistry, but also with important and useful aspects of design, analysis, handling, and applications. This volume is written by experts in the field who provide detailed descriptions as well as practical advice for producing