Separation Methods in Drug Synthesis and Purification

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  • Author : Klara Valko
  • Publisher : Elsevier
  • Pages : 612 pages
  • ISBN : 9780080541099
  • Rating : /5 from reviews
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Separation Methods in Drug Synthesis and Purification

Separation Methods in Drug Synthesis and Purification
  • Author : Klara Valko
  • Publisher : Elsevier
  • Release : 19 June 2020
GET THIS BOOK Separation Methods in Drug Synthesis and Purification

Separation Methods in Drug Synthesis and Purification, Second Edition, Volume Eight, provides an updated on the analytical techniques used in drug synthesis and purification. Unlike other books on either separation science or drug synthesis, this volume combines the two to explain the basic principles and comparisons of each separation technique. New sections to this volume include enantiomer separation using capillary electrophoresis (CE) and capillary electro- chromatography, the computer simulation of chromatographic separation for accelerating method development, the application of chromatography

Chirality in Drug Research

Chirality in Drug Research
  • Author : Eric Francotte,Wolfgang Lindner
  • Publisher : John Wiley & Sons
  • Release : 24 September 2007
GET THIS BOOK Chirality in Drug Research

Divided into the three main sections of synthesis, analysis and drug development, this handbook covers all stages of the drug development process, including large-scale synthesis and purification of chirally pure pharmaceuticals. The two editors from academia and a major pharmaceutical company have assembled an experienced, international team who provide first-hand practical advice and report previously unpublished data. In the first section, the isolation of chiral drugs from natural sources, their production in enzymatic processes and the resolution of racemic mixtures

Recent Advances in QSAR Studies

Recent Advances in QSAR Studies
  • Author : Tomasz Puzyn,Jerzy Leszczynski,Mark T. Cronin
  • Publisher : Springer Science & Business Media
  • Release : 19 January 2010
GET THIS BOOK Recent Advances in QSAR Studies

This book presents an interdisciplinary overview on the most recent advances in QSAR studies. The first part consists of a comprehensive review of QSAR methodology. The second part highlights the interdisciplinary aspects and new areas of QSAR modelling.

Chiral Separation Methods for Pharmaceutical and Biotechnological Products

Chiral Separation Methods for Pharmaceutical and Biotechnological Products
  • Author : Satinder Ahuja
  • Publisher : John Wiley & Sons
  • Release : 31 March 2011
GET THIS BOOK Chiral Separation Methods for Pharmaceutical and Biotechnological Products

Discusses chiral separations and offers guidance for selectingthe optimum method for desired results Chiral separations represent the most intriguing and, by somemeasures, most difficultseparations of chemical compounds. Thisbook provides researchers and students an under-standing of chiralseparations and offers a convenient route to selecting the bestseparation method, saving considerable time and cost in productdevelopment. Considering chiral separations in the biotechnological andpharmaceutical industries, as well as for food applications, Dr.Ahuja provides insights into a broad range of topics. Opening witha broad

Separation Techniques in Clinical Chemistry

Separation Techniques in Clinical Chemistry
  • Author : Hassan Y. Aboul-Enein
  • Publisher : CRC Press
  • Release : 28 May 2003
GET THIS BOOK Separation Techniques in Clinical Chemistry

This reference examines innovations in separation science for improved sensitivity and cost-efficiency, increased speed, higher sample throughput and lower solvent consumption in the assessment, evaluation, and validation of emerging drug compounds. It investigates breakthroughs in sample pretreatment, HPLC, mass spectrometry, capillary electrophor

Bioanalytical Separations

Bioanalytical Separations
  • Author : Anonim
  • Publisher : Elsevier
  • Release : 03 September 2003
GET THIS BOOK Bioanalytical Separations

Bioanalytical Separations is volume 4 of the multi-volume series, Handbook of Analytical Separations, providing reviews of analytical separation methods and techniques used for the determination of analytes across a whole range of applications. The theme for this volume is bioanalysis, in this case specifically meaning the analysis of drugs and their metabolites in biological fluids. - Discusses new developments in instrumentation and methods of analyzing drugs and their metabolites in biological fluids - Provides guidance to the different methods, their relative

Integrated Strategies for Drug Discovery Using Mass Spectrometry

Integrated Strategies for Drug Discovery Using Mass Spectrometry
  • Author : Mike S. Lee
  • Publisher : John Wiley & Sons
  • Release : 02 September 2005
GET THIS BOOK Integrated Strategies for Drug Discovery Using Mass Spectrometry

New strategies and techniques for today's fast-paced discoveryprocess Today, the pressure is on for high-throughput approaches toaccelerate the generation, identification, and optimization ofmolecules with desirable drug properties. As traditional methods ofanalysis become antiquated, new analytical strategies andtechniques are necessary to meet sample throughput requirements andmanpower constraints. Among them, mass spectrometry has grown to bea front-line tool throughout drug discovery. Integrated Strategies for Drug Discovery Using Mass Spectrometryprovides a thorough review of current analytical approaches,industry practices, and strategies in drug

Drug Bioavailability

Drug Bioavailability
  • Author : Han van de Waterbeemd,Hans Lennernäs,Per Artursson
  • Publisher : John Wiley & Sons
  • Release : 06 March 2006
GET THIS BOOK Drug Bioavailability

The peroral application (swallowing) of a medicine means that the body must first resorb the active substance before it can begin to take effect. The efficacy of drug uptake depends on the one hand on the chemical characteristics of the active substance, above all on its solubility and membrane permeability. On the other hand, it is determined by the organism's ability to absorb pharmaceuticals by way of specific transport proteins or to excrete them. Since many pharmacologically active substances are

Physicochemical and Biomimetic Properties in Drug Discovery

Physicochemical and Biomimetic Properties in Drug Discovery
  • Author : Klara Valko
  • Publisher : John Wiley & Sons
  • Release : 25 November 2013
GET THIS BOOK Physicochemical and Biomimetic Properties in Drug Discovery

Demonstrating how and why to measure physicochemical and biomimetic properties in early stages of drug discovery for lead optimization, Physicochemical and Biomimetic Properties in Drug Discovery encourages readers to discover relationships between various measurements and develop a sense of interdisciplinary thinking that will add to new research in drug discovery. This practical guide includes detailed descriptions of state-of-the-art chromatographic techniques and uses real-life examples and models to help medicinal chemists and scientists and advanced graduate students apply measurement data for

Absorption and Drug Development

Absorption and Drug Development
  • Author : Alex Avdeef
  • Publisher : John Wiley & Sons
  • Release : 11 April 2012
GET THIS BOOK Absorption and Drug Development

Explains how to perform and analyze the results of the latest physicochemical methods With this book as their guide, readers have access to all the current information needed to thoroughly investigate and accurately determine a compound's pharmaceutical properties and their effects on drug absorption. The book emphasizes oral absorption, explaining all the physicochemical methods used today to analyze drug candidates. Moreover, the author provides expert guidance to help readers analyze the results of their studies in order to select the

Drug Monitoring and Clinical Chemistry

Drug Monitoring and Clinical Chemistry
  • Author : Georg Hempel
  • Publisher : Elsevier
  • Release : 15 May 2004
GET THIS BOOK Drug Monitoring and Clinical Chemistry

Drug Monitoring and Clinical Chemistry, the 5th volume in the Handbook of Analytical Separations series, gives an overview about methods to analyse drugs in biological fluids. The most widely used methods to analyse drugs in biological fluids. i.e. chromatographic methods, CE and immunoassays are described in detail. For important drugs, an overview about the methods available and a comparison of the techniques should be given to enable the reader to choose the right method depending on laboratory equipment, staff,

Chemometric Methods in Capillary Electrophoresis

Chemometric Methods in Capillary Electrophoresis
  • Author : Grady Hanrahan,Frank A. Gomez
  • Publisher : John Wiley & Sons
  • Release : 22 October 2009
GET THIS BOOK Chemometric Methods in Capillary Electrophoresis

Use chemometric techniques to develop optimum separation conditions for capillary electrophoreses For all its advantages, capillary electrophoresis (CE) also carries significant disadvantages for the researcher. Offering a unique blend of information from authors active in a variety of developments of chemometrics in CE, Chemometric Methods in Capillary Electrophoresis presents modern chemometric methods as an alternative to help alleviate the problems commonly encountered during routine analysis and method development. Focusing on current chemometric methods utilized in CE endeavours by research-active experts