Secondary Findings in Genomic Research

• Author : Anonim
• Publisher : Academic Press
• Release : 18 March 2020

Secondary Findings in Genomic Research offers a single, highly accessible resource on interpreting, managing and disclosing secondary findings in genomic research. With chapters written by experts in the field, this book is the first to concisely explain the ethical and practical issues raised by secondary genomics findings for a multi and interdisciplinary audience of genomic researchers, translational scientists, clinicians, medical students, genetic counselors, ethicists, legal experts and law students, public policy specialists and regulators. Contributors from Europe, North America, and

• Author : National Research Council,Division of Behavioral and Social Sciences and Education,Committee on National Statistics,Steering Committee for the Workshop on Guidelines for Returning Individual Results from Genome Research Using Population-Based Banked Specimens
• Publisher : National Academies Press
• Release : 08 September 2014

Population surveys traditionally collect information from respondents about their circumstances, behaviors, attitudes, and other characteristics. In recent years, many surveys have been collecting not only questionnaire answers, but also biologic specimens such as blood samples, saliva, and buccal swabs, from which a respondent's DNA can be ascertained along with other biomarkers (e.g., the level of a certain protein in the blood). The National Health and Nutrition Examination Survey (NHANES), sponsored by the National Center for Health Statistics (NCHS), has

• Author : Institute of Medicine,Board on Health Sciences Policy,Roundtable on Translating Genomic-Based Research for Health
• Publisher : National Academies Press
• Release : 19 August 2014

Rapid advances in technology have lowered the cost of sequencing an individual's genome from the several billion dollars that it cost a decade ago to just a few thousand dollars today and have correspondingly greatly expanded the use of genomic information in medicine. Because of the lack of evidence available for assessing variants, evaluation bodies have made only a few recommendations for the use of genetic tests in health care. For example, organizations, such as the Evaluation of Genomic Applications

• Author : Karen H. Rothenberg JD, MPA,Lynn Wein Bush PhD, MS, MA
• Publisher : Oxford University Press
• Release : 14 March 2014

Through the use of dramatic narratives, The Drama of DNA brings to life the complexities raised by the application of genomic technologies to health care and diagnosis. This creative, pedagogical approach shines a unique light on the ethical, psychosocial, and policy challenges that emerge as comprehensive sequencing of the human genome transitions from research to clinical medicine. Narrative genomics aims to enhance understanding of how we evaluate, process, and share genomic information, and to cultivate a deeper appreciation for difficult

• Author : Aad Tibben,Barbara B. Biesecker
• Publisher : Academic Press
• Release : 30 March 2019

Clinical Genome Sequencing: Psychological Aspects thoroughly details key psychological factors to consider while implementing genome sequencing in clinical practice, taking into account the subtleties of genetic risk assessment, patient consent and best practices for sharing genomic findings. Chapter contributions from leading international researchers and practitioners cover topics ranging from the current state of genomic testing, to patient consent, patient responses to sequencing data, common uncertainties, direct-to-consumer genomics, the role of genome sequencing in precision medicine, genetic counseling and genome sequencing,

• Author : Karen H. Rothenberg,Lynn W. Bush
• Publisher : Oxford University Press, USA
• Release : 07 June 2023

Through the use of dramatic narratives, The Drama of DNA brings to life the complexities raised by the application of genomic technologies to health care and diagnosis. This creative, pedagogical approach shines a unique light on the ethical, psychosocial, and policy challenges that emerge as comprehensive sequencing of the human genome transitions from research to clinical medicine. Narrative genomics aims to enhance understanding of how we evaluate, process, and share genomic information, and to cultivate a deeper appreciation for difficult

• Author : Susan M. Wolf,Brittney Crock,Brian Van Ness,PhD Lawrenz (Frances P.),Jeffrey P. Kahn,Laura M. Beskow,Mildred K. Cho,Michael Christman,Robert C. Green,JD Hall (Ralph),Judy Illes,M.A. Keane (Moira),Barbara Koenig,Bartha Maria Knoppers,Isaac Kohane,Bonnie LeRoy,Karen J. Maschke,Pilar Ossorio,William McGeveran,Lisa Parker,Gloria Petersen,Henry S. Richardson,Joan Scott,Sharon Terry,Benjamin Wilfond,Wendy A. Wolf
• Publisher : Unknown
• Release : 07 June 2023

Biobanks and archived data sets collecting samples and data have become crucial engines of genetic and genomic research. Unresolved, however, is what responsibilities biobanks should shoulder to manage incidental findings and individual research results of potential health, reproductive, or personal importance to individual contributors (using “biobank” here to refer both to collections of samples and collections of data). This article reports recommendations from a 2-year project funded by the National Institutes of Health. We analyze the responsibilities involved in managing

• Author : Matthew Herder,Conrad V Fernandez
• Publisher : Elsevier Inc. Chapters
• Release : 21 November 2013

Large-scale cancer genomics research projects raise a range of ethical and legal issues. We focus on two emerging themes challenged within genomic research: (1) issues surrounding the return of research results to research participants, whether in summary or individualized form, and (2) issues connected to the commercialization of research, including the patenting of biomedical discoveries and biological materials. We examine current thinking in these areas and highlight areas for further exploration.

• Author : Vinod Scaria,Sridhar Sivasubbu
• Publisher : Research in Genomics
• Release : 11 February 2015

A concise handbook on exome sequencing for clinicians and clinical geneticists.

• Author : Robert DeSalle,Michael Yudell
• Publisher : John Wiley & Sons
• Release : 21 April 2020

The popular introduction to the genomic revolution for non-scientists—the revised and updated new edition Welcome to the Genome is an accessible, up-to-date introduction to genomics—the interdisciplinary field of biology focused on the structure, function, evolution, mapping, and editing of an organism's complete set of DNA. Written for non-experts, this user-friendly book explains how genomes are sequenced and explores the discoveries and challenges of this revolutionary technology. Genomics is a mixture of many fields, including not only biology, engineering,

• Author : Richard R. Fabsitz,Amy L. McGuire,Richard R. Sharp,Mona Puggal,Laura M. Beskow,Leslie G. Biesecker,Ebony Bookman,Wylie Burke,Esteban Gonzalez Burchard,George Church,Ellen Wright Clayton,John H. Eckfeldt,Conrad V. Fernandez,Rebecca Fisher,Stephanie M. Fullerton,Stacey Gabriel,Francine Gachupin,Cynthia James,Gail P. Jarvik,Rick Kittles,Jennifer R. Leib,Christopher O'Donnell,P. Pearl O'Rourke,Laura Lyman Rodriguez,Sheri D. Schully,Alan R. Shuldiner,Rebecca K.F Sze,Joseph V. Thakuria,Susan M. Wolf,Gregory L. Burke
• Publisher : Unknown
• Release : 07 June 2023

Tremendous controversy surrounds return of individual research results and incidental findings in genetic and genomic research on human participants. Researchers traditionally have not offered individual research results back to human participants. However, with increasing recognition of the potential health importance of those results (which may indeed be life-saving), scholars, researchers, and policy makers have begun considering under what circumstances results should be offered back to participants, what results would warrant this effort, and how it should be done. This article

• Author : Sorin Hostiuc
• Publisher : Academic Press
• Release : 07 August 2018

Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies offers thorough discussions on preconception carrier screening, genetic engineering and the use of CRISPR gene editing, mitochondrial gene replacement therapy, sex selection, predictive testing, secondary findings, embryo reduction and the moral status of the embryo, genetic enhancement, and the sharing of genetic data. Chapter contributions from leading bioethicists and clinicians encourage a global, holistic perspective on applied challenges and the moral questions relating the implementation of genetic reproductive technology. The

• Author : Anonim
• Publisher : Academic Press
• Release : 18 November 2013

The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in our knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. Includes methods for testing with ethical, legal, and social implications Critically analyzes future

• Author : Anonim
• Publisher : ScholarlyEditions
• Release : 10 January 2013

Issues in Genomics and Non-Human Genetic Research: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Genomic Research. The editors have built Issues in Genomics and Non-Human Genetic Research: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Genomic Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Genomics and Non-Human Genetic

• Author : Isabel Allona,Matias Kirst,Wout Boerjan,Steven Strauss,Ronald Sederoff
• Publisher : Frontiers Media SA
• Release : 27 November 2019

This Research Topic addresses research in genomics and biotechnology to improve the growth and quality of forest trees for wood, pulp, biorefineries and carbon capture. Forests are the world’s greatest repository of terrestrial biomass and biodiversity. Forests serve critical ecological services, supporting the preservation of fauna and flora, and water resources. Planted forests also offer a renewable source of timber, for pulp and paper production, and the biorefinery. Despite their fundamental role for society, thousands of hectares of forests