Resident Stem Cells and Regenerative Therapy

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  • Author : Regina Coeli dos Santos Goldenberg
  • Publisher : Academic Press
  • Pages : 270 pages
  • ISBN : 0124160123
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Resident Stem Cells and Regenerative Therapy

Download or Read online Resident Stem Cells and Regenerative Therapy full in PDF, ePub and kindle. this book written by Regina Coeli dos Santos Goldenberg and published by Academic Press which was released on 15 June 2021 with total page 270 pages. We cannot guarantee that Resident Stem Cells and Regenerative Therapy book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. In the last 3 decades, stem cells have greatly impacted the scientific and lay communities, providing huge advances in the treatment of devastating human diseases, including myocardial infarction, diabetes, muscular dystrophy, cystic fibrosis, cirrhosis, and osteoporosis. Alongside debates of induced pluripotent stem cells and embryonic stem cells has been the discovery of adult stem cells in many different tissues. While these organ resident or progenitor stem cells offer prospects to contribute to tissue regeneration, they also present challenges because of the complexity of organ structures. This book will present the main findings to date and the important factors to be considered when considering resident stem cells in regenerative therapies. Chapters on cardiac, brain, neural, liver, kidney, skeletal muscle, bone, pancreatic, skin, and lung resident stem cells will assist in defining the level of success that has been achieved and the direction for the road ahead. With contributions from leading laboratories, open questions related to resident stem cells and regenerative therapies will also be presented for debate. Highlights basic research in tissue specific stem cells, experiments with animal models and clinical trials that are transforming the field of regeneration Provides a clear understanding of endogenous stem cells, their role in current regenerative therapies, and prospects for future research Reports on the main-stream clinical approaches and in vivo experiments published in primary literature to help categorizes the advances in various aspects of regenerative therapy and illustrate opportunities for clinical applications

Resident Stem Cells and Regenerative Therapy

Resident Stem Cells and Regenerative Therapy
  • Author : Regina Coeli dos Santos Goldenberg,Antonio Carlos Campos de Carvalho
  • Publisher : Academic Press
  • Release : 15 June 2021
GET THIS BOOK Resident Stem Cells and Regenerative Therapy

In the last 3 decades, stem cells have greatly impacted the scientific and lay communities, providing huge advances in the treatment of devastating human diseases, including myocardial infarction, diabetes, muscular dystrophy, cystic fibrosis, cirrhosis, and osteoporosis. Alongside debates of induced pluripotent stem cells and embryonic stem cells has been the discovery of adult stem cells in many different tissues. While these organ resident or progenitor stem cells offer prospects to contribute to tissue regeneration, they also present challenges because of the

Extracellular Matrix Enhances Therapeutic Effects of Stem Cells in Regenerative Medicine

Extracellular Matrix Enhances Therapeutic Effects of Stem Cells in Regenerative Medicine
  • Author : Yan Nie
  • Publisher : Unknown
  • Release : 15 June 2021
GET THIS BOOK Extracellular Matrix Enhances Therapeutic Effects of Stem Cells in Regenerative Medicine

Stem cell therapy is a promising option for regenerative of injured or diseased tissues. However, the extremely low survival and engraftment of transplanted cells and the obviously inadequate recruitment and activation of the endogenous resident stem cells are the major challenges for stem cell therapy. Fortunately, recent progresses show that extracellular matrix (ECM) could not only act as a spatial and mechanical scaffold to enhance cell viability but also provide a supportive niche for engraftment or accelerating stem cell differentiation.

Resident Stem Cells and Regenerative Therapy

Resident Stem Cells and Regenerative Therapy
  • Author : Regina Coeli dos Santos Goldenberg,Antonio Carlos Campos de Carvalho
  • Publisher : Academic Press
  • Release : 31 December 2012
GET THIS BOOK Resident Stem Cells and Regenerative Therapy

In the last 3 decades, stem cells have greatly impacted the scientific and lay communities, providing huge advances in the treatment of devastating human diseases, including myocardial infarction, diabetes, muscular dystrophy, cystic fibrosis, cirrhosis, and osteoporosis. Alongside debates of induced pluripotent stem cells and embryonic stem cells has been the discovery of adult stem cells in many different tissues. While these organ resident or progenitor stem cells offer prospects to contribute to tissue regeneration, they also present challenges because of the

Adult Stem Cells

Adult Stem Cells
  • Author : Donald G. Phinney
  • Publisher : Springer Science & Business Media
  • Release : 11 February 2011
GET THIS BOOK Adult Stem Cells

This is comprehensive overview of a vital area of scientific enquiry, which covers a broad spectrum of issues. With contributions from some of the key researchers in the field, Adult Stem Cells: Biology and Methods of Analysis offers readers a historical perspective as well as unique insights into cutting-edge thoughts. The volume contextualizes the recent discovery of stem/progenitor cell populations resident in many adult tissues and organs. It confronts the complexities scientists face in trying to validate these cells,

Stem Cell Biology and Regenerative Medicine in Ophthalmology

Stem Cell Biology and Regenerative Medicine in Ophthalmology
  • Author : Stephen Tsang
  • Publisher : Springer Science & Business Media
  • Release : 09 December 2012
GET THIS BOOK Stem Cell Biology and Regenerative Medicine in Ophthalmology

Patient specific and disease specific stem cell lines have already introduced groundbreaking advances into the research and practice of ophthalmology. This volume provides a comprehensive and engaging overview of the latest innovations in the field. Twelve chapters discuss the fastest growing areas in ophthalmological stem cell research, from disease modelling, drug screening and gene targeting to clinical genetics and regenerative treatments. Innovative results from stem cell research of the past decade are pointing the way toward practicable treatments for retinitis

Gene Therapy and Cell Fusion Enhances Stem Cell Mediated Cardiac Repair

Gene Therapy and Cell Fusion Enhances Stem Cell Mediated Cardiac Repair
  • Author : Pearl Jennine Quijada
  • Publisher : Unknown
  • Release : 15 June 2021
GET THIS BOOK Gene Therapy and Cell Fusion Enhances Stem Cell Mediated Cardiac Repair

Cardiovascular disease is the leading cause of mortality in the United States. Myocardial infarction (MI) induces massive cellular death and leads to a decline in cardiac function. Cardiomyocytes have limited proliferative capacity sparking interests in molecular and cellular strategies to promote stem cell conversion into new cardiomyocytes. Cardiac progenitor cells (CPCs) are tissue resident stem cells that give rise to cardiomyogenic structures. Although, CPCs introduced into the heart confer improvements in cardiac function after MI, these effects are not sufficient

Muse Cells

Muse Cells
  • Author : Mari Dezawa
  • Publisher : Springer
  • Release : 05 January 2019
GET THIS BOOK Muse Cells

This book provides the first comprehensive account of multilineage-differentiating stress-enduring (Muse) cells, a pluripotent and non-tumorigenic subpopulation of mesenchymal stem cells (MSCs) that have the ability to detect damage signals, migrate to damaged sites, and spontaneously differentiate into cells compatible with the affected tissue, thereby enabling repair of all tissue types. The coverage encompasses everything from the basic properties of Muse cells to their tissue repair effects and potential clinical applications—for example, in acute myocardial infarction, stroke, skin injuries

Multimodal Nanoparticles for Image guided Delivery of Mesenchymal Stem Cells in the Treatment of Myocardial Infarction

Multimodal Nanoparticles for Image guided Delivery of Mesenchymal Stem Cells in the Treatment of Myocardial Infarction
  • Author : Sean Sweeney
  • Publisher : Unknown
  • Release : 15 June 2021
GET THIS BOOK Multimodal Nanoparticles for Image guided Delivery of Mesenchymal Stem Cells in the Treatment of Myocardial Infarction

One of the leading causes of death and hospital stays in the United States, myocardial infarction (MI) occurs when coronary blockages lead to downstream ischemia in the myocardium. Following the MI, the heart activates a number of pathways to repair or remodel the infarcted zone. Endothelial cells respond to ischemia by de-differentiating to form neovasculature and myofibroblasts. The resident cardiac differentiable stem cells (CDCs) are recruited via local cytokines and chemokines to the infarct zone where they too differentiate into

Role of Stem Cells and Extracellular Matrix in the Regeneration of Skeletal Muscle

Role of Stem Cells and Extracellular Matrix in the Regeneration of Skeletal Muscle
  • Author : Andrew Dunn
  • Publisher : Unknown
  • Release : 15 June 2021
GET THIS BOOK Role of Stem Cells and Extracellular Matrix in the Regeneration of Skeletal Muscle

Adult skeletal muscle has a remarkable capacity to initiate a rapid and extensive repair process after damage due to injury or degenerative disease. Although satellite cells are the primary skeletal muscle stem cells, there are many reports of non-satellite cell populations with myogenic capacity resident within skeletal muscle. The activity of muscle-resident stem cells during the regeneration process is tightly controlled through the dynamic interactions between intrinsic factors within the cells and extrinsic factors constituting the muscle stem cell niche.

Stem Cell and Biologic Scaffold Engineering

Stem Cell and Biologic Scaffold Engineering
  • Author : Panagiotis Mallis
  • Publisher : MDPI
  • Release : 04 October 2019
GET THIS BOOK Stem Cell and Biologic Scaffold Engineering

Tissue engineering and regenerative medicine is a rapidly evolving research field which effectively combines stem cells and biologic scaffolds in order to replace damaged tissues. Biologic scaffolds can be produced through the removal of resident cellular populations using several tissue engineering approaches, such as the decellularization method. Indeed, the decellularization method aims to develop a cell-free biologic scaffold while keeping the extracellular matrix (ECM) intact. Furthermore, biologic scaffolds have been investigated for their in vitro potential for whole organ development.

Human Pluripotent Stem Cell derived Mesothelium Functions in Regenerative Medicine as a Multipotent Vascular Progenitor

Human Pluripotent Stem Cell derived Mesothelium Functions in Regenerative Medicine as a Multipotent Vascular Progenitor
  • Author : Thomas Anthony Colunga
  • Publisher : Unknown
  • Release : 15 June 2021
GET THIS BOOK Human Pluripotent Stem Cell derived Mesothelium Functions in Regenerative Medicine as a Multipotent Vascular Progenitor

The human body contains two major coelomic cavities, thoracic and abdominal, that are lined with an epithelial cell called mesothelium. Mesothelium also forms the outer layer of internal organs within these cavities and an additional protective pouch surrounding the heart called the pericardium. Mesothelium contributes to the development of the coelomic organs including the vasculature by acting as a multipotent vascular progenitor. During development and upon reactivation after injury, the mesothelium of the outer layer of organs loses its polarity

Stem Cell Research on Cardiology

Stem Cell Research on Cardiology
  • Author : Robert David
  • Publisher : Unknown
  • Release : 01 October 2020
GET THIS BOOK Stem Cell Research on Cardiology

Even today, cardiovascular diseases are the main cause of death worldwide, and therapeutic approaches are very restricted. Due to the limited regenerative capabilities of terminally differentiated cardiomyocytes post injury, new strategies to treat cardiac patients are urgently needed. Post myocardial injury, resident fibroblasts begin to generate the extracellular matrix, resulting in fibrosis, and finally, cardiac failure. Recently, preclinical investigations and clinical trials raised hope in stem cell-based approaches, to be an effective therapy option for these diseases. So far, several

Evaluation of the Potential for Repair of Degenerate Hyaline Cartilage in the Osteoarthritic Knee by Cartilage Stem Cells

Evaluation of the Potential for Repair of Degenerate Hyaline Cartilage in the Osteoarthritic Knee by Cartilage Stem Cells
  • Author : Larissa Nelson
  • Publisher : Unknown
  • Release : 15 June 2021
GET THIS BOOK Evaluation of the Potential for Repair of Degenerate Hyaline Cartilage in the Osteoarthritic Knee by Cartilage Stem Cells

Osteoarthritis (OA) is a highly prevalent, debilitating disease affecting many joints including the knee. Despite the involvement of several tissues, it is believed that the articular cartilage is the primary site of pathogenesis in humans. Within this study, a new scoring system of OA was devised, incorporating the articular cartilage and underlying bone, aimed at providing a more comprehensive means of grading the severity of tissue damage. We examined changes progressively from mild to severe and were able to deduce

The Vascular Niche in Tissue Repair A Therapeutic Target for Regeneration

The Vascular Niche in Tissue Repair  A Therapeutic Target for Regeneration
  • Author : Francisco J. Rivera,Ludwig Aigner
  • Publisher : Frontiers Media SA
  • Release : 13 March 2018
GET THIS BOOK The Vascular Niche in Tissue Repair A Therapeutic Target for Regeneration

Tissues and organs have, although sometimes limited, the capacity for endogenous repair, which is aimed to re-establish integrity and homeostasis. Tissue repair involves pro- and anti-inflammatory processes, new tissue formation and remodelling. Depending on the local microenvironment, tissue repair results either in scar tissue formation or in regeneration. The latter aims to recapitulate the original tissue structure and architecture with the proper functionality. Although some organisms (such as planarians) have a high regenerative capacity throughout the body, in humans this