Recent Advances In Ipsc Disease Modeling

Recent Advances In Ipsc Disease Modeling Volume 1 Book PDF
✏Book Title : Recent Advances in iPSC Disease Modeling Volume 1
✏Author : ALEXANDER BIRBRAIR
✏Publisher : Academic Press
✏Release Date : 2020-07-16
✏Pages : 320
✏ISBN : 9780128232699
✏Available Language : English, Spanish, And French

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✏Recent Advances in iPSC Disease Modeling Volume 1 Book Summary : Recent Advances in iPSC Disease Modeling, Volume 1 addresses how induced pluripotent stem cells can be used to model various diseases. Somatic cells are reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. This volume teaches readers about current advances in the field. This book describes the use of induced pluripotent stem cells to model several diseases in vitro, enabling us to study the cellular and molecular mechanisms involved in different pathologies. Further insights into these mechanisms will have important implications for our understanding of disease appearance, development, and progression. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues, and organs using state-of-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several disorders. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of induced pluripotent stem cell technology, regenerative medicine, and therapeutics Covers the following diseases: severe congenital neutropenia, sickle cell and Diamond-Blackfan anemias, muscular dystrophies, Bernard-Soulier syndrome, familial hypercholesterolemia type II A, Werner syndrome, lysosomal storage diseases, and more Contains description of cutting-edge research on the development of disease-specific human pluripotent stem cells. These cells allow us to study cellular and molecular processes involved in several human diseases

Recent Advances In Parkinson S Disease Book PDF
✏Book Title : Recent Advances in Parkinson s Disease
✏Author : Angela Cenci-Nilsson
✏Publisher : Academic Press
✏Release Date : 2020-03
✏Pages : 358
✏ISBN : 9780444642608
✏Available Language : English, Spanish, And French

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✏Recent Advances in Parkinson s Disease Book Summary : Recent Advances in Parkinson ́s Disease Research, Volume 252, represents a follow-up on two previous volumes presented in the Progress in Brain Research series, Volumes 193 and 193, both published in 2010. It contains a collection of overview articles written by leading researchers in Parkinson's, discussing the most important advances made in basic, translational and clinical research. Topics of note in this new release include What can we learn from iPS cell models of PD, What can we learn from animal models of PD?, Molecular basis of selective neuronal vulnerability in PD, Role of innate and adaptive immunity in Parkinson ́s disease, and much more.

📒Recent Advances In Stem Cells ✍ Essam M. Abdelalim

Recent Advances In Stem Cells Book PDF
✏Book Title : Recent Advances in Stem Cells
✏Author : Essam M. Abdelalim
✏Publisher : Springer
✏Release Date : 2016-09-14
✏Pages : 269
✏ISBN : 9783319332703
✏Available Language : English, Spanish, And French

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✏Recent Advances in Stem Cells Book Summary : This volume explores recent advances in the use of pluripotent stem cells (PSCs) and adult stem cells (ASCs) in basic and clinical applications. The chapters discuss use of PSCs for drug screening, genome editing, modeling of kidney, motor neuron diseases, and diabetes as well as their application in cancer; ASCs are discussed in the contexts of banking of umbilical cord stem cells, use of multipotential stromal cells (MSCs) for bone repair, cellular interactions during fracture repair stages, and therapeutic applications of neural crest stem cells and lung stem cells. The text is organized by sections dealing with PSCs and ASCs specifically, presenting the reader with a comprehensive examination of both these forms of stem cells. Expertly authored and drawing from a wealth of international perspectives, Recent Advances in Stem Cells: From Basic Research to Clinical Applications presents a succinct yet detailed review of cutting-edge research in this rapidly expanding field. This installment of Springer’s Stem Cell Biology and Regenerative Medicine series is essential reading for academics, researchers, and clinicians in the fields of cell biology, genetics, nephrology, osteology, oncology, and pulmonology.

Recent Advances In Neurodegeneration Book PDF
✏Book Title : Recent Advances in Neurodegeneration
✏Author : Antonella Borreca
✏Publisher : BoD – Books on Demand
✏Release Date : 2019-10-09
✏Pages : 100
✏ISBN : 9781838812331
✏Available Language : English, Spanish, And French

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✏Recent Advances in Neurodegeneration Book Summary : This Edited Volume Recent Advances in Neurodegeneration is a is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the field of neurodegeneration. The book comprises single chapters authored by various researchers and edited by an expert active in the neurodegeneration research area. All chapters are complete in itself but united under a common research study topic. This publication aims at providing a thorough overview of the latest research efforts by international authors on neurodegeneration, and open new possible research paths for further novel developments.

Induced Pluripotent Stem Cells In Brain Diseases Book PDF
✏Book Title : Induced Pluripotent Stem Cells in Brain Diseases
✏Author : Vivi M. Heine
✏Publisher : Springer Science & Business Media
✏Release Date : 2011-11-23
✏Pages : 59
✏ISBN : 9400728166
✏Available Language : English, Spanish, And French

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✏Induced Pluripotent Stem Cells in Brain Diseases Book Summary : Brain diseases can have a large impact on patients and society, and treatment is often not available. A new approach in which somatic cells are reprogrammed into induced pluripotent cells (iPS cells) is a significant breakthrough for regenerative medicine. This promises patient-specific tissue for replacement therapies, as well as disease-specific cells for developmental modeling and drug treatment screening. However, this method faces issues of low reprogramming efficiency, and poorly defined criteria for determining the conversion of one cell type to another. Cells contain epigenetic “memories” of what they were that can affect reprogramming. This book discusses the various methods to reprogram cells, the control and determination of cell identity, the epigenetic models that have emerged and the application of iPS cell therapy for brain diseases, in particular Parkinson’s disease and Vanishing White Matter (VWM).​

Motor Neuron Disease In Adults Book PDF
✏Book Title : Motor Neuron Disease in Adults
✏Author : Mark Bromberg
✏Publisher : Oxford University Press
✏Release Date : 2014-10-02
✏Pages : 352
✏ISBN : 9780190202262
✏Available Language : English, Spanish, And French

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✏Motor Neuron Disease in Adults Book Summary : Motor Neuron Disease in Adults reviews new information as it applies to all aspects of motor neuron disease (ALS, PLS, PMA). The choice of articles is for those that use evidence-based methods to ensure that the new information is solid and advances the topic or issue. The book can be used by anyone who provides any type of care to ALS patients. In particular, neurologists will find the latest information on diagnosis and management, as well as new information on genetics and frontotemporal lobe involvement. Allied health providers will find useful information for their discipline. Patients will also find both specific and general information to help understand what they are experiencing and how to help manage their symptoms.

Genome Wide Approaches For Understanding Disease Mechanisms In Human Ips Derived Cells Book PDF
✏Book Title : Genome wide Approaches for Understanding Disease Mechanisms in Human IPS Derived Cells
✏Author : Valerie Sapp
✏Publisher :
✏Release Date : 2020
✏Pages : 130
✏ISBN : OCLC:1196382376
✏Available Language : English, Spanish, And French

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✏Genome wide Approaches for Understanding Disease Mechanisms in Human IPS Derived Cells Book Summary : Human iPSCs derived cells provide the context to uncover novel mechanisms of development and disease in patient specific primary cells. The establishment of genome-scale functional genomics based approaches in iPSC derived cells complements recent advances in disease modeling in these cells and is well poised to highlight novel human specific, cell-autonomous mechanisms of disease. In the decade since their discovery, iPSC derived cardiomyocyte models have been developed for a range of conditions from hereditary cardiomyopathies and channelopathies to drug induced cardiotoxicity. The ability to leverage iPSC derived cells to understand disease mechanisms at genome-scale had been limited by a lack of pooled-format functional genomics screening approaches in these cells. In Chapter 2 of this dissertation I outline the optimized methods we developed for CRISPR screening in human iPS derived cells which optimize for infection with a genome-scale CRISPR library and allow screening in functional iPS derived cardiomyocytes with preserved library representation. In Chapter 3 we apply this to uncover novel mechanisms of drug induced cardiotoxicity, which is both a major impediment to new drug approval and a limiting factor in the utilization of approved drugs. We discover the transporter SLCO1A2 as a novel mediator of doxorubicin induced cardiotoxicity in cardiomyocytes, but not breast cancer cells. Through this discovery we highlight the utility of genome-scale functional genomics screening in specifically human differentiated cells of interest. In addition to their utility for modeling human disease, iPS cells have also provided a context to identify novel factors governing pluripotency maintenance and cell fate specification and have provided critical insights into the contribution of transcriptional and signaling pathways in cell fate decisions. Experiments to identify the role of signaling metabolites in cell fate specification have been limited by insufficient techniques to measure and characterize the vast majority of signaling metabolites. Recent advances in untargeted mass-spectrometry afford us the opportunity for to profile thousands of novel signaling lipids in cardiomyocyte specification. We identify a saturated dihydroxy fatty acids as a new family of pluripotency associated metabolites, which have the potential to govern stemness.

Generation Of Disease Specific Autopsy Confirmed Ipscs Lines From Postmortem Isolated Peripheral Blood Mononuclear Cells Book PDF
✏Book Title : Generation of Disease specific Autopsy confirmed IPSCs Lines from Postmortem Isolated Peripheral Blood Mononuclear Cells
✏Author :
✏Publisher :
✏Release Date : 2017
✏Pages :
✏ISBN : OCLC:1052057692
✏Available Language : English, Spanish, And French

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✏Generation of Disease specific Autopsy confirmed IPSCs Lines from Postmortem Isolated Peripheral Blood Mononuclear Cells Book Summary : Highlights: IPSC can be derived rapidly from patient samples retrieved after death. Postmortem blood drawn within 20 h after death can serve as reprogramming material. Autopsy confirmed patient samples are the gold standard for modeling heterogeneous and idiopathic disease. Abstract: Understanding the molecular mechanisms that underlie neurodegenerative disorders has been hampered by a lack of readily available model systems that replicate the complexity of the human disease. Recent advances in stem cell technology have facilitated the derivation of patient-specific stem cells from a variety of differentiated cell types. These induced pluripotent stem cells (iPSCs) are attractive disease models since they can be grown and differentiated to produce large numbers of disease-relevant cell types. However, most iPSC lines are derived in advance of, and without the benefit of, neuropathological confirmation of the donor − the gold standard for many disease classifications and measurement of disease severity. While others have reported the generation of autopsy-confirmed iPSC lines from patient explants, these methods require outgrowth of cadaver tissue, which require additional time and is often only successful ∼50% of the time. Here we report the rapid generation of autopsy-confirmed iPSC lines from peripheral blood mononuclear cells (PBMCs) drawn postmortem. Since this approach doesn't require the propagation of previously frozen cadaver tissue, iPSC can be rapidly and efficiently produced from patients with autopsy-confirmed pathology. These matched iPSC-derived patient-specific neurons and postmortem brain tissue will support studies of specific mechanisms that drive the pathogenesis of neurodegenerative diseases.

Cell Biology And Translational Medicine Volume 7 Book PDF
✏Book Title : Cell Biology and Translational Medicine Volume 7
✏Author : Kursad Turksen
✏Publisher : Springer Nature
✏Release Date : 2020-02-03
✏Pages : 153
✏ISBN : 9783030378455
✏Available Language : English, Spanish, And French

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✏Cell Biology and Translational Medicine Volume 7 Book Summary : Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the seventh volume of a continuing series.

Lung Stem Cells In The Epithelium And Vasculature Book PDF
✏Book Title : Lung Stem Cells in the Epithelium and Vasculature
✏Author : Amy Firth
✏Publisher : Springer
✏Release Date : 2015-05-23
✏Pages : 345
✏ISBN : 9783319162324
✏Available Language : English, Spanish, And French

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✏Lung Stem Cells in the Epithelium and Vasculature Book Summary : This book covers the identification and role of endogenous lung stem cells in health and disease, particularly the most recent advances. In addition, it discusses the rapidly growing field of stem cells and cell therapy as it relates to lung biology and disease as well as ex vivo lung bioengineering. Such approaches may provide novel therapeutic approaches for lung diseases. Human pluripotent stem cell differentiation to model the pulmonary epithelium and vasculature is also discussed. World-recognized scientists who specialize in studying both the lung epithelium and pulmonary vasculature contribute the chapters. Topics covered include: stem cell niches in the lung, the role of progenitor cells in fibrosis and asthma, iPSC in modeling lung disease, vascular repair by endothelial progenitor cells and circulating fibrocytes in pulmonary vascular remodeling. This volume of the Stem Cell Biology and Regenerative Medicine series is essential reading for researchers and clinicians interested in stem cells, lung biology and regenerative medicine. It is also an invaluable resource for advanced students studying cell biology, regenerative medicine and lung physiology.

Programmed Cells From Basic Neuroscience To Therapy Book PDF
✏Book Title : Programmed Cells from Basic Neuroscience to Therapy
✏Author : Fred H. Gage
✏Publisher : Springer Science & Business Media
✏Release Date : 2013-05-13
✏Pages : 130
✏ISBN : 9783642366482
✏Available Language : English, Spanish, And French

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✏Programmed Cells from Basic Neuroscience to Therapy Book Summary : The recent advances in Programming Somatic Cell (PSC) including induced Pluripotent Stem Cells (iPS) and Induced Neuronal phenotypes (iN), has changed our experimental landscape and opened new possibilities. The advances in PSC have provided an important tool for the study of human neuronal function as well as neurodegenerative and neurodevelopmental diseases in live human neurons in a controlled environment. For example, reprogramming cells from patients with neurological diseases allows the study of molecular pathways particular to specific subtypes of neurons such as dopaminergic neurons in Parkinson’s Disease, Motor neurons for Amyolateral Sclerosis or myelin for Multiple Sclerosis. Detecting disease-specific molecular signatures in live human brain cells, opens possibilities for early intervention therapies and new diagnostic tools. Importantly, once the neurological neural phenotype is detected in vitro, the so-called “disease-in-a-dish” approach allows for the screening of drugs that can ameliorate the disease-specific phenotype. New therapeutic drugs could either act on generalized pathways in all patients or be patient-specific and used in a personalized medicine approach. However, there are a number of pressing issues that need to be addressed and resolved before PSC technology can be extensively used for clinically relevant modeling of neurological diseases. Among these issues are the variability in PSC generation methods, variability between individuals, epigenetic/genetic instability and the ability to obtain disease-relevant subtypes of neurons . Current protocols for differentiating PSC into specific subtypes of neurons are under development, but more and better protocols are needed. Understanding the molecular pathways involved in human neural differentiation will facilitate the development of methods and tools to enrich and monitor the generation of specific subtypes of neurons that would be more relevant in modeling different neurological diseases.

📒Organs On Chips ✍ Yu-suke Torisawa

Organs On Chips Book PDF
✏Book Title : Organs on chips
✏Author : Yu-suke Torisawa
✏Publisher : MDPI
✏Release Date : 2020-05-27
✏Pages : 262
✏ISBN : 9783039289172
✏Available Language : English, Spanish, And French

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✏Organs on chips Book Summary : Recent advances in microsystems technology and cell culture techniques have led to the development of organ-on-chip microdevices that produce tissue-level functionality, not possible with conventional culture models, by recapitulating natural tissue architecture and microenvironmental cues within microfluidic devices. Since the physiological microenvironments in living systems are mostly microfluidic in nature, the use of microfluidic devices facilitates engineering cellular microenvironments; the microfluidic devices allow for control of local chemical gradients and dynamic mechanical forces, which play important roles in cellular viability and function. The organ-on-chip microdevices have great potential to promote drug discovery and development, to model human physiology and disease, and to replace animal models for efficacy and toxicity testing. Recently, induced pluripotent stem (iPS) cells have been leveraged to develop organs-on-chips, which enable various types of organ models and disease models not possible with primary cells and cell lines. This Special Issue seeks to showcase research papers, short communications, and review articles that focus on: (1) microdevices to mimic or control cellular microenvironment; (2) microdevices to evaluate interactions between different organ models; (3) microdevices to maintain iPS cells or iPSC-derived cells; and (4) sensors and techniques to evaluate drug efficacy or toxicity.

Nontargeted Metabolite Profiling Of Induced Pluripotent Stem Cells Ipscs Derived Neural Cells Insights Into Mechanisms Of Brain Diseases Book PDF
✏Book Title : Nontargeted Metabolite Profiling of Induced Pluripotent Stem Cells iPSCs Derived Neural Cells Insights Into Mechanisms of Brain Diseases
✏Author : Šárka Lehtonen
✏Publisher :
✏Release Date : 2016
✏Pages :
✏ISBN : OCLC:1154178684
✏Available Language : English, Spanish, And French

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✏Nontargeted Metabolite Profiling of Induced Pluripotent Stem Cells iPSCs Derived Neural Cells Insights Into Mechanisms of Brain Diseases Book Summary : Since the discovery that introduction of four specific genes encoding transcription factors convert mature human somatic cells into induced pluripotent stem cells (iPSCs), there has been an enormous increase in the applications of iPSC technologies to medical sciences, especially in modeling human diseases. In this review, we summarize recent advances in applying human iPSC reprogramming to generate patient-specific neural subtypes in order to reveal molecular pathways affected in various neurodegenerative diseases. Metabolites provide a functional readout of various cellular states enabling identification of biomarker candidates for early diagnosis, segregation of patient cohorts, and to follow-up disease progression or disease responses to novel therapies. With emerging technologies, that is, mass spectrometry and nuclear magnetic resonance applications to metabolomics and various software solutions of bioinformatics, it has become possible to measure thousands of metabolites simultaneously. These fascinating new techniques provide a powerful tool for setting scientific hypotheses and linking cellular pathways to biological mechanism. This review focuses on mass spectrometry-based metabolomics as a tool for iPSC research.

Stem Cell Genetics For Biomedical Research Book PDF
✏Book Title : Stem Cell Genetics for Biomedical Research
✏Author : Raul Delgado-Morales
✏Publisher : Springer
✏Release Date : 2018-06-27
✏Pages : 426
✏ISBN : 9783319906959
✏Available Language : English, Spanish, And French

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✏Stem Cell Genetics for Biomedical Research Book Summary : This book looks at where stem cell technology is presently and how it is instrumental in advancing the field of disease modeling and cell transplantation. By focusing on major human disorders such as Alzheimer’s disease, cancer, and heart disorders, the book summarizes the major findings in the field of human stem cells and dissect the current limitations on our understanding of stem cells biology. The chapters focus on the genetics, genomics, epigenetics and physiology of stem cells models, together with technological advances on molecular biology such as CRISPR/Cas9 or epigenetic editing, that will be instrumental in the future of human disease modeling and treatment. In base of the limitations of current disease models and in front of the unmet necessity of finding therapeutical interventions for human disorders, the availability of stem cell technology has opened new doors for several fields. The unlimited self-renewal capacity and more extensive differentiation potential of stem cells offers a theoretically inexhaustible and replenishable source of any cell subtype. Since Professor Shinya Yamanaka described it, 10 years ago in his seminal paper, that somatic cells could be reprogrammed to inducible stem cells (iPSC) just by expressing four transcription factors, the field of has exploded, especially its applications in biomedical research.

📒Neurodevelopmental Disorders ✍ Emanuel DiCicco-Bloom

Neurodevelopmental Disorders Book PDF
✏Book Title : Neurodevelopmental Disorders
✏Author : Emanuel DiCicco-Bloom
✏Publisher : Springer Nature
✏Release Date : 2020-06-24
✏Pages : 305
✏ISBN : 9783030454937
✏Available Language : English, Spanish, And French

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✏Neurodevelopmental Disorders Book Summary : This book contains a compendium of induced pluripotent stem cells (iPSCs) articles and reviews concerning state of the art technologies and how they are being applied to human neurodevelopmental disorders. With the establishment of effective technologies to produce iPSCs and their derivatives, like neural precursors, neurons, and glia, researchers have new platforms to study neurodevelopmental disorders. iPSC technology enables researchers to study how human neurons develop in individuals with neurodevelopmental disorders, providing an unparalleled opportunity to investigate their etiology. In turn, researchers have now begun to understand the underlying molecular and cellular pathways that contribute to human diseases. iPSCs technologies also provide an emerging tool for future translational studies and disease classification. The chapters will emphasize how among the diverse idiopathic and genetic disorders, there are common clinical as well as cellular and molecular phenotypes.

Pluripotent Stem Cells Advances In Research And Application 2013 Edition Book PDF
✏Book Title : Pluripotent Stem Cells Advances in Research and Application 2013 Edition
✏Author :
✏Publisher : ScholarlyEditions
✏Release Date : 2013-06-21
✏Pages : 120
✏ISBN : 9781481691505
✏Available Language : English, Spanish, And French

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✏Pluripotent Stem Cells Advances in Research and Application 2013 Edition Book Summary : Pluripotent Stem Cells—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Pluripotent Stem Cells—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Pluripotent Stem Cells—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

New Mechanisms And Therapeutics In Neurodevelopmental Disorders Book PDF
✏Book Title : New mechanisms and therapeutics in neurodevelopmental disorders
✏Author : Daniela Tropea
✏Publisher : Frontiers E-books
✏Release Date :
✏Pages :
✏ISBN : 9782889190676
✏Available Language : English, Spanish, And French

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✏New mechanisms and therapeutics in neurodevelopmental disorders Book Summary : Neurodevelopmental disorders (NDDs) are severe, heritable conditions characterized by impaired brain development and disability in cognition, social interaction and behavior. Genetic predisposition appears to interact with environmental factors to produce the onset of the disease. In the last decade genomic analysis on NDDs advanced the knowledge of the genetic causes of these disorders: most of the genes identified were not predicted from known biology, and almost all of them engage in neurodevelopmental processes. However, the same studies revealed an unexpected outcome regarding the molecular etiology: many of the same susceptibility genes as well as molecular pathways are emerging across hitherto unrelated disorders- such as autism and schizophrenia- challenging how we conceptualize these conditions. These new discoveries call for the establishment of additional criteria for the classification of the genes and related phenotypes. Beyond the classical distinction according to diagnostic criteria, new parameters should be taken into account: the genetics, the neurobiology of the gene products and the molecular mechanisms that they control. Our broad understanding of NDDs, requires a combination of approaches, including human studies, animal models and theoretical computation. Indeed, progress in technology and the generation of accurate models are advancing the field, and the research is rapidly growing. This Research Topic presents recent advances in neurodevelopmental disorders from genes to systems, in single conditions and across different phenotypes, and report the newest treatments in use. Recognized experts in the field discuss recent findings in molecular studies, in vivo imaging, neuropsychology, neuropharmacology and computational neuroscience. This multidisciplinary approach enriches our understanding of the mechanisms involved in the onset and progression of NDDs with the perspective of revealing the biological signs of the disorders and identifying new therapeutics.

Stem Cells Advances In Research And Application 2012 Edition Book PDF
✏Book Title : Stem Cells Advances in Research and Application 2012 Edition
✏Author :
✏Publisher : ScholarlyEditions
✏Release Date : 2012-12-26
✏Pages : 958
✏ISBN : 9781464991257
✏Available Language : English, Spanish, And French

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✏Stem Cells Advances in Research and Application 2012 Edition Book Summary : Stem Cells—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Stem Cells. The editors have built Stem Cells—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Stem Cells in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Stem Cells—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

📒Neural Stem Cell Assays ✍ Navjot Kaur

Neural Stem Cell Assays Book PDF
✏Book Title : Neural Stem Cell Assays
✏Author : Navjot Kaur
✏Publisher : John Wiley & Sons
✏Release Date : 2014-11-24
✏Pages : 288
✏ISBN : 9781118308271
✏Available Language : English, Spanish, And French

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✏Neural Stem Cell Assays Book Summary : Neural stem cells offer a valuable model system for delineating the cellular and developmental processes in normal and diseased states of the central nervous system. In particular, neural stem cells have huge potential in regenerative medicine, owing to their expansion capability in culture and the ability to differentiate into multiple sub-neural lineages. Neural Stem Cell Assays provides a detailed and comprehensive review of the basic methods for neural stem cell cultures. Including an overview of progress in the field over the past decade, Neural Stem Cell Assays is a one-stop reference for consistent methods and reliable tools that span the entire assay work flow, from isolation or generation of neural stem cells to characterization, manipulation and final application of neural stem cells in disease paradigms such as Parkinson's disease, multiple sclerosis and amyotrophic lateral sclerosis. An excellent source of information for academic, pharmaceutical and biotechnology researchers who are new to the neural stem cell field, Neural Stem Cell Assays is an invaluable to experienced users who wish to integrate newly developed tools and technologies into their workflow. The book also covers important course material for students at the undergraduate and graduate level who are learning the basics of neural stem cell cultures, and differentiation to sub-neural lineages.

Combining Induced Pluripotent Stem Cells And Crispr Cas9 Gene Editing To Model And Characterize Rare Neurological Diseases Book PDF
✏Book Title : Combining Induced Pluripotent Stem Cells and CRISPR Cas9 Gene Editing to Model and Characterize Rare Neurological Diseases
✏Author : Scott Bell
✏Publisher :
✏Release Date : 2020
✏Pages :
✏ISBN : OCLC:1199004135
✏Available Language : English, Spanish, And French

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✏Combining Induced Pluripotent Stem Cells and CRISPR Cas9 Gene Editing to Model and Characterize Rare Neurological Diseases Book Summary : "The development of accurate and informative models is essential to the investigation of any disease. However, rare neurodevelopmental disorders have historically faced immense challenges developing effective models, as the scarcity of subjects and the invasive procedures required to obtain neural cells have limited the models available to researchers. However, recent advances in induced pluripotent stem cells (iPSCs) gene editing have the potential to dramatically lower the logistical barriers associated with studying rare neurological disease.This thesis will describe an improved methodology for generating iPSC based models of neurological disease, either by obtaining somatic cells from patients or using CRISPR/ Cas9 gene editing. These techniques were then validated by modelling a known disease causing mutation in the GRIN2B gene, and demonstrated that mutations in the gene caused impaired neuronal differentiation. Finally, these techniques were used to investigate mutations in a novel neurodevelopmental disease, caused by mutations in the ACTL6B gene. This work describes an improved methodology using iPSCs and gene editing to model rare neurodevelopmental disorders, validates its use in a known disease causing gene, and utilizes it to identify disease specific phenotypes in a novel neurodevelopmental disease"--

📒Advances In Stem Cell Research ✍ Hossein Baharvand

Advances In Stem Cell Research Book PDF
✏Book Title : Advances in Stem Cell Research
✏Author : Hossein Baharvand
✏Publisher : Springer Science & Business Media
✏Release Date : 2012-05-26
✏Pages : 398
✏ISBN : 9781617799402
✏Available Language : English, Spanish, And French

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✏Advances in Stem Cell Research Book Summary : Advances in Stem Cell Research discusses recent advances in stem cell science, including therapeutic applications. This volume covers such topics as biomanufacturing iPS cells for therapeutic applications, techniques for controlling stem cell fate decisions, as well as current basic research in such areas as germ line stem cells, genomics and proteomics in stem cell research. It is a useful book for biology and clinical scientists, especially young investigators and stem cell biology students who are newly entering the world of stem cells research. The editors hope that the new knowledge and research outlined in this book will help contribute to new therapies for a wide variety of diseases that presently afflict humanity.

Adult Stem Cells Advances In Research And Application 2013 Edition Book PDF
✏Book Title : Adult Stem Cells Advances in Research and Application 2013 Edition
✏Author :
✏Publisher : ScholarlyEditions
✏Release Date : 2013-06-21
✏Pages : 111
✏ISBN : 9781481681537
✏Available Language : English, Spanish, And French

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✏Adult Stem Cells Advances in Research and Application 2013 Edition Book Summary : Adult Stem Cells—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Adult Stem Cells—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Adult Stem Cells—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

📒Pluripotent Stem Cells ✍ Minoru Tomizawa

Pluripotent Stem Cells Book PDF
✏Book Title : Pluripotent Stem Cells
✏Author : Minoru Tomizawa
✏Publisher : BoD – Books on Demand
✏Release Date : 2016-07-20
✏Pages : 532
✏ISBN : 9789535124719
✏Available Language : English, Spanish, And French

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✏Pluripotent Stem Cells Book Summary : Pluripotent stem cells have distinct characteristics: self-renewal and the potential to differentiate into various somatic cells. In recent years, substantial advances have been made from basic science to clinical applications. The vast amount knowledge available makes obtaining concise yet sufficient information difficult, hence the purpose of this book. In this book, embryonic stem cells, induced pluripotent stem cells, and mesenchymal stem cells are discussed. The book is divided into five sections: pluripotency, culture methods, toxicology, disease models, and regenerative medicine. The topics covered range from new concepts to current technologies. Readers are expected to gain useful information from expert contributors.

New In Vitro Models To Study Amyotrophic Lateral Sclerosis Book PDF
✏Book Title : New In Vitro Models to Study Amyotrophic Lateral Sclerosis
✏Author :
✏Publisher :
✏Release Date : 2016
✏Pages :
✏ISBN : OCLC:1052001604
✏Available Language : English, Spanish, And French

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✏New In Vitro Models to Study Amyotrophic Lateral Sclerosis Book Summary : Abstract: Amyotrophic Lateral Sclerosis (ALS) is a complex multifactorial disorder, characterized by motor neuron loss with involvement of several other cell types, including astrocytes, oligodendrocytes and microglia. Studies in vivo and in in vitro models have highlighted that the contribution of non‐neuronal cells to the disease is a primary event and ALS pathogenesis is driven by both cell‐autonomous and non‐cell autonomous mechanisms. The advancements in genetics and in vitro modeling of the past 10 years have dramatically changed the way we investigate the pathogenic mechanisms involved in ALS. The identification of mutations in transactive response DNA‐binding protein gene (TARDBP), fused in sarcoma (FUS) and, more recently, a GGGGCC‐hexanucleotide repeat expansion in chromosome 9 open reading frame 72 (C9ORF72) and their link with familial ALS have provided new avenues of investigation and hypotheses on the pathophysiology of this devastating disease. In the same years, from 2007 to present, in vitro technologies to model neurological disorders have also undergone impressive developments. The advent of induced pluripotent stem cells (iPSCs) gave the field of ALS the opportunity to finally model in vitro not only familial, but also the larger part of ALS cases affected by sporadic disease. Since 2008, when the first human iPS‐derived motor neurons from patients were cultured in a petri dish, several different techniques have been developed to produce iPSC lines through genetic reprogramming and multiple direct conversion methods have been optimised. In this review, we will give an overview of how human in vitro models have been used so far, what discoveries they have led to since 2007, and how the recent advances in technology combined with the genetic discoveries, have tremendously widened the horizon of ALS research.

Harrison S Principles Of Internal Medicine 20 E Vol 1 Vol 2 Ebook  Book PDF
✏Book Title : Harrison s Principles of Internal Medicine 20 E Vol 1 Vol 2 ebook
✏Author : Dennis L. Kasper
✏Publisher : McGraw Hill Professional
✏Release Date : 2018-02-06
✏Pages :
✏ISBN : 9781259644047
✏Available Language : English, Spanish, And French

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✏Harrison s Principles of Internal Medicine 20 E Vol 1 Vol 2 ebook Book Summary : MASTER MODERN MEDICINE! Introducing the Landmark Twentieth Edition of the Global Icon of Internal Medicine The definitive guide to internal medicine is more essential than ever with the latest in disease mechanisms, updated clinical trial results and recommended guidelines, state-of-the art radiographic images, therapeutic approaches and specific treatments, hundreds of demonstrative full-color drawings, and practical clinical decision trees and algorithms Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison’s Principles of Internal Medicine gives you the informational foundation you need to provide the best patient care possible. Essential for practice and education, the landmark 20th Edition features: Thoroughly revised content—covering the many new breakthroughs and advances in clinical medicine that have occurred since the last edition of Harrison’s. Chapters on acute and chronic hepatitis, management of diabetes, immune-based therapies in cancer, multiple sclerosis, cardiovascular disease, HIV, and many more, deliver the very latest information on disease mechanisms, diagnostic options, and the specific treatment guidance you need to provide optimal patient care. State-of-the-art coverage of disease mechanisms: Harrison’s focuses on pathophysiology with rigor, and with the goal of linking disease mechanisms to treatments. Improved understanding of how diseases develop and progress not only promotes better decision-making and higher value care, but also makes for fascinating reading and improved retention. Harrison’s summarizes important new basic science developments, such as the role of mitochondria in programmed and necrotic cell death, the immune system’s role in cancer development and treatment, the impact of telomere shortening in the aging and disease processes, and the role of the microbiome in health and disease. Understanding the role of inflammation in cardiovascular disease, the precise mechanisms of immune deficiency in HIV/AIDS, prions and misfolded proteins in neurodegenerative diseases, and obesity as a predisposition to diabetes are just a few examples of how this edition provides essential pathophysiology information for health professionals. All-new sections covering a wide range of new and emerging areas of vital interest to all healthcare professionals. New sections include: Sex and Gender-based Issues in Medicine; Obesity, Diabetes Mellitus, and Metabolic Syndrome; and Consultative Medicine— Plus, a new Part covering cutting-edge topics in research and clinical medicine includes great new chapters on the role of Epigenetics in Health and Disease, Behavioral Strategies to Improve Health, Genomics and Infectious Diseases, Emerging Neuro-Therapeutic Technologies, and Telomere Function in Health and Disease, and Network System Medicine. Important and timely new chapters—such as Promoting Good Health, LGBT Health, Systems of Healthcare, Approach to Medical Consultation, Pharmacogenomics, Antimicrobial Resistance, Worldwide Changes in Patterns of Infectious Diseases, Neuromyelitis Optica, and more—offer the very latest, definitive perspectives on must-know topics in medical education and practice. Updated clinical guidelines, expert opinions, and treatment approaches from world-renowned editors and authors contribute to the accuracy and immediacy of the text material and present a clear blueprint for optimizing patient outcomes. End-of-chapter suggested readings reinforce the text material and provide a robust platform for further study and research.

Cardiovascular Regenerative Medicine Book PDF
✏Book Title : Cardiovascular Regenerative Medicine
✏Author : Vahid Serpooshan
✏Publisher : Springer
✏Release Date : 2019-06-29
✏Pages : 233
✏ISBN : 9783030200473
✏Available Language : English, Spanish, And French

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✏Cardiovascular Regenerative Medicine Book Summary : This book is a comprehensive and up-to-date resource on the use of regenerative medicine for the treatment of cardiovascular disease. It provides a much-needed review of the rapid development and evolution of bio-fabrication techniques to engineer cardiovascular tissues as well as their use in clinical settings. The book incorporates recent advances in the biology, biomaterial design, and manufacturing of bioengineered cardiovascular tissue with their clinical applications to bridge the basic sciences to current and future cardiovascular treatment. The book begins with an examination of state-of-the-art cellular, biomaterial, and macromolecular technologies for the repair and regeneration of diseased heart tissue. It discusses advances in nanotechnology and bioengineering of cardiac microtissues using acoustic assembly. Subsequent chapters explore the clinical applications and translational potential of current technologies such as cardiac patch-based treatments, cell-based regenerative therapies, and injectable hydrogels. The book examines how these methodologies are used to treat a variety of cardiovascular diseases including myocardial infarction, congenital heart disease, and ischemic heart injuries. Finally, the volume concludes with a summary of the most prominent challenges and perspectives on the field of cardiovascular tissue engineering and clinical cardiovascular regenerative medicine. Cardiovascular Regenerative Medicine is an essential resource for physicians, residents, fellows, and medical students in cardiology and cardiovascular regeneration as well as clinical and basic researchers in bioengineering, nanomaterial and technology, and cardiovascular biology.

Emerging Therapies Targeting The Pathophysiology Of Sickle Cell Disease An Issue Of Hematology Oncology Clinics  Book PDF
✏Book Title : Emerging Therapies Targeting the Pathophysiology of Sickle Cell Disease An Issue of Hematology Oncology Clinics
✏Author : Elliot Vichinsky
✏Publisher : Elsevier Health Sciences
✏Release Date : 2014-05-23
✏Pages : 281
✏ISBN : 9780323290005
✏Available Language : English, Spanish, And French

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✏Emerging Therapies Targeting the Pathophysiology of Sickle Cell Disease An Issue of Hematology Oncology Clinics Book Summary : This issue of Hematology/Oncology Clinics, guest edited by Dr. Elliott Vichinsky, is devoted to Sickle Cell Disease, and focuses on pathophysiology of hemoglobinopathies, therapeutic targets, and new approaches to correcting ineffective erythropoiesis and iron dysregulation. Articles in this issue include Polymerization and red cell membrane changes; Overview on reperfusion injury in the pathophysiology of SCD; Regulation of ineffective erythropoiesis in iron metabolism; Altering oxygen affinity; Cellular adhesion and the endothelium; Arginine therapy; Role of the hemostatic system on SCD pathophysiology and potential therapeutics; Adenosine signaling and novel therapies; New approaches to correcting ineffective erythropoiesis and iron dysregulation; New approaches to correcting ineffective erythropoiesis and iron dysregulation; Fetal hemoglobin induction; Gene therapy for hemoglobinopathies; and Oxidative injury and the role of antioxidant therapy.

Dystrophin Associated Proteins Advances In Research And Application 2013 Edition Book PDF
✏Book Title : Dystrophin Associated Proteins Advances in Research and Application 2013 Edition
✏Author :
✏Publisher : ScholarlyEditions
✏Release Date : 2013-06-21
✏Pages : 46
✏ISBN : 9781481687379
✏Available Language : English, Spanish, And French

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✏Dystrophin Associated Proteins Advances in Research and Application 2013 Edition Book Summary : Dystrophin-Associated Proteins—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Dystroglycans in a concise format. The editors have built Dystrophin-Associated Proteins—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Dystroglycans in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Dystrophin-Associated Proteins—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Special Issue Book PDF
✏Book Title : Special Issue
✏Author :
✏Publisher :
✏Release Date : 2009
✏Pages : 100
✏ISBN : STANFORD:36105063785294
✏Available Language : English, Spanish, And French

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✏Special Issue Book Summary :

Molecular Neuropharmacology A Foundation For Clinical Neuroscience Third Edition Book PDF
✏Book Title : Molecular Neuropharmacology A Foundation for Clinical Neuroscience Third Edition
✏Author : Eric J. Nestler
✏Publisher : McGraw Hill Professional
✏Release Date : 2015-03-22
✏Pages : 544
✏ISBN : 9780071827706
✏Available Language : English, Spanish, And French

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✏Molecular Neuropharmacology A Foundation for Clinical Neuroscience Third Edition Book Summary : GAIN A COMPLETE UNDERSTANDING OF NERVOUS SYSTEM FUNCTION AND ITS RELATIONSHIP TO HUMAN NEUROLOGIC DISORDERS Molecular Neuropharmacology first reviews the fundamental biochemistry of the functioning nervous system and then describes how nerve cells communicate with one another through numerous types of neurotransmitters involving amino acids, monoamines, neuropeptides, and neurotrophic factors, among several others. The neuropharmacology and neural circuits that underlie complex behaviors as well as major neural disorders are also discussed as are the drugs used to treat those conditions. In the final section, the authors use the concepts presented in the first two sections to explain how irregularities in the biochemistry of neuronal interactions can lead to a wide array of clinical manifestations. FEATURES NEW chapter on neuroinflammation All chemical structure illustrations have been redrawn and improved Fully updated to reflect the latest breakthroughs and new drugs The most well-written and easily understood work on the subject More than 300 full-color illustrations!