Real World Drug Discovery

📒Real World Drug Discovery ✍ Robert M. Rydzewski

Real World Drug Discovery Book PDF
✏Book Title : Real World Drug Discovery
✏Author : Robert M. Rydzewski
✏Publisher : Elsevier
✏Release Date : 2010-07-07
✏Pages : 600
✏ISBN : 0080914888
✏Available Language : English, Spanish, And French

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✏Real World Drug Discovery Book Summary : Drug discovery increasingly requires a common understanding by researchers of the many and diverse factors that go into the making of new medicines. The scientist entering the field will immediately face important issues for which his education may not have prepared him: project teams, patent law, consultants, target product profiles, industry trends, Gantt charts, target validation, pharmacokinetics, proteomics, phenotype assays, biomarkers, and many other unfamiliar topics for which a basic understanding must somehow be obtained. Even the more experienced scientist can find it frustratingly difficult to get an overview of the many factors involved in modern drug discovery and often only after years of exploring does a whole and integrated picture emerge in the mind of the researcher. Real World Drug Discovery: A Chemist’s Guide to Biotech and Pharmaceutical Research presents this kind of map of the landscape of drug discovery. In a single, readable volume it outlines processes and explains essential concepts and terms for the recent science graduate wondering what to expect in pharma or biotech, the medicinal chemist seeking a broader and more timely understanding of the industry, or the contractor or collaborator whose understanding of the commercial drug discovery process could increase the value of his contribution to it. Interviews with well-known experts in many of the fields involved, giving insightful comments from authorities on many of the sub-disciplines important to cutting edge drug discovery. Helpful suggestions gleaned from years of experience in biotech and pharma, which represents a repository drug discovery "lore" not previously available in any book. "Periodic Table of Drugs" listing current top-selling drugs arranged by target and laid out so that structural similarities and differences are plain and clear. Extensive use of diagrams to illustrate concepts like biotech startup models, preteomic profiling for target identification, Gantt charts for project planning, etc.

Real World Evidence In Drug Development And Evaluation Book PDF
✏Book Title : Real World Evidence in Drug Development and Evaluation
✏Author : YANG
✏Publisher : Chapman & Hall/CRC Biostatistics Series
✏Release Date : 2021-02-16
✏Pages : 208
✏ISBN : 036702621X
✏Available Language : English, Spanish, And French

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✏Real World Evidence in Drug Development and Evaluation Book Summary : Real-world evidence (RWE) has been at the forefront of pharmaceutical innovations. It plays an important role in transforming drug development from a process aimed at meeting regulatory expectations to an operating model that leverages data from disparate sources to aid business, regulatory, and healthcare decision making. Despite its many benefits, there is no single book systematically covering the latest development in the field. Written specifically for pharmaceutical practitioners, Real-World Evidence in Drug Development and Evaluation, presents a wide range of RWE applications throughout the lifecycle of drug product development. With contributions from experienced researchers in the pharmaceutical industry, the book discusses at length RWE opportunities, challenges, and solutions. Features Provides the first book and a single source of information on RWE in drug development Covers a broad array of topics on outcomes- and value-based RWE assessments Demonstrates proper Bayesian application and causal inference for real-world data (RWD) Presents real-world use cases to illustrate the use of advanced analytics and statistical methods to generate insights Offers a balanced discussion of practical RWE issues at hand and technical solutions suitable for practitioners with limited data science expertise

Big Data Pharmacogenomics And Real World Research In Pharmacology Book PDF
✏Book Title : Big Data Pharmacogenomics and Real World Research in Pharmacology
✏Author : James Cheng-Chung Wei
✏Publisher : Frontiers Media SA
✏Release Date : 2020-10-12
✏Pages :
✏ISBN : 9782889660667
✏Available Language : English, Spanish, And French

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✏Big Data Pharmacogenomics and Real World Research in Pharmacology Book Summary :

📒Real World Evidence Generation And Evaluation Of Therapeutics ✍ National Academies of Sciences, Engineering, and Medicine

Real World Evidence Generation And Evaluation Of Therapeutics Book PDF
✏Book Title : Real World Evidence Generation and Evaluation of Therapeutics
✏Author : National Academies of Sciences, Engineering, and Medicine
✏Publisher : National Academies Press
✏Release Date : 2017-07-05
✏Pages : 102
✏ISBN : 9780309455657
✏Available Language : English, Spanish, And French

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✏Real World Evidence Generation and Evaluation of Therapeutics Book Summary : The volume and complexity of information about individual patients is greatly increasing with use of electronic records and personal devices. Potential effects on medical product development in the context of this wealth of real-world data could be numerous and varied, ranging from the ability to determine both large-scale and patient-specific effects of treatments to the ability to assess how therapeutics affect patients' lives through measurement of lifestyle changes. In October 2016, the National Academies of Sciences, Engineering, and Medicine held a workshop to facilitate dialogue among stakeholders about the opportunities and challenges for incorporating real-world evidence into all stages in the process for the generation and evaluation of therapeutics. Participants explored unmet stakeholder needs and opportunities to generate new kinds of evidence that meet those needs. This publication summarizes the presentations and discussions from the workshop.

Thermodynamics And Kinetics Of Drug Binding Book PDF
✏Book Title : Thermodynamics and Kinetics of Drug Binding
✏Author : György Keserü
✏Publisher : John Wiley & Sons
✏Release Date : 2015-08-17
✏Pages : 360
✏ISBN : 9783527335824
✏Available Language : English, Spanish, And French

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✏Thermodynamics and Kinetics of Drug Binding Book Summary : This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications from recent lead finding and optimization projects. Divided into two parts on the thermodynamics and kinetics of drug-receptor interaction, the text provides the conceptual and methodological basis for characterizing binding mechanisms for drugs and other bioactive molecules. It covers all currently used methods, from experimental approaches, such as ITC or SPR, right up to the latest computational methods. Case studies of real-life lead or drug development projects are also included so readers can apply the methods learned to their own projects. Finally, the benefits of a thorough binding mode analysis for any drug development project are summarized in an outlook chapter written by the editors.

📒The Drug Development Paradigm In Oncology ✍ National Academies of Sciences, Engineering, and Medicine

The Drug Development Paradigm In Oncology Book PDF
✏Book Title : The Drug Development Paradigm in Oncology
✏Author : National Academies of Sciences, Engineering, and Medicine
✏Publisher : National Academies Press
✏Release Date : 2018-02-12
✏Pages : 144
✏ISBN : 9780309457972
✏Available Language : English, Spanish, And French

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✏The Drug Development Paradigm in Oncology Book Summary : Advances in cancer research have led to an improved understanding of the molecular mechanisms underpinning the development of cancer and how the immune system responds to cancer. This influx of research has led to an increasing number and variety of therapies in the drug development pipeline, including targeted therapies and associated biomarker tests that can select which patients are most likely to respond, and immunotherapies that harness the body's immune system to destroy cancer cells. Compared with standard chemotherapies, these new cancer therapies may demonstrate evidence of benefit and clearer distinctions between efficacy and toxicity at an earlier stage of development. However, there is a concern that the traditional processes for cancer drug development, evaluation, and regulatory approval could impede or delay the use of these promising cancer treatments in clinical practice. This has led to a number of effortsâ€"by patient advocates, the pharmaceutical industry, and the Food and Drug Administration (FDA)â€"to accelerate the review of promising new cancer therapies, especially for cancers that currently lack effective treatments. However, generating the necessary data to confirm safety and efficacy during expedited drug development programs can present a unique set of challenges and opportunities. To explore this new landscape in cancer drug development, the National Academies of Sciences, Engineering, and Medicine developed a workshop held in December 2016. This workshop convened cancer researchers, patient advocates, and representatives from industry, academia, and government to discuss challenges with traditional approaches to drug development, opportunities to improve the efficiency of drug development, and strategies to enhance the information available about a cancer therapy throughout its life cycle in order to improve its use in clinical practice. This publication summarizes the presentations and discussions from the workshop.

Biomolecular Simulations In Structure Based Drug Discovery Book PDF
✏Book Title : Biomolecular Simulations in Structure Based Drug Discovery
✏Author : Francesco L. Gervasio
✏Publisher : John Wiley & Sons
✏Release Date : 2019-04-29
✏Pages : 368
✏ISBN : 9783527342655
✏Available Language : English, Spanish, And French

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✏Biomolecular Simulations in Structure Based Drug Discovery Book Summary : A guide to applying the power of modern simulation tools to better drug design Biomolecular Simulations in Structure-based Drug Discovery offers an up-to-date and comprehensive review of modern simulation tools and their applications in real-life drug discovery, for better and quicker results in structure-based drug design. The authors describe common tools used in the biomolecular simulation of drugs and their targets and offer an analysis of the accuracy of the predictions. They also show how to integrate modeling with other experimental data. Filled with numerous case studies from different therapeutic fields, the book helps professionals to quickly adopt these new methods for their current projects. Experts from the pharmaceutical industry and academic institutions present real-life examples for important target classes such as GPCRs, ion channels and amyloids as well as for common challenges in structure-based drug discovery. Biomolecular Simulations in Structure-based Drug Discovery is an important resource that: -Contains a review of the current generation of biomolecular simulation tools that have the robustness and speed that allows them to be used as routine tools by non-specialists -Includes information on the novel methods and strategies for the modeling of drug-target interactions within the framework of real-life drug discovery and development -Offers numerous illustrative case studies from a wide-range of therapeutic fields -Presents an application-oriented reference that is ideal for those working in the various fields Written for medicinal chemists, professionals in the pharmaceutical industry, and pharmaceutical chemists, Biomolecular Simulations in Structure-based Drug Discovery is a comprehensive resource to modern simulation tools that complement and have the potential to complement or replace laboratory assays for better results in drug design.

Systems Biology In Drug Discovery And Development Book PDF
✏Book Title : Systems Biology in Drug Discovery and Development
✏Author : Daniel L. Young
✏Publisher : John Wiley & Sons
✏Release Date : 2011-10-18
✏Pages : 376
✏ISBN : 9780470261231
✏Available Language : English, Spanish, And French

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✏Systems Biology in Drug Discovery and Development Book Summary : The first book to focus on comprehensive systems biology as applied to drug discovery and development Drawing on real-life examples, Systems Biology in Drug Discovery and Development presents practical applications of systems biology to the multiple phases of drug discovery and development. This book explains how the integration of knowledge from multiple sources, and the models that best represent that integration, inform the drug research processes that are most relevant to the pharmaceutical and biotechnology industries. The first book to focus on comprehensive systems biology and its applications in drug discovery and development, it offers comprehensive and multidisciplinary coverage of all phases of discovery and design, including target identification and validation, lead identification and optimization, and clinical trial design and execution, as well as the complementary systems approaches that make these processes more efficient. It also provides models for applying systems biology to pharmacokinetics, pharmacodynamics, and candidate biomarker identification. Introducing and explaining key methods and technical approaches to the use of comprehensive systems biology on drug development, the book addresses the challenges currently facing the pharmaceutical industry. As a result, it is essential reading for pharmaceutical and biotech scientists, pharmacologists, computational modelers, bioinformaticians, and graduate students in systems biology, pharmaceutical science, and other related fields.

📒Drug Discovery ✍ Tamas Bartfai

Drug Discovery Book PDF
✏Book Title : Drug Discovery
✏Author : Tamas Bartfai
✏Publisher : Academic Press
✏Release Date : 2010-07-26
✏Pages : 328
✏ISBN : 9780080919232
✏Available Language : English, Spanish, And French

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✏Drug Discovery Book Summary : Everyone expects something from the drug industry. Physicians and patients, investors, regulators and administrators all have an active interest. Everyone wants to know what makes drugs ‘work’ medically and economically. Why are drugs so expensive? Is it the drug companies or investors who demand high profits? What governs the pharmacoeconomics? Why are so few diseases treatable? This book opens the windows and doors of the industry telling the story of drug development by using real stories from inside the process. * Co-written by Graham Lees and Tamas Bartfai who has been involved in the development of drugs taken by more that 20 million people every day * Opens the windows and doors of the most regulated industry in the world, the pharmaceutical industry * Tells the story of drug development by using real examples based on current research and events * Provides an objective, lucid account of the successes and failures, shortcomings and constraints of the pharmaceutical and biotech industries * Gives insights into the development of new drugs to combat multiple conditions including cancer and pain * Balanced, unbiased account of how better to translate basic science into drug discovery

📒Examining The Impact Of Real World Evidence On Medical Product Development ✍ National Academies of Sciences, Engineering, and Medicine

Examining The Impact Of Real World Evidence On Medical Product Development Book PDF
✏Book Title : Examining the Impact of Real World Evidence on Medical Product Development
✏Author : National Academies of Sciences, Engineering, and Medicine
✏Publisher : National Academies Press
✏Release Date : 2019-04-05
✏Pages : 230
✏ISBN : 9780309488327
✏Available Language : English, Spanish, And French

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✏Examining the Impact of Real World Evidence on Medical Product Development Book Summary : Randomized controlled trials (RCTs) have traditionally served as the gold standard for generating evidence about medical interventions. However, RCTs have inherent limitations and may not reflect the use of medical products in the real world. Additionally, RCTs are expensive, time consuming, and cannot answer all questions about a product or intervention. Evidence generated from real-world use, such as real-world evidence (RWE) may provide valuable information, alongside RCTs, to inform medical product decision making. To explore the potential for using RWE in medical product decision making, the National Academies of Sciences, Engineering, and Medicine planned a three-part workshop series. The series was designed to examine the current system of evidence generation and its limitations, to identify when and why RWE may be an appropriate type of evidence on which to base decisions, to learn from successful initiatives that have incorporated RWE, and to describe barriers that prevent RWE from being used to its full potential. This publication summarizes the discussions from the entire workshop series.

📒Molecular Pharmacology ✍ John Dickenson

Molecular Pharmacology Book PDF
✏Book Title : Molecular Pharmacology
✏Author : John Dickenson
✏Publisher : John Wiley & Sons
✏Release Date : 2012-11-30
✏Pages : 424
✏ISBN : 9781118451953
✏Available Language : English, Spanish, And French

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✏Molecular Pharmacology Book Summary : This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body. Drugs are then tailored to fit a treatment profile, rather than the traditional method of ‘trial and error’ drug discovery which focuses on testing chemicals on animals or cell cultures and matching their effects to treatments. Providing an invaluable resource for advanced under-graduate and MSc/PhD students, new researchers to the field and practitioners for continuing professional development, Molecular Pharmacology explores; recent advances and developments in the four major human drug target families (G-protein coupled receptors, ion channels, nuclear receptors and transporters), cloning of drug targets, transgenic animal technology, gene therapy, pharmacogenomics and looks at the role of calcium in the cell. Current - focuses on cutting edge techniques and approaches, including new methods to quantify biological activities in different systems and ways to interpret and understand pharmacological data. Cutting Edge - highlights advances in pharmacogenomics and explores how an individual’s genetic makeup influences their response to therapeutic drugs and the potential for harmful side effects. Applied - includes numerous, real-world examples and a detailed case-study based chapter which looks at current and possible future treatment strategies for cystic fibrosis. This case study considers the relative merits of both drug therapy for specific classes of mutation and gene therapy to correct the underlying defect. Accessible - contains a comprehensive glossary, suggestions for further reading at the end of each chapter and an associated website that provides a complete set of figures from within the book.

Bioisosteres In Medicinal Chemistry Book PDF
✏Book Title : Bioisosteres in Medicinal Chemistry
✏Author : Nathan Brown
✏Publisher : John Wiley & Sons
✏Release Date : 2012-06-18
✏Pages : 256
✏ISBN : 9783527654321
✏Available Language : English, Spanish, And French

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✏Bioisosteres in Medicinal Chemistry Book Summary : Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed. With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.

Drug Discovery And Development E Book Book PDF
✏Book Title : Drug Discovery and Development E Book
✏Author : Raymond G Hill
✏Publisher : Elsevier Health Sciences
✏Release Date : 2012-07-20
✏Pages : 368
✏ISBN : 9780702053160
✏Available Language : English, Spanish, And French

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✏Drug Discovery and Development E Book Book Summary : The modern pharmacopeia has enormous power to alleviate disease, and owes its existence almost entirely to the work of the pharmaceutical industry. This book provides an introduction to the way the industry goes about the discovery and development of new drugs. The first part gives a brief historical account from its origins in the mediaeval apothecaries’ trade, and discusses the changing understanding of what we mean by disease, and what therapy aims to achieve, as well as summarising case histories of the discovery and development of some important drugs. The second part focuses on the science and technology involved in the discovery process: the stages by which a promising new chemical entity is identified, from the starting point of a medical need and an idea for addressing it. A chapter on biopharmaceuticals, whose discovery and development tend to follow routes somewhat different from synthetic compounds, is included here, as well as accounts of patent issues that arise in the discovery phase, and a chapter on research management in this environment. The third section of the book deals with drug development: the work that has to be undertaken to turn the drug candidate that emerges from the discovery process into a product on the market. The definitive introduction to how a pharmaceutical company goes about its business of discovering and developing drugs. The second edition has a new editor: Professor Raymond Hill ● non-executive director of Addex Pharmaceuticals, Covagen and of Orexo AB ● Visiting Industrial Professor of Pharmacology in the University of Bristol ● Visiting Professor in the School of Medical and Health Sciences at the University of Surrey ● Visiting Professor in Physiology and Pharmacology at the University of Strathclyde ● President and Chair of the Council of the British Pharmacological Society ● member of the Nuffield Council on Bioethics and the Advisory Council on Misuse of Drugs. New to this edition: Completely rewritten chapter on The Role of Medicinal Chemistry in the Drug Discovery Process. New topic - DMPK Optimization Strategy in drug discovery. New chapter on Scaffolds: Small globular proteins as antibody substitutes. Totally updated chapters on Intellectual Property and Marketing 50 new illustrations in full colour Features Accessible, general guide to pharmaceutical research and development. Examines the interfaces between cost and social benefit, quality control and mass production, regulatory bodies, patent management, and all interdisciplinary intersections essential to effective drug development. Written by a strong team of scientists with long experience in the pharmaceutical industry. Solid overview of all the steps from lab bench to market in an easy-to-understand way which will be accessible to non-specialists. From customer reviews of the previous edition: ‘... it will have everything you need to know on this module. Deeply referenced and, thus, deeply reliable. Highly Commended in the medicine category of the BMA 2006 medical book competition Winner of the Royal Society of Medicine Library Prize for Medical Book of the Year

Drug Discovery And Development Volume 2 Book PDF
✏Book Title : Drug Discovery and Development Volume 2
✏Author : Mukund S. Chorghade
✏Publisher : John Wiley & Sons
✏Release Date : 2007-02-16
✏Pages : 416
✏ISBN : 0470085215
✏Available Language : English, Spanish, And French

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✏Drug Discovery and Development Volume 2 Book Summary : From first principles to real-world applications-here is the first comprehensive guide to drug discovery and development Modern drug discovery and development require the collaborative efforts of specialists in a broadarray of scientific, technical, and business disciplines-from biochemistry to molecular biology, organic chemistry to medicinal chemistry, pharmacology to marketing. Yet surprisingly, until now, there were no authoritative references offering a complete, fully integrated picture of the process. The only comprehensive guide of its kind, this groundbreaking two-volume resource provides an overview of the entire sequence of operations involved in drug discovery and develop-?ment-from initial conceptualization to commercialization to clinicians and medical practitioners. Volume 1: Drug Discovery describes all the steps in the discovery process, including conceptualizing a drug, creating a library of candidates for testing, screening candidates for in vitro and in vivo activity, conducting and analyzing the results of clinical trials, and modifying a drug as necessary. Volume 2: Drug Development delves into the nitty-gritty details of optimizing the synthetic route, drug manufacturing, outsourcing, and marketing-including drug coloring and delivery methods. Featuring contributions from a world-class team of experts, Drug Discovery and Development: Features fascinating case studies, including the discovery and development of erythromycin analogs, Tagamet, and Ultiva (remifentanil) Discusses the discovery of medications for bacterial infections, Parkinson's disease, psoriasis, peptic ulcers, atopic dermatitis, asthma, and cancer Includes chapters on combinatorial chemistry, molecular biology-based drug discovery, genomics, and chemogenomics Drug Discovery and Development is an indispensable working resource for industrial chemists, biologists, biochemists, and executives who work in the pharmaceutical industry.

Drug Discovery And Development Volume 1 Book PDF
✏Book Title : Drug Discovery and Development Volume 1
✏Author : Mukund S. Chorghade
✏Publisher : John Wiley & Sons
✏Release Date : 2006-07-18
✏Pages : 476
✏ISBN : 9780471780090
✏Available Language : English, Spanish, And French

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✏Drug Discovery and Development Volume 1 Book Summary : This two volume set provides a comprehensive account of the entiresequence of operations involved in discovering a drug through theactual delivery of the drug to clinicians and medicalpractitioners. Includes case studies of the discovery of erythromycin analogs(antibiotics), Tagamet, and Ultiva (remifentanil) Discusses the discovery of agents for the treatment andmanagement of bacterial infections, Parkinson's disease, psoriasis,ulcers and stomach pain, atopic dermatitis, asthma, and cancer Contains chapters on combinatorial chemistry, molecularbiology-based drug discovery, genomics, and chemogenomics The first volume of this set thoroughly describesconceptualizing a drug, creating a library of candidates fortesting, screening those candidates for in vitro and in vivoactivity, conducting and analyzing the results of clinical trials,and revising the drug as necessary.

Drug Discovery For The Treatment Of Addiction Book PDF
✏Book Title : Drug Discovery for the Treatment of Addiction
✏Author : Brian S. Fulton
✏Publisher : John Wiley & Sons
✏Release Date : 2014-08-06
✏Pages : 358
✏ISBN : 9781118889572
✏Available Language : English, Spanish, And French

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✏Drug Discovery for the Treatment of Addiction Book Summary : With addiction a key target for drug discovery efforts, this bookfills an important and timely need for medicinal chemists who needto understand complex neuroscience issues. The author illustratesmedicinal chemistry's prominent role in treating addiction andcovers specific drugs of abuse including narcotics, stimulants,depressants, nicotine, and marijuana. • Interprets complex neuro- biological andpharmacological information, like the drug-reward system, formedicinal chemists • Emphasizes neurotransmitters and neurochemicalmechanisms of addictive drugs • Pulls together information on the many potential drugtargets for treating addiction • Stresses unique medicinal chemistry problems whendescribing pharmacology testing methods and drug development

High Throughput Lead Optimization In Drug Discovery Book PDF
✏Book Title : High Throughput Lead Optimization in Drug Discovery
✏Author : Tushar Kshirsagar
✏Publisher : CRC Press
✏Release Date : 2008-03-04
✏Pages : 256
✏ISBN : 9781420006964
✏Available Language : English, Spanish, And French

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✏High Throughput Lead Optimization in Drug Discovery Book Summary : A Single Source on Parallel Synthesis for Lead Optimization The end of the previous millennium saw an explosion in the application of parallel synthesis techniques for making compounds for high-throughput screening. Over time, it became clear that more thought in the design phase of library development is necessary to generate high qualit

Innovative Approaches In Drug Discovery Book PDF
✏Book Title : Innovative Approaches in Drug Discovery
✏Author : Bhushan Patwardhan
✏Publisher : Academic Press
✏Release Date : 2016-10-03
✏Pages : 480
✏ISBN : 9780128018224
✏Available Language : English, Spanish, And French

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✏Innovative Approaches in Drug Discovery Book Summary : Despite considerable technological advances, the pharmaceutical industry is experiencing a severe innovation deficit, especially in the discovery of new drugs. Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting provides a critical review and analysis of health, disease and medicine, and explores possible reasons behind the present crisis in drug discovery. The authors illustrate the benefits of systems biology and pharmacogenomics approaches, and advocate the expansion from disease-centric discovery to person-centric therapeutics involving holistic, multi-target, whole systems approaches. This book lays a path for reigniting pharmaceutical innovation through a disciplined reemergence of pharmacognosy, embracing open innovation models and collaborative, trusted public-private partnerships. With unprecedented advances made in the development of biomedically-relevant tools and technologies, the need is great and the time is now for a renewed commitment towards expanding the repertoire of medicines. By incorporating real-life examples and state-of-the-art reviews, this book provides valuable insights into the discovery and development strategies for professionals, academicians, and students in the pharmaceutical sciences. Analyzes the reasons behind historical drug failures to provide valuable insights on lessons learned Uses current scientific research to promote learning from traditional knowledge systems and through the integration of traditional and western medicines Discusses advances in technologies and systems biology to support the transition from formulation discovery to therapeutic discovery

📒Discovery Science ✍ João Gama

Discovery Science Book PDF
✏Book Title : Discovery Science
✏Author : João Gama
✏Publisher : Springer Science & Business Media
✏Release Date : 2009-10-05
✏Pages : 474
✏ISBN : 9783642047466
✏Available Language : English, Spanish, And French

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✏Discovery Science Book Summary : This book constitutes the refereed proceedings of the twelfth International Conference, on Discovery Science, DS 2009, held in Porto, Portugal, in October 2009. The 35 revised full papers presented were carefully selected from 92 papers. The scope of the conference includes the development and analysis of methods for automatic scientific knowledge discovery, machine learning, intelligent data analysis, theory of learning, as well as their applications.

Chemoinformatics And Advanced Machine Learning Perspectives Complex Computational Methods And Collaborative Techniques Book PDF
✏Book Title : Chemoinformatics and Advanced Machine Learning Perspectives Complex Computational Methods and Collaborative Techniques
✏Author : Lodhi, Huma
✏Publisher : IGI Global
✏Release Date : 2010-07-31
✏Pages : 418
✏ISBN : 9781615209125
✏Available Language : English, Spanish, And French

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✏Chemoinformatics and Advanced Machine Learning Perspectives Complex Computational Methods and Collaborative Techniques Book Summary : "This book is a timely compendium of key elements that are crucial for the study of machine learning in chemoinformatics, giving an overview of current research in machine learning and their applications to chemoinformatics tasks"--Provided by publisher.

📒In Silico Drug Discovery And Design ✍ Claudio N. Cavasotto

In Silico Drug Discovery And Design Book PDF
✏Book Title : In Silico Drug Discovery and Design
✏Author : Claudio N. Cavasotto
✏Publisher : CRC Press
✏Release Date : 2017-07
✏Pages :
✏ISBN : 1138747580
✏Available Language : English, Spanish, And French

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✏In Silico Drug Discovery and Design Book Summary : In Silico Drug Discovery and Design: Theory, Methods, Challenges, and Applications provides a comprehensive, unified, and in-depth overview of the current methodological strategies in computer-aided drug discovery and design. Its main aims are to introduce the theoretical framework and algorithms, discuss the range of validity, strengths and limitations of each methodology, and present applications to real world problems in the drug discovery arena. Special emphasis has been given to the emerging and most pressing methodological challenges in in silico drug discovery and design. The book assumes a basic knowledge of physical principles and molecular modeling. Particular attention has been paid to outline the underlying physico-chemical foundation of the methods described, thus providing the necessary background to avoid a -black-box- approach. In each self-contained chapter, this is presented together with the latest developments and applications, and the challenges that lie ahead. Assembling a unique team of experts to weigh in on the most important issues influencing modern computational drug discovery and design, this book constitutes both a desktop reference to academic and industrial researchers in the field, and a textbook for students in the area of molecular modeling and drug discovery. Comprised of 18 chapters and divided into three parts, this book: Provides a comprehensive, unified, and in-depth overview of the current methodological strategies in computer-aided drug discovery and design Outlines the underlying physico-chemical foundation of the methods described Presents several applications of computational methods to real world problems in the drug design field Helps to avoid a -black-box- approach to in silico drug discovery Constitutes an actual textbook for students in the area of molecular modeling and drug discovery Gives the reader the adequate background to face the current challenges of the field In Silico Drug Discovery and Design: Theory, Methods, Challenges, and Applications describes the theoretical framework, methods, practical applications and case examples relevant to computer-aided drug lead discovery and design. This text will surely aid in understanding the underlying physical foundation of computational tools and their range of application, thus facilitating the interpretation of simulation results.

📒Real World Micro 15th Edition ✍ Daniel Fireside

Real World Micro 15th Edition Book PDF
✏Book Title : Real World Micro 15th Edition
✏Author : Daniel Fireside
✏Publisher :
✏Release Date : 2008
✏Pages : 176
✏ISBN : 1878585711
✏Available Language : English, Spanish, And French

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✏Real World Micro 15th Edition Book Summary :

Natural Products And Drug Discovery Book PDF
✏Book Title : Natural Products and Drug Discovery
✏Author : Subhash C. Mandal
✏Publisher : Elsevier
✏Release Date : 2018-02-16
✏Pages : 776
✏ISBN : 9780081021040
✏Available Language : English, Spanish, And French

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✏Natural Products and Drug Discovery Book Summary : Natural Products and Drug Discovery: An Integrated Approach provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active compounds in new ways, they are once again coming to the forefront of drug discovery. Combining the potential of traditional medicine with the refinement of modern chemical technology, the use of natural products as the basis for drugs can help in the development of more environmentally sound, economical, and effective drug discovery processes. Natural Products & Drug Discovery: An Integrated Approach reflects on the current changes in this field, giving context to the current shift and using supportive case studies to highlight the challenges and successes faced by researchers in integrating traditional medicinal sources with modern chemical technologies. It therefore acts as a useful reference to medicinal chemists, phytochemists, biochemists, pharma R&D professionals, and drug discovery students and researchers. Reviews the changing role of natural products in drug discovery, integrating traditional knowledge with modern molecular technologies Highlights the potential future role of natural products in preventative medicine Supported by real world case studies throughout

Libertarian Philosophy In The Real World Book PDF
✏Book Title : Libertarian Philosophy in the Real World
✏Author : Mark D. Friedman
✏Publisher : Bloomsbury Publishing
✏Release Date : 2014-12-18
✏Pages : 240
✏ISBN : 9781472573414
✏Available Language : English, Spanish, And French

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✏Libertarian Philosophy in the Real World Book Summary : Robert Nozick's Anarchy, State, and Utopia is widely recognized as one of the most influential works of modern political philosophy. Libertarian Philosophy in the Real World not only provides a concise and accessible introduction to Nozick's ideal rights-based, minimal libertarian state, but for the first time applies this moral framework to America's liberal democracy. Mark D. Friedman clearly presents Nozick's arguments for natural rights, showing that his theory undermines the very idea of social justice, and enables libertarians to rebut the most common objections to their doctrine. The book delivers a withering moral critique of the American welfare state, with chapters devoted to property rights, freedom of expression and association, paternalism, and the state's intervention in discrete aspects of modern life such as public education and healthcare. Friedman argues that reducing the liberal democratic state to its core functions would not produce the sort of moral catastrophe that might make us reconsider our commitment to individual rights. So, what is to be done? Friedman concludes with effective argumentative strategies for moving American politics in a more libertarian direction. Ideal for undergraduates and above studying political philosophy, political science, political ideology, rights and public policy, this text provides crucial insights into libertarian theory and its application.

Introduction To Biological And Small Molecule Drug Research And Development Book PDF
✏Book Title : Introduction to Biological and Small Molecule Drug Research and Development
✏Author : C. Robin Ganellin
✏Publisher : Academic Press
✏Release Date : 2013-05-07
✏Pages : 472
✏ISBN : 9780123977700
✏Available Language : English, Spanish, And French

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✏Introduction to Biological and Small Molecule Drug Research and Development Book Summary : Introduction to Biological and Small Molecule Drug Research and Development provides, for the first time, an introduction to the science behind successful pharmaceutical research and development programs. The book explains basic principles, then compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs, presenting an overview of the business and management issues of these approaches. The latter part of the book provides carefully selected real-life case studies illustrating how the theory presented in the first part of the book is actually put into practice. Studies include Herceptin/T-DM1, erythropoietin (Epogen/Eprex/NeoRecormon), anti-HIV protease inhibitor Darunavir, and more. Introduction to Biological and Small Molecule Drug Research and Development is intended for late-stage undergraduates or postgraduates studying chemistry (at the biology interface), biochemistry, medicine, pharmacy, medicine, or allied subjects. The book is also useful in a wide variety of science degree courses, in post-graduate taught material (Masters and PhD), and as basic background reading for scientists in the pharmaceutical industry. For the first time, the fundamental scientific principles of biopharmaceuticals and small molecule chemotherapeutics are discussed side-by-side at a basic level Edited by three senior scientists with over 100 years of experience in drug research who have compiled the best scientific comparison of small molecule and biopharmaceuticals approaches to new drugs Illustrated with key examples of important drugs that exemplify the basic principles of pharmaceutical drug research and development

📒Omics ✍ Debmalya Barh

Omics Book PDF
✏Book Title : OMICS
✏Author : Debmalya Barh
✏Publisher : CRC Press
✏Release Date : 2016-04-19
✏Pages : 622
✏ISBN : 9781439850091
✏Available Language : English, Spanish, And French

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✏OMICS Book Summary : A reflection of the explosion of research and development in this field, OMICS: Biomedical Perspectives and Applications explores applications of omics in bioinformatics, cancer research and therapy, diabetes research, plant science, molecular biology, and neurosciences. A select editorial panel of experts discusses their cutting edge omics research and novel technologies, supplying a basic platform of methods and applications and a resource for enhanced cross-pollination in a multiomics approach to future endeavors in the fertile fields of omics research. After an introduction on the omics universe, the book presents modern omics and its applications in nanotechnology, genomics, proteomics, metagenomics, toxicogenomics, immunomics, nutrigenomics, diabetes, neurology, cardiology, and cancer to name just a few. The book begins with an overview of omics and omic technologies such as cellomics, glycomics, and lipidomics. It also discusses bioinformatics, demonstrating how it can be a tool in omics, and examines the various approaches of omics technology in toxicology research and applications in biomedical sciences. While there are a long list of omics books available, most focus narrowly on one area. Presenting a wide view of the current status of integrative omics, this resource contains complete coverage of omics in research and therapy, ranging from neuroscience to cardiology. It collates recent developments in the field into a state-of-the-art framework for this discipline.

A Comprehensive Guide To Toxicology In Preclinical Drug Development Book PDF
✏Book Title : A Comprehensive Guide to Toxicology in Preclinical Drug Development
✏Author : Ali S. Faqi
✏Publisher : Academic Press
✏Release Date : 2012-11-16
✏Pages : 885
✏ISBN : 9780123878151
✏Available Language : English, Spanish, And French

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✏A Comprehensive Guide to Toxicology in Preclinical Drug Development Book Summary : A Comprehensive Guide to Toxicology in Preclinical Drug Development is a resource for toxicologists in industry and regulatory settings, as well as directors working in contract resource organizations, who need a thorough understanding of the drug development process. Incorporating real-life case studies and examples, the book is a practical guide that outlines day-to-day activities and experiences in preclinical toxicology. This multi-contributed reference provides a detailed picture of the complex and highly interrelated activities of preclinical toxicology in both small molecules and biologics. The book discusses discovery toxicology and the international guidelines for safety evaluation, and presents traditional and nontraditional toxicology models. Chapters cover development of vaccines, oncology drugs, botanic drugs, monoclonal antibodies, and more, as well as study development and personnel, the role of imaging in preclinical evaluation, and supporting materials for IND applications. By incorporating the latest research in this area and featuring practical scenarios, this reference is a complete and actionable guide to all aspects of preclinical drug testing. Chapters written by world-renowned contributors who are experts in their fields Includes the latest research in preclinical drug testing and international guidelines Covers preclinical toxicology in small molecules and biologics in one single source

📒Real World Micro ✍ Randy Albelda

Real World Micro Book PDF
✏Book Title : Real World Micro
✏Author : Randy Albelda
✏Publisher :
✏Release Date : 1991-07-01
✏Pages : 95
✏ISBN : PSU:000019626963
✏Available Language : English, Spanish, And French

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✏Real World Micro Book Summary :

📒The Role Of Digital Health Technologies In Drug Development ✍ National Academies of Sciences, Engineering, and Medicine

The Role Of Digital Health Technologies In Drug Development Book PDF
✏Book Title : The Role of Digital Health Technologies in Drug Development
✏Author : National Academies of Sciences, Engineering, and Medicine
✏Publisher : National Academies Press
✏Release Date : 2020-11-28
✏Pages : 142
✏ISBN : 9780309679596
✏Available Language : English, Spanish, And French

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✏The Role of Digital Health Technologies in Drug Development Book Summary : On March 24, 2020, a 1-day public workshop titled The Role of Digital Health Technologies in Drug Development was convened by the National Academies of Sciences, Engineering, and Medicine. This workshop builds on prior efforts to explore how virtual clinical trials facilitated by digital health technologies (DHTs) might change the landscape of drug development. To explore the challenges and opportunities in using DHTs for improving the probability of success in drug R&D, enabling better patient care, and improving precision medicine, the workshop featured presentations and panel discussions on the integration of DHTs across all phases of drug development. Throughout the workshop, participants considered how DHTs could be applied to achieve the greatest impactâ€"and perhaps even change the face of how clinical trials are conductedâ€"in ways that are also ethical, equitable, safe, and effective. This publication summarizes the presentations and discussions from the workshop.

Sustainable Development For The Healthcare Industry Book PDF
✏Book Title : Sustainable Development for the Healthcare Industry
✏Author : Pierre A. Morgon
✏Publisher : Springer
✏Release Date : 2014-12-13
✏Pages : 154
✏ISBN : 9783319125268
✏Available Language : English, Spanish, And French

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✏Sustainable Development for the Healthcare Industry Book Summary : This volume addresses the dynamics of sustainable development in the healthcare industry, covering all major aspects, including R&D, manufacturing, regulation, market access, commercialization, and general management. Healthcare markets are evolving under demographic and economic pressures. In mature markets, patients navigate complex systems with limited control on healthcare quality and outcomes, while in developing markets, patients have limited awareness, access, and ability to pay for healthcare. The industry needs to identify which business targets are genuinely attractive for major or new investments. At the same time, development of new products and services must be tackled within the context of environmental sustainability. Rather than focusing on the traditional issues of innovation, cost management, and commercial effectiveness associated with growth, the authors explore such emerging topics as: The mutations of innovation management The need to foster patient-centricity along the entire value chain of the healthcare industry and company-wide Issues related to improving healthcare access and disease management The allocation of educational resources focused on the patient to increase the effectiveness of disease management The preservation of natural resources and the environmental effect of pollution and hazards created by the handling of pharmaceutical products Issues related to the size of medical need and/or market demand The private-public partnerships necessary to address the full spectrum of public health issues, from basic patient access to care to managing global health crises The required organizational and governance evolutions for the healthcare industry to maintain profitability and sustainable growth. Featuring contributions from leading academics and industry insiders with emphasis on environmental, economically, and socially sustainable practices, the authors present a unique, multi-faceted set of perspectives on this vital and rapidly evolving field.