The Emerging Discipline of Quantitative Systems Pharmacology

Produk Detail:
  • Author : Tarek A. Leil
  • Publisher : Frontiers Media SA
  • Pages : 99 pages
  • ISBN : 2889196429
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>The Emerging Discipline of Quantitative Systems Pharmacology

Download or Read online The Emerging Discipline of Quantitative Systems Pharmacology full in PDF, ePub and kindle. this book written by Tarek A. Leil and published by Frontiers Media SA which was released on 07 September 2015 with total page 99 pages. We cannot guarantee that The Emerging Discipline of Quantitative Systems Pharmacology book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. In 2011, the National Institutes of Health (NIH), in collaboration with leaders from the pharmaceutical industry and the academic community, published a white paper describing the emerging discipline of Quantitative Systems Pharmacology (QSP), and recommended the establishment of NIH-supported interdisciplinary research and training programs for QSP. QSP is still in its infancy, but has tremendous potential to change the way we approach biomedical research. QSP is really the integration of two disciplines that have been increasingly useful in biomedical research; “Systems Biology” and “Quantitative Pharmacology”. Systems Biology is the field of biomedical research that seeks to understand the relationships between genes and biologically active molecules to develop qualitative models of these systems; and Quantitative Pharmacology is the field of biomedical research that seeks to use computer aided modeling and simulation to increase our understanding of the pharmacokinetics (PK) and pharmacodynamics (PD) of drugs, and to aid in the design of pre-clinical and clinical experiments. The purpose of QSP modeling is to develop quantitative computer models of biological systems and disease processes, and the effects of drug PK and PD on those systems. QSP models allow testing of numerous potential experiments “in-silico” to eliminate those associated with a low probability of success, avoiding the potential costs of evaluating all of those failed experiments in the real world. At the same time, QSP models allow us to develop our understanding of the interaction between drugs and biological systems in a more systematic and rigorous manner. As the need to be more cost-efficient in the use of research funding increases, biomedical researchers will be required to gain the maximum insight from each experiment that is conducted. This need is even more acute in the pharmaceutical industry, where there is tremendous competition to develop innovative therapies in a highly regulated environment, combined with very high research and development (R&D) costs for bringing new drugs to market (~$1.3 billion/drug). Analogous modeling & simulation approaches have been successfully integrated into other disciplines to improve the fundamental understanding of the science and to improve the efficiency of R&D (e.g., physics, engineering, economics, etc.). The biomedical research community has been slow to integrate computer aided modeling & simulation for many reasons: including the perception that biology and pharmacology are “too complex” and “too variable” to be modeled with mathematical equations; a lack of adequate graduate training programs; and the lack of support from government agencies that fund biomedical research. However, there is an active community of researchers in the pharmaceutical industry, the academic community, and government agencies that develop QSP and quantitative systems biology models and apply them both to better characterize and predict drug pharmacology and disease processes; as well as to improve efficiency and productivity in pharmaceutical R&D.

The Emerging Discipline of Quantitative Systems Pharmacology

The Emerging Discipline of Quantitative Systems Pharmacology
  • Author : Tarek A. Leil,Sergey Ermakov
  • Publisher : Frontiers Media SA
  • Release : 07 September 2015
GET THIS BOOK The Emerging Discipline of Quantitative Systems Pharmacology

In 2011, the National Institutes of Health (NIH), in collaboration with leaders from the pharmaceutical industry and the academic community, published a white paper describing the emerging discipline of Quantitative Systems Pharmacology (QSP), and recommended the establishment of NIH-supported interdisciplinary research and training programs for QSP. QSP is still in its infancy, but has tremendous potential to change the way we approach biomedical research. QSP is really the integration of two disciplines that have been increasingly useful in biomedical research; “Systems

Quantitative Systems Pharmacology

Quantitative Systems Pharmacology
  • Author : Davide Manca
  • Publisher : Elsevier
  • Release : 18 July 2018
GET THIS BOOK Quantitative Systems Pharmacology

Quantitative Systems Pharmacology: Models and Model-Based Systems with Applications, Volume 42, provides a quantitative approach to problem-solving that is targeted to engineers. The book gathers the contributions of doctors, pharmacists, biologists, and chemists who give key information on the elements needed to model a complex machine like the human body. It presents information on diagnoses, administration and release of therapeutics, distribution metabolism and excretion of drugs, compartmental pharmacokinetics, physiologically-based pharmacokinetics, pharmacodynamics, identifiability of models, numerical methods for models identification, design of

Systems Pharmacology and Pharmacodynamics

Systems Pharmacology and Pharmacodynamics
  • Author : Donald E. Mager,Holly H.C. Kimko
  • Publisher : Springer
  • Release : 29 November 2016
GET THIS BOOK Systems Pharmacology and Pharmacodynamics

While systems biology and pharmacodynamics have evolved in parallel, there are significant interrelationships that can enhance drug discovery and enable optimized therapy for each patient. Systems pharmacology is the relatively new discipline that is the interface between these two methods. This book is the first to cover the expertise from systems biology and pharmacodynamics researchers, describing how systems pharmacology may be developed and refined further to show practical applications in drug development. There is a growing awareness that pharmaceutical companies

Computational Systems Pharmacology and Toxicology

Computational Systems Pharmacology and Toxicology
  • Author : Rudy J Richardson,Dale E Johnson
  • Publisher : Royal Society of Chemistry
  • Release : 01 March 2017
GET THIS BOOK Computational Systems Pharmacology and Toxicology

The network approaches of systems pharmacology and toxicology serve as early predictors of the most relevant screening approach to pursue both in drug discovery and development and ecotoxicological assessments. Computational approaches have the potential to improve toxicological experimental design, enable more rapid drug efficacy and safety testing and also reduce the number of animals used in experimentation. Rapid advances in availability of computing technology hold tremendous promise for advancing applied and basic science and increasing the efficiency of risk assessment.

Translational Systems Medicine and Oral Disease

Translational Systems Medicine and Oral Disease
  • Author : Stephen Sonis,Alessandro Villa
  • Publisher : Academic Press
  • Release : 14 September 2019
GET THIS BOOK Translational Systems Medicine and Oral Disease

Translational Systems Medicine and Oral Disease bridges the gap between discovery science and clinical oral medicine, providing opportunities for both the scientific and clinical communities to understand how to apply recent findings in cell biology, genomic profiling, and systems medicine to favorably impact the diagnosis, treatment and management of oral diseases. Fully illustrated chapters from leading international contributors explore clinical applications of genomics, proteomics, metabolomics, microbiomics and epigenetics, as well as analytic methods and functional omics in oral medicine. Disease

Systems Medicine

Systems Medicine
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 24 August 2020
GET THIS BOOK Systems Medicine

Technological advances in generated molecular and cell biological data are transforming biomedical research. Sequencing, multi-omics and imaging technologies are likely to have deep impact on the future of medical practice. In parallel to technological developments, methodologies to gather, integrate, visualize and analyze heterogeneous and large-scale data sets are needed to develop new approaches for diagnosis, prognosis and therapy. Systems Medicine: Integrative, Qualitative and Computational Approaches is an innovative, interdisciplinary and integrative approach that extends the concept of systems biology and

An Introduction to Computational Systems Biology

An Introduction to Computational Systems Biology
  • Author : Karthik Raman
  • Publisher : CRC Press
  • Release : 30 May 2021
GET THIS BOOK An Introduction to Computational Systems Biology

This book delivers a comprehensive and insightful account of applying mathematical modelling approaches to very large biological systems and networks—a fundamental aspect of computational systems biology. The book covers key modelling paradigms in detail, while at the same time retaining a simplicity that will appeal to those from less quantitative fields. Key Features: A hands-on approach to modelling Covers a broad spectrum of modelling, from static networks to dynamic models and constraint-based models Thoughtful exercises to test and enable

Antibody Drug Conjugates

Antibody Drug Conjugates
  • Author : Kenneth J. Olivier, Jr.,Sara A. Hurvitz
  • Publisher : John Wiley & Sons
  • Release : 14 November 2016
GET THIS BOOK Antibody Drug Conjugates

Providing practical and proven solutions for antibody-drug conjugate (ADC) drug discovery success in oncology, this book helps readers improve the drug safety and therapeutic efficacy of ADCs to kill targeted tumor cells. • Discusses the basics, drug delivery strategies, pharmacology and toxicology, and regulatory approval strategies • Covers the conduct and design of oncology clinical trials and the use of ADCs for tumor imaging • Includes case studies of ADCs in oncology drug development • Features contributions from highly-regarded experts on the frontlines of

Medical Empathy Pharmacological Systems and Treatment Strategies in Integrative Cardiovascular Chinese Medicine

Medical Empathy  Pharmacological Systems  and Treatment Strategies in Integrative Cardiovascular Chinese Medicine
  • Author : Anika Niambi Al-Shura
  • Publisher : Academic Press
  • Release : 18 October 2019
GET THIS BOOK Medical Empathy Pharmacological Systems and Treatment Strategies in Integrative Cardiovascular Chinese Medicine

Medical Empathy, Pharmacological Systems, and Treatment Strategies in Integrative Cardiovascular Chinese Medicine, volume two in the Integrative Cardiovascular Chinese Medicine series, presents sections on holism and humanity in medicine, considering the patient, medical empathy in prescribing, modifying and weaning, an overview of pharmacologic systems, an overview of pharmacology sciences and the cardiovascular drug classes and types as revealed from perspectives of Chinese and Western medicine, including descriptions of pharmaceutical drugs from China and the United States, with current pictures and

Case Studies in Systems Biology

Case Studies in Systems Biology
  • Author : Pavel Kraikivski
  • Publisher : Springer Nature
  • Release : 06 October 2021
GET THIS BOOK Case Studies in Systems Biology

This book provides case studies that can be used in Systems Biology related classes. Each case study has the same structure which answers the following questions: What is the biological problem and why is it interesting? What are the relevant details with regard to cell physiology and molecular mechanisms? How are the details put together into a mathematical model? How is the model analyzed and simulated? What are the results of the model? How do they compare to the known

Advanced Issue Resolution in Safety Pharmacology

Advanced Issue Resolution in Safety Pharmacology
  • Author : Mary Jeanne Kallman,Michael Pugsley
  • Publisher : Academic Press
  • Release : 05 September 2018
GET THIS BOOK Advanced Issue Resolution in Safety Pharmacology

Advanced Issue Resolution in Safety Pharmacology not only discusses unique issues that may emerge during the development of new medicines, but also provides detailed insights on how to resolve them. The book employs a valuable strategy that integrates preclinical findings with the clinical resolution of those findings. In addition, it introduces key interdisciplinary topics in an accessible and systematic format. Edited and written by leaders in the field of safety pharmacology, this book considerably advances the discussion on issue resolution

Concepts and Principles of Pharmacology

Concepts and Principles of Pharmacology
  • Author : James E. Barrett,Clive P. Page,Martin C. Michel
  • Publisher : Springer Nature
  • Release : 24 December 2019
GET THIS BOOK Concepts and Principles of Pharmacology

Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.

Biologics and Biosimilars

Biologics and Biosimilars
  • Author : Xiaodong Feng,Hong-Guang Xie,Ashim Malhotra,Catherine F. Yang
  • Publisher : CRC Press
  • Release : 14 June 2022
GET THIS BOOK Biologics and Biosimilars

Biologics and Biosimilars: Drug Discovery and Clinical Applications is a systematic integration and evaluation of all aspects of biologics and biosimilars, encompassing research and development, clinical use, global regulation, and more. Biosimilars are biological therapeutic agents designed to imitate a reference biologic with high similarities in structure, efficacy, and safety, but also with potential clinical effective and cost-efficient options for the manufacturers, payers, clinicians, and patients. Most of the top-selling prescription drugs in the current market are biologics, which have