Proteomic and Metabolomic Approaches to Biomarker Discovery

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  • Author : Haleem J. Issaq
  • Publisher : Academic Press
  • Pages : 504 pages
  • ISBN : 0128197889
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Proteomic and Metabolomic Approaches to Biomarker Discovery

Download or Read online Proteomic and Metabolomic Approaches to Biomarker Discovery full in PDF, ePub and kindle. this book written by Haleem J. Issaq and published by Academic Press which was released on 24 October 2019 with total page 504 pages. We cannot guarantee that Proteomic and Metabolomic Approaches to Biomarker Discovery book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Proteomic and Metabolomic Approaches to Biomarker Discovery, Second Edition covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution. The book describes methods and presents a standard operating procedure for sample selection, preparation and storage, as well as data analysis and modeling. This new standard effectively eliminates the differing methodologies used in studies and creates a unified approach. Readers will learn the advantages and disadvantages of the various techniques discussed, as well as potential difficulties inherent to all steps in the biomarker discovery process. This second edition has been fully updated and revised to address recent advances in MS and NMR instrumentation, high-field NMR, proteomics and metabolomics for biomarker validation, clinical assays of biomarkers and clinical MS and NMR, identifying microRNAs and autoantibodies as biomarkers, MRM-MS assay development, top-down MS, glycosylation-based serum biomarkers, cell surface proteins in biomarker discovery, lipodomics for cancer biomarker discovery, and strategies to design studies to identify predictive biomarkers in cancer research. Addresses the full range of proteomic and metabolomic methods and technologies used for biomarker discovery and validation Covers all steps involved in biomarker discovery, from study design to study execution Serves as a vital resource for biochemists, biologists, analytical chemists, bioanalytical chemists, clinical and medical technicians, researchers in pharmaceuticals and graduate students

Proteomic and Metabolomic Approaches to Biomarker Discovery

Proteomic and Metabolomic Approaches to Biomarker Discovery
  • Author : Haleem J. Issaq,Timothy D. Veenstra
  • Publisher : Academic Press
  • Release : 15 January 2020
GET THIS BOOK Proteomic and Metabolomic Approaches to Biomarker Discovery

Disease biomarker discovery is one of the most vibrant and important areas of research today, as the identification of reliable biomarkers has an enormous impact on disease diagnosis, selection of treatment regimens, and therapeutic monitoring. Various techniques are used in the biomarker discovery process, including proteomics, the study of the proteins that make up an organism, and metabolomics, the study of chemical fingerprints created from cellular processes. Proteomic and Metabolomic Approaches to Biomarker Discovery, Second Edition covers techniques from both

Proteomic and Metabolomic Approaches to Biomarker Discovery

Proteomic and Metabolomic Approaches to Biomarker Discovery
  • Author : Haleem J. Issaq,Timothy D. Veenstra
  • Publisher : Academic Press
  • Release : 24 October 2019
GET THIS BOOK Proteomic and Metabolomic Approaches to Biomarker Discovery

Proteomic and Metabolomic Approaches to Biomarker Discovery, Second Edition covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution. The book describes methods and presents a standard operating procedure for sample selection, preparation and storage, as well as data analysis and modeling. This new standard effectively eliminates the differing methodologies used in studies and creates a unified approach. Readers will learn the advantages and disadvantages of the various techniques

Surrogate Tissue Analysis

Surrogate Tissue Analysis
  • Author : Michael E. Burczynski,John C. Rockett
  • Publisher : CRC Press
  • Release : 10 November 2005
GET THIS BOOK Surrogate Tissue Analysis

Despite rapidly expanding interest in potential applications of surrogate tissue analysis and intense competition to identify and validate biomarkers in appropriate surrogate tissues, very few peer reviewed publications describing the use of this approach have appeared in the scientific press. One of the first publications on this topic, Surrogate Tissue Analysis: Genomic, Proteomic, and Metabolomic Approaches describes initial applications and considerations for "omic" technologies in the field of surrogate tissue analysis. Highlighting important issues to consider when conducting profiling studies

Proteomic Applications in Cancer Detection and Discovery

Proteomic Applications in Cancer Detection and Discovery
  • Author : Timothy D. Veenstra
  • Publisher : John Wiley & Sons
  • Release : 30 May 2013
GET THIS BOOK Proteomic Applications in Cancer Detection and Discovery

Helps researchers in proteomics and oncology work together tounderstand, prevent, and cure cancer Proteomic data is increasingly important to understanding theorigin and progression of cancer; however, most oncologicresearchers who depend on proteomics for their studies do notcollect the data themselves. As a result, there is a knowledge gapbetween scientists, who devise proteomic techniques and collect thedata, and the oncologic researchers, who are expected to interpretand apply proteomic data. Bridging the gap between proteomics andoncology research, this book explains how proteomic

Biomarker Discovery in the Developing World Dissecting the Pipeline for Meeting the Challenges

Biomarker Discovery in the Developing World  Dissecting the Pipeline for Meeting the Challenges
  • Author : Sanjeeva Srivastava
  • Publisher : Springer
  • Release : 30 September 2016
GET THIS BOOK Biomarker Discovery in the Developing World Dissecting the Pipeline for Meeting the Challenges

This book is oriented towards post-graduates and researchers with interest in proteomics and its applications in clinical biomarker discovery pipeline. Biomarker discovery has long been the research focus of many life scientists globally. However, the pipeline starting from discovery to validation to regulation as a diagnostic or therapeutic molecule follows a complex trajectory. This book aims to provide an in-depth synopsis on each of these developmental phases attendant to biomarker “life cycle” with emphasis on the emerging and significant role

Emerging Sample Treatments in Proteomics

Emerging Sample Treatments in Proteomics
  • Author : José-Luis Capelo-Martínez
  • Publisher : Springer
  • Release : 24 June 2019
GET THIS BOOK Emerging Sample Treatments in Proteomics

Proteomics is a well-established area of Science; yet with a strong area in constant evolution, namely sample treatment. There few books that currently cover the field of emerging sample treatments in proteomics, this new volume will be the first to cover all emerging and existing studies. This unique book presents the latest advances in the field focusing on emerging trends linked to high-resolution mass spectrometry, technology addressed to treat samples faster and to attempts to simplify the proteome for the

Genetic Programming for Biomarker Detection in Classification of Mass Spectrometry Data

Genetic Programming for Biomarker Detection in Classification of Mass Spectrometry Data
  • Author : Soha Ahmed
  • Publisher : Unknown
  • Release : 14 June 2021
GET THIS BOOK Genetic Programming for Biomarker Detection in Classification of Mass Spectrometry Data

Mass spectrometry (MS) is currently the most commonly used technology in biochemical research for proteomic analysis. The primary goal of proteomic profiling using mass spectrometry is the classification of samples from different experimental states. To classify the MS samples, the identification of protein or peptides (biomarker detection) that are expressed differently between the classes, is required. However, due to the high dimensionality of the data and the small number of samples, classification of MS data is extremely challenging. Another important

Multi omic Data Integration

Multi omic Data Integration
  • Author : Paolo Tieri,Christine Nardini,Jennifer Elizabeth Dent
  • Publisher : Frontiers Media SA
  • Release : 17 September 2015
GET THIS BOOK Multi omic Data Integration

Stable, predictive biomarkers and interpretable disease signatures are seen as a significant step towards personalized medicine. In this perspective, integration of multi-omic data coming from genomics, transcriptomics, glycomics, proteomics, metabolomics is a powerful strategy to reconstruct and analyse complex multi-dimensional interactions, enabling deeper mechanistic and medical insight. At the same time, there is a rising concern that much of such different omic data –although often publicly and freely available- lie in databases and repositories underutilised or not used at all.

Metabolome Analyses

Metabolome Analyses
  • Author : Seetharaman Vaidyanathan,George G. Harrigan,Royston Goodacre
  • Publisher : Springer Science & Business Media
  • Release : 20 March 2006
GET THIS BOOK Metabolome Analyses

Metabolome analysis is now recognized as a crucial component of functional genomic and systems biology investigations. Innovative approaches to the study of metabolic regulation in microbial, plant and animal systems are increasingly facilitating the emergence of systems approaches in biology. This book highlights analytical and bioinformatics strategies now available for investigating metabolic networks in microbial, plant and animal systems. The contributing authors are world leaders in this field and they present an unambiguous case for pursuing metabolome analysis as a

Bioinformatics and Biomarker Discovery

Bioinformatics and Biomarker Discovery
  • Author : Francisco Azuaje
  • Publisher : John Wiley & Sons
  • Release : 24 August 2011
GET THIS BOOK Bioinformatics and Biomarker Discovery

This book is designed to introduce biologists, clinicians and computational researchers to fundamental data analysis principles, techniques and tools for supporting the discovery of biomarkers and the implementation of diagnostic/prognostic systems. The focus of the book is on how fundamental statistical and data mining approaches can support biomarker discovery and evaluation, emphasising applications based on different types of "omic" data. The book also discusses design factors, requirements and techniques for disease screening, diagnostic and prognostic applications. Readers are provided

The Handbook of Biomarkers

The Handbook of Biomarkers
  • Author : Kewal K. Jain
  • Publisher : Humana Press
  • Release : 16 September 2017
GET THIS BOOK The Handbook of Biomarkers

Involved in nearly every therapeutic area, particularly cancer, biomarkers have experienced tremendous advances since the first edition of this book, both in the discovery of biomarkers and in their applications. To aid in this imperative research, Prof. Kewal K. Jain’s Handbook of Biomarkers, Second Edition features a full revision and additional chapters to thoroughly describe many different types of biomarkers and their discovery using various "-omics" technologies, along with the background information needed for the evaluation of biomarkers as

Metabolic Profiling Its Role in Biomarker Discovery and Gene Function Analysis

Metabolic Profiling  Its Role in Biomarker Discovery and Gene Function Analysis
  • Author : George G. Harrigan,Royston Goodacre
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOK Metabolic Profiling Its Role in Biomarker Discovery and Gene Function Analysis

It is evident that biochemical control is not strictly hierarchical and that intermediary metabolism can contribute to control of regulatory pathways. Metabolic studies are therefore increasingly important in gene function analyses, and an increased interest in metabolites as biomarkers for disease progression or response to therapeutic intervention is also evident in the pharmaceutical industry. This book offers guidelines to currently available technology and bioinformatics and database strategies now being developed. Evidence is presented that metabolic profiling is a valuable addition