Protein Homeostasis Diseases

Produk Detail:
  • Author : Angel L. Pey
  • Publisher : Academic Press
  • Pages : 450 pages
  • ISBN : 9780128191323
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Protein Homeostasis Diseases

Download or Read online Protein Homeostasis Diseases full in PDF, ePub and kindle. this book written by Angel L. Pey and published by Academic Press which was released on 21 February 2020 with total page 450 pages. We cannot guarantee that Protein Homeostasis Diseases book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. Contributions from international experts discuss the biochemical and genetic components of protein homeostasis disorders, the mechanisms by which genetic variants may cause loss-of-function and gain-of-toxic-function, and how natural ligands can restore protein function and homeostasis in genetic diseases. Applied chapters provide guidance on employing high throughput sequencing and screening methodologies to develop pharmacological chaperones and repurpose approved drugs to treat protein homeostasis disorders. Provides an interdisciplinary examination of protein homeostasis disorders, with an emphasis on treatment strategies employing small natural and pharmacological ligands Offers applied approaches in employing high throughput sequencing and screening to develop pharmacological chaperones to treat protein homeostasis disease Gathers expertise from a range of international chapter authors who work across various biological methods and disease specific disciplines of relevance

Protein Homeostasis Diseases

Protein Homeostasis Diseases
  • Author : Angel L. Pey
  • Publisher : Academic Press
  • Release : 21 February 2020
GET THIS BOOK Protein Homeostasis Diseases

Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. Contributions from international experts discuss the biochemical and genetic components of protein homeostasis disorders, the mechanisms by which genetic variants may cause loss-of-function and gain-of-toxic-function, and how natural ligands can restore protein function and homeostasis in genetic diseases. Applied chapters

Proteostasis and Disease

Proteostasis and Disease
  • Author : Rosa Barrio,James D. Sutherland,Manuel S. Rodriguez
  • Publisher : Springer Nature
  • Release : 09 April 2020
GET THIS BOOK Proteostasis and Disease

This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In

Finding Balance in Huntington s Disease

Finding Balance in Huntington s Disease
  • Author : Joseph Ochaba
  • Publisher : Unknown
  • Release : 29 November 2021
GET THIS BOOK Finding Balance in Huntington s Disease

The disruption of protein quality control networks that ensure proper folding and degradation of cellular proteins is likely central to pathology in Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and other "protein misfolding" diseases (La Spada and Taylor, 2010; Wilkinson et al., 2010). A detailed understanding of the proteostasis network components and their contributions to pathology are therefore crucial to developing improved therapeutic interventions. HD is caused by the abnormal expansion of a CAG repeat within the HD gene resulting

Proteostasis and Chaperone Surveillance

Proteostasis and Chaperone Surveillance
  • Author : Laishram Rajendrakumar Singh,Tanveer Ali Dar,Parvaiz Ahmad
  • Publisher : Springer
  • Release : 26 November 2015
GET THIS BOOK Proteostasis and Chaperone Surveillance

Proteostasis is central to the development of various human diseases caused due to excessive protein misfolding and the disregulation of the protein quality control system. In this book, respected researchers from many leading institutions contribute their insights on proteostasis maintenance. The coverage mainly focuses on the basics of maintaining proteostasis, the consequences of proteostatic system failure, and how chaperone systems constantly maintain proteostasis. In addition, the book presents in detail different treatment strategies for diseases caused by proteostatic system failure,

Protein Homeostasis

Protein Homeostasis
  • Author : Richard Morimoto
  • Publisher : Perspectives Cshl
  • Release : 29 November 2021
GET THIS BOOK Protein Homeostasis

The entire life cycle of a protein-from synthesis and folding to transport and degradation-is carefully controlled by the proteostasis network. This network, consisting of many interconnected pathways and processes, manages protein homeostasis by dynamically responding to the needs of the cell. Stress and aging can challenge the proteostasis network, resulting in the aggregation of misfolded proteins-a feature of numerous neurodegenerative conditions. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a

The Networking of Chaperones by Co chaperones

The Networking of Chaperones by Co chaperones
  • Author : Gregory Lloyd Blatch,Adrienne Lesley Edkins
  • Publisher : Springer
  • Release : 08 December 2014
GET THIS BOOK The Networking of Chaperones by Co chaperones

Co-chaperones are important mediators of the outcome of chaperone assisted protein homeostasis, which is a dynamic balance between the integrated processes of protein folding, degradation and translocation. The Networking of Chaperones by Co-chaperones describes how the function of the major molecular chaperones is regulated by a cohort of diverse non-client proteins, known as co-chaperones. The second edition includes the current status of the field and descriptions of a number of novel co-chaperones that have been recently identified. This new edition

Protein Homeostasis Diseases

Protein Homeostasis Diseases
  • Author : Angel L. Pey
  • Publisher : Academic Press
  • Release : 13 February 2020
GET THIS BOOK Protein Homeostasis Diseases

Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. Contributions from international experts discuss the biochemical and genetic components of protein homeostasis disorders, the mechanisms by which genetic variants may cause loss-of-function and gain-of-toxic-function, and how natural ligands can restore protein function and homeostasis in genetic diseases. Applied chapters

Immunity Tumors and Aging The Role of HSP70

Immunity  Tumors and Aging  The Role of HSP70
  • Author : Igor Malyshev
  • Publisher : Springer Science & Business Media
  • Release : 08 January 2013
GET THIS BOOK Immunity Tumors and Aging The Role of HSP70

The book is dedicated to the topical area of biology and medicine and the role of stress proteins HSP70 in the regulation of intracellular protein homeostasis, signaling transduction and cell protection. The book is divided into chapters, which describe the discovery of HSP70 and its molecular structure, the mechanism of the synthesis and function in normal and damaged cells, examine the role of HSP70 in immunity, cancerogenesis, aging, Alzheimer's disease and cardiac surgery. In this book, the author looks at

Heat Shock Factor

Heat Shock Factor
  • Author : Akira Nakai
  • Publisher : Springer
  • Release : 06 January 2016
GET THIS BOOK Heat Shock Factor

This book presents a large amount of information related to the heat shock response and heat shock factor (HSF), describes core observations about molecular mechanisms and pathophysiological roles, and provides fundamental concepts on the basis of information from diverse aspects. This adaptive response to high temperature or protein misfolding is a fundamental mechanism to maintain the capacity of protein homeostasis, or proteostasis, and is evolutionally conserved among all living organisms, including bacteria and humans, on the earth. Furthermore, physiological and

HSF1 and Molecular Chaperones in Biology and Cancer

HSF1 and Molecular Chaperones in Biology and Cancer
  • Author : Marc Laurence Mendillo,David Pincus,Ruth Scherz-Shouval
  • Publisher : Springer Nature
  • Release : 15 April 2020
GET THIS BOOK HSF1 and Molecular Chaperones in Biology and Cancer

Protein homeostasis, or “Proteostasis”, lies at the heart of human health and disease. From the folding of single polypeptide chains into functional proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues and throughout the body, the proteostasis network operates to support cell health and physiological fitness. However, cancer cells also hijack the proteostasis network and many of these same processes to sustain the growth and spread of tumors. The chapters in this

Characterization of Proteostasis Loss in Neurodegeneration Using a Proteomics Approach

Characterization of Proteostasis Loss in Neurodegeneration Using a Proteomics Approach
  • Author : Seung Woo Ryu
  • Publisher : Unknown
  • Release : 29 November 2021
GET THIS BOOK Characterization of Proteostasis Loss in Neurodegeneration Using a Proteomics Approach

Chaperones such as HSP70s are the key proteins in the maintenance of protein homeostasis. They maintain protein balance from translation of nascent protein to degradation of misfolded proteins and aggregates. Therefore, chaperone–client interactions provide insights into protein homeostasis within cells. Here I show that chaperone-client interactions can be deciphered using ubiquitin-activated interaction traps (UBAITs). Using LC/MS label-free proteomics together with HSP/HSC70 UBAITs, I have identified both chaperone clients and their co-chaperones with higher confidence compared to