Protein Folding in Silico

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  • Author : Irena Roterman-Konieczna
  • Publisher : Elsevier
  • Pages : 240 pages
  • ISBN : 1908818255
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Protein Folding in Silico

Download or Read online Protein Folding in Silico full in PDF, ePub and kindle. this book written by Irena Roterman-Konieczna and published by Elsevier which was released on 04 October 2012 with total page 240 pages. We cannot guarantee that Protein Folding in Silico book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Protein folding is a process by which a protein structure assumes its functional shape of conformation, and has been the subject of research since the publication of the first software tool for protein structure prediction. Protein folding in silico approaches this issue by introducing an ab initio model that attempts to simulate as far as possible the folding process as it takes place in vivo, and attempts to construct a mechanistic model on the basis of the predictions made. The opening chapters discuss the early stage intermediate and late stage intermediate models, followed by a discussion of structural information that affects the interpretation of the folding process. The second half of the book covers a variety of topics including ligand binding site recognition, the "fuzzy oil drop" model and its use in simulation of the polypeptide chain, and misfolded proteins. The book ends with an overview of a number of other ab initio methods for protein structure predictions and some concluding remarks. Discusses a range of ab initio models for protein structure prediction Introduces a unique model based on experimental observations Describes various methods for the quantitative assessment of the presented models from the viewpoint of information theory

Protein Folding in Silico

Protein Folding in Silico
  • Author : Irena Roterman-Konieczna
  • Publisher : Elsevier
  • Release : 04 October 2012
GET THIS BOOK Protein Folding in Silico

Protein folding is a process by which a protein structure assumes its functional shape of conformation, and has been the subject of research since the publication of the first software tool for protein structure prediction. Protein folding in silico approaches this issue by introducing an ab initio model that attempts to simulate as far as possible the folding process as it takes place in vivo, and attempts to construct a mechanistic model on the basis of the predictions made. The

Protein Folding in Silico

Protein Folding in Silico
  • Author : Irena Roterman-Konieczna
  • Publisher : Woodhead Publishing
  • Release : 18 October 2012
GET THIS BOOK Protein Folding in Silico

Protein folding is a process by which a protein structure assumes its functional shape of conformation, and has been the subject of research since the publication of the first software tool for protein structure prediction. Protein folding in silico approaches this issue by introducing an ab initio model that attempts to simulate as far as possible the folding process as it takes place in vivo, and attempts to construct a mechanistic model on the basis of the predictions made. The

Protein Folding in Silico

Protein Folding in Silico
  • Author : Irena Roterman-Konieczna
  • Publisher : Woodhead Publishing
  • Release : 13 November 2017
GET THIS BOOK Protein Folding in Silico

Protein folding is a process by which a protein structure assumes its functional shape of conformation, and has been the subject of research since the publication of the first software tool for protein structure prediction. Protein folding in silico approaches this issue by introducing an ab initio model that attempts to simulate as far as possible the folding process as it takes place in vivo, and attempts to construct a mechanistic model on the basis of the predictions made. The

Combining in Vivo and in Silico Screening for Protein Stability

Combining in Vivo and in Silico Screening for Protein Stability
  • Author : Nora Hisham Barakat
  • Publisher : Unknown
  • Release : 23 September 2021
GET THIS BOOK Combining in Vivo and in Silico Screening for Protein Stability

In the in vivo 'chimeric' screen a target protein is expressed as a fusion protein with a DNA binding domain fused at the N-terminus and a transactivation domain at the C-terminus. This three-component fusion protein acts as a functional transcription factor for a reporter gene. If the central target protein is relatively unstable it is more flexible and thereby allows the DNA binding domain and the transactivation domain to achieve an optimal orientation for transcriptional activation. Conversely, if the central

Multiscale Approaches to Protein Modeling

Multiscale Approaches to Protein Modeling
  • Author : Andrzej Kolinski
  • Publisher : Springer Science & Business Media
  • Release : 13 October 2010
GET THIS BOOK Multiscale Approaches to Protein Modeling

The book gives a comprehensive review of the most advanced multiscale methods for protein structure prediction, computational studies of protein dynamics, folding mechanisms and macromolecular interactions. It approaches span a wide range of the levels of coarse-grained representations, various sampling techniques and variety of applications to biomedical and biophysical problems. This book is intended to be used as a reference book for those who are just beginning their adventure with biomacromolecular modeling but also as a valuable source of detailed

Combining in Vivo and in Silico Screening for Protein Stability

Combining in Vivo and in Silico Screening for Protein Stability
  • Author : Anonim
  • Publisher : Unknown
  • Release : 23 September 2021
GET THIS BOOK Combining in Vivo and in Silico Screening for Protein Stability

In any protein design endeavor, thermal stability is an important issue. Increasing protein stability is currently one of the main goals of the field of protein design as well as the biomedical industry. It is important for developing stable protein-based therapeutics and ultimately enhances our understanding of the principles of protein folding. The overall goal of my project is to develop and combine in vivo and in silico screening and analysis to select stable proteins from a large combinatorial library

Systems Biology

Systems Biology
  • Author : Leszek Konieczny,Irena Roterman-Konieczna,Paweł Spólnik
  • Publisher : Springer Science & Business Media
  • Release : 01 October 2013
GET THIS BOOK Systems Biology

The objective of this book is to present the strategies employed by living organisms on a molecular level and to help understand the basics of Systems Biology. Its content is organized in a way to meet the exponential growth in the volume of biological knowledge, and the need for a multidisciplinary approach in the practice of teaching modern biology. For this reason, the whole material is divided into five chapters, each devoted to a fundamental concept: Structure-Function, Energy, Information, Regulation

Abridged Thermodynamic and Thermochemical Tables

Abridged Thermodynamic and Thermochemical Tables
  • Author : Frederick Douglas Hamblin
  • Publisher : Pergamon
  • Release : 23 September 1968
GET THIS BOOK Abridged Thermodynamic and Thermochemical Tables

The phenomenon of amyloidosis has attracted the attention of numerous researchers for two main reasons: (1) it involves unexpected changes in protein conformation (without chemical intervention) and (2) has practical implications, such as elucidating the mechanisms which drive neurodegenerative diseases carries. In particular, understanding the process of amyloidosis is a fundamental prerequisite in the search for new, effective drugs and therapies targeting the key area of neurodegenerative diseases. The book proposes a model and a mechanism which explain protein misfolding. The concepts

Identification of Ligand Binding Site and Protein Protein Interaction Area

Identification of Ligand Binding Site and Protein Protein Interaction Area
  • Author : Irena Roterman-Konieczna
  • Publisher : Springer Science & Business Media
  • Release : 19 October 2012
GET THIS BOOK Identification of Ligand Binding Site and Protein Protein Interaction Area

This volume presents a review of the latest numerical techniques used to identify ligand binding and protein complexation sites. It should be noted that there are many other theoretical studies devoted to predicting the activity of specific proteins and that useful protein data can be found in numerous databases. The aim of advanced computational techniques is to identify the active sites in specific proteins and moreover to suggest a generalized mechanism by which such protein-ligand (or protein-protein) interactions can be

Molecular Biology of Protein Folding

Molecular Biology of Protein Folding
  • Author : P. Michael Conn
  • Publisher : Academic Press
  • Release : 09 January 2009
GET THIS BOOK Molecular Biology of Protein Folding

Nucleic acids are the fundamental building blocks of DNA and RNA and are found in virtually every living cell. Molecular biology is a branch of science that studies the physicochemical properties of molecules in a cell, including nucleic acids, proteins, and enzymes. Increased understanding of nucleic acids and their role in molecular biology will further many of the biological sciences including genetics, biochemistry, and cell biology. Progress in Nucleic Acid Research and Molecular Biology is intended to bring to light

Advances in Protein Chemistry and Structural Biology

Advances in Protein Chemistry and Structural Biology
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 11 March 2014
GET THIS BOOK Advances in Protein Chemistry and Structural Biology

This eclectic volume features two major topics: applications of mass spectrometry in bioscience; and computational methods for analysis of protein structure and interactions with other macromolecules. Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics. Describes advances in application of

Protein Folding

Protein Folding
  • Author : Claudio Gomes,Patricia Faisca
  • Publisher : Springer
  • Release : 25 May 2018
GET THIS BOOK Protein Folding

This snapshot volume is designed to provide a smooth entry into the field of protein folding. Presented in a concise manner, each section introduces key concepts while providing a brief overview of the relevant literature. Outlook subsections will pinpoint specific aspects related to emerging methodologies, concepts and trends.

Multiscale Approaches to Protein Modeling

Multiscale Approaches to Protein Modeling
  • Author : Andrzej Kolinski
  • Publisher : Springer
  • Release : 15 October 2010
GET THIS BOOK Multiscale Approaches to Protein Modeling

The book gives a comprehensive review of the most advanced multiscale methods for protein structure prediction, computational studies of protein dynamics, folding mechanisms and macromolecular interactions. It approaches span a wide range of the levels of coarse-grained representations, various sampling techniques and variety of applications to biomedical and biophysical problems. This book is intended to be used as a reference book for those who are just beginning their adventure with biomacromolecular modeling but also as a valuable source of detailed