Prognostic Epigenetics

Prognostic Epigenetics Book PDF
✏Book Title : Prognostic Epigenetics
✏Author :
✏Publisher : Academic Press
✏Release Date : 2019-11-01
✏Pages : 442
✏ISBN : 9780128142608
✏Available Language : English, Spanish, And French

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✏Prognostic Epigenetics Book Summary : This volume provides comprehensive information on how mapping an individual’s epigenome can be medically relevant and holds the potential to improve preventive medicine and precision therapeutics at an early-stage (prior to disease onset). In order to advance clinical adoption of the recently developed epigenetic approaches, it is necessary for translational scientists, clinicians, and students to gain a better understanding about epigenetic mechanisms that are associated with a particular disorder; and to be able to effectively identify biomarkers that can be applied in drug development and for better diagnosis and prognosis of diseases. Prognostic Epigenetics is the most-inclusive volume to-date specifically dedicated to epigenetic markers that have been developed for prognosis of diseases, recent advances in this field, the clinical implementation of this research, and the future outlook. Compiles all known information on prognostic epigenetics and its role in preventive medicine and drug discovery Covers the basic functionality of epigenetic mechanisms involved in early disease prognosis and diagnosis, and provides tools for the identification and development of these biomarkers for a wide range of diseases Enables clinicians, researchers, and pharmacologists to improve preventive medicine and precision therapeutics throughout a person’s lifetime Features chapter contributions from leading international researchers

Exam Prep For Prognostic Epigenetics Book PDF
✏Book Title : Exam Prep for Prognostic Epigenetics
✏Author :
✏Publisher :
✏Release Date :
✏Pages :
✏ISBN :
✏Available Language : English, Spanish, And French

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✏Exam Prep for Prognostic Epigenetics Book Summary :

📒Medical Epigenetics ✍ Trygve Tollefsbol

Medical Epigenetics Book PDF
✏Book Title : Medical Epigenetics
✏Author : Trygve Tollefsbol
✏Publisher : Academic Press
✏Release Date : 2016-06-21
✏Pages : 924
✏ISBN : 9780128032404
✏Available Language : English, Spanish, And French

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✏Medical Epigenetics Book Summary : Medical Epigenetics provides a comprehensive analysis of the importance of epigenetics to health management. The purpose of this book is to fill a current need for a comprehensive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic diseases that affect these systems and modes of treating epigenetic-based disorders and diseases. The intent of this book is to provide a stand-alone comprehensive volume that will cover all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. The overall goal is to provide the leading book on medical epigenetics that will be useful not only to physicians, nurses, medical students and many others directly involved with health care, but also investigators in life sciences, biotech companies, graduate students and many others who are interested in more applied aspects of epigenetics. Research in the area of translational epigenetics is a cornerstone of this volume. Critical reviews dedicated to the burgeoning role of epigenetics in medical practice Coverage of emerging topics including twin epigenetics as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Encompasses a disease-oriented perspective of medical epigenetics as well as diagnostic and prognostic epigenetic approaches to applied medicine

📒Epigenetics Methods ✍ Trygve Tollefsbol

Epigenetics Methods Book PDF
✏Book Title : Epigenetics Methods
✏Author : Trygve Tollefsbol
✏Publisher : Academic Press
✏Release Date : 2020-07-08
✏Pages : 736
✏ISBN : 9780128194157
✏Available Language : English, Spanish, And French

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✏Epigenetics Methods Book Summary : In recent years, the field of epigenetics has grown significantly, driving new understanding of human developmental processes and disease expression, as well as advances in diagnostics and therapeutics. As the field of epigenetics continues to grow, methods and technologies have multiplied, resulting in a wide range of approaches and tools researchers might employ. Epigenetics Methods offers comprehensive instruction in methods, protocols, and experimental approaches applied in field of epigenetics. Here, across thirty-five chapters, specialists offer step-by-step overviews of methods used to study various epigenetic mechanisms, as employed in basic and translational research. Leading the reader from fundamental to more advanced methods, the book begins with thorough instruction in DNA methylation techniques and gene or locus-specific methylation analyses, followed by histone modification methods, chromatin evaluation, enzyme analyses of histone methylation, and studies of non-coding RNAs as epigenetic modulators. Recently developed techniques and technologies discussed include single-cell epigenomics, epigenetic editing, computational epigenetics, systems biology epigenetic methods, and forensic epigenetic approaches. Epigenetics methods currently in-development, and their implication for future research, are also considered in-depth. In addition, as with the wider life sciences, reproducibility across experiments, labs, and subdisciplines is a growing issue for epigenetics researchers. This volume provides consensus-driven methods instruction and overviews. Tollefsbol and contributing authors survey the range of existing methods; identify best practices, common themes, and challenges; and bring unity of approach to a diverse and ever-evolving field. Includes contributions by leading international investigators involved in epigenetic research and clinical and therapeutic application Integrates technology and translation with fundamental chapters on epigenetics methods, as well as chapters on more novel and advanced epigenetics methods Written at verbal and technical levels that can be understood by scientists and students alike Includes chapters on state-of-the-art techniques such as single-cell epigenomics, use of CRISPR/Cas9 for epigenetic editing, and epigenetics methods applied to forensics

Epigenetics And Reproductive Health Book PDF
✏Book Title : Epigenetics and Reproductive Health
✏Author :
✏Publisher : Academic Press
✏Release Date : 2020-09-12
✏Pages : 444
✏ISBN : 9780128197547
✏Available Language : English, Spanish, And French

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✏Epigenetics and Reproductive Health Book Summary : Epigenetics and Reproductive Health, a new volume in the Translational Epigenetics series, provides a thorough overview and discussion of epigenetics in reproduction and implications for reproductive medicine. Twenty international researchers discuss epigenetic mechanisms operating during the formation of male and female gametes, fertilization and subsequent embryo and placental development, particularly in mammals and transgenerational epigenetic inheritance. This volume also addresses aberrant epigenetic changes influencing male and female infertility, pregnancy related disorders, and those potentially linked to therapeutic manipulations and assisted reproductive technologies. Emphasis is placed on identifying biomarkers for early detection of aberrant epigenetic mechanisms. Later chapters examine the possibility of correcting these epigenetic dysfunctions, as well as current challenges and next steps in research, enabling new translational discoveries and efforts towards developing therapeutics. Thoroughly examines the influence of aberrant epigenetics during gametogenesis and embryogenesis, affecting parents, gametes and embryos, offspring and future generations Explores health outcomes for reproductive senescence, endocrine disruption, testicular cancer, prostrate cancer, breast cancer, ovarian, cancer, endometrial cancer and cervical cancers Features chapter contributions from international researchers in the field

Developmental Human Behavioral Epigenetics Book PDF
✏Book Title : Developmental Human Behavioral Epigenetics
✏Author : Livio Provenzi
✏Publisher : Academic Press
✏Release Date : 2020-11-20
✏Pages : 188
✏ISBN : 9780128192634
✏Available Language : English, Spanish, And French

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✏Developmental Human Behavioral Epigenetics Book Summary : Developmental Human Behavioral Epigenetics: Principles, Methods, Evidence, and Future Directions, Volume 23, a new volume in the Translational Epigenetics series, offers the first systematic account of theoretical G79 frameworks, methodological approaches, findings, and future directions in the field of human behavioral epigenetics. Featuring contributions from leading scientists and international researchers, this book provides a comprehensive overview of human behavioral epigenetics, with a close examination of evidence gathered to-date from animal models, challenges of human-based research and clinical translation, pathways towards drug discovery, and next steps in research. Areas of focus include prenatal stress exposures, preterm behavioral epigenetics, intergenerational exposures, trauma and neglect, socio-economic conditions, maternal caregiving and attachment, study design, and epigenetics and psychotherapy. Enables more effective study design and methods application in behavioral epigenetics research across human and animal models Examines findings in human behavioral epigenetics to-date Features contributions from leading international researchers in behavioral epigenetics

Diagnostic Prognostic And Therapeutic Value Of Gene Signatures Book PDF
✏Book Title : Diagnostic Prognostic and Therapeutic Value of Gene Signatures
✏Author : Antonio Russo
✏Publisher : Springer Science & Business Media
✏Release Date : 2011-11-03
✏Pages : 182
✏ISBN : 1617793582
✏Available Language : English, Spanish, And French

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✏Diagnostic Prognostic and Therapeutic Value of Gene Signatures Book Summary : Gene expression studies have revealed diagnostic profiles and upregulation of specific pathways in many solid tumors. The explosion of new information in gene expression profiling could potentially lead to the development of tailored treatments in many solid tumors. In addition many studies are ongoing to validate these signatures also in predicting response to hormonal, chemotherapeutic and targeted agents in breast cancer as well as in other tumors. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures provides readers a useful and comprehensive resource about the range of applications of microarray technology in oncological diseases. Topics covered include gene signatures and soft tissue sarcomas, prognostic relevance of breast cancer signatures, gene expression profiling of colorectal cancer and liver metastasis, gene signatures in GISTs, CNVs and gene expression profiles in pancreatic cancer, and gene signatures in head/neck, lung and gastric tumors. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures will be of great value to residents and fellows, physicians, pathologists and medical oncologists.

📒Epigenetics And Disease ✍ Susan M. Gasser

Epigenetics And Disease Book PDF
✏Book Title : Epigenetics and Disease
✏Author : Susan M. Gasser
✏Publisher : Springer Science & Business Media
✏Release Date : 2010-10-17
✏Pages : 270
✏ISBN : 3764389893
✏Available Language : English, Spanish, And French

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✏Epigenetics and Disease Book Summary : Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders. Recent biomedical interest in this regulatory system stems from the fact that epigenetic, in contrast to genetic, alterations are in principle amenable to pharmacological intervention. A few epigenetically active drugs, for example histone deacetylase inhibitors (HDACi) and DNA methyltransferase (DNMT) inhibitors, have been approved by FDA for treatment of cancers such as CTCL, MDS, and AML. This volume explores the scientific background for clinical applications of epigenetically active drugs. Included are descriptions of epigenetic controls over gene expression, the post-transcriptional silencing of genes by RNA interference (RNAi) and microRNAs, as well as new findings from stem cell research which are relevant to pharmacological applications.

📒Epigenetics And Cancer ✍ Fazlul H. Sarkar

Epigenetics And Cancer Book PDF
✏Book Title : Epigenetics and Cancer
✏Author : Fazlul H. Sarkar
✏Publisher : Springer Science & Business Media
✏Release Date : 2013-05-29
✏Pages : 287
✏ISBN : 9789400766129
✏Available Language : English, Spanish, And French

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✏Epigenetics and Cancer Book Summary : Overall, this book illustrates the complexities of the regulation and deregulation of genes mediated through epigenetics in the development and progression of human malignancies. All the articles have been carefully chosen to represent several cancer systems with state of our knowledge on the role of epigenetic deregulation of microRNAs (miRNAs) and their target mRNAs along with epigenetic deregulation of mRNAs. This book also illustrates the role of several dietary agents, collectively called nutraceuticals or natural agents in modulating the epigenetic reprogramming of miRNAs and mRNAs for the prevention and/or treatment of human malignancies. It is well known that genetic aberrations, especially inherited through parents (somatic genetic alterations) contribute to the development of less than 10% of all cancer yet epigenetic alterations in genes especially through selective methylation and acetylation appears to be responsible for the development and progression of the vast majority of all cancers. Therefore, understanding the role of epigenetics in the regulation of genes especially through deregulated expression of miRNAs as presented in this book will allow scientists to devise targeted therapeutic strategies for re-expression of the lost genes or down-regulate the genes that are over-expressed in order to eradicate cancer. It is hoped that targeting epigenetics will not only target cancer cells but it will also target the tumor microenvironment (more like the entire tumor environment such as the entire host) for achieving better treatment outcomes for patients diagnosed with cancer which will lead to achieve the long-term objective for complete eradication of cancer. This book contains fifteen chapters which begins with the concept of systems and network biology for investigating the epigenetics of cancer followed by a series of articles on the role of miRNAs and their target genes in the biology of pancreatic cancer and other cancers such as breast, kidney, prostate and and colon. Since it is becoming increasingly clear that cancer stem cells (CSCs) are important in the development and progression of cancer, and CSCs are important in therapeutic resistance, treatment failure and tumor recurrence, thus the importance of CSCs and epigenetics has been highlighted by a very timely article on epigenetic variations of stem cell markers in cancer including miRNAs. Moreover, just targeting heterogeneous cancer cell populations may not be optimal to eradicate tumors and for which one must take a holistic approach for developing drugs that could also target the tumor microenvironment and tumor dormancy that are regulated through epigenetics. Keeping abreast with this thought process the concluding chapter provides a concept towards curative cancer therapy with maspin, which could be a unique window of opportunity to target tumor dormancy. Therefore, it suggest that targeting the tumor dormancy and the tumor microenvironment using novel therapeutics specifically by targeting epigenetics would become the future of medicine.

Epigenetics In Biology And Medicine Book PDF
✏Book Title : Epigenetics in Biology and Medicine
✏Author : Manel Esteller
✏Publisher : CRC Press
✏Release Date : 2008-09-17
✏Pages : 312
✏ISBN : 1420007076
✏Available Language : English, Spanish, And French

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✏Epigenetics in Biology and Medicine Book Summary : Anomalous epigenetic patterns touch many areas of study including biomedical, scientific, and industrial. With perspectives from international experts, this resource offers an all-inclusive overview of epigenetics, which bridge DNA information and function by regulating gene expression without modifying the DNA sequence itself. Epigenetics, in its

Diagnostic And Prognostic Biomarkers And Therapeutic Targets In Melanoma Book PDF
✏Book Title : Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma
✏Author : Michael J. Murphy
✏Publisher : Springer Science & Business Media
✏Release Date : 2011-12-02
✏Pages : 322
✏ISBN : 1607614332
✏Available Language : English, Spanish, And French

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✏Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma Book Summary : This book describes both the technologies used in the discovery of melanoma biomarkers and the clinical application of these biomarkers for diagnosis and staging of disease, determination of prognosis, treatment planning, monitoring of response to therapy, identification of novel therapeutic targets and drug development. A broad range of biomarkers (DNA/chromosomal, mRNA, microRNA, mitochondrial DNA, epigenetic and protein) is outlined. As therapies for melanoma become increasingly more target specific, the identification, validation and use of biomarkers will invariably play a greater role in the management of patients with this disease. Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma is an essential resource for oncologists, dermatologists, dermatopathologists, general pathologists with an interest in melanoma, and melanoma researchers.

📒Epigenetics And Human Health ✍ Alexander Haslberger

Epigenetics And Human Health Book PDF
✏Book Title : Epigenetics and Human Health
✏Author : Alexander Haslberger
✏Publisher : John Wiley & Sons
✏Release Date : 2011-08-24
✏Pages : 316
✏ISBN : 9783527644759
✏Available Language : English, Spanish, And French

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✏Epigenetics and Human Health Book Summary : After first introducing the concept of epigenetics, this handbook and ready reference provides an overview of the main research on epigenetics. It adopts a multidisciplinary approach, involving molecular biology, molecular epidemiology and nutritional science, with a special focus of the book is on disease prevention and treatment. Of interest to all healthcare-related professionals as well as nutritionists, and the medical community focusing on disease prevention.

Epigenetics And Cancer Book PDF
✏Book Title : Epigenetics and Cancer
✏Author :
✏Publisher : Academic Press
✏Release Date : 2010-11-23
✏Pages : 314
✏ISBN : 0123808650
✏Available Language : English, Spanish, And French

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✏Epigenetics and Cancer Book Summary : Genes interact with the environment, experience, and biology of the brain to shape an animal’s behavior. This latest volume in Advances in Genetics, organized according to the most widely used model organisms, describes the latest genetic discoveries in relation to neural circuit development and activity. Explores the latest topics in neural circuits and behavior research in zebrafish, drosophila, C.elegans, and mouse models Includes methods for testing with ethical, legal, and social implications Critically analyzes future prospects

Epigenetics And Dermatology Book PDF
✏Book Title : Epigenetics and Dermatology
✏Author : Qianjin Lu
✏Publisher : Academic Press
✏Release Date : 2015-02-16
✏Pages : 520
✏ISBN : 9780128012727
✏Available Language : English, Spanish, And French

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✏Epigenetics and Dermatology Book Summary : Epigenetics and Dermatology explores the role of epigenetics in the pathogenesis of autoimmune-related skin diseases and skin cancer. Leading contributors cover common and uncommon skin conditions in which extensive epigenetic research has been done. They explain how environmental exposures (chemicals, drugs, sunlight, diet, stress, smoking, infection, etc.) in all stages of life (from a fetus in-utero to an elderly person) may result in epigenetic changes that lead to development of some skin diseases in life. They also discuss the possibilities of new and emergent epigenetic treatments which are gradually being adopted in management of various skin diseases. Chapters follow a conventional structure, covering fundamental biology of the disease condition, etiology and pathogenesis, diagnosis, commonly available treatments, and epigenetic therapy where applicable. Discusses the basic biology of skin diseases and skin cancers induced or aggravated by aberrant epigenetic changes Evaluates how to approach autoimmune-related skin diseases from a therapeutic perspective using the wealth of emergent epigenetic clinical trials Offers a coherent and structured table of contents with basic epigenetic biology followed by discussion of the spectrum of rheumatologic through neoplastic skin diseases, finally ending with a discourse on epigenetic therapy

Alterations Of Epigenetics And Micrornas In Cancer And Cancer Stem Cell Book PDF
✏Book Title : Alterations of Epigenetics and MicroRNAs in Cancer and Cancer Stem Cell
✏Author : Yoshimasa Saito
✏Publisher : Frontiers E-books
✏Release Date : 2014-11-10
✏Pages : 79
✏ISBN : 9782889193455
✏Available Language : English, Spanish, And French

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✏Alterations of Epigenetics and MicroRNAs in Cancer and Cancer Stem Cell Book Summary : Studies have shown that alterations of epigenetics and microRNAs (miRNAs) play critical roles in the initiation and progression of human cancer. Epigenetic silencing of tumor suppressor genes in cancer cells is generally mediated by DNA hypermethylation of CpG island promoter and histone modification such as methylation of histone H3 lysine 9 (H3K9) and tri-methylation of H3K27. MiRNAs are small non-coding RNAs that regulate expression of various target genes. Specific miRNAs are aberrantly expressed and play roles as tumor suppressors or oncogenes during carcinogenesis. Important tumor suppressor miRNAs are silenced by epigenetic alterations, resulting in activation of target oncogenes in human malignancies. Stem cells have the ability to perpetuate themselves through self-renewal and to generate mature cells of various tissues through differentiation. Accumulating evidence suggests that a subpopulation of cancer cells with distinct stem-like properties is responsible for tumor initiation, invasive growth, and metastasis formation, which is defined as cancer stem cells. Cancer stem cells are considered to be resistant to conventional chemotherapy and radiation therapy, suggesting that these cells are important targets of cancer therapy. DNA methylation, histone modification and miRNAs may be deeply involved in stem-like properties in cancer cells. Restoring the expression of tumor suppressor genes and miRNAs by chromatin modifying drugs may be a promising therapeutic approach for cancer stem cells. In this Research Topic, we discuss about alterations of epigenetics and miRNAs in cancer and cancer stem cell and understand the molecular mechanism underlying the formation of cancer stem cell, which may provide a novel insight for treatment of refractory cancer.

Specific Gene Expression And Epigenetics Book PDF
✏Book Title : Specific Gene Expression and Epigenetics
✏Author : Kasirajan Ayyanathan
✏Publisher : CRC Press
✏Release Date : 2014-03-18
✏Pages : 328
✏ISBN : 9781771880367
✏Available Language : English, Spanish, And French

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✏Specific Gene Expression and Epigenetics Book Summary : This new volume on gene expression and epigenetics discusses environmental effects related to specific gene expression. The book also shows methods for bioinformatic analysis of the epigenome. The book is broken into two sections: the first looks at eukaryotic DNA methylation and the second addresses how to integrate genomic medicine into clinical practice. The book includes chapters on these topics: • Gene expression in colon cancer tissue • Epigenetics in human acute kidney injury • Embryologically relevant candidate genes in MRKH patients • DNA methylation in common skeletal disorders • Causal relationships in genomics • Predicting severe asthma exacerbations in children • Epigenetic understanding of gene-environment interactions in psychiatric disorders

📒Epigenetics In Human Disease ✍ Trygve Tollefsbol

Epigenetics In Human Disease Book PDF
✏Book Title : Epigenetics in Human Disease
✏Author : Trygve Tollefsbol
✏Publisher : Academic Press
✏Release Date : 2012-07-26
✏Pages : 592
✏ISBN : 9780123884169
✏Available Language : English, Spanish, And French

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✏Epigenetics in Human Disease Book Summary : Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usage Side-by-side coverage of the basis of epigenetic diseases and their treatments Evaluation of recent epigenetic clinical breakthroughs

📒Cns Cancer ✍ Erwin G. Van Meir

Cns Cancer Book PDF
✏Book Title : CNS Cancer
✏Author : Erwin G. Van Meir
✏Publisher : Springer Science & Business Media
✏Release Date : 2009-08-15
✏Pages : 1284
✏ISBN : 1603275533
✏Available Language : English, Spanish, And French

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✏CNS Cancer Book Summary : Cancers of the central nervous system are among the most lethal of human neoplasms. They are recalcitrant to even intensive multimodality therapies that include surgery, radiotherapy, and chemotherapy. Moreover, especially in children, the consequences of these therapies can itself be devastating and involve serious cognitive and developmental disorders. It is small wonder that such cancers have come under the intense scrutiny of each of the subspecialties of clinical care and investigation as well as attracting some of the best basic research scientists. Their joint efforts are gradually peeling away the mysteries surrounding the genesis and progression of these tumors and inroads are being steadily made into understanding why they resist therapies. This makes it an especially opportune time to assemble some of the best investigators in the field to review the ‘‘state of the art’’ in the various arenas that comprise the assault on CNS tumors. The breadth of this effort by the clinical and basic neuro-oncology community is quite simply amazing. To a large extent, it evolves from the knowledge of the human genome and its regulation that has been hard won over the past two decades.

📒Cancer Epigenetics ✍ Mukesh Verma

Cancer Epigenetics Book PDF
✏Book Title : Cancer Epigenetics
✏Author : Mukesh Verma
✏Publisher : Humana Press
✏Release Date : 2014-11-25
✏Pages : 804
✏ISBN : 1493918036
✏Available Language : English, Spanish, And French

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✏Cancer Epigenetics Book Summary : This volume shares technologies that detect common epigenetic changes which are very important in the early detection, progression, and prognosis of cancer as well as the design of new therapeutic tools against cancer cells. Beginning with a bit of background on epigenetic mechanisms, Cancer Epigenetics: Risk Assessment, Diagnosis, Treatment, and Prognosis continues with cancer specific type epigenetic change, methods and technologies used for detecting epigenetic changes, factors that influence epigenetic changes in cancer, as well as a final section on future directions in the field. Written for the highly successful Methods in Molecular Biology series, chapters in this volume include the kind of detailed implementation advice that guarantees easily reproducible results. Comprehensive and practical, Cancer Epigenetics: Risk Assessment, Diagnosis, Treatment, and Prognosis provides the most up-to-date knowledge of epigenetics and its implication in cancer prevention by risk assessment and screening and cancer control by treatment.

📒Patho Epigenetics Of Disease ✍ Janos Minarovits

Patho Epigenetics Of Disease Book PDF
✏Book Title : Patho Epigenetics of Disease
✏Author : Janos Minarovits
✏Publisher : Springer Science & Business Media
✏Release Date : 2012-06-14
✏Pages : 466
✏ISBN : 9781461433453
✏Available Language : English, Spanish, And French

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✏Patho Epigenetics of Disease Book Summary : In multicellular organisms the establishment, maintenance, and programmed alterations of cell-type specific gene expression patterns are regulated by epigenetic mechanisms. Thus, epigenetic alterations (DNA methylation, DNA associated Polycomb-Trithorax protein complexes, histone modifications) ensure the unique transcriptional activity and phenotypic diversity of diploid cells that carry identical or nearly identical DNA sequences. Because DNA methyltransferase I (DNMT1) associates with replication foci during S phase and prefers hemimethylated DNA as a substrate, DNMT1 ensures the clonal propagation of cytosine methylation patterns (maintenance methylation). Thus, DNA methylation may provide a memory function by helping progeny cells to “remember” their proper cellular identity. An alternative system of epigenetic memory, the Polycomb and Trithorax groups of protein complexes, that may operate both independently from and in concert with DNA methylation, ensures the heritable regulation of gene expression via modification of histone tails. The complex interplay of epigenetic regulatory mechanisms permits both the dynamic modulation of gene expression and the faithful transmission of gene expression patterns to each progeny cell upon division. These carefully orchestrated processes can go wrong, however, resulting in epigenetic reprogramming of the cells that may manifest in pathological changes, as it was first realized during the studies of epigenetic alterations in malignant tumors. By now it became a well established fact that not only genetic changes, but also the disruption of epigenetic regulation can result in carcinogenesis and tumor progression. Scientists working in other fields soon followed the pioneering work of cancer researchers, and revealed that epigenetic dysregulation forms the basis of a wide spectrum of human diseases.

Dna Methylation Epigenetics And Metastasis Book PDF
✏Book Title : DNA Methylation Epigenetics and Metastasis
✏Author : Manel Esteller
✏Publisher : Springer Science & Business Media
✏Release Date : 2006-03-30
✏Pages : 310
✏ISBN : 9781402036422
✏Available Language : English, Spanish, And French

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✏DNA Methylation Epigenetics and Metastasis Book Summary : This book provides a broad and rich outline of the epigenetic mechanisms involved in cancer progression and the generation of metastasis. It describes the tumor suppressor genes undergoing transcriptional silencing by CpG island promoter hypermethylation in the different tumor types of the human anatomy and their association with tumoral behaviour. It also provides a comprehensive insightful look at the molecular players involved in DNA methylation, histone modification and chromatin remodelling complexes causing epigenetic lesions linked to the metastasic phenotypes. Finally, it explains how epigenetic lesions associated with cancer spreading can be targeted using new and potent chemotherapy drugs. The book is a state-of-the-art reference to all scientific researchers and clinicians interested in the understanding of the biological processes leading to tumor dissemination and to those that are keen to translate this knowledge to a better management of cancer patients. Each contributor is a specialist in their epigenetic area and their joint effort has created a unique view of the DNA methylation, histone and chromatin changes that define cancer metastasis.

📒Metastasis Of Colorectal Cancer ✍ Nicole Beauchemin

Metastasis Of Colorectal Cancer Book PDF
✏Book Title : Metastasis of Colorectal Cancer
✏Author : Nicole Beauchemin
✏Publisher : Springer Science & Business Media
✏Release Date : 2010-07-23
✏Pages : 416
✏ISBN : 9048188334
✏Available Language : English, Spanish, And French

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✏Metastasis of Colorectal Cancer Book Summary : Colorectal cancer is the third most common cancer worldwide, and in many parts of the western world, it is the second leading cause of cancer-related deaths. This book covers colon cancer metastasis from the most fundamental aspects to clinical practice. Major topics include physiopathology, genetic and epigenetic controls, cancer initiating cells, epithelial-mesenchymal transition, growth factors and signalling, cell adhesion, natures of liver metastasis, angiogenesis and lymphangiogenesis, inflammatory response, prognostic markers, sentinel node and staging, and finally diagnosis and treatment. Each chapter has been contributed by leaders in the field. A key feature is that it connects with a large readership including students, fundamentalists and clinicians. Another specific feature of the book is that the chapters are written in a didactic and illustrative fashion. These characteristics coupled with the choice of the topics and authors, makes this book a reference in the field. It represents an essential acquisition for medical libraries, clinicians as well as medical and graduate students.

Methods Of Cancer Diagnosis Therapy And Prognosis Book PDF
✏Book Title : Methods of Cancer Diagnosis Therapy and Prognosis
✏Author : M. A. Hayat
✏Publisher : Springer Science & Business Media
✏Release Date : 2008-11-21
✏Pages : 602
✏ISBN : 9781402084423
✏Available Language : English, Spanish, And French

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✏Methods of Cancer Diagnosis Therapy and Prognosis Book Summary : Cancer is the leading cause of death, in the number of older cancer patients is after cardiovascular diseases, in the expected. Approximately, 77% of all types United States. A total of ? 1,399,790 new of cancers are diagnosed in persons of 55 cancer cases and ? 564,830 deaths were years and older. It was estimated that o- reported in the year 2006 in the country. third of the 559,650 cancer deaths in 2007 Approximately, one in every two men and in the United States were related to ov- one in every three women in the country weight or obesity, physical inactivity, and will have some type of cancer during nutrition, and thus could also be prevented their lifetime. Healthcare costs exceed (Am. Cancer Society, 2007). However, 1. 7 trillion dollars per year in the United in developed countries, including United States, which is ? 15% of the country’s States, the average person of 65 years can gross domestic product. expect to live another 15 years in a fairly Tobacco use is the most serious prevent- good health. Persons of 75 or 85 years old able cause of cancer. Tobacco use causes have an average expectancy of 10 and 6 cancer of the lung, throat, mouth, pancreas, years, respectively. urinary bladder, stomach, liver, kidney, and During the last three decades, intensive other types. Passive smoking causes lung clinical research has resulted in reduced cancer.

Epigenetics In Cancer The Myelodysplastic Syndrome As A Model To Study Epigenetic Alterations As Diagnostic And Prognostic Biomarkers Book PDF
✏Book Title : Epigenetics in Cancer The Myelodysplastic Syndrome as a Model to Study Epigenetic Alterations as Diagnostic and Prognostic Biomarkers
✏Author : Teresa de Souza
✏Publisher :
✏Release Date : 2012
✏Pages :
✏ISBN : OCLC:1154240525
✏Available Language : English, Spanish, And French

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✏Epigenetics in Cancer The Myelodysplastic Syndrome as a Model to Study Epigenetic Alterations as Diagnostic and Prognostic Biomarkers Book Summary : Epigenetics in Cancer: The Myelodysplastic Syndrome as a Model to Study Epigenetic Alterations as Diagnostic and Prognostic Biomarkers.

Bioinformatics For Diagnosis Prognosis And Treatment Of Complex Diseases Book PDF
✏Book Title : Bioinformatics for Diagnosis Prognosis and Treatment of Complex Diseases
✏Author : Bairong Shen
✏Publisher : Springer Science & Business Media
✏Release Date : 2013-11-25
✏Pages : 220
✏ISBN : 9789400779754
✏Available Language : English, Spanish, And French

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✏Bioinformatics for Diagnosis Prognosis and Treatment of Complex Diseases Book Summary : The book introduces the bioinformatics tools, databases and strategies for the translational research, focuses on the biomarker discovery based on integrative data analysis and systems biological network reconstruction. With the coming of personal genomics era, the biomedical data will be accumulated fast and then it will become reality for the personalized and accurate diagnosis, prognosis and treatment of complex diseases. The book covers both state of the art of bioinformatics methodologies and the examples for the identification of simple or network biomarkers. In addition, bioinformatics software tools and scripts are provided to the practical application in the study of complex diseases. The present state, the future challenges and perspectives were discussed. The book is written for biologists, biomedical informatics scientists and clinicians, etc. Dr. Bairong Shen is Professor and Director of Center for Systems Biology, Soochow University; he is also Director of Taicang Center for Translational Bioinformatics.

Circulating Nucleic Acids In Early Diagnosis Prognosis And Treatment Monitoring Book PDF
✏Book Title : Circulating Nucleic Acids in Early Diagnosis Prognosis and Treatment Monitoring
✏Author : Peter B. Gahan
✏Publisher : Springer
✏Release Date : 2014-11-18
✏Pages : 471
✏ISBN : 9789401791687
✏Available Language : English, Spanish, And French

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✏Circulating Nucleic Acids in Early Diagnosis Prognosis and Treatment Monitoring Book Summary : DNA and RNA fractions can be isolated from a variety of body fluids including whole blood, serum, plasma, urine, saliva and cerebrospinal fluid from both patients and healthy individuals. Such isolates can be exploited in the early detection of clinical disorders, stratification of patients for treatment, treatment monitoring and clinical follow-up. In addition, the use in fetal medicine allows the early detection of fetal sex, Rh factor and aneuploid disorders as well as following both fetal and premature born infant development. This volume is intended as a primer for those who are interested in entering the field of circulating nucleic acids. The areas covered in this volume include: · Background and general biology of circulating nucleic acids · Methodology · Applications of circulating nucleic acids · Quality Assurance · Ethics

Epigenetics In Cancer Prevention Book PDF
✏Book Title : Epigenetics in Cancer Prevention
✏Author : Mukesh Verma
✏Publisher :
✏Release Date : 2003
✏Pages : 330
✏ISBN : UVA:X004686584
✏Available Language : English, Spanish, And French

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✏Epigenetics in Cancer Prevention Book Summary : This volume addresses the question of how knowledge of epigenetic phenomena like DNA methylation and acetylation can be applied to early cancer detection and risk assessment. The objectives of the papers include defining the terminology used in epigenetics.

📒Epigenetic Markers ✍ M. Widschwendter

Epigenetic Markers Book PDF
✏Book Title : Epigenetic Markers
✏Author : M. Widschwendter
✏Publisher : IOS Press
✏Release Date : 2007
✏Pages : 137
✏ISBN : 1586037226
✏Available Language : English, Spanish, And French

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✏Epigenetic Markers Book Summary : DNA methylation is an epigenetic process that occurs when a methyl group binds to one of DNA's four bases, cytosine. These changes are responsible for controlling the activity of genes by turning them off. This book contains ten articles that explore the details and challenges of cancer epigenetics.

Leukemia Book PDF
✏Book Title : Leukemia
✏Author :
✏Publisher : Demos Medical Publishing
✏Release Date : 2011-08-29
✏Pages : 264
✏ISBN : 9781935281429
✏Available Language : English, Spanish, And French

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✏Leukemia Book Summary : This issue of Emerging Cancer Therapeutics provides a comprehensive review for practitioners on the current status of leukemia treatment. Leukemia treatment has undergone major change over the course of the past few years and Leukemia addresses current best practices in the light of the most recent evidence. With contributions from experts across the US and Canada, Leukemia details the current management of different types of leukemia and reviews new therapies in development for various forms of acute leukemia, chronic leukemia, myelodysplastic syndrome, and myeloproliferative disorders. Coverage includes new developments in hematopoitic cell transplantation, leukemia pathology and management, immunotherapy and targeted therapies. It is a valuable tool for clinicians, nurses, researchers, medical students, residents, and fellows. Emerging Cancer Therapeutics Series Titles Features: Editorial board of nationally recognized experts across the spectrum of Cancer Therapeutics In-depth, up-to-date expert reviews and analysis of major new developments in all areas of Cancer Therapeutics Issues edited by an authority in specific subject area Focuses on major topics in Cancer Therapeutics with in-depth articles covering advances in clinical and translational research developments, as well as clinical applications and experience Emphasizes multidisciplinary approaches to research and practice

Prognostic Variables In Node Negative And Node Positive Breast Cancer Book PDF
✏Book Title : Prognostic variables in node negative and node positive breast cancer
✏Author : Giampietro Gasparini
✏Publisher : Springer Science & Business Media
✏Release Date : 2012-12-06
✏Pages : 428
✏ISBN : 9781461551959
✏Available Language : English, Spanish, And French

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✏Prognostic variables in node negative and node positive breast cancer Book Summary :