Process Intensification

Re Engineering The Chemical Processing Plant Book PDF
✏Book Title : Re Engineering the Chemical Processing Plant
✏Author : Andrzej Stankiewicz
✏Publisher : CRC Press
✏Release Date : 2018-12-14
✏Pages : 368
✏ISBN : 0203913299
✏Available Language : English, Spanish, And French

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✏Re Engineering the Chemical Processing Plant Book Summary : The first guide to compile current research and frontline developments in the science of process intensification (PI), Re-Engineering the Chemical Processing Plant illustrates the design, integration, and application of PI principles and structures for the development and optimization of chemical and industrial plants. This volume updates professionals on emerging PI equipment and methodologies to promote technological advances and operational efficacy in chemical, biochemical, and engineering environments and presents clear examples illustrating the implementation and application of specific process-intensifying equipment and methods in various commercial arenas.

Process Intensification Book PDF
✏Book Title : Process Intensification
✏Author : David Reay
✏Publisher : Butterworth-Heinemann
✏Release Date : 2013-06-05
✏Pages : 624
✏ISBN : 9780080983059
✏Available Language : English, Spanish, And French

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✏Process Intensification Book Summary : Process Intensification: Engineering for Efficiency, Sustainability and Flexibility is the first book to provide a practical working guide to understanding process intensification (PI) and developing successful PI solutions and applications in chemical process, civil, environmental, energy, pharmaceutical, biological, and biochemical systems. Process intensification is a chemical and process design approach that leads to substantially smaller, cleaner, safer, and more energy efficient process technology. It improves process flexibility, product quality, speed to market and inherent safety, with a reduced environmental footprint. This book represents a valuable resource for engineers working with leading-edge process technologies, and those involved research and development of chemical, process, environmental, pharmaceutical, and bioscience systems. No other reference covers both the technology and application of PI, addressing fundamentals, industry applications, and including a development and implementation guide Covers hot and high growth topics, including emission prevention, sustainable design, and pinch analysis World-class authors: Colin Ramshaw pioneered PI at ICI and is widely credited as the father of the technology

Process Intensification Book PDF
✏Book Title : Process Intensification
✏Author : David Reay
✏Publisher : Butterworth-Heinemann
✏Release Date : 2011-04-08
✏Pages : 472
✏ISBN : 0080558089
✏Available Language : English, Spanish, And French

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✏Process Intensification Book Summary : Process intensification (PI) is a chemical and process design approach that leads to substantially smaller, cleaner, safer and more energy-efficient process technology. A hot topic across the chemical and process industries, this is the first book to provide a practical working guide to understanding and developing successful PI solutions that deliver savings and efficiencies. It will appeal to engineers working with leading-edge process technologies and those involved research and development of chemical, process, environmental, pharmaceutical, and bioscience systems. * Shows chemical and process engineers how to apply process intensification to their system, process or operation * A hard-working reference and user guide to the technology AND application of PI, covering fundamentals, industry applications, supplemented by a development and implementation guide * Leading author team, including Professor Colin Ramshaw, developer of the HiGee high-gravity distillation process at ICI, widely credited as the instigator of PI principles

📒Process Intensification ✍ Fernando Israel Gómez-Castro

Process Intensification Book PDF
✏Book Title : Process Intensification
✏Author : Fernando Israel Gómez-Castro
✏Publisher : de Gruyter
✏Release Date : 2019-09-15
✏Pages : 320
✏ISBN : 3110596075
✏Available Language : English, Spanish, And French

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✏Process Intensification Book Summary : Intensified processes have found widespread application in the chemical and petrochemical industries. The use of intensified systems allows for a reduction of operating costs and supports the "greening" of chemical processes. However, the design of intensified equipment requires special methodologies. This book describes the fundamentals and applications of these design methods, making it a valuable resource for use in both industry and academia.

Process Intensification Technologies For Green Chemistry Book PDF
✏Book Title : Process Intensification Technologies for Green Chemistry
✏Author : Kamelia Boodhoo
✏Publisher : John Wiley & Sons
✏Release Date : 2013-01-03
✏Pages : 432
✏ISBN : 9781118498538
✏Available Language : English, Spanish, And French

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✏Process Intensification Technologies for Green Chemistry Book Summary : The successful implementation of greener chemical processesrelies not only on the development of more efficient catalysts forsynthetic chemistry but also, and as importantly, on thedevelopment of reactor and separation technologies which candeliver enhanced processing performance in a safe, cost-effectiveand energy efficient manner. Process intensification has emerged asa promising field which can effectively tackle the challenges ofsignificant process enhancement, whilst also offering the potentialto diminish the environmental impact presented by the chemicalindustry. Following an introduction to process intensification and theprinciples of green chemistry, this book presents a number ofintensified technologies which have been researched and developed,including case studies to illustrate their application to greenchemical processes. Topics covered include: • Intensified reactor technologies: spinning discreactors, microreactors, monolith reactors, oscillatory flowreactors, cavitational reactors • Combined reactor/separator systems: membrane reactors,reactive distillation, reactive extraction, reactiveabsorption • Membrane separations for green chemistry • Industry relevance of process intensification,including economics and environmental impact, opportunities forenergy saving, and practical considerations for industrialimplementation. Process Intensification for Green Chemistry is a valuableresource for practising engineers and chemists alike who areinterested in applying intensified reactor and/or separator systemsin a range of industries to achieve green chemistry principles.

The Fundamentals Of Process Intensification Book PDF
✏Book Title : The Fundamentals of Process Intensification
✏Author : Andrzej Stankiewicz
✏Publisher : John Wiley & Sons
✏Release Date : 2019-06-13
✏Pages : 350
✏ISBN : 9783527680153
✏Available Language : English, Spanish, And French

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✏The Fundamentals of Process Intensification Book Summary : This advanced textbook covering the fundamentals and industry applications of process intensification (PI) discusses both the theoretical and conceptual basis of the discipline. Since interdisciplinarity is a key feature of PI, the material contained in the book reaches far beyond the classical area of chemical engineering. Developments in other relevant disciplines, such as chemistry, catalysis, energy technology, applied physics, electronics and materials science, are extensively described and discussed, while maintaining a chemical engineering perspective. Divided into three major parts, the first introduces the PI principles in detail and illustrates them using practical examples. The second part is entirely devoted to fundamental approaches of PI in four domains: spatial, thermodynamic, functional and temporal. The third and final part explores the methodology for applying fundamental PI approaches in practice. As well as detailing technologies, the book focuses on safety, energy and environmental issues, giving guidance on how to incorporate PI in plant design and operation -- safely, efficiently and effectively.

Process Intensification Technologies For Biodiesel Production Book PDF
✏Book Title : Process Intensification Technologies for Biodiesel Production
✏Author : Anton Alexandru Kiss
✏Publisher : Springer Science & Business Media
✏Release Date : 2014-03-15
✏Pages : 103
✏ISBN : 9783319035543
✏Available Language : English, Spanish, And French

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✏Process Intensification Technologies for Biodiesel Production Book Summary : This book is among the first to address the novel process intensification technologies for biodiesel production, in particular the integrated reactive separations. It provides a comprehensive overview illustrated with many industrially relevant examples of novel reactive separation processes used in the production of biodiesel (e.g. fatty acid alkyl esters): reactive distillation, reactive absorption, reactive extraction, membrane reactors, and centrifugal contact separators. Readers will also learn about the working principles, design and control of integrated processes, while also getting a relevant and modern overview of the process intensification opportunities for biodiesel synthesis. Biodiesel is a biodegradable and renewable fuel that currently enjoys much attention. In spite of the recent advances, the existing biodiesel processes still suffer from problems associated with the use of homogeneous catalysts (e.g. salt waste streams) and the key limitations imposed by the chemical reaction equilibrium, thus leading to severe economic and environmental penalties. The integration of reaction and separation into one operating unit overcomes equilibrium limitations and provides key benefits such as low capital investment and operating costs. Many of these processes can be further enhanced by heat-integration and powered by heterogeneous catalysts, to eliminate all conventional catalyst related operations, using the raw materials efficiently and the reaction volume, while offering high conversion and selectivity, and significant energy savings. The targeted audience of this book includes both academia (students and researchers) and industry (project leaders, technology managers, researchers, biodiesel producers, and equipment suppliers).

📒Process Intensification ✍ Jan Harmsen

Process Intensification Book PDF
✏Book Title : Process Intensification
✏Author : Jan Harmsen
✏Publisher : de Gruyter
✏Release Date : 2020-07-31
✏Pages : 220
✏ISBN : 3110657341
✏Available Language : English, Spanish, And French

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✏Process Intensification Book Summary : Process Intensification: Industrial practices is a book about Selection, Design, Modelling, Validation and Scale-up using integrated guiding principles of the Triple I model and Process Intensification (PI) methods. The book is of interest to industrial process developers, advanced students and educators, and all those looking to obtain process solutions in harmony with all modal aspects of reality.

Process Intensification And Integration For Sustainable Design Book PDF
✏Book Title : Process Intensification and Integration for Sustainable Design
✏Author : Dominic C. Y. Foo
✏Publisher : John Wiley & Sons
✏Release Date : 2021-02-16
✏Pages : 352
✏ISBN : 9783527345472
✏Available Language : English, Spanish, And French

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✏Process Intensification and Integration for Sustainable Design Book Summary : Presents comprehensive coverage of process intensification and integration for sustainable design, along with fundamental techniques and experiences from the industry Drawing from fundamental techniques and recent industrial experiences, this book discusses the many developments in process intensification and integration and focuses on increasing sustainability via several overarching topics such as Sustainable Manufacturing, Energy Saving Technologies, and Resource Conservation and Pollution Prevention Techniques. Process Intensification and Integration for Sustainable Design starts discussions on: shale gas as an option for the production of chemicals and challenges for process intensification; the design and techno-economic analysis of separation units to handle feedstock variability in shale gas treatment; RO-PRO desalination; and techno-economic and environmental assessment of ultrathin polysulfone membranes for oxygen-enriched combustion. Next, it looks at process intensification of membrane-based systems for water, energy, and environment applications; the design of internally heat-integrated distillation column (HIDiC); and graphical analysis and integration of heat exchanger networks with heat pumps. Decomposition and implementation of large-scale interplant heat integration is covered, as is the synthesis of combined heat and mass exchange networks (CHAMENs) with renewables. The book also covers optimization strategies for integrating and intensifying housing complexes; a sustainable biomass conversion process assessment; and more. Covers the many advances and changes in process intensification and integration Provides side-by-side discussions of fundamental techniques and recent industrial experiences to guide practitioners in their own processes Presents comprehensive coverage of topics relevant, among others, to the process industry, biorefineries, and plant energy management Offers insightful analysis and integration of reactor and heat exchanger network Looks at optimization of integrated water and multi-regenerator membrane systems involving multi-contaminants Process Intensification and Integration for Sustainable Design is an ideal book for process engineers, chemical engineers, engineering scientists, engineering consultants, and chemists.

📒Process Intensification In Chemical Engineering ✍ Juan Gabriel Segovia-Hernández

Process Intensification In Chemical Engineering Book PDF
✏Book Title : Process Intensification in Chemical Engineering
✏Author : Juan Gabriel Segovia-Hernández
✏Publisher : Springer
✏Release Date : 2016-04-02
✏Pages : 336
✏ISBN : 9783319283920
✏Available Language : English, Spanish, And French

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✏Process Intensification in Chemical Engineering Book Summary : This book will provide researchers and graduate students with an overview of the recent developments and applications of process intensification in chemical engineering. It will also allow the readers to apply the available intensification techniques to their processes and specific problems. The content of this book can be readily adopted as part of special courses on process control, design, optimization and modelling aimed at senior undergraduate and graduate students. This book will be a useful resource for researchers in process system engineering as well as for practitioners interested in applying process intensification approaches to real-life problems in chemical engineering and related areas.

Modeling Of Process Intensification Book PDF
✏Book Title : Modeling of Process Intensification
✏Author : Frerich Keil
✏Publisher : John Wiley & Sons
✏Release Date : 2007-04-09
✏Pages : 405
✏ISBN : 9783527311439
✏Available Language : English, Spanish, And French

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✏Modeling of Process Intensification Book Summary : Combining the knowledge involved in process engineering and process modeling, this title covers modeling methods applicable to process intensification.

Process Synthesis And Process Intensification Book PDF
✏Book Title : Process Synthesis and Process Intensification
✏Author : Ben-Guang Rong
✏Publisher : Walter de Gruyter GmbH & Co KG
✏Release Date : 2017-09-25
✏Pages : 426
✏ISBN : 9783110465150
✏Available Language : English, Spanish, And French

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✏Process Synthesis and Process Intensification Book Summary : Process synthesis and process intensification arebecomingstate-of-the-art scientific fields that provide the methods and tools to improve process technologies in terms of high energy efficiency, low capital investment, low emissions, improved safety, and less hazardous byproducts to achieve sustainable products and processes. The book covers manufacturing processes from both fossil- and biomass-based feedstocks for graduate students.

Process Intensification By Ultrasound Controlled Cavitation Book PDF
✏Book Title : Process Intensification by Ultrasound Controlled Cavitation
✏Author :
✏Publisher :
✏Release Date : 2019
✏Pages :
✏ISBN : 9177903846
✏Available Language : English, Spanish, And French

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✏Process Intensification by Ultrasound Controlled Cavitation Book Summary :

Process Intensification Dedicated To The Xx Brazilian Congress On Chemical Engineering Book PDF
✏Book Title : Process Intensification Dedicated to the XX Brazilian Congress on Chemical Engineering
✏Author : Regina de Fátima Peralta Muniz Moreira
✏Publisher :
✏Release Date : 2016
✏Pages :
✏ISBN : OCLC:964516931
✏Available Language : English, Spanish, And French

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✏Process Intensification Dedicated to the XX Brazilian Congress on Chemical Engineering Book Summary :

Microreactor Technology And Process Intensification Book PDF
✏Book Title : Microreactor Technology and Process Intensification
✏Author : Yong Wang
✏Publisher : Amer Chemical Society
✏Release Date : 2005
✏Pages : 444
✏ISBN : UOM:39015062426799
✏Available Language : English, Spanish, And French

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✏Microreactor Technology and Process Intensification Book Summary : Microreaction technology, with its unprecedented heat and mass transfer advantages as well as uniform residence time and flow pattern, is one of the few technologies with potential to develop efficient, environmentally benign, and compact processes. Novel fabrication and processing techniques, equipment, and operational methods are resulting in spectacular developments that go beyond "traditional" chemical engineering. These new developments promise improvements in process plants, and lead to the transformation of our concept of chemical plants into compact, safe, energy-efficient, and environmentally sustainable processes. Microsystems are now available in many devices for commercial applications including: micromixers and microreactors as alternative to batch production in pharmaceutical and fine chemical industry, lab-on-chip devices, microsensors, advanced rapid throughput chemical and catalyst screening tools (e.g. combi), distributed or portable power and chemical production, distributed heating and cooling, and even out of this world applications with NASA. A wide diversity of subjects are discussed in this book ranging from catalysis to fuel processing to combinatorial techniques to separations to novel reactors all of which are enabled by microtechnology principles. World renowned pioneers (Klavs Jensen, Volker Hessel, Jennifer Holmgren, and Galip Akay) provide accounts on both historical developments and the current state of the art as well as insights into future research and development in microreactor and process intensification. Research and developments are presented by industry, universities, U.S. National Laboratories, and other laboratories located in the United States and throughout the world. It is composed of peer-reviewed chapters from both contributing and invited authors. The review and original research topics include (1) introductory and general overviews, (2) microreactors- including catalysts for microreactors, fuel processors, milli-second contact time catalysis, gas to liquid technology, and biomass conversion; and (3) process intensification such as micro mixers, reactive membranes, and intensification of separation operations.

📒Process Integration And Intensification ✍ Jirí Jaromír KlemeÅ¡

Process Integration And Intensification Book PDF
✏Book Title : Process Integration and Intensification
✏Author : Jirí Jaromír Klemeš
✏Publisher : Walter de Gruyter GmbH & Co KG
✏Release Date : 2014-05-26
✏Pages : 265
✏ISBN : 9783110368246
✏Available Language : English, Spanish, And French

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✏Process Integration and Intensification Book Summary : "The authors have provided all the elements required for complete understanding of the basic concepts in heat recovery and water minimization in chemical and related processes, and followed these with carefully selected and developed problems and solutions in order to ensure that the concepts delivered can be applied." Simon Perry, The University of Manchester. This graduate textbook covers fundamentals of the key areas of Process Integration and Intensification for intra-process heat recovery (Heat Integration), inter-process heat recovery and cogeneration (Total Site) as well as water conservation. Step by step working sessions are illustrated for deeper understanding of the taught materials. The textbook also provides a wealth of pointers as well as further information for readers to acquire more extensive materials on the diverse industrial applications and the latest development trends in Process Integration and Intensification. It is addressed to graduate students as well as professionals to help the effectively application of Process Integration and Intensification in plant design and operation.

Intensification Of Biobased Processes Book PDF
✏Book Title : Intensification of Biobased Processes
✏Author : Andrzej Gorak
✏Publisher : Royal Society of Chemistry
✏Release Date : 2018-06-18
✏Pages : 518
✏ISBN : 9781788010320
✏Available Language : English, Spanish, And French

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✏Intensification of Biobased Processes Book Summary : In recent years bioprocessing has increased in popularity and importance, however, bioprocessing still poses various important techno-economic and environmental challenges, such as product yields, excessive energy consumption for separations in highly watery systems, batch operation or the downstream processing bottlenecks in the production of biopharmaceutical products. Many of those challenges can be addressed by application of different process intensification technologies discussed in the present book. The first book dedicated entirely to this area, Intensification of Biobased Processesprovides a comprehensive overview of modern process intensification technologies used in bioprocessing. The book focusses on four different categories of biobased products: bio-fuels and platform chemicals; cosmeceuticals; food products; and polymers and advanced materials. It will cover various intensification aspects of the processes concerned, including (bio)reactor intensification; intensification of separation, recovery and formulation operations; and process integration. This is an invaluable source of information for researchers and industrialists working in chemical engineering, biotechnology and process engineering.

Reactive Separation For Process Intensification And Sustainability Book PDF
✏Book Title : Reactive Separation for Process Intensification and Sustainability
✏Author : Carlos Ariel Cardona Alzate
✏Publisher : CRC Press
✏Release Date : 2019-12-10
✏Pages : 272
✏ISBN : 0367281511
✏Available Language : English, Spanish, And French

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✏Reactive Separation for Process Intensification and Sustainability Book Summary : This book describes, analyses and discusses the main principles, phenomena and design strategies of reactive separation processes with an emphasis on the intensification as a basis of the sustainability. Different reactive separation processes are explained in detail to show the phenomena and with the purpose of understanding when their use allows advantages based on the output results. Case examples are analysed and the perspective of these processes in the future is discussed. The overall sustainability of reactive separation processes in the industry is also explained separately.

Laboratory Protocols For Process Intensification Book PDF
✏Book Title : Laboratory Protocols for Process Intensification
✏Author : I. E. Reynolds
✏Publisher :
✏Release Date : 2004
✏Pages : 265
✏ISBN : OCLC:1109659789
✏Available Language : English, Spanish, And French

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✏Laboratory Protocols for Process Intensification Book Summary :

📒Modular Plants And Process Intensification ✍ VOLKER. VURAL GURSEL HESSEL (IRIS.)

Modular Plants And Process Intensification Book PDF
✏Book Title : Modular Plants and Process Intensification
✏Author : VOLKER. VURAL GURSEL HESSEL (IRIS.)
✏Publisher :
✏Release Date : 2020
✏Pages :
✏ISBN : 3527339051
✏Available Language : English, Spanish, And French

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✏Modular Plants and Process Intensification Book Summary :

Advances In Process Intensification Through Multifunctional Reactor Engineering Book PDF
✏Book Title : Advances in Process Intensification Through Multifunctional Reactor Engineering
✏Author :
✏Publisher :
✏Release Date : 2012
✏Pages :
✏ISBN : OCLC:1065672802
✏Available Language : English, Spanish, And French

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✏Advances in Process Intensification Through Multifunctional Reactor Engineering Book Summary : This project was designed to advance the art of process intensification leading to a new generation of multifunctional chemical reactors. Experimental testing was performed in order to fully characterize the hydrodynamic operating regimes critical to process intensification and implementation in commercial applications. Physics of the heat and mass transfer and chemical kinetics and how these processes are ultimately scaled were investigated. Specifically, we progressed the knowledge and tools required to scale a multifunctional reactor for acid-catalyzed C4 paraffin/olefin alkylation to industrial dimensions. Understanding such process intensification strategies is crucial to improving the energy efficiency and profitability of multifunctional reactors, resulting in a projected energy savings of 100 trillion BTU/yr by 2020 and a substantial reduction in the accompanying emissions.

Process Intensification In Practice Book PDF
✏Book Title : Process Intensification in Practice
✏Author : J. Semel
✏Publisher : Wiley-Blackwell
✏Release Date : 1997-03-14
✏Pages : 319
✏ISBN : UOM:39015042166168
✏Available Language : English, Spanish, And French

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✏Process Intensification in Practice Book Summary : The papers from this second international conference bring ogether practical applications with research to promote opportunities for the exploitaion of process intensification and acclerate implementation.

📒Challenges In Process Intensification ✍ Christopher Adrian Pickles

Challenges In Process Intensification Book PDF
✏Book Title : Challenges in Process Intensification
✏Author : Christopher Adrian Pickles
✏Publisher :
✏Release Date : 1996
✏Pages : 523
✏ISBN : PSU:000032677867
✏Available Language : English, Spanish, And French

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✏Challenges in Process Intensification Book Summary :

Process Intensification For The Chemical Industry Book PDF
✏Book Title : Process Intensification for the Chemical Industry
✏Author : C. Ramshaw
✏Publisher : Wiley-Blackwell
✏Release Date : 1995-03-02
✏Pages : 184
✏ISBN : UOM:39015037437087
✏Available Language : English, Spanish, And French

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✏Process Intensification for the Chemical Industry Book Summary : This is a collection of the papers presented at the 1st International Conference on Process Intensification for the Chemical Industry, organized and sponsored by the BHR Group Limited, and held in Antwerp, Belgium on 6-8 December 1995.

Intensification Of Liquid Liquid Processes Book PDF
✏Book Title : Intensification of Liquid Liquid Processes
✏Author : Laurence R. Weatherley
✏Publisher : Cambridge University Press
✏Release Date : 2020-04-16
✏Pages : 376
✏ISBN : 9781108421010
✏Available Language : English, Spanish, And French

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✏Intensification of Liquid Liquid Processes Book Summary : Explore and review novel techniques for intensifying transport and reaction in liquid-liquid and related systems with this essential toolkit. Topics include discussion of the principles of process intensification, the nexus between process intensification and sustainable engineering, and the fundamentals of liquid-liquid contacting, from an expert with over forty-five years' experience in the field. Providing promising directions for investment and for new research in process intensification, in addition to a unique review of the fundamentals of the topic, this book is the perfect guide for senior undergraduate students, graduate students, developers, and research staff in chemical engineering and biochemical engineering.

Industrial Catalysis And Separations Book PDF
✏Book Title : Industrial Catalysis and Separations
✏Author : K. V. Raghavan
✏Publisher : CRC Press
✏Release Date : 2014-07-01
✏Pages : 514
✏ISBN : 9781926895963
✏Available Language : English, Spanish, And French

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✏Industrial Catalysis and Separations Book Summary : With contributions from experts from both the industry and academia, this book presents the latest developments in the identified areas. In addition, a thorough and updated coverage of the traditional aspects of heterogeneous catalysis such as preparation, characterization and use in well-established technologies such as nitration, ammoxidation and hydrofluorination is included. This book incorporates appropriate case studies, explanatory notes, and schematics for more clarity and better understanding.

Membrane Unit Operations In The Process Intensification Of Industrial Processes Book PDF
✏Book Title : Membrane Unit Operations in the Process Intensification of Industrial Processes
✏Author : E. Drioli
✏Publisher :
✏Release Date : 2003
✏Pages :
✏ISBN : OCLC:1139353697
✏Available Language : English, Spanish, And French

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✏Membrane Unit Operations in the Process Intensification of Industrial Processes Book Summary :

Recent Trends In Exploration Exploitation And Processing Of Petroleum Resources Book PDF
✏Book Title : Recent trends in exploration exploitation and processing of petroleum resources
✏Author : Sukumar Laik
✏Publisher : Tata McGraw-Hill Education
✏Release Date : 2009
✏Pages : 623
✏ISBN : 0070077282
✏Available Language : English, Spanish, And French

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✏Recent trends in exploration exploitation and processing of petroleum resources Book Summary :

Process Intensification Of Spodoptera Frugiperda Sf Cell Growth Via Multi Parallel Bioreactor System Book PDF
✏Book Title : Process Intensification of Spodoptera Frugiperda Sf Cell Growth Via Multi Parallel Bioreactor System
✏Author : Randy Stein (M.B.A.)
✏Publisher :
✏Release Date : 2020
✏Pages : 106
✏ISBN : OCLC:1191226292
✏Available Language : English, Spanish, And French

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✏Process Intensification of Spodoptera Frugiperda Sf Cell Growth Via Multi Parallel Bioreactor System Book Summary : The objective of this project is to improve the yield of the fed-batch manufacturing process for the production of Flublok influenza vaccine, which was approved by the FDA in 2018. In short, Spodoptera frugiperda (SF+) insect cells are grown to a specific target cell density and then infected with baculovirus containing the gene of interest (GOI). For this particular process, the recombinant hemagglutinin (rHA) is extracted from the cell and used to produce the influenza vaccine. Protein Sciences developed a fed-batch process which improved on the traditional batch process by feeding supplementary nutrients to boost cell growth. The Fed-Batch process doubled the target cell density at the time of infection which resulted in a two-fold increase in the final yield of rHA and a 30% reduction in cost of goods. This Fed-Batch process can be further optimized to increase rHA yield and reduce the cost of goods. It is important to note that simply increasing cell biomass is not enough; the cells must also be able to produce rHA at a similar specific productivity in order to increase the yield. Exploratory process improvement experiments were performed on the ambr250 ® multi-parallel bioreactor system, with the goal of identifying the growth conditions for maximizing SF+ cell density. The conditions yielding the best results from these experiments were replicated in 3L glass bioreactors. Using data from these experiments, an optimized Fed-batch process can be developed. In addition, a statistical model was developed to relate key process parameters to SF+ cell density. This model can be used to quantitively ascertain how cell density is impacted by changing process parameters.

Proceedings Of The 8th International Conference On Foundations Of Computer Aided Process Design Book PDF
✏Book Title : Proceedings of the 8th International Conference on Foundations of Computer Aided Process Design
✏Author :
✏Publisher : Elsevier
✏Release Date : 2014-07-14
✏Pages : 840
✏ISBN : 9780444634429
✏Available Language : English, Spanish, And French

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✏Proceedings of the 8th International Conference on Foundations of Computer Aided Process Design Book Summary : This volume collects together the presentations at the Eighth International Conference on Foundations of Computer-Aided Process Design, FOCAPD-2014, an event that brings together researchers, educators, and practitioners to identify new challenges and opportunities for process and product design. The chemical industry is currently entering a new phase of rapid evolution. The availability of low-cost feedstocks from natural gas is causing renewed investment in basic chemicals in the OECD, while societal pressures for sustainability and energy security continue to be key drivers in technology development and product selection. This dynamic environment creates opportunities to launch new products and processes and to demonstrate new methodologies for innovation, synthesis and design. FOCAPD-2014 fosters constructive interaction among thought leaders from academia, industry, and government and provides a showcase for the latest research in product and process design. Focuses exclusively on the fundamentals and applications of computer-aided design for the process industries. Provides a fully archival and indexed record of the FOCAPD14 conference Aligns the FOCAPD series with the ESCAPE and PSE series