Principles of Asymmetric Synthesis

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  • Author : Robert E. Gawley
  • Publisher : Elsevier
  • Pages : 555 pages
  • ISBN : 0080448607
  • Rating : /5 from reviews
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Download or Read online Principles of Asymmetric Synthesis full in PDF, ePub and kindle. this book written by Robert E. Gawley and published by Elsevier which was released on 10 August 2022 with total page 555 pages. We cannot guarantee that Principles of Asymmetric Synthesis book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis (more than 1300 references), the aim of this book is to present a detailed analysis of the factors that govern stereoselectivity in organic reactions. It is important to note that the references were each individually checked by the authors to verify relevance to the topics under discussion. The study of stereoselectivity has evolved from issues of diastereoselectivity, through auxiliary-based methods for the synthesis of enantiomerically pure compounds (diastereoselectivity followed by separation and auxiliary cleavage), to asymmetric catalysis. In the latter instance, enantiomers (not diastereomers) are the products, and highly selective reactions and modern purification techniques allow preparation - in a single step - of chiral substances in 99% ee for many reaction types. After an explanation of the basic physical-organic principles of stereoselectivity, the authors provide a detailed, annotated glossary of stereochemical terms. A chapter on "Analytical Methods" provides a critical overview of the most common methods for analysis of stereoisomers. The authors then follow the 'tried-and-true' format of grouping the material by reaction type. Thus, there are four chapters on carbon-carbon bond forming reactions (enolate alkylations, organometal additions to carbonyls, aldol and Michael reactions, and cycloadditions and rearrangements), one chapter on reductions and hydroborations (carbon-hydrogen bond forming reactions), and one on oxidations (carbon-oxygen and carbon-nitrogen bond forming reactions). Leading references are provided to natural product synthesis that have been accomplished using a given reaction as a key step. In addition to tables of examples that show high selectivity, a transition state analysis is presented to explain - to the current level of understanding - the stereoselectivity of each reaction. In one case (Cram's rule) the evolution of the current theory is detailed from its first tentative (1952) postulate to the current Felkin-Anh-Heathcock formalism. For other reactions, only the currently accepted rationale is presented. Examination of these rationales also exposes the weaknesses of current theories, in that they cannot always explain the experimental observations. These shortcomings provide a challenge for future mechanistic investigations. Authoritative glossary to aid understanding of stereochemical terminology Explanations of the key factors influencing stereoselectivity with numerous examples, organized by reaction type A handy reference guide to the literature of asymmetric synthesis for practitioners in the field

Principles of Asymmetric Synthesis

Principles of Asymmetric Synthesis
  • Author : Robert E. Gawley,Jeffrey Aubé
  • Publisher : Elsevier
  • Release : 10 August 2022
GET THIS BOOK Principles of Asymmetric Synthesis

The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis (more than 1300 references), the aim of this book is to present a detailed analysis of the factors that govern stereoselectivity in organic reactions. It is important to note that the references were each individually checked by the authors to verify relevance

Principles of Asymmetric Synthesis

Principles of Asymmetric Synthesis
  • Author : R.E. Gawley,J. Aubé
  • Publisher : Elsevier
  • Release : 21 November 1996
GET THIS BOOK Principles of Asymmetric Synthesis

The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis (more than 1300 references), the aim of this book is to present a detailed analysis of the factors that govern stereoselectivity in organic reactions. It is important to note that the references were each individually checked by the authors to verify relevance

Principles and Applications of Asymmetric Synthesis

Principles and Applications of Asymmetric Synthesis
  • Author : Guo-Qiang Lin,Yue-Ming Li,Albert S. C. Chan
  • Publisher : John Wiley & Sons
  • Release : 21 February 2001
GET THIS BOOK Principles and Applications of Asymmetric Synthesis

Asymmetric synthesis remains a challenge to practicing scientists as the need for enantiomerically pure or enriched compounds continues to increase. Over the last decade, a large amount of literature has been published in this field. Principles and Applications of Asymmetric Synthesis consolidates and evaluates the most useful methodologies into a one-volume resource for the convenience of practicing scientists and students. Authored by internationally renowned scientists in the field, this reliable reference covers more than 450 reactions and includes important stoichiometric as

Asymmetric Synthesis

Asymmetric Synthesis
  • Author : Garry Procter
  • Publisher : Oxford University Press on Demand
  • Release : 10 August 1996
GET THIS BOOK Asymmetric Synthesis

This book covers a wide range of reactions which are of importance in the asymmetric synthesis of organic compounds. The principles of asymmetric additions to carbonyls, enolate alkylation, aldol reactions, additions to C-C double bonds, reduction and oxidation, rearrangements, and hydrolysis/ esterification reactions are covered, and selected examples used to illustrated the various topics. Numerous references to original literature should be of ues to organic chemists interested in the area of asymmetric synthesis.

Principles and Applications of Asymmetric Synthesis

Principles and Applications of Asymmetric Synthesis
  • Author : Guo-Qiang Lin,Yue-Ming Li,Albert S. C. Chan
  • Publisher : John Wiley & Sons
  • Release : 29 May 2003
GET THIS BOOK Principles and Applications of Asymmetric Synthesis

Asymmetric synthesis remains a challenge to practicing scientistsas the need for enantiomerically pure or enriched compoundscontinues to increase. Over the last decade, a large amount ofliterature has been published in this field. Principles andApplications of Asymmetric Synthesis consolidates and evaluates themost useful methodologies into a one-volume resource for theconvenience of practicing scientists and students. Authored by internationally renowned scientists in the field, thisreliable reference covers more than 450 reactions and includesimportant stoichiometric as well as catalytic asymmetric reactions.The first chapter

Fundamentals of Asymmetric Catalysis

Fundamentals of Asymmetric Catalysis
  • Author : Patrick J. Walsh,Marisa C. Kozlowski
  • Publisher : University Science Books
  • Release : 02 January 2009
GET THIS BOOK Fundamentals of Asymmetric Catalysis

This book describes the essential aspects of enantioselective catalysis in a clear, logical fashion, with chapters organized by concept rather than by reaction type. Each concept in Fundamentals of Asymmetric Catalysis is supported by carefully selected examples of a wide range of catalysts, reactions and reaction mechanisms.

Asymmetric Synthesis

Asymmetric Synthesis
  • Author : R. Alan Aitken,S. Nicholas Kilényi
  • Publisher : Springer
  • Release : 29 October 2012
GET THIS BOOK Asymmetric Synthesis

Very few fields in science have shown. such an acceleration from theory to practice as the field of asymIfletric synthesis. When one considers that the phrase 'asymmetric synthesis' was just a mechanistic curiosity in 1965 with no one seriously believing that this could someday be an important part of molecular synthesis, the rate of progress has been quite remarkable. In just over twenty years the organic chemist has transformed this virtually unknown aspect of synthesis into a serious route to virtually

Asymmetric Synthesis of Natural Products

Asymmetric Synthesis of Natural Products
  • Author : Ari M. P. Koskinen
  • Publisher : John Wiley & Sons
  • Release : 15 June 2012
GET THIS BOOK Asymmetric Synthesis of Natural Products

Asymmetric Synthesis of Natural Products, 2nd Edition introduces students to this rapidly growing field of organic chemistry. The initial chapters present the foundations of asymmetric synthesis, including the theory and applications of individual asymmetric reactions. This is followed by chapters on each of the major individual classes of natural products; their structures, biosynthesis and interrelationships as well as examples of asymmetric syntheses and the practical value of these compounds. Natural product classes covered include carbohydrates, amino acids, peptides, proteins, nucleosides,

Stereochemistry and Organic Reactions

Stereochemistry and Organic Reactions
  • Author : Dipak Kumar Mandal
  • Publisher : Academic Press
  • Release : 21 April 2021
GET THIS BOOK Stereochemistry and Organic Reactions

Stereochemistry and Organic Reactions: Conformation, Configuration, Stereoelectronic Effects and Asymmetric Synthesis provides coverage on the stereochemistry of reactions of all mechanistic types, ranging from ionic, pericyclic and transition metal-catalyzed to radical and photochemical. Chapters cover acyclic molecules, cyclic molecules, the stereochemistry of organic reactions, the perturbation molecular orbital theory for the origin of stereoelectronic effects, and an introduction to the principles of stereoselectivity and hierarchical levels of asymmetric synthesis. Each chapter includes problems that reinforce main themes, making it valuable

Asymmetric Synthesis of Three Membered Rings

Asymmetric Synthesis of Three Membered Rings
  • Author : Hélène Pellissier,Alessandra Lattanzi,Renato Dalpozzo
  • Publisher : John Wiley & Sons
  • Release : 28 March 2017
GET THIS BOOK Asymmetric Synthesis of Three Membered Rings

The first handbook to focus on the asymmetric synthesis of different types of three-membered rings. The outstanding and experienced authors have an excellent international reputation and cover cyclopropanes, epoxides and aziridines as well as chiral oxaziridines in equal measure. To this end, they describe in detail different synthetic approaches starting with chiral substrates as well as the application of chiral metal- or organocatalysts. Furthermore, methods for the kinetic resolution of initially racemic products are treated alongside recent advances and novel

Asymmetric Catalysis In Organic Synthesis

Asymmetric Catalysis In Organic Synthesis
  • Author : Ryoji Noyori
  • Publisher : Wiley-Interscience
  • Release : 03 February 1994
GET THIS BOOK Asymmetric Catalysis In Organic Synthesis

Deals with basic principles of asymmetric catalysis focusing on its synthetic significance. Covers homogeneous asymmetric hydrogenation, asymmetric catalysis via chiral metal complexes, heterogeneous catalysis and non-organometallic catalysis. The collection of a range of stereoselective reactions illustrate various strategies and methodologies as well as their general utility.