Precision Medicine For Autoimmune Diseases

Precision Medicine For Autoimmune Diseases Book PDF
✏Book Title : Precision Medicine for Autoimmune Diseases
✏Author : Georg Lautscham
✏Publisher : Academic Press
✏Release Date : 2020-09-01
✏Pages : 366
✏ISBN : 9780128227657
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Precision Medicine for Autoimmune Diseases Book Summary : Autoimmune diseases have significant economic and social impacts and represent the second-most important market for pharmaceutical companies, which is unsurprising when you consider that, while 1 in 33 American will suffer from cancer, 1 in 22 Americans will suffer from an autoimmune disease, costing the US over $ 100 billion a year. However, the uptake of precision medicine in this area has been slow at best, even though it can be extremely difficult to accurately diagnose and treat patients effectively using the tools that are currently available. If the adoption of precision medicine is to truly gather pace among diseases outside of cancer, there are still several regulatory, technological, and funding-related hurdles to be overcome. Taking lessons learned from within the field of oncology and systematically applying them to areas such as autoimmune disease will enable the development of more effective drugs across a wider range of illnesses. Most importantly, this will lead to a better outcome for patients. Precision Medicine for Autoimmune Diseases summarizes the status, the ongoing activities and provides an outlook to the future. Addresses the fact that only one drug to treat autoimmune diseases was approved by FDA Shows the need to pick up and establish the need of personalized and precision medicine for autoimmune diseases Provides insight on how novel therapies, novel diagnostics and artificial intelligence work better together to advance the field of precision medicine in Autoimmune diseases Helps to establish a precision medicine approach for the benefit of patients, payers and industry

Precision Medicine And Artificial Intelligence Book PDF
✏Book Title : Precision Medicine and Artificial Intelligence
✏Author : Michael Mähler
✏Publisher : Academic Press
✏Release Date : 2021-04-01
✏Pages : 316
✏ISBN : 9780323854320
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Precision Medicine and Artificial Intelligence Book Summary : Precision Medicine and Artificial Intelligence: The Perfect Fit covers background on AI, its link to PM, and examples of AI in healthcare, especially autoimmunity. The book highlights future perspectives and potential directions as artificial intelligence (AI) has gained significant attention in the past decade. Autoimmune diseases are complex and heterogeneous conditions, but exciting new developments and implementation tactics surrounding automated systems has enabled the generation of large amounts of data, making autoimmunity an ideal target for AI in the field of Precision Medicine (PM). More and more diagnostic products utilize AI, which is also starting to be supported by regulatory agencies such as the Food and Drug Administration (FDA). Knowledge generation by leveraging large data sets including demographic, environmental, clinical and biomarker data has the potential to not only impact the diagnosis of patients, but also disease prediction, prognosis and treatment options. Allows the readers to get a good overview of the field of Precision Medicine for autoimmune diseases and Artificial Intelligence Provides background, milestone and examples of precision medicine for autoimmune disease and artificial intelligence Proves the paradigm shift towards precision medicine driven by value based systems Discusses future applications of precision medicine research using artificial intelligence

Precision Medicine And The Reinvention Of Human Disease Book PDF
✏Book Title : Precision Medicine and the Reinvention of Human Disease
✏Author : Jules J. Berman
✏Publisher : Academic Press
✏Release Date : 2018-01-26
✏Pages : 398
✏ISBN : 9780128143940
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Precision Medicine and the Reinvention of Human Disease Book Summary : Despite what you may have read in the popular press and in social media, Precision Medicine is not devoted to finding unique treatments for individuals, based on analyzing their DNA. To the contrary, the goal of Precision Medicine is to find general treatments that are highly effective for large numbers of individuals who fall into precisely diagnosed groups. We now know that every disease develops over time, through a sequence of defined biological steps, and that these steps may differ among individuals, based on genetic and environmental conditions. We are currently developing rational therapies and preventive measures, based on our precise understanding of the steps leading to the clinical expression of diseases. Precision Medicine and the Reinvention of Human Disease explains the scientific breakthroughs that have changed the way that we understand diseases, and reveals how medical scientists are using this new knowledge to launch a medical revolution. Clarifies the foundational concepts of Precision Medicine, distinguishing this field from its predecessors such as genomics, pharmacogenetics, and personalized medicine. Gathers the chief conceptual advances in the fields of genetics, pathology, and bioinformatics, and synthesizes a coherent narrative for the field of Precision Medicine. Delivers its message in plain language, and in a relaxed, conversational writing style, making it easy to understand the complex subject matter. Guides the reader through a coherent and logical narrative, gradually providing expertise and skills along the way. Covers the importance of data sharing in Precision Medicine, and the many data-related challenges that confront this fragile new field.

Handbook Of Biomarkers And Precision Medicine Book PDF
✏Book Title : Handbook of Biomarkers and Precision Medicine
✏Author : Claudio Carini
✏Publisher : CRC Press
✏Release Date : 2019-04-16
✏Pages : 631
✏ISBN : 9780429576737
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Handbook of Biomarkers and Precision Medicine Book Summary : "The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development. Features: Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings’s College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.

Omics For Personalized Medicine Book PDF
✏Book Title : Omics for Personalized Medicine
✏Author : Debmalya Barh
✏Publisher : Springer Science & Business Media
✏Release Date : 2013-10-14
✏Pages : 832
✏ISBN : 9788132211846
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Omics for Personalized Medicine Book Summary : “Omics for Personalized Medicine” will give to its prospective readers the insight of both the current developments and the future potential of personalized medicine. The book brings into light how the pharmacogenomics and omics technologies are bringing a revolution in transforming the medicine and the health care sector for the better. Students of biomedical research and medicine along with medical professionals will benefit tremendously from the book by gaining from the diverse fields of knowledge of new age personalized medicine presented in the highly detailed chapters of the book. The book chapters are divided into two sections for convenient reading with the first section covering the general aspects of pharmaocogenomic technology that includes latest research and development in omics technologies. The first section also highlights the role of omics in modern clinical trials and even discusses the ethical consideration in pharmocogenomics. The second section is focusing on the development of personalized medicine in several areas of human health. The topics covered range from metabolic and neurological disorders to non-communicable as well as infectious diseases, and even explores the role of pharmacogenomics in cell therapy and transplantation technology. Thirty-four chapters of the book cover several aspects of pharmacogenomics and personalized medicine and have taken into consideration the varied interest of the readers from different fields of biomedical research and medicine. Advent of pharmacogenomics is the future of modern medicine, which has resulted from culmination of decades of research and now is showing the way forward. The book is an honest endeavour of researchers from all over the world to disseminate the latest knowledge and knowhow in personalized medicine to the community health researchers in particular and the educated public in general.

Clinical And Statistical Considerations In Personalized Medicine Book PDF
✏Book Title : Clinical and Statistical Considerations in Personalized Medicine
✏Author : Claudio Carini
✏Publisher : CRC Press
✏Release Date : 2014-03-27
✏Pages : 376
✏ISBN : 9781466593879
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Clinical and Statistical Considerations in Personalized Medicine Book Summary : The Future of Clinical Research and Health Care: From Empirical to Precision Medicine Clinical and Statistical Considerations in Personalized Medicine explores recent advances related to biomarkers and their translation into clinical development. Leading clinicians, biostatisticians, regulators, commercial professionals, and researchers address the opportunities and challenges in successfully applying biomarkers in drug discovery and preclinical and clinical development. Robust Biomarkers for Drug Development and Disease Treatment The first four chapters discuss biomarker development from a clinical perspective. Coverage ranges from an introduction to biomarkers to advances in RNAi screens, epigenetics, and rare diseases as targets for personalized medicine approaches. Subsequent chapters examine the statistical considerations in applying a personalized medicine approach, including multiplicity in pharmacogenomics. The last chapter assesses the regulatory issues involved in using biomarkers. Improve Patient Care and Reduce Costs and Side Effects Despite the vast amount of literature on biomarkers, there is no comprehensive book that integrates the clinical and statistical components. This book is one of the first to incorporate both the clinical and statistical aspects of biomarkers in the personalized medicine paradigm. Covering a wide spectrum of personalized medicine-related topics, it presents state-of-the-art techniques for advancing the application of biomarkers in drug discovery and development.

Epigenetics In Allergy And Autoimmunity Book PDF
✏Book Title : Epigenetics in Allergy and Autoimmunity
✏Author : Christopher Chang
✏Publisher : Springer Nature
✏Release Date : 2020-05-22
✏Pages : 403
✏ISBN : 9789811534492
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Epigenetics in Allergy and Autoimmunity Book Summary : This book will address the growing roles of epigenetics in disease pathogenesis, and review the contribution of epigenetic modifications to disease onset and progression. The roles that epigenetics plays in facilitating effects of the environment on allergy and immunologic diseases will be reviewed. The book is divided into three parts – the first is an introduction to epigenetics and the methods that have been developed to study epigenetics, the second addresses epigenetics in allergic diseases and the third part will cover epigenetics in autoimmune diseases. With the rapid expansion of knowledge of how genes are regulated and how this regulation affects disease phenotypes, this book will be attractive to experienced researchers as well as those just launching an epigenetics research program. It will also be of interest to allergist, immunologists, rheumatologists and dermatologist who are engaged in clinical practice as a resource for understanding the basis for personalized and precision medicine. For example, the role that epigenetics plays in the pathogenesis in various allergic and autoimmune disorders and how this determines disease phenotypes will be covered extensively in this book. This book will thus help fill the gap in available resources on epigenetics in allergy and autoimmune diseases.

Genomic And Personalized Medicine Book PDF
✏Book Title : Genomic and Personalized Medicine
✏Author :
✏Publisher : Academic Press
✏Release Date : 2012-10-30
✏Pages : 1350
✏ISBN : 9780123822284
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Genomic and Personalized Medicine Book Summary : Genomic and Personalized Medicine, Second Edition — winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — is a major discussion of the structure, history, and applications of the field, as it emerges from the campus and lab into clinical action. As with the first edition, leading experts review the development of the new science, the current opportunities for genome-based analysis in healthcare, and the potential of genomic medicine in future healthcare. The inclusion of the latest information on diagnostic testing, population screening, disease susceptability, and pharmacogenomics makes this work an ideal companion for the many stakeholders of genomic and personalized medicine. With advancing knowledge of the genome across and outside protein-coding regions of DNA, new comprehension of genomic variation and frequencies across populations, the elucidation of advanced strategic approaches to genomic study, and above all in the elaboration of next-generation sequencing, genomic medicine has begun to achieve the much-vaunted transformative health outcomes of the Human Genome Project, almost a decade after its official completion in April 2003. Highly Commended 2013 BMA Medical Book Award for Medicine More than 100 chapters, from leading researchers, review the many impacts of genomic discoveries in clinical action, including 63 chapters new to this edition Discusses state-of-the-art genome technologies, including population screening, novel diagnostics, and gene-based therapeutics Wide and inclusive discussion encompasses the formidable ethical, legal, regulatory and social challenges related to the evolving practice of genomic medicine Clearly and beautifully illustrated with 280 color figures, and many thousands of references for further reading and deeper analysis

📒Genomics Personalized Medicine And Oral Disease ✍ Stephen T. Sonis, DMD, DMSc

Genomics Personalized Medicine And Oral Disease Book PDF
✏Book Title : Genomics Personalized Medicine and Oral Disease
✏Author : Stephen T. Sonis, DMD, DMSc
✏Publisher : Springer
✏Release Date : 2015-09-17
✏Pages : 408
✏ISBN : 9783319179421
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Genomics Personalized Medicine and Oral Disease Book Summary : The objective of this book is to catalyze the application of genomics to the diagnosis and treatment of oral diseases by comprehensively presenting focused discussions on the current state of knowledge. The first section book provides basic information about genetics, genomics and personalized medicine and the informatical methods available to apply and organize genetic data so that it has clinical relevance. Recognizing the genetic robustness of the oral cavity, the introductory section includes chapters on the oral micro biome and host genomics and response to infectious agents. The next two sections contain chapters which describe the genomics of specific oral diseases and conditions, including the genetic basis for mechanism and risk of treatment toxicities associated with cancer therapy and bisphosphonates. Four chapters focus on gene-based therapies and the pharmacogenomics applied to oral disease. The final chapter presents a provocative summary which describes a comprehensive vision of the melding of genomics to personalized medicine and the potential actionable outcomes that will likely affect clinical practice in the upcoming years.

The Personalized Medicine Revolution Book PDF
✏Book Title : The Personalized Medicine Revolution
✏Author : Pieter Cullis
✏Publisher : Greystone Books
✏Release Date : 2015-02-10
✏Pages : 176
✏ISBN : 9781771640398
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏The Personalized Medicine Revolution Book Summary : Every one of us is unique. With recent advances in technology, we now know that that statement is more true that ever: we are each individuals, right down to a molecular level — a one-of-a-kind combination of genes, proteins, and metabolism. So why does healthcare still take a one-size-fits-all approach? The same methods are used on everyone to diagnose illness, and the same drugs are used to treat it — despite the fact that those methods and treatments are not effective for everyone and are even harmful for some. Shouldn’t our medicine be tailored to our differences? The Personalized Medicine Revolution explores recent advances in genomics, the study of the human genome — as well as its cousins proteomics, metabolomics, microbiomics, and the like — and explains how technology is even now changing the way medicine is delivered. Along the way, it takes the reader through the five critical healthcare areas that will be transformed most radically by personalized medicine — prediction, prevention, diagnosis, treatment, and monitoring — and examines the practical and ethical issues involved. Finally, it details how readers can use personalized medicine to take charge of their own health and build a stronger and safer medical system.

Systems Medicine Modeling For Multiple Sclerosis Book PDF
✏Book Title : Systems Medicine Modeling for Multiple Sclerosis
✏Author :
✏Publisher :
✏Release Date : 2017
✏Pages :
✏ISBN : OCLC:1051789815
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Systems Medicine Modeling for Multiple Sclerosis Book Summary : Abstract: Multiple Sclerosis (MS) is an autoimmune disease in which axons and myelin of the central nervous system (CNS) are damaged by inflammation and degenerative processes leading to significant disability. The course of the MS is hard to predict, limiting the decision making process for patient management and therapeutic options. Many genetic, lifestyle and environmental factors could influence the risks of MS development. Subtle abnormalities in the control of the immune response can be amplified and deregulated decades later suggesting that MS and other autoimmune diseases can be envisioned as dynamic diseases. Based on this premise, mathematical modeling of MS pathogenesis is an approach that would bring this dynamic concept to the understanding of the disease and therefore be useful for improving our understanding for the application of precision medicine. Modeling can be focused on different biological scales from genes and signaling pathways to cell–cell interactions, interplay between inflammatory and degenerative processes at tissue level, and predictions of clinical outcomes. Models of the autoimmune process as well as the damage of the CNS has been developed using ordinary differential equations and fitted parameters with experimental datasets. Simulations support the concept of MS as a dynamic disease that is being produced by subtle differences in the molecular and cellular control of the immune-nervous interplay amplified along time. These new systems medicine tools can now be applied for patient stratification and personalized medicine. Highlights: Predicting disease course and response to therapy is difficult in MS. Systems medicine models of MS focused in network and mathematical models. Computational models of MS will allow systems medicine applications.

Personalized Treatment Options In Dermatology Book PDF
✏Book Title : Personalized Treatment Options in Dermatology
✏Author : Thomas Bieber
✏Publisher : Springer
✏Release Date : 2015-02-23
✏Pages : 146
✏ISBN : 9783662458402
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Personalized Treatment Options in Dermatology Book Summary : This book is a quick reference guide to the new, more personalized approaches to the management of skin disorders that have emerged as a result of progress in our understanding of the genetic background and pathophysiology of skin diseases and the diversity of mechanisms underlying their clinical heterogeneity. A wide range of personalized and targeted therapies are described, including those for different skin cancers, chronic inflammatory skin diseases, and autoimmune diseases. In addition, readers will find that the book documents how research results in personalized medicine can be effectively transferred to dermatological practice and looks forward to future treatments that might be developed on the basis of recent research findings. The authors are all recognized experts in the field, and the text is presented in a reader-friendly format and well illustrated.

📒The Autoimmune Diseases ✍ Noel R. Rose

The Autoimmune Diseases Book PDF
✏Book Title : The Autoimmune Diseases
✏Author : Noel R. Rose
✏Publisher : Academic Press
✏Release Date : 2019-10-15
✏Pages : 1532
✏ISBN : 9780128122426
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏The Autoimmune Diseases Book Summary : The Autoimmune Diseases, Sixth Edition, emphasizes the "3 P’s" of 21st Century medicine: precision, prediction and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ("omics") coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients. Chapters emphasize the immunologic basis of the disease as well as the use of immunologic diagnostic methods and treatments. The book also covers several cross-cutting issues related to the recognition and treatment of autoimmune diseases, including chapters on the measurement of autoantibodies and T cells, the use of biomarkers as early predictors of disease, and new methods of treatment. Gives a thorough and important overview on the entire field, framing individual disease chapters with information that compares and contrasts each disorder and its therapy Provides thorough, up-to-date information on specific diseases, along with clinical applications in an easily found reference for clinicians and researchers interested in certain diseases Keeps readers abreast of current trends and emerging areas in the field Ensures that content is not only up-to-date, but applicable and relevant Includes new, updated chapters that emphasize hot topics in the field, e.g., research on auto inflammatory diseases and autoimmune responses following cancer immunotherapy

Genomic Biomarkers For Pharmaceutical Development Book PDF
✏Book Title : Genomic Biomarkers for Pharmaceutical Development
✏Author : Yihong Yao
✏Publisher : Academic Press
✏Release Date : 2013-07-16
✏Pages : 208
✏ISBN : 9780123977946
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Genomic Biomarkers for Pharmaceutical Development Book Summary : Genomic Biomarkers for Pharmaceutical Development: Advancing Personalized Health Care provides an in-depth review of the state of translational science across all stages of pharmaceutical development with a special focus on personalized health care. This book provides a complete picture of biomarker development and validation in a pharmaceutical setting while addressing the inherent challenges of targeting the appropriate indications, biomarker robustness, regulatory hurdles, commercialization and much more. It features case studies devoted to the applications of pharmacogenomics, toxicogenomics, and other genetic technologies as they support drug discovery and development. With chapters written by international authorities in industry and academia, this work is a truly unique presentation of the thoughts and approaches that lead to the development of personalized medicine. Intended for all those involved in clinical translational research, this book is the ideal resource for scientists searching for the applications, strategies and successful approaches of translational science in pharmaceutical development. Provides case studies in applications of pharmacodynamic and predictive markers in drug development in oncology, autoimmunity, respiratory diseases and infectious diseases Shows how to identify potential new therapeutic targets in different diseases and provides examples of potential new disease indications for life cycle management of drugs Authored by leading international experts from industry and academia

Essentials Of Genomic And Personalized Medicine Book PDF
✏Book Title : Essentials of Genomic and Personalized Medicine
✏Author : Geoffrey S. Ginsburg
✏Publisher : Academic Press
✏Release Date : 2009-10-02
✏Pages : 850
✏ISBN : 0080958117
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Essentials of Genomic and Personalized Medicine Book Summary : Derived from the comprehensive two-volume set, Genomic and Personalized Medicine also edited by Drs. Willard and Ginsburg, this work serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing one of the most promising avenues for advances in diagnosis, prevention and treatment of human disease. From principles, methodology and translational approaches to genome discoveries and clinical applications, Essentials of Genomic and Personalized Medicine will be a valuable resource for various professionals and students across medical disciplines, including human genetics and genomics, oncology, neuroscience, gene therapy, molecular medicine, pharmacology, and biomedical sciences. Updates with regard to diagnostic testing, pharmacogenetics, predicting disease susceptibility, and other important research components as well as chapters dedicated to cardiovascular disease, oncology, inflammatory disease, metabolic disease, neuropsychiatric disease, and infectious disease, present this book as an essential tool for a variety of professionals and students who are endeavouring into the developing the diverse and practical field of genomic and personalized medicine. * Full color throughout * Includes contributions on genetic counselling, ethical, legal/regulatory, and social issues related to the practice of genomic medicine from leaders in the field * Introductory chapter highlights differences between personalized and traditional medicine, promising areas of current research, and challenges to incorporate the latest research discoveries and practice * Ancillary material includes case studies and lab questions which highlight the collaborative approach to the science

Immunomodulatory Effects Of Drugs For Treatment Of Immune Related Diseases Book PDF
✏Book Title : Immunomodulatory Effects of Drugs for Treatment of Immune Related Diseases
✏Author : Azzam A. Maghazachi
✏Publisher : Frontiers Media SA
✏Release Date : 2017-09-18
✏Pages :
✏ISBN : 9782889452880
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Immunomodulatory Effects of Drugs for Treatment of Immune Related Diseases Book Summary : More than 90% of diseases possess immunological abnormalities. Disorders such as inflammation, hypersensitivity, autoimmunity and immunodeficiency are simple examples of how the immune system misinterprets its surroundings and goes awry. Multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel diseases, among many others are manifestations of immune cells attacking normal tissues. On the other hand, damping the immune system leads to diseases such as cancer, AIDS, and severe combined immunodeficiency. The last ten years witnessed an explosion in developing drugs that target the immune system. Several novel monoclonal antibodies have been approved for treatment of various diseases confirming that personalized medicine approach is robust in combating diseases. Hence, the future holds great promise for using personalized and targeted medicine rather than generalized medications that, in most circumstances, proven to be ineffective and characteristically exert side effects. Approaches such as generating novel adjuvants that can stimulate the immune system without harmful side effects, targeting inflammatory cytokines and chemokines, harnessing and activating innate immune cells such as natural killer cells or dendritic cells, are examples of future approaches to treat autoimmune diseases, AIDS, and various forms of cancer resulting from chronic inflammation. More recently, targeting immune checkpoint molecules have shown therapeutic response against lung cancer and melanoma. Identifying molecules involved in autophagy is another example of how personalized medicine might help treat patients with refractory asthma and autoimmune diseases. This topic introduces the reader to these novel approaches of manipulating the immune system and developing targeted therapeutic strategies for treatment of various diseases.

Physiologic Autoimmunity And Preventive Medicine Book PDF
✏Book Title : Physiologic Autoimmunity and Preventive Medicine
✏Author : Alexander B. Poletaev
✏Publisher : Bentham Science Publishers
✏Release Date : 2013-06-03
✏Pages : 254
✏ISBN : 9781608057245
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Physiologic Autoimmunity and Preventive Medicine Book Summary : The immune system is a natural component, regulator and direct participant in the physiological activities in a healthy body. A considerable number of immune functions, including those related to antimicrobial defense, derive from autoclearance as well as construction and support of multicellularity. Various pathological processes in any organ are usually accompanied by different patterns of cell death and, thus, by increased exposure and presentation of self antigens. These events induce the secondary rise in production of autoantibodies with appropriate specificity (opsonins), which provides augmentation of clearance by facilitating the efficacy of macrophage-dependent consumption of debris in the affected organ. Secondary changes in production and serum content of autoantibodies can be considered the universal and earliest detectable marker of any chronic disease. Experimental and clinical production antibodies reveal antibodies against nuclear antigens, which penetrate into living cell nuclei and alter nuclear acid synthesis, cell proliferation and function. Autoantibodies can thus be regarded as hormone-like bioregulators of gene expression. The immune system is apparently able to reproduce complementary regulators for various cell receptors, including nuclear ones. The book focuses on physiological autoimmunity models and delves into the relation between autoimmunity and autoallergy in the context of disease prevention and prediction. The E-book is a unique and comprehensive monograph and includes a history and contemporary research on natural autoimmunity - a fundamental concept essential for many branches of medicine and pathology. The concepts described in this e-book also have broad practical implications for the healthcare sector, because it establishes effective method of early prediction for many different diseases and creates a basis for prophylaxis. The reference gives medical and clinical professionals a chance to revisit old dogmas and acquire fruitful perspectives for theoretical reasoning and research planning.

Precision Medicine A Guide To Genomics In Clinical Practice Book PDF
✏Book Title : Precision Medicine A Guide to Genomics in Clinical Practice
✏Author : Jeanette J. McCarthy
✏Publisher : McGraw Hill Professional
✏Release Date : 2017-01-05
✏Pages : 304
✏ISBN : 9781259644146
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Precision Medicine A Guide to Genomics in Clinical Practice Book Summary : Incorporate genomics into every applicable area of your clinical practice with this complete how-to guide Precision Medicine: A Guide to Genomics in Clinical Practice is a comprehensive, yet succinct overview of the practice of genomic medicine. It is written for general healthcare practitioners, specialists, and trainees with the goal of providing detailed guidance on how to incorporate genomic medicine into daily practice. Features that make this book valuable to every practice: •Intentionally avoids excessive technical content and consistently emphasizes real-life patient care and decision support •Follows the course of a human life, beginning before conception through pregnancy, childhood, and adulthood, discussing the current and future applications of genomics and precision medicine at each stage •Organization allows healthcare providers to quickly and easily find the information relevant to their practice. •The authors highlight common pitfalls – technical and ethical – that might complicate the delivery of quality genomic healthcare •Enhanced by eleven valuable appendices that cover important topics ranging from the basics of genetics to ethical issues to regulation and reimbursement If you are searching for a clinically relevant, non-technical resource that will teach you how genomic medicine can and should be practiced in your specific field of interest, Precision Medicine: A Guide to Genomics in Clinical Practicebelongs on your desk.

Autoimmune Blistering Disease Part I An Issue Of Dermatologic Clinics E Book Book PDF
✏Book Title : AutoImmune Blistering Disease Part I An Issue of Dermatologic Clinics E Book
✏Author : Dédée F. Murrell
✏Publisher : Elsevier Health Sciences
✏Release Date : 2011-06-29
✏Pages : 192
✏ISBN : 9781455712472
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏AutoImmune Blistering Disease Part I An Issue of Dermatologic Clinics E Book Book Summary : In the first volume of this two part issue devoted to Autoimmune Blistering Diseases (AIBD), diagnosis and clinical features of these diseases are covered by an internationally recognized group of authors. Topics include Pemphigus Vulgaris, Pemphigus Foliaceus, Linear IgA Bullous Disease, and Hair and Nail Loss in AIBD.

Progress In Systemic Lupus Erythematosus Research Book PDF
✏Book Title : Progress in Systemic Lupus Erythematosus Research
✏Author : Tomas I. Seward
✏Publisher : Nova Publishers
✏Release Date : 2007
✏Pages : 264
✏ISBN : 160021861X
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Progress in Systemic Lupus Erythematosus Research Book Summary : This new book is devoted to leading-edge research developments in lupus which is a condition of chronic inflammation caused by an autoimmune disease. Autoimmune diseases are illnesses that occur when the body's tissues are attacked by its own immune system. The immune system is a complex system within the body that is designed to fight infectious agents, for example, bacteria, and other foreign invaders. One of the mechanisms that the immune system uses to fight infections is the production of antibodies. Patients with lupus produce abnormal antibodies in their blood that target tissues within their own body rather than foreign infectious agents. Because the antibodies and accompanying cells of inflammation can involve tissues anywhere in the body, lupus has the potential to affect a variety of areas of the body. Sometimes lupus can cause disease of the skin, heart, lungs, kidneys, joints, and/or nervous system. When only the skin is involved, the condition is called discoid lupus. When internal organs are involved, the condition is called systemic lupus erythematosus (SLE).

📒Genome Wide Association Studies ✍ Tatsuhiko Tsunoda

Genome Wide Association Studies Book PDF
✏Book Title : Genome Wide Association Studies
✏Author : Tatsuhiko Tsunoda
✏Publisher : Springer Nature
✏Release Date : 2019-10-31
✏Pages : 209
✏ISBN : 9789811381775
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Genome Wide Association Studies Book Summary : This book examines the utility of genome-wide association studies (GWAS) in the era of next-generation sequencing and big data, identifies limitations and potential means of overcoming them, and looks to the future of GWAS and what may lay beyond. GWAS are among the most powerful tools for elucidating the genetic aspects of human and disease diversity. In Genome-Wide Association Studies, experts in the field explore in depth the impacts of GWAS on genomic research into a variety of common diseases, including cardiovascular, autoimmune, diabetic, cancer, and infectious diseases. The book will equip readers with a sound understanding both of the types of disease and phenotypes that are suited for GWAS and of the ways in which a road map resulting from GWAS can lead to the realization of personalized/precision medicine: functional analysis, drug seeds, pathway analysis, disease mechanism, risk prediction, and diagnosis.

Treatment Of Bipolar Disorder In Children And Adolescents Book PDF
✏Book Title : Treatment of Bipolar Disorder in Children and Adolescents
✏Author : Barbara Geller
✏Publisher : Guilford Press
✏Release Date : 2008-04-28
✏Pages : 418
✏ISBN : 9781606238493
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Treatment of Bipolar Disorder in Children and Adolescents Book Summary : Recent advances in evidence-based treatment of pediatric bipolar disorder are comprehensively reviewed in this authoritative volume. The prominent editors and contributors examine the current status of widely used medications and psychosocial therapies, and explore new horizons in tailoring treatment to individuals' neurobiological and clinical profiles. Chapters on specific populations discuss strategies for addressing common co-occurring disorders in children and adolescents with bipolar disorder, treating preschoolers, targeting depressive symptoms, and improving early intervention and prevention. Other essential topics include medication side effects and approaches to monitoring and ameliorating them, and ethical issues related to treatment and research.

📒Reinventing Patient Recruitment ✍ Joan F. Bachenheimer

Reinventing Patient Recruitment Book PDF
✏Book Title : Reinventing Patient Recruitment
✏Author : Joan F. Bachenheimer
✏Publisher : Gower Publishing, Ltd.
✏Release Date : 2007
✏Pages : 261
✏ISBN : 0566087170
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Reinventing Patient Recruitment Book Summary : During the last five years, clinical research and development costs have risen exponentially without a proportionate increase in the number of new medications. While patient recruitment for clinical studies is only one component in the development of a new medicine or treatment, it is one of the most significant bottlenecks in the overall drug development process. Now it is imperative that industry leaders see beyond reactive measures and recognize that advancing their approach to patient recruitment is absolutely essential to advancing medicine and continuing the stability of their corporate brand across the globe. Reinventing Patient Recruitment: Revolutionary Ideas for Clinical Trial Success is a definitive guide to planning, implementing and evaluating recruitment strategies and campaigns globally. The combined experience of the authors provides a depth of perspective and boldness of innovative leadership to set the standards for future patient recruitment programs and practices. This book is a must-have for pharmaceutical, biotechnology and medical device industry professionals concerned with enrolling for domestic and multinational clinical studies and remaining on time and on budget.

The Microbiome In Rheumatic Diseases And Infection Book PDF
✏Book Title : The Microbiome in Rheumatic Diseases and Infection
✏Author : Gaafar Ragab
✏Publisher : Springer
✏Release Date : 2018-06-19
✏Pages : 490
✏ISBN : 9783319790268
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏The Microbiome in Rheumatic Diseases and Infection Book Summary : This book discusses the role of the microbiome in rheumatic diseases and details its implications for patient treatment. Recently, with technological advances, there has been significant research into the microbiome. This has enabled us to more profoundly understand its role in our immune system maturation as well as the role played by microorganisms in autoimmunity and the deeply related rheumatic diseases. This book comprehensively explains the emerging microbiome research through the interrelationships of biomedical sciences, including: immunology, microbiology, bioinformatics, and, with special emphasis, the clinical aspect of rheumatology. It examines the interplay between infectious organisms and major autoimmune diseases, including rheumatoid arthritis, psoriatic arthritis, juvenile arthritis, systemic lupus erythematosus, and vasculitis, and explains how to apply that knowledge to diagnostic techniques and treatment decisions. The international team of expert authors provides insight into current therapies and future interventions specifically targeting the microbiota and explores the impact of our deeper understanding on enhancing personalized medicine. The Microbiome in Rheumatic Diseases and Infection is an essential resource for rheumatologists, pediatricians, internists, microbiologists, and critical care providers caring for children and adults with rheumatic diseases.

Sine Syndromes In Rheumatology Book PDF
✏Book Title : Sine Syndromes in Rheumatology
✏Author : Jozef Rovenský
✏Publisher : Springer Science & Business Media
✏Release Date : 2013-12-09
✏Pages : 120
✏ISBN : 9783709115411
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Sine Syndromes in Rheumatology Book Summary : Sine syndromes (SSs) represent atypical forms of inflammatory rheumatic diseases, the courses of which are often severe. While the diagnosis of rheumatic diseases can be determined according to an established set of diagnostic criteria based on clinical characteristics and laboratory parameters, Sine Syndromes do not fulfill the standard criteria used to assist in the classification of patients with rheumatological disorders. This concise book gives an overview of atypical courses in common inflammatory rheumatic diseases such as Wegener’s granulomatosis, systemic sclerosis, Sjögren's syndrome, or systemic lupus erythematosus. Each chapter reviews similar cases reported in the literature and presents current data on treatment options. Drawing on their vast clinical experience, the editors provide a series of detailed case reports in order to illustrate the different types of disease. The book is intended to facilitate early diagnosis and effective therapy in patients where a schematic approach may not prove sufficient. Sine Syndromes in Rheumatology will serve as a useful and easily accessible reference for specialists in rheumatology as well as for practitioners in the fields of internal medicine, pediatrics, and orthopedics.

Molecular Counting Book PDF
✏Book Title : Molecular Counting
✏Author :
✏Publisher : Stanford University
✏Release Date : 2010
✏Pages :
✏ISBN : STANFORD:cw095xw9265
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Molecular Counting Book Summary : The concept of a personal genome stems from the fact that every human genome is unique. Measuring the unique features of a personal genome would help uncover the genetic basis of diseases and traits, and would be increasingly important in clinical diagnosis especially with the growing emphasis on personalized medicine. This thesis focuses on exploring the power of molecular counting to develop novel strategies that address the inadequacy of existing technologies in measuring the unique features of a human genome. The first focus of the thesis is aneuploidy detection, which has major application in prenatal diagnosis. While karyotyping of fetal cells is well-established for detecting aneuploidy, invasive sampling of fetal materials impose a small but significant risk to the health of both the mother and the fetus. A major research focus in the field of prenatal diagnosis has been to develop a noninvasive test for detecting fetal aneuploidy. Here, the concept of single molecule counting was applied to the problem of aneuploidy detection. The concept was first tested with digital PCR on invasively collected fetal materials, and subsequently extended to the noninvasive setting by shotgun sequencing maternal plasma DNA, which contains a small amount of fetal DNA. The former work led to the development of a polymorphism-independent method for rapid invasive diagnosis of aneuploidy, while the later work marked the development of the first polymorphism-independent method for the noninvasive diagnosis of fetal aneuploidy documented in the literature. The second focus of the thesis is molecular haplotyping. Present sequencing and other molecular techniques concentrate at identifying variants at isolated locations throughout a genome but largely ignore the haplotypes formed by these variants. Direct experimental determination of the haplotypes of an individual is challenging because of the lack of techniques to separate the two highly similar homologous copies of a chromosome. Here, a whole-genome haplotyping method was devised by analyzing amplified materials from single intact chromosomes within single cells, made possible by microfluidics. Such strategy enabled, for the first time, completely deterministic measurement of personal whole-genome haplotypes. It sets the stage for the direct sequencing of the two unique haploid genomes of any individual human, which has not been achieved by any personal genomes sequenced to date, and can potentially facilitate noninvasive fetal genome sequencing.

📒Immune Rebalancing ✍ Diana Boraschi

Immune Rebalancing Book PDF
✏Book Title : Immune Rebalancing
✏Author : Diana Boraschi
✏Publisher : Academic Press
✏Release Date : 2016-01-25
✏Pages : 298
✏ISBN : 9780128033364
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Immune Rebalancing Book Summary : Immune Rebalancing: The Future of Immunosuppression summarizes the most promising perspectives of immunopharmacology, in particular in the area of immunosuppression by considering molecular pathways, personalized medicine, microbiome and nanomedicine. Modulation of immune responses for therapeutic purposes is a particularly relevant area, given the central role of anomalous immunity in diseases. These diseases vary from the most typically immune-related syndromes (autoimmune diseases, allergy and asthma, immunodeficiencies) to those in which altered immunity and inflammation define the pathological outcomes (chronic infections, tumours, chronic inflammatory and degenerative diseases, metabolic disorders, etc. Visits immunosuppression from a modern point of view of signalling mechanisms at the light of the current knowledge of signalling mechanisms and regulatory networks allows the reader to formulate new ideas and concepts on how to use immunosuppression the therapeutic purposes Encourages researchers to engage into exploring the field of pharmacological modulation of immune responses in depth, and with the new knowledge and tools available, designs more effective therapeutic strategies to autoimmune and inflammatory diseases, cancer, degenerative diseases and infections Examines the link between molecular pathways associated to immune-suppression and the new immunopharmacology approaches Provides information on the new strategies for drug development in this field Considers the role of microbes in the development of the mammalian immune system and immune responses, which will widen the reader’s strategy for addressing therapeutic immune modulations

Precision Anticoagulation Medicine Book PDF
✏Book Title : Precision Anticoagulation Medicine
✏Author : Hadi Goubran
✏Publisher : Springer Nature
✏Release Date : 2019-12-30
✏Pages : 308
✏ISBN : 9783030257828
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Precision Anticoagulation Medicine Book Summary : This book provides a practical guide to the use of novel and conventional anticoagulants for a variety of medical conditions and patients profiled. It reviews data for selecting the most appropriate medication for a given presentation based on a patient’s background while highlighting current best practices. Chapters discuss the choice of agents and optimum duration of therapy while including the relevant literature review and evidence. Specific sections focus on the use of anticoagulants in patients with cardiovascular disease, autoimmune and rheumatologic disorders, antiphospholipid syndrome, cancer, and in the surgical contexts. The book also examines anticoagulation in pregnant and lactating women, pediatric and elderly populations, and patients with extreme weights. Intended for use in daily practice, Precision Anticoagulation Medicine - A Practical Guide is an essential resource for physicians and related professionals, residents, fellows, and graduate students in hematology, cardiology, rheumatology, oncology, surgery, anesthesiology, and intensive care.

Fundamentals Of Oral Histology And Physiology Book PDF
✏Book Title : Fundamentals of Oral Histology and Physiology
✏Author : Arthur R. Hand
✏Publisher : John Wiley & Sons
✏Release Date : 2014-11-13
✏Pages : 296
✏ISBN : 9781118938300
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Fundamentals of Oral Histology and Physiology Book Summary : Fundamentals of Oral Histology and Physiology is a landmark new text streamlining the essentials of histology and physiology into one clinically accessible textbook. Written for predoctoral dental students, the book brings together structure, function, and clinical correlations for maximum retention and ease of use. Assuming a background in basic biologic sciences, this text focuses on the histology and physiology that students need to know to practice dentistry and to understand and evaluate the current literature, without repeating basic information learned in other courses. Fundamentals of Oral Histology and Physiology concentrates on Oral Structures and Features, including Development, Teeth, Tooth and Jaw Support, Mucosal Structure and Function, and Effectors.

Springer Handbook Of Bio Neuro Informatics Book PDF
✏Book Title : Springer Handbook of Bio Neuro Informatics
✏Author : Nikola Kasabov
✏Publisher : Springer Science & Business Media
✏Release Date : 2013-11-30
✏Pages : 1229
✏ISBN : 9783642305740
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Springer Handbook of Bio Neuro Informatics Book Summary : The Springer Handbook of Bio-/Neuro-Informatics is the first published book in one volume that explains together the basics and the state-of-the-art of two major science disciplines in their interaction and mutual relationship, namely: information sciences, bioinformatics and neuroinformatics. Bioinformatics is the area of science which is concerned with the information processes in biology and the development and applications of methods, tools and systems for storing and processing of biological information thus facilitating new knowledge discovery. Neuroinformatics is the area of science which is concerned with the information processes in biology and the development and applications of methods, tools and systems for storing and processing of biological information thus facilitating new knowledge discovery. The text contains 62 chapters organized in 12 parts, 6 of them covering topics from information science and bioinformatics, and 6 cover topics from information science and neuroinformatics. Each chapter consists of three main sections: introduction to the subject area, presentation of methods and advanced and future developments. The Springer Handbook of Bio-/Neuroinformatics can be used as both a textbook and as a reference for postgraduate study and advanced research in these areas. The target audience includes students, scientists, and practitioners from the areas of information, biological and neurosciences. With Forewords by Shun-ichi Amari of the Brain Science Institute, RIKEN, Saitama and Karlheinz Meier of the University of Heidelberg, Kirchhoff-Institute of Physics and Co-Director of the Human Brain Project.