Polyunsaturated Fatty Acid Metabolism

Polyunsaturated Fatty Acid Metabolism Book PDF
✏Book Title : Polyunsaturated Fatty Acid Metabolism
✏Author : Graham C. Burdge
✏Publisher : Elsevier
✏Release Date : 2018-05-04
✏Pages : 252
✏ISBN : 9780128112311
✏Available Language : English, Spanish, And French

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✏Polyunsaturated Fatty Acid Metabolism Book Summary : Polyunsaturated Fatty Acid Metabolism explores a number of major roles of PUFA in the body, including its role as a component of cell membranes and how it provides substrates for the synthesis of lipid second messengers. Recent studies are unraveling the effect of interactions between diet and endocrine factors and genetic and epigenetic variation on the regulation of PUFA biosynthesis in animals. Together, these recent findings provide novel insights into the impact of differences in PUFA supply on health. This book captures these findings in a manner that marks the state-of-the-art, placing them in the wider context of PUFA metabolism and nutritional science. Users will find a comprehensive discussion on the topic that presents the contributions of leading researchers who combine their knowledge to create a cohesive academic resource for researchers, those involved in production, and health policymakers. Provides a comprehensive view of polyunsaturated fatty acid metabolism Describes underlying metabolism on lipids that include polyunsaturated fatty acids Includes discussions on recent findings on the genetic and epigenetic regulation of polyunsaturated fatty acid metabolism

Polyunsaturated Fatty Acids Modulate Arachidonic Acid Metabolism And Cell Growth In Human Prostatic Cancer Cells Book PDF
✏Book Title : Polyunsaturated Fatty Acids Modulate Arachidonic Acid Metabolism and Cell Growth in Human Prostatic Cancer Cells
✏Author : Kao Vang
✏Publisher :
✏Release Date : 2004
✏Pages : 166
✏ISBN : UCAL:X69012
✏Available Language : English, Spanish, And French

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✏Polyunsaturated Fatty Acids Modulate Arachidonic Acid Metabolism and Cell Growth in Human Prostatic Cancer Cells Book Summary :

📒Male Fertility And Lipid Metabolism ✍ Stephanie R. De Vriese

Male Fertility And Lipid Metabolism Book PDF
✏Book Title : Male Fertility and Lipid Metabolism
✏Author : Stephanie R. De Vriese
✏Publisher : The American Oil Chemists Society
✏Release Date : 2003-05-30
✏Pages : 277
✏ISBN : 1893997391
✏Available Language : English, Spanish, And French

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✏Male Fertility and Lipid Metabolism Book Summary : Interest in lipid metabolism and polyunsaturated fatty acids in relation to sperm production has increased during the last decade. The motivation for the research described in this book originates from the discovery that sperm lipids contain extremely high proportions of long-chain polyunsaturated fatty acids, thus establishing a link between lipid biochemistry and male fertility. Moreover, the fact that polyunsaturated fatty acids must, in some form, be supplied in the diet suggests a relationship between fertility and nutrition and raises the possibility of improving male fertility by dietary means. This book gives the reader an up-to-date view of several aspects of male fertility in relation to lipid and fatty acid metabolism. Researchers in the domain of male fertility, fatty acid metabolism, and antioxidants; medical personnel involved in the treatment of male infertility; fat technologists; students in nutrition, dietetics, biochemistry, pharmacy, and medicine; and everybody interested in the field will find this book useful.

📒Fatty Acids And Lipids ✍ International Society for the Study of Fatty Acids and Lipids. Congress

Fatty Acids And Lipids Book PDF
✏Book Title : Fatty Acids and Lipids
✏Author : International Society for the Study of Fatty Acids and Lipids. Congress
✏Publisher : Karger Medical and Scientific Publishers
✏Release Date : 2001-01-01
✏Pages : 259
✏ISBN : 9783805571821
✏Available Language : English, Spanish, And French

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✏Fatty Acids and Lipids Book Summary : The publication at hand gives an outline of recent advances in both of these topics, including a general discussion on fatty acid nutrition amd metabolism. Moreover, issues such as vascular functions, inflammation, bone metabolism, cancer, obesity and lipoprotein metabolism are dealt with in this context. Finally, the book also contains new findings on bioactive lipids such as anandamide and related compounds, as well as on conjugated linoleic acid. Scientists interested in nutrition, cardiovascular disease, behavior and psychiatry as well as fatty acid metabolism and lipids in general will find this publication a most welcome source of information.

Polyunsaturated Fatty Acids In Human Nutrition Book PDF
✏Book Title : Polyunsaturated Fatty Acids in Human Nutrition
✏Author : Umberto Bracco
✏Publisher : Raven Press (ID)
✏Release Date : 1992
✏Pages : 243
✏ISBN : UOM:39015029460410
✏Available Language : English, Spanish, And French

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✏Polyunsaturated Fatty Acids in Human Nutrition Book Summary : This volume highlights the important clinical implications of recent findings on the biochemistry, metabolism, and physiological functions of long chain polyunsaturated fatty acids (LCPUFAs). Leading experts define the relationships between dietary LCPUFAs and their structural-metabolic physiological role, examine the influence of LCPUFAs and other essential fatty acids on infant development, discuss the evidence linking various disorders to essential fatty acid imbalance, and describe new approaches to problems relating to dietary LCPUFAs, particularly in infant feeding. The contributors review the most significant research on the transport and cellular utilization of LCPUFAs, their role in phospholipid molecular species, their extracellular and intracellular fates, their metabolism to oxidative derivatives, and their functions as mediators - through eicosanoid-dependent and/or independent mechanisms - brain and retinal development, immunomodulation, and other physiological processes. Extensive studies explore the relationship between essential fatty acid balance and cystic fibrosis, behavior problems, chronic diseases, atopic dermatitis, gynecological and reproductive disorders, and disturbances of lipoprotein metabolism. Full consideration is given to the intake, digestion, absorption, and metabolism of LCPUFAs in newborn infants and the special problems of premature infants and infants with peroxisomal disorders. Practical issues concerning sources and uses of dietary LCPUFAs are also discussed in detail. Polyunsaturated Fatty Acids in Human Nutrition is an essential source of information for nutritionists, pediatricians, and clinicians treating disorders involving fatty acid imbalance. The book will also be a valuable stimulus for basic researchers investigating the role of fatty acids in human biology.

Platelet Arachidonic Acid Metabolism And Serum Fatty Acids In Multiple Sclerosis And Systemic Lupus Erythematosus Book PDF
✏Book Title : Platelet Arachidonic Acid Metabolism and Serum Fatty Acids in Multiple Sclerosis and Systemic Lupus Erythematosus
✏Author : Sunghee Cho
✏Publisher :
✏Release Date : 1982
✏Pages : 188
✏ISBN : CORNELL:31924002017691
✏Available Language : English, Spanish, And French

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✏Platelet Arachidonic Acid Metabolism and Serum Fatty Acids in Multiple Sclerosis and Systemic Lupus Erythematosus Book Summary :

Fatty Acid Metabolism And Its Regulation Book PDF
✏Book Title : Fatty Acid Metabolism and its Regulation
✏Author :
✏Publisher : Elsevier
✏Release Date : 1984-01-01
✏Pages : 208
✏ISBN : 0080860656
✏Available Language : English, Spanish, And French

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✏Fatty Acid Metabolism and its Regulation Book Summary : Fatty Acid Metabolism and its Regulation

Proceedings Of The Aocs Short Course On Polyunsaturated Fatty Acids And Eicosanoids Book PDF
✏Book Title : Proceedings of the AOCS Short Course on Polyunsaturated Fatty Acids and Eicosanoids
✏Author : William E. M. Lands
✏Publisher : The American Oil Chemists Society
✏Release Date : 1987
✏Pages : 574
✏ISBN : 0935315152
✏Available Language : English, Spanish, And French

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✏Proceedings of the AOCS Short Course on Polyunsaturated Fatty Acids and Eicosanoids Book Summary :

📒Dietary 3 And 6 Fatty Acids ✍ Corraldo Galli

Dietary 3 And 6 Fatty Acids Book PDF
✏Book Title : Dietary 3 and 6 Fatty Acids
✏Author : Corraldo Galli
✏Publisher : Springer Science & Business Media
✏Release Date : 2013-06-29
✏Pages : 452
✏ISBN : 9781475720433
✏Available Language : English, Spanish, And French

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✏Dietary 3 and 6 Fatty Acids Book Summary : On June 24-26, 1985, a major International Conference on the Hea1th Effects of P01yunsaturated Fatty Acids in Seafoods was held in Washington, D. C. The conference had two objectives: (1) to review the research data on the health effects of polyunsaturated fatty acids in seafoods in terms of the impact of omega-3 fatty acids on eicosanoid formation, thrombosis and inflammation, and the role of docosahexaenoic acid in membrane function and metabolism, and (2) to develop a research agenda to determine the spectrum of the health effects of polyunsaturated fatty acids of seafood origin in the American diet. The 1985 conference established the fact that omega-3 fatty acids of marine origin - eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) - play important roles in prostaglandin metabolism, thrombosis and atherosc1erosis, immunology and inflammation, and membrane function. In response to the conference recommendations, the Congress of the United States provided special funding for the establishment of a "test materials 1aboratory" within the US Department of Commerce to produce under documented quality contr01 the types and quanti ties of omega-3 te~3t materials required by biomedica1 researchers. The forms of test materials to be produced include refined fish oil, polyunsaturated fatty acid enhanced triglycerides, concentrates of esters of fatty acids, purified omega-3 fatty acids, and omega-3 mono-, di- and tri~lyceride mixtures.

Fatty Acids In Foods And Their Health Implications Third Edition Book PDF
✏Book Title : Fatty Acids in Foods and their Health Implications Third Edition
✏Author : Ching Kuang Chow
✏Publisher : CRC Press
✏Release Date : 2007-11-19
✏Pages : 1296
✏ISBN : 1420006908
✏Available Language : English, Spanish, And French

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✏Fatty Acids in Foods and their Health Implications Third Edition Book Summary : Since the publication of the bestselling second edition, mounting research into fatty acids reveals new and more defined links between the consumption of dietary fats and their biological health effects. Whether consuming omega-3 to prevent heart disease or avoiding trans fats to preserve heart health, it is more and more clear that not only the quantity but the type of fatty acid plays an important role in the etiology of the most common degenerative diseases. Keeping abreast of the mechanisms by which fatty acids exert their biological effects is crucial to unraveling the pathogenesis of a number of debilitating chronic disorders and can contribute to the development of effective preventive measures. Thoroughly revised to reflect the most resent research findings, Fatty Acids in Foods and their Health Implications, Third Edition retains the highly detailed, authoritative quality of the previous editions to present the current knowledge of fatty acids in food and food products and reveal diverse health implications. This edition includes eight entirely new chapters covering fatty acids in fermented foods, the effects of heating and frying on oils, the significance of dietary ?-linolenate in biological systems and inflammation, biological effects of conjugated linoleic acid and alpha-linolenic acid, and the role of fatty acids in food intake and energy homeostasis, as well as cognition, behavior, brain development, and mood disease. Several chapters underwent complete rewrites in light of new research on fatty acids in meat, meat products, and milk fat; fatty acid metabolism; eicosanoids; fatty acids and aging; and fatty acids and visual dysfunction. The most complete resource available on fatty acids and their biological effects, Fatty Acids in Foods and their Health Implications, Third Edition provides state-of-the-science information from all corners of nutritional and biomedical research.

Metabolism Of Essential Fatty Acids In Non Human Primates And Rats Studied Using Stable Isotopes And High Precision Mass Spectrometry Book PDF
✏Book Title : Metabolism of Essential Fatty Acids in Non human Primates and Rats Studied Using Stable Isotopes and High Precision Mass Spectrometry
✏Author : Rebecca Sheaff Greiner
✏Publisher :
✏Release Date : 1997
✏Pages : 284
✏ISBN : CORNELL:31924076529050
✏Available Language : English, Spanish, And French

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✏Metabolism of Essential Fatty Acids in Non human Primates and Rats Studied Using Stable Isotopes and High Precision Mass Spectrometry Book Summary : Omega-3 fatty (n-3) acids are important for the growth and development of the human central nervous system (CNS). Docosahexaenoic acid (DHA, 22:6n-3) is highly concentrated in the brain and retina of many species. The precise biochemical role of this compound is unknown, however, decreases in 22:6n-3 in human brain and plasma are associated with abnormal vision supporting the importance of this fatty acid. In this dissertation, several aspects of n-3 fatty acid metabolism are investigated in various species using high precision mass spectrometry.

Alpha Linolenic Acid Metabolism In The Egg And The Developing Chick Embryo Book PDF
✏Book Title : Alpha linolenic Acid Metabolism in the Egg and the Developing Chick Embryo
✏Author : Geetha Cherian
✏Publisher : National Library of Canada = Bibliothèque nationale du Canada
✏Release Date : 1993
✏Pages : 306
✏ISBN : CORNELL:31924067951503
✏Available Language : English, Spanish, And French

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✏Alpha linolenic Acid Metabolism in the Egg and the Developing Chick Embryo Book Summary :

Pyruvate And Fatty Acid Metabolism Book PDF
✏Book Title : Pyruvate and Fatty Acid Metabolism
✏Author : Marcel Florkin
✏Publisher : Elsevier
✏Release Date : 2016-01-11
✏Pages : 126
✏ISBN : 9781483193168
✏Available Language : English, Spanish, And French

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✏Pyruvate and Fatty Acid Metabolism Book Summary : Comprehensive Biochemistry, Volume 18S: Pyruvate and Fatty Acid Metabolism focuses on the processes, methodologies, principles, and reactions involved in pyruvate and fatty acid metabolism, including broad outlines of the metabolism of amino acids, proteins, carbohydrates, lipids, and their derived products. The selection first ponders on pyruvate dehydrogenase complex and citric acid cycle. Numerical analyses of the various reaction sequences are presented. The text also takes a look at fatty acid metabolism. Discussions focus on fatty acid oxidation and biosynthesis, elongation and desaturation of fatty acids, and control of fatty acid oxidation and biosynthesis. The book is a valuable reference for researchers interested in pyruvate and fatty acid metabolism.

Handbook Of Essential Fatty Acid Biology Book PDF
✏Book Title : Handbook of Essential Fatty Acid Biology
✏Author : David I. Mostofsky
✏Publisher : Springer Science & Business Media
✏Release Date : 2013-03-09
✏Pages : 470
✏ISBN : 9781475725827
✏Available Language : English, Spanish, And French

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✏Handbook of Essential Fatty Acid Biology Book Summary : Internationally eminent scientists illuminate the most important scientific aspects of essential fatty acids (EFAs)-from their biochemistry to their physiological consequences in both health and illness. The distinguished contributors integrate a wide range of topics, including the basic biochemistry of EFAs and lipid metabolism, the role of EFAs in the neuronal membrane, the effects of EFAs and lipids in various diseases, and the effects of normal levels and EFA deficiencies on cognition and behavior. The book's consolidation of our knowledge of the biology and metabolism of the EFAs lays the groundwork for dramatic advances in our understanding of these ubiquitous biochemicals and their role in health and illness.

Disorders Of Lipid Metabolism Book PDF
✏Book Title : Disorders of Lipid Metabolism
✏Author : G.V. Marinetti
✏Publisher : Springer Science & Business Media
✏Release Date : 2012-12-06
✏Pages : 240
✏ISBN : 9781461595649
✏Available Language : English, Spanish, And French

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✏Disorders of Lipid Metabolism Book Summary : For the past 30 years I have been teaching lipid biochemistry to'inedical students, graduate students, and undergraduate students. The major topics covered in my courses were fatty acids, prostaglandins, leukotrienes, phospholipids, glyco lipids, triacylglycerols, cholesterol, bile acids, and plasma lipoproteins. Empha sis was placed on the regulation and disorders of lipid metabolism. The latter included hyperlipidemias, atherosclerosis, and alcohol-induced liver damage. In this volume, I have chosen to focus on the disorders of lipid metabolism at a level appropriate both for medical students and for graduate and undergradu ate students majoring in the biological sciences. The biochemistry, nutrition, genetics, and cell biology aspects of lipids and lipid metabolism will be covered as they relate to lipid disorders. I am not aware of any textbook that integrates the disorders of lipid metabolism in this manner. Chapter 1 includes a brief discussion of the basic structures, properties, and metabolism of lipids. This chapter is not very detailed, since the material covered is available in basic textbooks on biochemistry. The major fpcus of this volume is the various lipid disorders, with emphasis on polyunsaturated fatty acids, the molecular biology and pathogenesis of the hyperlipidemias, dietary and drug therapy for the hyperlipidemias, and alcohol-induced liver damage. The material presented has been obtained from several textbooks on biochemistry and from a variety of recent articles in the scientific literature.

📒Plant Lipid Metabolism ✍ J.C. Kader

Plant Lipid Metabolism Book PDF
✏Book Title : Plant Lipid Metabolism
✏Author : J.C. Kader
✏Publisher : Springer Science & Business Media
✏Release Date : 2013-04-18
✏Pages : 588
✏ISBN : 9789401583947
✏Available Language : English, Spanish, And French

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✏Plant Lipid Metabolism Book Summary : A collection of papers that comprehensively describe the major areas of research on lipid metabolism of plants. State-of-the-art knowledge about research on fatty acid and glycerolipid biosynthesis, isoprenoid metabolism, membrane structure and organization, lipid oxidation and degradation, lipids as intracellular and extracellular messengers, lipids and environment, oil seeds and gene technology is reviewed. The different topics covered show that modern tools of plant cellular and molecular biology, as well as molecular genetics, have been recently used to characterize several key enzymes of plant lipid metabolism (in particular, desaturases, thioesterases, fatty acid synthetase) and to isolate corresponding cDNAs and genomic clones, allowing the use of genetic engineering methods to modify the composition of membranes or storage lipids. These findings open fascinating perspectives, both for establishing the roles of lipids in membrane function and intracellular signalling and for adapting the composition of seed oil to the industrial needs. This book will be a good reference source for research scientists, advanced students and industrialists wishing to follow the considerable progress made in recent years on plant lipid metabolism and to envision the new opportunities offered by genetic engineering for the development of novel oil seeds.

📒Lipid Metabolism ✍ Rodrigo Valenzuela Baez

Lipid Metabolism Book PDF
✏Book Title : Lipid Metabolism
✏Author : Rodrigo Valenzuela Baez
✏Publisher : BoD – Books on Demand
✏Release Date : 2013-01-23
✏Pages : 474
✏ISBN : 9789535109440
✏Available Language : English, Spanish, And French

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✏Lipid Metabolism Book Summary : Lipids (fats and oils) are a wide range of organic molecules that serve several functions in organisms. Lipids are essential components of our diet, highlighting their important contribution in energy, representing 9 kcal/g (or 37.7 kJ/g), and by some components relevant to the metabolism, such as essential fatty acids, fat soluble vitamins and sterols (cholesterol and phytosterols). Besides this, lipids have key roles in human growth and development, along with promoting, preventing and/or participating in the origin or eventually in the treatment of various diseases. This book presents a systematic and comprehensive review about the structure and metabolism of lipids, particularly highlighting the importance of these molecules in the body and considering the interest of some lipids in health and disease.

📒Intestinal Lipid Metabolism ✍ Charles M. Mansbach II

Intestinal Lipid Metabolism Book PDF
✏Book Title : Intestinal Lipid Metabolism
✏Author : Charles M. Mansbach II
✏Publisher : Springer Science & Business Media
✏Release Date : 2001
✏Pages : 434
✏ISBN : 0306462419
✏Available Language : English, Spanish, And French

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✏Intestinal Lipid Metabolism Book Summary : This book presents an in-depth review by recognized experts of what is known about the digestion, absorption, and transport of lipids by the intestine. Because lipids affect energy metabolism and the development of arteriosclerosis and obesity, the book will appeal to a large audience including clinicians, physiologists, and biochemists.

Health Effects Of Polyunsaturated Fatty Acids In Seafoods Book PDF
✏Book Title : Health Effects of Polyunsaturated Fatty Acids in Seafoods
✏Author : Artemis P Simopoulos
✏Publisher : Academic Press
✏Release Date : 2012-12-02
✏Pages : 473
✏ISBN : 9780323138116
✏Available Language : English, Spanish, And French

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✏Health Effects of Polyunsaturated Fatty Acids in Seafoods Book Summary : Health Effects of the Polyunsaturated Fatty Acids in Seafoods emerged from the 1985 Proceedings of a Conference on Health Effects of Polyunsaturated Fatty Acids in Seafoods held in Washington, D.C., spearheaded by the National Fisheries Institutes of Health (NIH), the Department of Commerce (DOC), and the National Fisheries Institute (NFI). The conference aims to review the data about the health effects of polyunsaturated fatty acids in seafood; the impact of omega-3 fatty acids on eicosanoid formation, thrombosis, and inflammation; and the role of docosahexaenoic acid in membrane function and metabolism. It also encourages the researchers to study the possible origin of the health effects of seafood in the American diet. Composed of seven parts, the book begins by discussing the summary, conclusions, and recommendations the chairman of each working groups presented during the conference. It also explains the effects of fatty acids on lipoprotein and generation of products of the 5-Lipoxygenase pathway and the membrane functioning and metabolism. Moreover, it discusses the status of the fishery industries worldwide, the different classes of lipids that contain fatty acids, and recipes with seafood as the main ingredient. This book will be of great interest to the scientists such as basic researchers, clinical investigators, and epidemiologists, as well as to health personnel and consumers.

Metabolic Engineering For The Production Of Polyunsaturated Fatty Acids Book PDF
✏Book Title : Metabolic Engineering for the Production of Polyunsaturated Fatty Acids
✏Author : Brian Patrick Frushour
✏Publisher :
✏Release Date : 2003
✏Pages : 88
✏ISBN : UCAL:C3486120
✏Available Language : English, Spanish, And French

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✏Metabolic Engineering for the Production of Polyunsaturated Fatty Acids Book Summary :

Personalized Nutrition For The Diverse Needs Of Infants And Children Book PDF
✏Book Title : Personalized Nutrition for the Diverse Needs of Infants and Children
✏Author : Dennis M. Bier
✏Publisher : Karger Medical and Scientific Publishers
✏Release Date : 2008
✏Pages : 261
✏ISBN : 9783805585538
✏Available Language : English, Spanish, And French

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✏Personalized Nutrition for the Diverse Needs of Infants and Children Book Summary : Research shows that humans respond differently to diets and, moreover, that they display varying predispositions to many diet-dependent metabolic and degenerative diseases. The focus of nutritional science is thus shifting from dietary guidelines for populations to individualized foods and diets. It is the aim of nutrigenomics to assign this human diversity in nutritional response to diet - as well as the subsequent consequences to human health - to specific genetic elements. At the same time, evidence suggests that diet itself is a critical determinant of human diversity. Supplying answers to some crucial issues, as well as identifying directions for further research and practical applications by the food industry, this publication is an important source of information for all those involved in the subject of diet and individual responses.

Regulation And Function Of Branched Chain Amino Acid Metabolism In Adipocytes Book PDF
✏Book Title : Regulation and Function of Branched chain Amino Acid Metabolism in Adipocytes
✏Author : Courtney Renee Green
✏Publisher :
✏Release Date : 2019
✏Pages : 191
✏ISBN : OCLC:1135500690
✏Available Language : English, Spanish, And French

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✏Regulation and Function of Branched chain Amino Acid Metabolism in Adipocytes Book Summary : Metabolism is essential for the maintenance of cellular homeostasis as cells must either import or synthesize substrates for use in biosynthetic and energy generating reactions. Different cell types have different metabolic functions, and adipocyte metabolism changes dramatically during adipogenesis or in response to overnutrition/obesity. The metabolism of substrates such as glucose and fatty acids (FA) are well-studied in adipocytes, but evidence suggests that the metabolism of the essential branched-chain amino acids (BCAA- leucine, isoleucine, and valine) is particularly altered in obesity. The chapters of this dissertation are independent bodies of work that explore how BCAA metabolism changes in differentiating adipocytes, contributes to de novo lipogenesis (DNL), and regulates the fatty acid profile within the lipidome. Chapter 1, titled "Studying adipose tissue branched-chain amino acid metabolism in obesity and diabetes using stable-isotope tracing" is a review of the relevant adipose- and BCAA-related literature and the utility of stable-isotope tracing and metabolic flux analysis (MFA) to the study adipocyte metabolism. Chapter 2, titled "Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis," uses stable-isotope tracing and mass spectrometry to quantify the increase in the contribution of BCAA catabolism to the TCA cycle and DNL throughout differentiation. This chapter also details a vitamin B12 deficiency in typical adipocyte cell culture and demonstrates adipocytes' ability to reprogram metabolism to maintain BCAA levels in physiological media with lower amino acid concentrations. Chapter 3, titled "Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues," is a broad characterization of branched-chain fatty acid (BCFA) synthesis in adipocytes and in mammals using a variety of stable-isotope tracers. We show that BCFAs are highly synthesized in adipose tissue due to expression of a critical protein in AT that facilitates their synthesis, are synthesized from intermediate metabolites in BCAA catabolism, and are decreased in a high-fat diet via a hypoxia-related mechanism. Chapter 4, titled "Altered branched-chain amino acid catabolism drives distinct changes in the TCA cycle and lipidome," is currently being prepared for submission for publication. In this manuscript, we interrogate the metabolic and functional impacts of reduced BCAA catabolism through CRISPR/Cas9-mediated deficiency of Bckdha. While differentiation is unaffected by Bckdha deficiency, oxygen consumption rates are reduced, and relative glucose metabolism increases to support DNL. Furthermore, Bckdha deficiency decreased the levels of polyunsaturated fatty acid (PUFA)-containing sphingomyelin and increased the levels of PUFA-containing phosphatidylcholine. We hypothesize that the dramatic reduction of BCFAs and OCFAs in Bckdha deficient adipocytes is driving this FA reorganization phenotype. The functional impact of this change is unknown but membrane fluidity and permeability could be affected. Taken together, these collective studies demonstrate the importance of understanding the regulation and function of BCAA metabolism in adipocytes in the obese or insulin resistant state. These findings could impact biomarker development and improve our understanding of the progression of diabetes.

Essential Fatty Acids And Eicosanoids Book PDF
✏Book Title : Essential Fatty Acids and Eicosanoids
✏Author : Yongsheng Huang
✏Publisher : The American Oil Chemists Society
✏Release Date : 2003-10-30
✏Pages : 372
✏ISBN : 1893997413
✏Available Language : English, Spanish, And French

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✏Essential Fatty Acids and Eicosanoids Book Summary :

Fatty Acid Digestion Synthesis And Metabolism In Broiler Chickens And Pigs Book PDF
✏Book Title : Fatty Acid Digestion Synthesis and Metabolism in Broiler Chickens and Pigs
✏Author : Willem Smink
✏Publisher :
✏Release Date : 2012
✏Pages : 141
✏ISBN : 9461733062
✏Available Language : English, Spanish, And French

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✏Fatty Acid Digestion Synthesis and Metabolism in Broiler Chickens and Pigs Book Summary :

Understanding Lipid Metabolism With Microarrays And Other Omic Approaches Book PDF
✏Book Title : Understanding Lipid Metabolism with Microarrays and Other Omic Approaches
✏Author : Alvin Berger
✏Publisher : CRC Press
✏Release Date : 2004-11-30
✏Pages : 472
✏ISBN : 1420030922
✏Available Language : English, Spanish, And French

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✏Understanding Lipid Metabolism with Microarrays and Other Omic Approaches Book Summary : Reviewing current studies and previously unpublished research from leading laboratories around the world, Unraveling Lipid Metabolism with Microarrays demonstrates the use of microarrays and transcriptomic approaches to clarify the biological function of lipids. With contributions from world-class researchers, the book focuses on the use of microar

Fatty Acids And Cardiometabolic Health Book PDF
✏Book Title : Fatty Acids and Cardiometabolic Health
✏Author : Jason Wu
✏Publisher : MDPI
✏Release Date : 2019-05-09
✏Pages : 202
✏ISBN : 9783038978909
✏Available Language : English, Spanish, And French

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✏Fatty Acids and Cardiometabolic Health Book Summary : The impact of fat intake on hypercholesterolemia and related atherosclerotic cardiovascular diseases has been studied for decades. However, the current evidence base suggests that fatty acids also influences cardiometabolic diseases through other mechanisms including effects on glucose metabolism, body fat distribution, blood pressure, inflammation, and heart rate. Furthermore, studies evaluating single fatty acids have challenged the simplistic view of shared health effects within fatty acid groups categorized by degree of saturation. In addition, investigations of endogenous fatty acid metabolism, including genetic studies of fatty acid metabolizing enzymes, and the identification of novel metabolically derived fatty acids have further increased the complexity of fatty acids’ health impacts. This Special Issue aims to include original research and up-to-date reviews on genetic and dietary modulation of fatty acids, and the role and function of dietary and metabolically derived fatty acids in cardiometabolic health.

Health Effects Of Dietary Fatty Acids Book PDF
✏Book Title : Health Effects of Dietary Fatty Acids
✏Author : Gary J. Nelson
✏Publisher : The American Oil Chemists Society
✏Release Date : 1991
✏Pages : 274
✏ISBN : 0935315314
✏Available Language : English, Spanish, And French

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✏Health Effects of Dietary Fatty Acids Book Summary :

Lipid Metabolism In Ruminant Animals Book PDF
✏Book Title : Lipid Metabolism in Ruminant Animals
✏Author : William W. Christie
✏Publisher : Elsevier
✏Release Date : 2014-05-19
✏Pages : 460
✏ISBN : 9781483152721
✏Available Language : English, Spanish, And French

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✏Lipid Metabolism in Ruminant Animals Book Summary : Lipid Metabolism in Ruminant Animals is a nine-chapter book that first discusses the anatomy, physiology, and microbiology of the ruminant digestive tract. Subsequent chapters center on lipid metabolism in the rumen; digestion, absorption and transport of lipids in ruminant animals; the composition, structure and function of lipids in the tissues of ruminant animals; and the effects of diet and other factors on the lipid composition of ruminant tissues and milk. Other chapters focus on lipid metabolism in the mammary gland, adipose tissue, liver, and other selected tissues of ruminant animals.

Biology Of Metabolism In Growing Animals Book PDF
✏Book Title : Biology of Metabolism in Growing Animals
✏Author : Douglas G. Burrin
✏Publisher : Elsevier Health Sciences
✏Release Date : 2005
✏Pages : 483
✏ISBN : 9780444510136
✏Available Language : English, Spanish, And French

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✏Biology of Metabolism in Growing Animals Book Summary : The book is intended to provide in-depth reviews of the recent advances in major areas of metabolism in growing domestic animals. The study of metabolism represents a nexus of biological phenomenon that integrates the impact of nutrition, physiology, endocrinology, immunology, biochemistry, and cell biology in an organism. The development of new methodological techniques and experimental approaches have provide scientists with a greater understanding of how key nutrients or substrates are metabolized at the cellular, organ, and whole animal level. This book presents contributions from leading scientists in nutrition and physiology that highlight important new developments in interorgan and tissue-specific metabolism of protein and amino acids, lipids and fatty acids, and carbohydrates in monogastric and runinant species. Authors will describe the impact of specific biochemical pathways and expression of critical enzymes, routes of nutrient or substrate input, and anatomical or structural influences on the rates of metabolism in a given tissue or cell type. Major substrates/ fuels for oxidative metabolism, key signaling pathways, and intracellular molecules that regulate the major metabolic processes will be described. Also included is how the metabolism of growing animals is influenced by ontogeny, stage of differentiation, and major changes in diet, or the environment. The concepts and specific findings in each area are discussed in the context of their impact on the nutrient requirements, growth, environmental impact, healt and well-being of animals. The book will be a useful reference for research scientists, teachers and students interested in and advanced understanding of metabolism in growing animals. The book is written by leading experts and highlights some of the most recent advances in the field of metabolism. It is a useful reference for researchers and advanced level graduate students in nutrition, physiology and animal science. Presents recent advances in the field of metabolism.

Biochemistry Of Arachidonic Acid Metabolism Book PDF
✏Book Title : Biochemistry of Arachidonic Acid Metabolism
✏Author : William E.M. Lands
✏Publisher : Springer Science & Business Media
✏Release Date : 2012-12-06
✏Pages : 442
✏ISBN : 9781461325970
✏Available Language : English, Spanish, And French

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✏Biochemistry of Arachidonic Acid Metabolism Book Summary : Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time, the concept that arachidonic acid metabolites may be in volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec tively. Cyclooxygenase products consist of diverse products such as prosta glandin E, (POE,), prostacyclin (POI2) and thromboxane A2 (TXA2), whereas lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lip oxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids.