Piperidine Based Drug Discovery

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  • Author : Ruben Vardanyan
  • Publisher : Elsevier
  • Pages : 358 pages
  • ISBN : 0128134283
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Piperidine Based Drug Discovery

Download or Read online Piperidine Based Drug Discovery full in PDF, ePub and kindle. this book written by Ruben Vardanyan and published by Elsevier which was released on 12 June 2017 with total page 358 pages. We cannot guarantee that Piperidine Based Drug Discovery book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Piperidine-Based Drug Discovery outlines the complexities of Piperidine scaffold use in drug discovery, including derivative chemistry, structural properties, methods of synthesis and practical implementations. Piperidine scaffolds are the cornerstones of over 70 commercialized drugs (including multiple blockbusters). Designed as a guide for both experts and students working in this and related areas, it is hoped that this volume will encourage and inspire the continued design and development of novel pharmaceuticals based on Piperidine and its derivatives. Heterocyclic compounds are of central importance to medicinal chemistry, as demonstrated by the high percentage of marketable drugs that feature heterocyclic fragments in their structures. As starting points for drug discovery they offer a broad range of attractive properties, and a detailed understanding of the particular characteristics of each is of great benefit to researchers. The most commonly used heterocycle among US FDA approved pharmaceuticals, Piperidine is an extremely important building block in the synthesis of medicinal agents. This heterocycle and its derivatives exhibit a number of important functionalities and have been employed variously as CNS modulators, antiaggregants, anticoagulants, antihistamines, anti-cancer drugs and analgesics. Explores this extremely important heterocycle to a high level of detail Describes synthesis methods for 70 current drugs based on Piperidine scaffolds Gives drug designers all the key knowledge required to develop new drugs utilizing Piperidine Provides pharmacologists a solid overview of the chemical background of existing Piperidine-based drugs

Piperidine Based Drug Discovery

Piperidine Based Drug Discovery
  • Author : Ruben Vardanyan
  • Publisher : Elsevier
  • Release : 12 June 2017
GET THIS BOOK Piperidine Based Drug Discovery

Piperidine-Based Drug Discovery outlines the complexities of Piperidine scaffold use in drug discovery, including derivative chemistry, structural properties, methods of synthesis and practical implementations. Piperidine scaffolds are the cornerstones of over 70 commercialized drugs (including multiple blockbusters). Designed as a guide for both experts and students working in this and related areas, it is hoped that this volume will encourage and inspire the continued design and development of novel pharmaceuticals based on Piperidine and its derivatives. Heterocyclic compounds are of central

Privileged Structures in Drug Discovery

Privileged Structures in Drug Discovery
  • Author : Larry Yet
  • Publisher : John Wiley & Sons
  • Release : 27 March 2018
GET THIS BOOK Privileged Structures in Drug Discovery

A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that reviews privileged structures from the point of view of medicinal chemistry and contains the synthetic routes to these structures. In this text, the author—a noted expert in the field—

Fragment based Drug Discovery

Fragment based Drug Discovery
  • Author : Daniel A. Erlanson,Wolfgang Jahnke,Raimund Mannhold,Hugo Kubinyi,Gerd Folkers
  • Publisher : John Wiley & Sons
  • Release : 23 February 2016
GET THIS BOOK Fragment based Drug Discovery

From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed. The first part discusses basic considerations of when to use fragment-based methods, how to select targets, and

Imidazole Based Drug Discovery

Imidazole Based Drug Discovery
  • Author : Shikha Agarwal
  • Publisher : Elsevier
  • Release : 10 December 2021
GET THIS BOOK Imidazole Based Drug Discovery

Imidazole-Based Drug Discovery covers all categories of imidazole and its derivatives, synthesis, pharmacological applications and drug-based studies. Imidazole scaffolds act as a channel between organic synthesis and medicinal chemistry and compel researchers to explore new drug candidates. This book provides detailed coverage of several greener synthetic protocols and pharmacological applications of imidazole derivatives that are useful to researchers working on designing more promising clinical lead compounds with this scaffold. It also includes information on past decades of research on the

Drug Discovery with Privileged Building Blocks

Drug Discovery with Privileged Building Blocks
  • Author : Jie Jack Li,Minmin Yang
  • Publisher : CRC Press
  • Release : 21 October 2021
GET THIS BOOK Drug Discovery with Privileged Building Blocks

Drug Discovery with Privileged Building Blocks traces back PharmaBlock’s founding philosophy of designing privileged building blocks. High-quality building blocks are crucial not only to biological activities of different molecules but also to ADMET properties, which eventually will impact the success rate of drug discovery projects. A thorough study of how building blocks perform in drug molecules and a regular analysis of new building block structures in the latest researches have proven to be a fruitful strategy to generate novel

Computational and Structural Approaches to Drug Discovery

Computational and Structural Approaches to Drug Discovery
  • Author : Robert Stroud,Janet Finer-Moore
  • Publisher : Royal Society of Chemistry
  • Release : 31 October 2007
GET THIS BOOK Computational and Structural Approaches to Drug Discovery

Computational methods impact all aspects of modern drug discovery and most notably these methods move rapidly from academic exercises to becoming drugs in clinical trials... This insightful book represents the experience and understanding of the global experts in the field and spotlights both the structural and medicinal chemistry aspects of drug design. The need to 'encode' the factors that determine adsorption, distribution, metabolism, excretion and toxicology are explored, as they remain the critical issues in this area of research. This

Piperidine

Piperidine
  • Author : Mario Rubiralta,Ernest Giralt,Anna Diez
  • Publisher : Elsevier Science Limited
  • Release : 08 December 1991
GET THIS BOOK Piperidine

Piperidine, one of the simplest heterocyclic systems, is found in nature as part of several alkaloid compounds. Both natural and especially unnatural piperidine derivatives present interesting pharmacological properties. From a structural viewpoint, the conformation of piperidine has been the subject of one of the fiercest controversies in structural organic chemistry in the last few years. As a result of the combined use of several spectroscopic techniques, the conformational behavior of most types of piperidine-related compounds has been clarified. Some piperidine

Carbohydrate based Drug Discovery

Carbohydrate based Drug Discovery
  • Author : Chi-Huey Wong
  • Publisher : John Wiley & Sons
  • Release : 06 March 2006
GET THIS BOOK Carbohydrate based Drug Discovery

To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following: > Chemical Synthesis of Carbohydrates > Carbohydrate Biosynthesis and Metabolism > Carbohydrate Analysis > Cellular Functions of Carbohydrates > Development of Carbohydrate-based Drugs A premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume

Kinase Drug Discovery

Kinase Drug Discovery
  • Author : Richard A. Ward,Frederick W. Goldberg
  • Publisher : Royal Society of Chemistry
  • Release : 10 October 2018
GET THIS BOOK Kinase Drug Discovery

Kinase inhibition remains an area of significant interest, and growing importance, across academia and the pharmaceutical industry. There are now many marketed drugs that target kinases and a significant number of compounds are currently in various stages of clinical development. This book is a forward-looking analysis of a number of key areas for kinase inhibition in the coming years.

Privileged Structures in Drug Discovery

Privileged Structures in Drug Discovery
  • Author : Larry Yet
  • Publisher : John Wiley & Sons
  • Release : 07 March 2018
GET THIS BOOK Privileged Structures in Drug Discovery

A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that reviews privileged structures from the point of view of medicinal chemistry and contains the synthetic routes to these structures. In this text, the author—a noted expert in the field—

Drug Discovery for Psychiatric Disorders

Drug Discovery for Psychiatric Disorders
  • Author : Zoran Rankovic,Richard Hargreaves,Matilda Bingham
  • Publisher : Royal Society of Chemistry
  • Release : 08 October 2012
GET THIS BOOK Drug Discovery for Psychiatric Disorders

The discovery and development of effective medicines for the treatment of psychiatric disorders such as schizophrenia and depression has been heralded as one of the great medical achievements of the past century. Indeed, the profound impact of these medicines on our understanding of the pathophysiology underlying these diseases, the treatment of psychiatric patients and even our social perception of mental illnesses cannot be underestimated. However, there is still an urgent medical need for even more effective, safe and well-tolerated treatments.

Scaffold Hopping in Medicinal Chemistry

Scaffold Hopping in Medicinal Chemistry
  • Author : Nathan Brown
  • Publisher : John Wiley & Sons
  • Release : 06 November 2013
GET THIS BOOK Scaffold Hopping in Medicinal Chemistry

This first systematic treatment of the concept and practice of scaffold hopping shows the tricks of the trade and provides invaluable guidance for the reader's own projects. The first section serves as an introduction to the topic by describing the concept of scaffolds, their discovery, diversity and representation, and their importance for finding new chemical entities. The following part describes the most common tools and methods for scaffold hopping, whether topological, shape-based or structure-based. Methods such as CATS, Feature Trees,

Chemokines

Chemokines
  • Author : Nuska Tschammer
  • Publisher : Springer
  • Release : 02 March 2015
GET THIS BOOK Chemokines

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series

Methods and Algorithms for Molecular Docking Based Drug Design and Discovery

Methods and Algorithms for Molecular Docking Based Drug Design and Discovery
  • Author : Dastmalchi, Siavoush
  • Publisher : IGI Global
  • Release : 03 May 2016
GET THIS BOOK Methods and Algorithms for Molecular Docking Based Drug Design and Discovery

The role of technology in the medical field has resulted in significant developments within the pharmaceutical industry. Computational approaches have emerged as a crucial method in further advancing drug design and development. Methods and Algorithms for Molecular Docking-Based Drug Design and Discovery presents emerging research on the application of computer-assisted design methods for drugs, emphasizing the benefits and improvements that molecular docking has caused within the pharmaceutical industry. Focusing on validation methods, search algorithms, and scoring functions, this book is

Anti fibrotic Drug Discovery

Anti fibrotic Drug Discovery
  • Author : Jehrod Brenneman,Malliga R. Iyer
  • Publisher : Royal Society of Chemistry
  • Release : 28 February 2020
GET THIS BOOK Anti fibrotic Drug Discovery

Fibrosis is a condition with globally high unmet medical need, and as such is a highly active area of academic and pharmaceutical research covering multiple treatment targets, organs, tissues and therapeutic approaches. Anti-fibrotic Drug Discovery is a single source reference for the latest drug-discovery approaches to tackle fibrosis in various tissues, comprehensively covering recent success and future perspectives on emerging therapeutic intervention points. The book highlights significant pre-clinical and clinical drugs currently being developed globally for this disorder. This book