Physiology and Pathology of Chloride Transporters and Channels in the Nervous System

Produk Detail:
  • Author : F. Javier Alvarez-Leefmans
  • Publisher : Academic Press
  • Pages : 630 pages
  • ISBN : 9780080922034
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Physiology and Pathology of Chloride Transporters and Channels in the Nervous System

Download or Read online Physiology and Pathology of Chloride Transporters and Channels in the Nervous System full in PDF, ePub and kindle. this book written by F. Javier Alvarez-Leefmans and published by Academic Press which was released on 22 August 2009 with total page 630 pages. We cannot guarantee that Physiology and Pathology of Chloride Transporters and Channels in the Nervous System book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change in this simplistic view. We now know that most animal cells, neurons included, exhibit a non-equilibrium distribution of Cl- across their plasma membranes. Over the last 10 to 15 years, with the growth of molecular biology and the advent of new optical methods, an enormous amount of exciting new information has become available on the molecular structure and function of Cl- channels and carriers. In nerve cells, Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control. Disruption of Cl- homeostasis in neurons underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation. This book is about how chloride ions are regulated and how they cross the plasma membrane of neurons. It spans from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases. The first comprehensive book on the structure, molecular biology, cell physiology, and role in diseases of chloride transporters / channels in the nervous system in almost 20 years Chloride is the most abundant free anion in animal cells. THis book summarizes and integrates for the first time the important research of the past two decades that has shown that Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control The first book that systematically discusses the result of disruption of Cl- homeostasis in neurons which underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation Spanning topics from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases Involves all of the leading researchers in the field Includes an extensive introductory section that covers basic thermodynamic and kinetics aspects of Cl- transport, as well as current methods for studying Cl- regulation, spanning from fluorescent dyes in single cells to knock-out models to make the book available for a growing population of graduate students and postdocs entering the field

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System
  • Author : F. Javier Alvarez-Leefmans,Eric Delpire
  • Publisher : Academic Press
  • Release : 22 August 2009
GET THIS BOOK Physiology and Pathology of Chloride Transporters and Channels in the Nervous System

The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change

Cell Physiology Sourcebook

Cell Physiology Sourcebook
  • Author : Nicholas Sperelakis
  • Publisher : Academic Press
  • Release : 01 January 2012
GET THIS BOOK Cell Physiology Sourcebook

This authoritative book gathers together a broad range of ideas and topics that define the field. It provides clear, concise, and comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics. The Fourth Edition contains substantial new material. Most chapters have been thoroughly reworked. The book includes chapters on important topics such as sensory transduction, the physiology of protozoa and bacteria, and synaptic transmission. Authored by leading researchers in the field Clear, concise, and comprehensive

Studies of Epithelial Transporters and Ion Channels

Studies of Epithelial Transporters and Ion Channels
  • Author : Kirk L. Hamilton,Daniel C. Devor
  • Publisher : Springer Nature
  • Release : 04 March 2021
GET THIS BOOK Studies of Epithelial Transporters and Ion Channels

This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. The authors will show, that each of these channels and transporters play crucial roles in transepithelial ion and fluid transport across epithelia and their responsibility in maintaining homeostasis. The reader gains an understanding of the fundamentals of epithelial ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the third of

Erythrocytes

Erythrocytes
  • Author : Florian Lang,Michael Föller
  • Publisher : World Scientific Publishing Company
  • Release : 23 July 2012
GET THIS BOOK Erythrocytes

The book covers the functional significance and properties of erythrocytes, their generation, senescence, and suicidal death. It further summarizes knowledge about hormones influencing erythrocyte formation including erythropoietin as well as disorders affecting and involving erythrocytes such as anemia, malaria, and sepsis. This seminal work forms a unique reference on the most abundant cell type in mammals and will be an invaluable resource for students in the life sciences.

Membrane Transporters in the Pathogenesis of Cardiovascular and Lung Disorders

Membrane Transporters in the Pathogenesis of Cardiovascular and Lung Disorders
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 05 June 2019
GET THIS BOOK Membrane Transporters in the Pathogenesis of Cardiovascular and Lung Disorders

Membrane Transporters in the Pathogenesis of Cardiovascular and Lung Disorders, Volume 83, the latest release in the Current Topics in Membranes series, highlights new advances in the field, with this volume presenting chapters from recognized experts on topics such as cardiotonic steroids, Na+, K+ pumps and vascular fibrosis, purinergic signaling in the lung, structural models of a2-subunit N-termini and binding interfaces, ubiquitous and cell type-specific transcriptomic changes triggered by dissipation of monovalent cation gradients, the Na, K-ATPase alpha2 isoform in

Cell Volume Regulation

Cell Volume Regulation
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 20 September 2018
GET THIS BOOK Cell Volume Regulation

Cell Volume Regulation and Fluid Secretion, Volume 81, the latest release in the Current Topics in Membranes series highlights new advances in the field, with this new volume presenting interesting chapters on General principles of cell volume regulation, Cell volume maintenance: water and salt homeostasis, The search for ubiquitous cell volume sensor: the role of plasma membrane and cytoplasmic hydrogel, More than membranes, Cellular and membrane biomechanics of CVR response, Molecular identities of volume-regulatory anion channels, Molecular biology and physiology of

Ion Channels and Transporters of Epithelia in Health and Disease

Ion Channels and Transporters of Epithelia in Health and Disease
  • Author : Kirk L. Hamilton,Daniel C Devor
  • Publisher : Springer
  • Release : 14 December 2015
GET THIS BOOK Ion Channels and Transporters of Epithelia in Health and Disease

This book sheds new light on the physiology, molecular biology and pathophysiology of epithelial ion channels and transporters. It combines the basic cellular models and functions by means of a compelling clinical perspective, addressing aspects from the laboratory bench to the bedside. The individual chapters, written by leading scientists and clinicians, explore specific ion channels and transporters located in the epithelial tissues of the kidney, intestine, pancreas and respiratory tract, all of which play a crucial part in maintaining homeostasis.

Ion Transport Across Epithelial Tissues and Disease

Ion Transport Across Epithelial Tissues and Disease
  • Author : Kirk L. Hamilton,Daniel C. Devor
  • Publisher : Springer Nature
  • Release : 12 December 2020
GET THIS BOOK Ion Transport Across Epithelial Tissues and Disease

This book discusses the unique ion channels and transporters found within the epithelial tissues of various organs, including the kidney, intestine, pancreas and respiratory tract. Authors focus on demonstrating the crucial roles that each of these channels and transporters play in transepithelial ion and fluid transport across epithelia, as well as in maintaining homeostasis. It allows readers to gain an understanding of the fundamentals of ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the

Optogenetics

Optogenetics
  • Author : Hiromu Yawo,Hideki Kandori,Amane Koizumi
  • Publisher : Springer
  • Release : 05 June 2015
GET THIS BOOK Optogenetics

The subject of optogenetics is comprehensively covered in this book, including physical, chemical, and biological topics of light-sensing proteins and their application in biological systems, particularly in neuroscience and medicine and the related opto-electronics. Optogenetics is a new technology that combines genetics and optics. It enables one to manipulate or measure the function of identified cells or neurons in a tissue by light with an accuracy in the range of milliseconds, even in a freely moving animal. Optogenetics has already

Advanced Time Correlated Single Photon Counting Applications

Advanced Time Correlated Single Photon Counting Applications
  • Author : Wolfgang Becker
  • Publisher : Springer
  • Release : 13 April 2015
GET THIS BOOK Advanced Time Correlated Single Photon Counting Applications

This book is an attempt to bridge the gap between the instrumental principles of multi-dimensional time-correlated single photon counting (TCSPC) and typical applications of the technique. Written by an originator of the technique and by sucessful users, it covers the basic principles of the technique, its interaction with optical imaging methods and its application to a wide range of experimental tasks in life sciences and clinical research. The book is recommended for all users of time-resolved detection techniques in biology,

Encyclopedia of the Neurological Sciences

Encyclopedia of the Neurological Sciences
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 29 April 2014
GET THIS BOOK Encyclopedia of the Neurological Sciences

The Encyclopedia of the Neurological Sciences, Second Edition develops from the first edition, covering all areas of neurological sciences through over 1000 entries focused on a wide variety of topics in neurology, neurosurgery, psychiatry and other related areas of neuroscience. The contributing authors represent all aspects of neurology from many viewpoints and disciplines to provide a complete overview of the field. Entries are designed to be understandable without detailed background knowledge in the subject matter, and cross-referencing and suggested further reading

The Oxford Handbook of the Neurobiology of Pain

The Oxford Handbook of the Neurobiology of Pain
  • Author : Professor John N. Wood
  • Publisher : Oxford University Press
  • Release : 17 June 2020
GET THIS BOOK The Oxford Handbook of the Neurobiology of Pain

The Oxford Handbook of the Neurobiology of Pain represents a state of the art overview of the rapidly developing field of pain research. As populations age, the number of people in pain is growing dramatically, with half the population living with pain. The opioid crisis has highlighted this problem. The present volume is thus very timely, providing expert overviews of many complex topics in pain research that are likely to be of interest not just to pain researchers, but also

Brain Neurotrauma

Brain Neurotrauma
  • Author : Firas H. Kobeissy
  • Publisher : CRC Press
  • Release : 25 February 2015
GET THIS BOOK Brain Neurotrauma

Every year, an estimated 1.7 million Americans sustain brain injury. Long-term disabilities impact nearly half of moderate brain injury survivors and nearly 50,000 of these cases result in death. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma, including brain injury pathophysiology, biomarker research, experimental models of CNS injury, diagnostic methods, and neurotherapeutic interventions as well as neurorehabilitation strategies in the field of neurotraum research. The book includes several

Otolaryngology

Otolaryngology
  • Author : Balwant Singh Gendeh
  • Publisher : BoD – Books on Demand
  • Release : 23 May 2012
GET THIS BOOK Otolaryngology

This book emphasizes on different aspects of otolaryngology - the medical sciences of diagnosis and treatment of ENT disorders. "Otolaryngology" is divided into various clinical sub-specialities, namely otology, rhinology, laryngology, and head and neck. This book incorporates new developments, as well as future perspectives in otolaryngology. I would like to dedicate this book to those of you who will pick up the torch and by continued research, close clinical observation and the highest quality of clinical care, as well as

Nanomaterials for Drug Delivery and Therapy

Nanomaterials for Drug Delivery and Therapy
  • Author : Alexandru Mihai Grumezescu
  • Publisher : William Andrew
  • Release : 14 March 2019
GET THIS BOOK Nanomaterials for Drug Delivery and Therapy

Nanomaterials for Drug Delivery and Therapy presents recent advances in the field of nanobiomaterials and their important applications in drug delivery, therapy and engineering. The book offers pharmaceutical perspectives, exploring the development of nanobiomaterials and their interaction with the human body. Chapters show how nanomaterials are used in treatments, including neurology, dentistry and cancer therapy. Authored by a range of contributors from global institutions, this book offers a broad, international perspective on how nanotechnology-based advances are leading to novel drug