Physiologically Based Pharmacokinetic PBPK Modeling and Simulations

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  • Author : Sheila Annie Peters
  • Publisher : John Wiley & Sons
  • Pages : 450 pages
  • ISBN : 1118140303
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Physiologically Based Pharmacokinetic PBPK Modeling and Simulations

Download or Read online Physiologically Based Pharmacokinetic PBPK Modeling and Simulations full in PDF, ePub and kindle. this book written by Sheila Annie Peters and published by John Wiley & Sons which was released on 17 February 2012 with total page 450 pages. We cannot guarantee that Physiologically Based Pharmacokinetic PBPK Modeling and Simulations book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. The only book dedicated to physiologically-based pharmacokineticmodeling in pharmaceutical science Physiologically-based pharmacokinetic (PBPK) modeling has becomeincreasingly widespread within the pharmaceutical industry over thelast decade, but without one dedicated book that provides theinformation researchers need to learn these new techniques, itsapplications are severely limited. Describing the principles,methods, and applications of PBPK modeling as used inpharmaceutics, Physiologically-Based Pharmacokinetic (PBPK)Modeling and Simulations fills this void. Connecting theory with practice, the book explores theincredible potential of PBPK modeling for improving drug discoveryand development. Comprised of two parts, the book first provides adetailed and systematic treatment of the principles behindphysiological modeling of pharmacokinetic processes,inter-individual variability, and drug interactions for smallmolecule drugs and biologics. The second part looks in greaterdetail at the powerful applications of PBPK to drug research. Designed for a wide audience encompassing readers looking for abrief overview of the field as well as those who need more detail,the book includes a range of important learning aids. Featuringend-of-chapter keywords for easy reference—a valuable assetfor general or novice readers without a PBPK background—alongwith an extensive bibliography for those looking for furtherinformation, Physiologically- Based Pharmacokinetic (PBPK) Modelingand Simulations is the essential single-volume text on one of thehottest topics in the pharmaceutical sciences today.

Physiologically Based Pharmacokinetic PBPK Modeling and Simulations

Physiologically Based Pharmacokinetic  PBPK  Modeling and Simulations
  • Author : Sheila Annie Peters
  • Publisher : John Wiley & Sons
  • Release : 17 February 2012
GET THIS BOOK Physiologically Based Pharmacokinetic PBPK Modeling and Simulations

The only book dedicated to physiologically-based pharmacokineticmodeling in pharmaceutical science Physiologically-based pharmacokinetic (PBPK) modeling has becomeincreasingly widespread within the pharmaceutical industry over thelast decade, but without one dedicated book that provides theinformation researchers need to learn these new techniques, itsapplications are severely limited. Describing the principles,methods, and applications of PBPK modeling as used inpharmaceutics, Physiologically-Based Pharmacokinetic (PBPK)Modeling and Simulations fills this void. Connecting theory with practice, the book explores theincredible potential of PBPK modeling for improving drug discoveryand

Physiologically Based Pharmacokinetic Modeling

Physiologically Based Pharmacokinetic Modeling
  • Author : Micaela Reddy,R. S. Yang,Melvin E. Andersen,Harvey J. Clewell III
  • Publisher : John Wiley & Sons
  • Release : 14 June 2005
GET THIS BOOK Physiologically Based Pharmacokinetic Modeling

A definitive, single source of information on PBPK modeling Physiologically-based pharmacokinetic (PBPK) modeling is becomingincreasingly important in human health risk assessments and insupporting pharmacodynamic modeling for toxic responses. Organizedby classes of compounds and modeling purposes so users can quicklyaccess information, this is the first comprehensive reference ofits kind. This book presents an overview of the underlying principles of PBPKmodel development. Then it provides a compendium of PBPK modelinginformation, including historical development, specific modelingchallenges, and current practices for: * Halogenated Alkanes * Halogenated

Physiologically Based Pharmacokinetic Toxicokinetic Modeling in Risk Assessment

Physiologically Based Pharmacokinetic Toxicokinetic Modeling in Risk Assessment
  • Author : Anonim
  • Publisher : Unknown
  • Release : 04 December 2021
GET THIS BOOK Physiologically Based Pharmacokinetic Toxicokinetic Modeling in Risk Assessment

Physiologically-based pharmacokinetic (PBPK) modeling has become the tool of choice to develop estimates of target site dosimetries in animals and humans for risk assessment purposes. PBPK model compartments correspond directly to the tissues and organs in the species. The drawbacks of PBPK modeling primarily relate to the time, effort and cost involved in appropriately developing, validating and applying a model. We outline some of the practical issues involved in the appropriate development of a PBPK model. Among the first models

Physiologically Based Pharmacokinetic Modeling

Physiologically Based Pharmacokinetic Modeling
  • Author : Jasmine Davda
  • Publisher : LAP Lambert Academic Publishing
  • Release : 01 August 2009
GET THIS BOOK Physiologically Based Pharmacokinetic Modeling

This book describes the application of physiologically based pharmacokinetic (PBPK) modeling to characterize the disposition of therapeutic monoclonal antibodies (MAbs). These macromolecules exhibit distinctly different pharmacokinetic features compared with conventional small-molecule drugs. A PBPK model was developed to characterize the biodistribution of the pancarcinoma MAb CC49 in normal and neoplastic tissues of nude mice. The model included all the major processes involved in determining the disposition characteristics of MAbs. The applicability of the model was tested by predicting the disposition

Physiologically Based Pharmacokinetic PBPK Models for the Description of Sequential Metabolism of Codeine to Morphine and Morphine 3 Glucuronide M3G in Man and Rat

Physiologically Based Pharmacokinetic  PBPK  Models for the Description of Sequential Metabolism of Codeine to Morphine and Morphine 3 Glucuronide  M3G  in Man and Rat
  • Author : Shu Chen
  • Publisher : Unknown
  • Release : 04 December 2021
GET THIS BOOK Physiologically Based Pharmacokinetic PBPK Models for the Description of Sequential Metabolism of Codeine to Morphine and Morphine 3 Glucuronide M3G in Man and Rat

Whole-body PBPK models were developed based on both the intestinal traditional model (TM) and segregated-flow model (SFM) to describe codeine sequential metabolism in man/rat. Model parameters were optimized with ScientistRTM and SimcypRTM simulator to predict literature data after oral (p.o.) and intravenous (i.v.) codeine administration in man/rat. In vivo codeine PK studies on rats were performed to provide more data for simulation. The role of fm' (fractional formation clearance of morphine from codeine) in model discrimination

Physiologically Based Pharmacokinetic PBPK Modelling of Cisplatin in Rats and Humans

Physiologically Based Pharmacokinetic  PBPK  Modelling of Cisplatin in Rats and Humans
  • Author : Hyunjin Park
  • Publisher : Unknown
  • Release : 04 December 2021
GET THIS BOOK Physiologically Based Pharmacokinetic PBPK Modelling of Cisplatin in Rats and Humans

The physiologically based pharmacokinetic (PBPK) modelling has been accepted as one of the most effective mechanistic techniques to analyze pharmacokinetics (PK) of drugs in the drug development process. Its effectiveness in predicting the PK of drugs is important not only to the current drug development industry but also to potential growth of the pharmaceutical industry as it helps resolve ethical challenges. The PK of cisplatin as an anticancer drug, and its metabolic disposition are investigated by proposing a PBPK modelling

Physiologically Based Pharmacokinetic PBPK Modeling

Physiologically Based Pharmacokinetic  PBPK  Modeling
  • Author : Jeffrey W. Fisher,Jeffery Gearhart,Zhoumeng Lin
  • Publisher : Academic Press
  • Release : 20 May 2020
GET THIS BOOK Physiologically Based Pharmacokinetic PBPK Modeling

Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment presents foundational principles, advanced techniques and applications of PBPK modeling. Contributions from experts in PBPK modeling cover topics such as pharmacokinetic principles, classical physiological models, the application of physiological models for dose-response and risk assessment, the use of in vitro information, and in silico methods. With end-of-chapter exercises that allow readers to practice and learn the skills associated with PBPK modeling, dose-response, and its applications to safety