Physiologically Based Pharmacokinetic Pbpk Modeling

Physiologically Based Pharmacokinetic Pbpk Modeling And Simulations Book PDF
✏Book Title : Physiologically Based Pharmacokinetic PBPK Modeling and Simulations
✏Author : Sheila Annie Peters
✏Publisher : John Wiley & Sons
✏Release Date : 2012-02-17
✏Pages : 450
✏ISBN : 9781118140307
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Physiologically Based Pharmacokinetic PBPK Modeling and Simulations Book Summary : The only book dedicated to physiologically-based pharmacokineticmodeling in pharmaceutical science Physiologically-based pharmacokinetic (PBPK) modeling has becomeincreasingly widespread within the pharmaceutical industry over thelast decade, but without one dedicated book that provides theinformation researchers need to learn these new techniques, itsapplications are severely limited. Describing the principles,methods, and applications of PBPK modeling as used inpharmaceutics, Physiologically-Based Pharmacokinetic (PBPK)Modeling and Simulations fills this void. Connecting theory with practice, the book explores theincredible potential of PBPK modeling for improving drug discoveryand development. Comprised of two parts, the book first provides adetailed and systematic treatment of the principles behindphysiological modeling of pharmacokinetic processes,inter-individual variability, and drug interactions for smallmolecule drugs and biologics. The second part looks in greaterdetail at the powerful applications of PBPK to drug research. Designed for a wide audience encompassing readers looking for abrief overview of the field as well as those who need more detail,the book includes a range of important learning aids. Featuringend-of-chapter keywords for easy reference—a valuable assetfor general or novice readers without a PBPK background—alongwith an extensive bibliography for those looking for furtherinformation, Physiologically- Based Pharmacokinetic (PBPK) Modelingand Simulations is the essential single-volume text on one of thehottest topics in the pharmaceutical sciences today.

Physiologically Based Pharmacokinetic Modeling Book PDF
✏Book Title : Physiologically Based Pharmacokinetic Modeling
✏Author : Micaela Reddy
✏Publisher : John Wiley & Sons
✏Release Date : 2005-06-14
✏Pages : 420
✏ISBN : 9780471478775
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Physiologically Based Pharmacokinetic Modeling Book Summary : A definitive, single source of information on PBPK modeling Physiologically-based pharmacokinetic (PBPK) modeling is becomingincreasingly important in human health risk assessments and insupporting pharmacodynamic modeling for toxic responses. Organizedby classes of compounds and modeling purposes so users can quicklyaccess information, this is the first comprehensive reference ofits kind. This book presents an overview of the underlying principles of PBPKmodel development. Then it provides a compendium of PBPK modelinginformation, including historical development, specific modelingchallenges, and current practices for: * Halogenated Alkanes * Halogenated Alkenes * Alkene and Aromatic Compounds * Reactive Vapors in the Nasal Cavity * Alkanes, Oxyhydrocarbons, and Related Compounds * Pesticides and Persistent Organic Pollutants * Dioxin and Related Compounds * Metals and Inorganic Compounds * Drugs * Antineoplastic Agents * Perinatal Transfer * Mixtures * Dermal Exposure Models In addition to pinpointing specific information, readers canexplore diverse modeling techniques and applications. Anauthoritative reference for toxicologists, ecotoxicologists, riskassessors, regulators, pharmacologists, pharmacists, and graduatestudents in pharmacokinetics and toxicology, Physiologically-BasedPharmacokinetic Modeling compiles information from leaders in thefield and discusses future directions for PBPK modeling.

Physiologically Based Pharmacokinetic Pbpk Modeling Book PDF
✏Book Title : Physiologically Based Pharmacokinetic PBPK Modeling
✏Author : Jeffrey W. Fisher
✏Publisher : Academic Press
✏Release Date : 2020-05-20
✏Pages : 346
✏ISBN : 9780128196823
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Physiologically Based Pharmacokinetic PBPK Modeling Book Summary : Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment presents foundational principles, advanced techniques and applications of PBPK modeling. Contributions from experts in PBPK modeling cover topics such as pharmacokinetic principles, classical physiological models, the application of physiological models for dose-response and risk assessment, the use of in vitro information, and in silico methods. With end-of-chapter exercises that allow readers to practice and learn the skills associated with PBPK modeling, dose-response, and its applications to safety and risk assessments, this book is a foundational resource that provides practical coverage of PBPK modeling for graduate students, academics, researchers, and more. Provides end-of-chapter exercises to teach hands-on computational tools used in toxicology Supplies computer code and explanations and includes examples of applied models used in regulatory toxicology and research Authored by expert editors and contributors who are among the best PBPK modelers in the world

Physiologically Based Pharmacokinetic Pbpk Modeling And Simulations Book PDF
✏Book Title : Physiologically Based Pharmacokinetic PBPK Modeling and Simulations
✏Author : Sheila Annie Peters
✏Publisher : John Wiley & Sons
✏Release Date : 2012-02-29
✏Pages : 450
✏ISBN : 9781118140383
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Physiologically Based Pharmacokinetic PBPK Modeling and Simulations Book Summary : The only book dedicated to physiologically-based pharmacokineticmodeling in pharmaceutical science Physiologically-based pharmacokinetic (PBPK) modeling has becomeincreasingly widespread within the pharmaceutical industry over thelast decade, but without one dedicated book that provides theinformation researchers need to learn these new techniques, itsapplications are severely limited. Describing the principles,methods, and applications of PBPK modeling as used inpharmaceutics, Physiologically-Based Pharmacokinetic (PBPK)Modeling and Simulations fills this void. Connecting theory with practice, the book explores theincredible potential of PBPK modeling for improving drug discoveryand development. Comprised of two parts, the book first provides adetailed and systematic treatment of the principles behindphysiological modeling of pharmacokinetic processes,inter-individual variability, and drug interactions for smallmolecule drugs and biologics. The second part looks in greaterdetail at the powerful applications of PBPK to drug research. Designed for a wide audience encompassing readers looking for abrief overview of the field as well as those who need more detail,the book includes a range of important learning aids. Featuringend-of-chapter keywords for easy reference—a valuable assetfor general or novice readers without a PBPK background—alongwith an extensive bibliography for those looking for furtherinformation, Physiologically- Based Pharmacokinetic (PBPK) Modelingand Simulations is the essential single-volume text on one of thehottest topics in the pharmaceutical sciences today.

Physiologically Based Pharmacokinetic Pbpk Modeling And Simulations Book PDF
✏Book Title : Physiologically Based Pharmacokinetic PBPK Modeling and Simulations
✏Author : Sheila Annie Peters
✏Publisher : Wiley
✏Release Date : 2021-04-27
✏Pages : 512
✏ISBN : 111949768X
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Physiologically Based Pharmacokinetic PBPK Modeling and Simulations Book Summary : Physiologically Based Pharmacokinetic (PBPK) Modelling and Simulations: Principles, Methods and Applications in the Pharma Industry is the only book of its kind to serve the rapidly growing PBPK user community, developing principles from basics in clear, concise language. Connecting theory with practice, the book explores the incredible potential of PBPK modeling for improving drug discovery and development. The new edition provides stronger emphasis on applications and relevant case studies, along with a companion website with datasets, covering many key developments in the field of PBPK modelling and simulations since the first editions publication in 2012.

Physiologically Based Pharmacokinetic Pbpk Models For The Description Of Sequential Metabolism Of Codeine To Morphine And Morphine 3 Glucuronide M3g In Man And Rat Book PDF
✏Book Title : Physiologically Based Pharmacokinetic PBPK Models for the Description of Sequential Metabolism of Codeine to Morphine and Morphine 3 Glucuronide M3G in Man and Rat
✏Author : Shu Chen
✏Publisher :
✏Release Date : 2010
✏Pages : 250
✏ISBN : 0494725419
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Physiologically Based Pharmacokinetic PBPK Models for the Description of Sequential Metabolism of Codeine to Morphine and Morphine 3 Glucuronide M3G in Man and Rat Book Summary : Whole-body PBPK models were developed based on both the intestinal traditional model (TM) and segregated-flow model (SFM) to describe codeine sequential metabolism in man/rat. Model parameters were optimized with ScientistRTM and SimcypRTM simulator to predict literature data after oral (p.o.) and intravenous (i.v.) codeine administration in man/rat. In vivo codeine PK studies on rats were performed to provide more data for simulation. The role of fm' (fractional formation clearance of morphine from codeine) in model discrimination between the TM and SFM was investigated. A greater difference between the [AUC M3G/AUCMorphine]p.o. and [ AUCM3G/AUCMorphine]i.v. ratio existed for the SFM, especially when the fm' was low. It was found that our tailor-made PBPK models using ScientistRTM were superior to those from SimcypRTM in describing codeine sequential metabolism. Residual sum of squares and AUC's were calculated for each model, which demonstrated superiority of the SFM over TM in predicting codeine sequential metabolism in man/rat.

Mechanistic Physiologically Based Pharmacokinetic Pbpk Modeling Of Renal And Systemic Disposition Of Drugs And Metabolites Book PDF
✏Book Title : Mechanistic Physiologically Based Pharmacokinetic PBPK Modeling of Renal and Systemic Disposition of Drugs and Metabolites
✏Author : Weize Huang
✏Publisher :
✏Release Date : 2020
✏Pages : 263
✏ISBN : OCLC:1196247018
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Mechanistic Physiologically Based Pharmacokinetic PBPK Modeling of Renal and Systemic Disposition of Drugs and Metabolites Book Summary : Physiologically-based pharmacokinetic (PBPK) models integrate system specific anatomy and physiology information with drug specific physicochemical and pharmacokinetic properties to predict drug disposition. Such integration permits items, events, processes, and pathways to communicate and influence each other interactively. By taking advantage of such mechanistic nature of PBPK modeling, drug dispositions under untested scenarios could be predicted by extrapolation from observed data in known conditions. Renal clearance is one of the major pathways governing drug dispositions, which has three main mechanisms: unbound filtration, passive reabsorption, and active secretion. In comparison to intestinal absorption and hepatic metabolism, renal clearance has been relatively underappreciated. Controlled clinical experiments that test renal clearance changes under altered conditions and mechanisms have been primarily focusing on drug-drug interaction on active secretion. However, huge gaps in understanding renal clearance still exist in other areas such as altered urine pH and impaired renal function. Further, passive reabsorption has not been paid significant attention by the pharmaceutical field. Therefore, the overarching goal of this thesis is to leverage mechanistic PBPK modeling technique to understand and predict renal clearance of drugs and metabolites under altered urine pH and impaired renal function, with a special focus on compounds undergoing significant renal passive reabsorption. In Chapter 2, to predict the spatiodynamic process of renal passive reabsorption in human, we developed a dynamic physiologically-based mechanistic kidney model based on human data that can integrate drug permeability, tubular surface area, ionization status, and drug concentration gradient between lumen and system to estimate renal passive reabsorption and predict renal clearance of drugs. Using 46 test compounds with a variety of physicochemical properties, the model successfully predicted the renal clearances of 87% compounds within 2-fold and 98% compounds within 3-fold. Further, by incorporating active secretion, the model also successfully predicted the renal clearances of para-aminohippuric acid (PAH), cimetidine, salicylic acid, and memantine. In Chapter 3, to ensure the simulation output from PBPK models can be meaningfully compared to the arm vein plasma drug concentrations collected in clinical studies, we developed a forearm model that captures the tissue distribution at the peripheral sampling site using human arm physiology data, allowing for a better prediction of plasma drug concentrations that are comparable to observed data. The model was successfully verified using arterial and venous concentrations of nicotine, ketamine, lidocaine, and fentanyl simultaneously. Further, I demonstrated that use of a discrepant sampling site in PBPK modeling than observed clinical studies may lead to biased model evaluation, erroneous model parameterization, and misleading prediction in unstudied clinical scenarios. In Chapter 4, to predict the altered renal excretion and systemic AUC of drug and metabolite when urine pH is changed, the mechanistic kidney model developed and verified from Chapter 2 was integrated with the peripheral arm sampling and full body PBPK model developed from Chapter 3. The model was successfully verified with methamphetamine and amphetamine under varying urine pH statuses, and showed feasibility to predict quantitatively and clinically significant changes in drug and metabolite disposition under comedications and diseases that can alter urine pH. In Chapter 5, to predict renal clearance in patients with impaired renal function such as chronic kidney diseases, physiological changes in tubular flow and urine flow observed in chronic kidney disease patients were incorporated into the mechanistic kidney model developed and verified from Chapter 2. The model accounts for the adaptive renal tubular filtrate flows that decrease disproportionately with glomerular filtration rate, and was successfully verified using three parent-metabolite pairs, six non-permeable drugs, six permeable drugs, and two secreted drugs. In conclusion, in this thesis, I developed and verified a physiologically-based mechanistic kidney model to translate drug properties such as plasma protein binding, transcellular permeability, and active transport into renal clearance of drugs and metabolites. This mechanistic kidney model allows prediction of alterations in renal clearance of drugs and metabolites upon changes in urine pH and renal functions, and can be incorporated into a full-body PBPK model to predict alterations in systemic disposition of drugs and metabolites.

Development And Evaluation Of A Physiologically Based Pharmacokinetic Pbpk Population Model For Elderly Individuals Book PDF
✏Book Title : Development and Evaluation of a Physiologically Based Pharmacokinetic PBPK Population Model for Elderly Individuals
✏Author : Jan-Frederik Schlender
✏Publisher :
✏Release Date : 2019
✏Pages :
✏ISBN : 384394055X
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Development and Evaluation of a Physiologically Based Pharmacokinetic PBPK Population Model for Elderly Individuals Book Summary :

Principles And Methods Of Toxicology Fifth Edition Book PDF
✏Book Title : Principles and Methods of Toxicology Fifth Edition
✏Author : A. Wallace Hayes
✏Publisher : CRC Press
✏Release Date : 2007-09-25
✏Pages : 2296
✏ISBN : 084933778X
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Principles and Methods of Toxicology Fifth Edition Book Summary : Founded on the paradox that all things are poisons and the difference between poison and remedy is quantity, the determination of safe dosage forms the base and focus of modern toxicology. In order to make a sound determination there must be a working knowledge of the biologic mechanisms involved and of the methods employed to define these mechanisms. While the vastness of the field and the rapid accumulation of data may preclude the possibility of absorbing and retaining more than a fraction of the available information, a solid understanding of the underlying principles is essential. Extensively revised and updated with four new chapters and an expanded glossary, this fifth edition of the classic text, Principles and Methods of Toxicology provides comprehensive coverage in a manageable and accessible format. New topics include 'toxicopanomics', plant and animal poisons, information resources, and non-animal testing alternatives. Emphasizing the cornerstones of toxicology-people differ, dose matters, and things change, the book begins with a review of the history of toxicology and followed by an explanation of basic toxicological principles, agents that cause toxicity, target organ toxicity, and toxicological testing methods including many of the test protocols required to meet regulatory needs worldwide. The book examines each method or procedure from the standpoint of technique and interpretation of data and discusses problems and pitfalls that may be associated with each. The addition of several new authors allow for a broader and more diverse treatment of the ever-changing and expanding field of toxicology. Maintaining the high-quality information and organizational framework that made the previous editions so successful, Principles and Methods of Toxicology, Fifth Edition continues to be a valuable resource for the advanced practitioner as well as the new disciple of toxicology.

Adme And Translational Pharmacokinetics Pharmacodynamics Of Therapeutic Proteins Book PDF
✏Book Title : ADME and Translational Pharmacokinetics Pharmacodynamics of Therapeutic Proteins
✏Author : Honghui Zhou
✏Publisher : John Wiley & Sons
✏Release Date : 2015-10-26
✏Pages : 472
✏ISBN : 9781118898802
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏ADME and Translational Pharmacokinetics Pharmacodynamics of Therapeutic Proteins Book Summary : With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs. • Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs • Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective • Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines • Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan • Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain

Pharmacokinetic Modeling Of Jp 8 Jet Fuel Components I Nonane And C9 C12 Aliphatic Components Book PDF
✏Book Title : Pharmacokinetic Modeling of JP 8 Jet Fuel Components I Nonane and C9 C12 Aliphatic Components
✏Author :
✏Publisher :
✏Release Date : 2000
✏Pages : 37
✏ISBN : OCLC:64438445
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Pharmacokinetic Modeling of JP 8 Jet Fuel Components I Nonane and C9 C12 Aliphatic Components Book Summary : Exposures to JP-8 can occur from vapor, liquid or aerosol. Inhalation and dermal are the most prevalent routes of exposure, and acute effects include neurobehavioral deficits. Occupational exposures of interest include aircraft fuel tank workers and exhaust workers. JP-8 is a complex mixture of hundreds of components including straight chain alkanes, branched chain alkanes, cycloalkanes, diaromatics and napthalenes. A first step to developing a physiologically-based pharmacokinetic (PBPK) model for JP-8 is to develop models for representative components. Nonane is a good biomarker in breath for JP-8 aliphatic exposure (fingerprint compound). Nonane is a highly lipophilic compound (log Kow = 5.65), and has been observed to distribute preferentially in brain tissue. Its behavior in the body can he described in terms of a physiologically-based pharmacokinetic (PBPK) model that includes the blood, lungs, liver, muscle, and fat. Such a model is developed on the basis of in-house rat inhalation data (with measured blood levels), and validated by applying it to published rat inhalation data (blood and brain levels). The model is used to predict body burdens of nonane under occupational exposure conditions (ambient air concentrations for fuel tank workers and aircraft attendants) and is consistent with limited occupational body burden data (exhaled breath levels).

The Practical Applicability Of Toxicokinetic Models In The Risk Assessment Of Chemicals Book PDF
✏Book Title : The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals
✏Author : J. Krüse
✏Publisher : Springer Science & Business Media
✏Release Date : 2002-10-31
✏Pages : 194
✏ISBN : 1402009348
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals Book Summary : In this conference a vast range of areas were treated in relation to toxicological modeling and risk assessment, such as occupational toxicology and biomonitoring, exposure to organic solvents and crop protection products, dose-response relations in carcinogenicity, regulatory toxicology, estimation of dermal penetration, uptake and disposition of organic chemicals in fish and the possibilities of in vitro methods in hazards and risk assessment and the extrapolation between animal and human species.

📒Biosimulation ✍ Daniel A. Beard

Biosimulation Book PDF
✏Book Title : Biosimulation
✏Author : Daniel A. Beard
✏Publisher : Cambridge University Press
✏Release Date : 2012-04-12
✏Pages : 307
✏ISBN : 9780521768238
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Biosimulation Book Summary : A hands-on guide to devising, designing and analyzing simulations of biophysical processes for applications in biological and biomedical sciences. Practical examples are given throughout, representing real-world case studies of key application areas, and all data and complete codes for simulation and data analysis are provided online.

Human Biomonitoring For Environmental Chemicals Book PDF
✏Book Title : Human Biomonitoring for Environmental Chemicals
✏Author : National Research Council
✏Publisher : National Academies Press
✏Release Date : 2006-10-30
✏Pages : 316
✏ISBN : 0309133904
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Human Biomonitoring for Environmental Chemicals Book Summary : Biomonitoring—a method for measuring amounts of toxic chemicals in human tissues—is a valuable tool for studying potentially harmful environmental chemicals. Biomonitoring data have been used to confirm exposures to chemicals and validate public health policies. For example, population biomonitoring data showing high blood lead concentrations resulted in the U.S. Environmental Protection Agency's (EPA's) regulatory reduction of lead in gasoline; biomonitoring data confirmed a resultant drop in blood lead concentrations. Despite recent advances, the science needed to understand the implications of the biomonitoring data for human health is still in its nascent stages. Use of the data also raises communication and ethical challenges. In response to a congressional request, EPA asked the National Research Council to address those challenges in an independent study. Human Biomonitoring for Environmental Chemicals provides a framework for improving the use of biomonitoring data including developing and using biomarkers (measures of exposure), research to improve the interpretation of data, ways to communicate findings to the public, and a review of ethical issues.

Pesticides In Stream Sediment And Aquatic Biota Book PDF
✏Book Title : Pesticides in Stream Sediment and Aquatic Biota
✏Author : Lisa H. Nowell
✏Publisher : CRC Press
✏Release Date : 2019-06-12
✏Pages : 1040
✏ISBN : 1439822700
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Pesticides in Stream Sediment and Aquatic Biota Book Summary : More than 20 years after the ban of DDT and other organochlorine pesticides, pesticides continue to be detected in air, rain, soil, surface water, bed sediment, and aquatic and terrestrial biota throughout the world. Recent research suggests that low levels of some of these pesticides may have the potential to affect the development, reproduction,

Inhalation Toxicology Third Edition Book PDF
✏Book Title : Inhalation Toxicology Third Edition
✏Author : Harry Salem
✏Publisher : CRC Press
✏Release Date : 2014-08-19
✏Pages : 623
✏ISBN : 9781466552746
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Inhalation Toxicology Third Edition Book Summary : The lungs provide a significant opportunity for the introduction of both therapeutic and toxic chemicals into the human body. In occupational and domestic environments, hazardous chemicals can enter the body through the lungs via gases, aerosols, and particulates from natural and anthropogenic sources. Fully updated with new research and discoveries since the last edition, Inhalation Toxicology, Third Edition presents contributions from internationally recognized scientists in the academic, commercial/industrial, and governmental sectors. A pragmatic resource for practicing professionals and students, the book comprehensively examines the relationship between the respiratory system and the toxicology of inhaled substances. Topics include: Regulatory aspects of exposure and testing Testing equipment and procedures Respiratory allergy and irritation of the respiratory tract Risk assessment Toxicology theory Toxicology modeling Toxic effects of some individual toxicants New topics in this third edition include collection and characterization of airborne particulate matter, the inhalation toxicology of asbestos fibers and nanoparticles, and the development of lung-on-a-chip technology for predicting in vivo responses. Each chapter concludes with thought-provoking questions and answers, enhancing the book’s educational utility.

Hydrophilic Matrix Tablets For Oral Controlled Release Book PDF
✏Book Title : Hydrophilic Matrix Tablets for Oral Controlled Release
✏Author : Peter Timmins
✏Publisher : Springer
✏Release Date : 2014-10-11
✏Pages : 326
✏ISBN : 9781493915194
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Hydrophilic Matrix Tablets for Oral Controlled Release Book Summary : This detailed volume addresses key issues and subtle nuances involved in developing hydrophilic matrix tablets as an approach to oral controlled release. It brings together information from more than five decades of research and development on hydrophilic matrix tablets and provides perspective on contemporary issues. Twelve comprehensive chapters explore a variety of topics including polymers (hypromellose, natural polysaccharides and polyethylene oxide) and their utilization in hydrophilic matrices, critical interactions impacting tablet performance, in vitro physical and imaging techniques, and microenvironmental pH control and mixed polymer approaches, among others. In one collective volume, Hydrophilic Matrix Tablets for Oral Controlled Release provides a single source of current knowledge, including sections of previously unpublished data. It is an important resource for industrial and academic scientists investigating and developing these oral controlled release formulations.

📒Iodotrifluoromethane ✍ National Research Council

Iodotrifluoromethane Book PDF
✏Book Title : Iodotrifluoromethane
✏Author : National Research Council
✏Publisher : National Academies Press
✏Release Date : 2004-12-23
✏Pages : 112
✏ISBN : 9780309093071
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Iodotrifluoromethane Book Summary : The U.S. military is considering using a compound called iodotrifluoromethane (CF3I) for fire suppression to replace previously-used compounds (halons) that are being phased out because they deplete the ozone layer. This report reviews available toxicological data on CF3I and evaluates the scientific basis of the U.S. Army's proposed exposure limit of 2,000 parts per million (ppm). The report recommends that CF3I be used for fire suppression in normally unoccupied spaces because of its potential to cause cardiac sensitization in test animals. The report also recommends that further genotoxicity testing be conducted (testing for changes in genetic material), and that CF3I be assessed for its potential to cause cancer. Should the Army decide to use CF3I, information should be collected and evaluated on how much of the chemical or any of its degradation products might be released and how often.

Issues In Neurological Surgery And Specialties 2011 Edition Book PDF
✏Book Title : Issues in Neurological Surgery and Specialties 2011 Edition
✏Author :
✏Publisher : ScholarlyEditions
✏Release Date : 2012-01-09
✏Pages : 1895
✏ISBN : 9781464964183
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Issues in Neurological Surgery and Specialties 2011 Edition Book Summary : Issues in Neurological Surgery and Specialties: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Neurological Surgery and Specialties. The editors have built Issues in Neurological Surgery and Specialties: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Neurological Surgery and Specialties in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Neurological Surgery and Specialties: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

📒Health Implications Of Perchlorate Ingestion ✍ National Research Council

Health Implications Of Perchlorate Ingestion Book PDF
✏Book Title : Health Implications of Perchlorate Ingestion
✏Author : National Research Council
✏Publisher : National Academies Press
✏Release Date : 2005-05-18
✏Pages : 276
✏ISBN : 9780309095686
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Health Implications of Perchlorate Ingestion Book Summary : Perchlorateâ€"a powerful oxidant used in solid rocket fuels by the military and aerospace industryâ€"has been detected in public drinking water supplies of over 11 million people at concentrations of at least 4 parts per billion (ppb). High doses of perchlorate can decrease thyroid hormone production by inhibiting the uptake of iodide by the thyroid. Thyroid hormones are critical for normal growth and development of the central nervous system of fetuses and infants. This report evaluates the potential health effects of perchlorate and the scientific underpinnings of the 2002 draft risk assessment issued by the U.S. Environmental Protection Agency (EPA). The report finds that the body can compensate for iodide deficiency, and that iodide uptake would likely have to be reduced by at least 75% for months or longer for adverse health effects, such as hypothryroidism, to occur. The report recommends using clinical studies of iodide uptake in humans as the basis for determining a reference dose rather than using studies of adverse health effects in rats that serve as EPA’s basis. The report suggests that daily ingestion of 0.0007 milligrams of perchlorate per kilograms of body weightâ€"an amount more than 20 times the reference dose proposed by EPAâ€"should not threaten the health of even the most sensitive populations.

Acute Exposure Guideline Levels For Selected Airborne Chemicals Book PDF
✏Book Title : Acute Exposure Guideline Levels for Selected Airborne Chemicals
✏Author : National Research Council
✏Publisher : National Academies Press
✏Release Date : 2009-10-30
✏Pages : 462
✏ISBN : 9780309159449
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Acute Exposure Guideline Levels for Selected Airborne Chemicals Book Summary : This book is the ninth volume in the series Acute Exposure Guideline Levels for Selected Airborne Chemicals, and reviews AEGLs for bromine, ethylene oxide, furan, hydrogen sulfide, propylene oxide, and xylenes.

📒Comparative Pharmacokinetics ✍ Jim E. Riviere

Comparative Pharmacokinetics Book PDF
✏Book Title : Comparative Pharmacokinetics
✏Author : Jim E. Riviere
✏Publisher : John Wiley & Sons
✏Release Date : 2011-01-14
✏Pages : 432
✏ISBN : 0470959886
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Comparative Pharmacokinetics Book Summary : Now in a revised edition, Comparative Pharmacokinetics: Principles, Techniques, and Applications presents the principles and techniques of comparative and veterinary pharmacokinetics in a detailed yet practical manner. Developed as a tool for ensuring that pharmacokinetics studies are properly designed and correctly interpreted, the book provides complete coverage of the conceptual basis of pharmacokinetics as used for quantifying biological processes from the perspectives of physiology and medicine. New chapters have been added on quantitative structure permeability relationships and bioequivalence, and a number of existing chapters have been significantly revised and expanded to provide a current resource for veterinary and comparative pharmacokinetics.

Issues In General Economic Research And Application 2011 Edition Book PDF
✏Book Title : Issues in General Economic Research and Application 2011 Edition
✏Author :
✏Publisher : ScholarlyEditions
✏Release Date : 2012-01-09
✏Pages : 873
✏ISBN : 9781464965043
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Issues in General Economic Research and Application 2011 Edition Book Summary : Issues in General Economic Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about General Economic Research and Application. The editors have built Issues in General Economic Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about General Economic Research and Application in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in General Economic Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Environmental Toxicology And Pharmacology Of Human Development Book PDF
✏Book Title : Environmental Toxicology And Pharmacology Of Human Development
✏Author : Sam Kacew
✏Publisher : CRC Press
✏Release Date : 1997-03-10
✏Pages : 336
✏ISBN : 1439805652
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Environmental Toxicology And Pharmacology Of Human Development Book Summary : Despite the many benefits, the extensive use of chemicals and pharmaceutical products in agriculture, energy production, transportation, pharmaceuticals and other products can result in the inadvertent exposure of the fetus and the neonate. This text reviews the current knowledge of the pharmacokinetic characteristics, metabolism and renal handling of chemical and drugs in the fetus, lactating infant and newborn and goes on to deal with the fetus and the manner in which chemicals can affect the outcome of the newborn.

Trihalomethanes Advances In Research And Application 2013 Edition Book PDF
✏Book Title : Trihalomethanes Advances in Research and Application 2013 Edition
✏Author :
✏Publisher : ScholarlyEditions
✏Release Date : 2013-05-01
✏Pages : 284
✏ISBN : 9781490105321
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Trihalomethanes Advances in Research and Application 2013 Edition Book Summary : Trihalomethanes—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Trihalomethanes—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Trihalomethanes—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Issues In Environment Health And Pollution 2013 Edition Book PDF
✏Book Title : Issues in Environment Health and Pollution 2013 Edition
✏Author :
✏Publisher : ScholarlyEditions
✏Release Date : 2013-05-01
✏Pages : 1180
✏ISBN : 9781490106700
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Issues in Environment Health and Pollution 2013 Edition Book Summary : Issues in Environment, Health, and Pollution: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Environmental Health. The editors have built Issues in Environment, Health, and Pollution: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Environmental Health in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Environment, Health, and Pollution: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Issues In Radiation Biology And Toxicology Research 2011 Edition Book PDF
✏Book Title : Issues in Radiation Biology and Toxicology Research 2011 Edition
✏Author :
✏Publisher : ScholarlyEditions
✏Release Date : 2012-01-09
✏Pages : 712
✏ISBN : 9781464965791
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Issues in Radiation Biology and Toxicology Research 2011 Edition Book Summary : Issues in Radiation Biology and Toxicology Research: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Radiation Biology and Toxicology Research. The editors have built Issues in Radiation Biology and Toxicology Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Radiation Biology and Toxicology Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Radiation Biology and Toxicology Research: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

📒Dermatotoxicology 4ed ✍ Francis Nicholas Marzulli

Dermatotoxicology 4ed Book PDF
✏Book Title : DERMATOTOXICOLOGY 4ED
✏Author : Francis Nicholas Marzulli
✏Publisher : CRC Press
✏Release Date : 1991-06-01
✏Pages : 1063
✏ISBN : 1560320559
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏DERMATOTOXICOLOGY 4ED Book Summary : This volume offers fundamental information on the mechanisms of the action of toxicants on the skin, the varied responses of skin to specific toxicants and approaches to evaluating dermal toxicity. Testing methods are examined and there is a review of dermatologic drugs and various chemicals.

Applications Of Toxicogenomics In Safety Evaluation And Risk Assessment Book PDF
✏Book Title : Applications of Toxicogenomics in Safety Evaluation and Risk Assessment
✏Author : Darrell R. Boverhof
✏Publisher : John Wiley & Sons
✏Release Date : 2011-10-11
✏Pages : 392
✏ISBN : 1118008987
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Applications of Toxicogenomics in Safety Evaluation and Risk Assessment Book Summary : This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process – including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm.

📒Ecotoxicology ✍ Michael C. Newman

Ecotoxicology Book PDF
✏Book Title : Ecotoxicology
✏Author : Michael C. Newman
✏Publisher : CRC Press
✏Release Date : 2007-12-13
✏Pages : 880
✏ISBN : 1420005014
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Ecotoxicology Book Summary : Integrating ecotoxicological concepts across a range of hierarchical levels, Ecotoxicology: A Comprehensive Treatment focuses on the paradigms and fundamental themes of ecotoxicology while providing the detail and practical application of concepts often found in more specialized books. By synthesizing the best qualities of a general textbook and the narrower, more specific scope of a technical reference, the authors create a volume flexible enough to cover a variety of instructional vantages and thorough enough to engender a respect for the importance of understanding and integrating concepts from all levels of biological organization. Divided into six sections, the book builds progressively from the biomolecular level toward a discussion of effects on the global biosphere. It begins with the fundamentals of hierarchical ecotoxicology and vantages for exploring ecotoxicological issues. The second section introduces organismal ecotoxicology and examines effects to biochemicals, cells, organs, organ systems, and whole organisms, and bioaccumulation and bioavailability of contaminants. Population ecotoxicology, section three, places the discussion in the larger context of entire populations by analyzing epidemiology, population dynamics, demographics, genetics, and natural selection. Section four encompasses issues of community ecotoxicology. This section presents biotic and abiotic factors influencing communities, biomonitoring and community response, and the application of multimetric and multivariate approaches. Section five evaluates the entire ecosystem by describing assessment approaches, identifying patterns, analyzing relationships between species, and reviewing the effects of global atmospheric stressors. A detailed conclusion integrating the concepts discussed and promoting a balanced assessment of the overarching paradigms rounds out the coverage in section six.