Phenotypic Switching

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  • Author : Herbert Levine
  • Publisher : Academic Press
  • Pages : 762 pages
  • ISBN : 012817997X
  • Rating : /5 from reviews
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Download or Read online Phenotypic Switching full in PDF, ePub and kindle. this book written by Herbert Levine and published by Academic Press which was released on 10 June 2020 with total page 762 pages. We cannot guarantee that Phenotypic Switching book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Phenotypic Switching: Implications in Biology and Medicine provides a comprehensive examination of phenotypic switching across biological systems, including underlying mechanisms, evolutionary significance, and its role in biomedical science. Contributions from international leaders discuss conceptual and theoretical aspects of phenotypic plasticity, its influence over biological development, differentiation, biodiversity, and potential applications in cancer therapy, regenerative medicine and stem cell therapy, among other treatments. Chapters discuss fundamental mechanisms of phenotypic switching, including transition states, cell fate decisions, epigenetic factors, stochasticity, protein-based inheritance, specific areas of human development and disease relevance, phenotypic plasticity in melanoma, prostate cancer, breast cancer, non-genetic heterogeneity in cancer, hepatitis C, and more. This book is essential for active researchers, basic and translational scientists, clinicians, postgraduates and students in genetics, human genomics, pathology, bioinformatics, developmental biology, evolutionary biology and adaptive opportunities in yeast. Thoroughly addresses the conceptual, experimental and translational aspects that underlie phenotypic plasticity Emphasizes quantitative approaches, nonlinear dynamics, mechanistic insights and key methodologies to advance phenotypic plasticity studies Features a diverse range of chapter contributions from international leaders in the field

Phenotypic Switching

Phenotypic Switching
  • Author : Herbert Levine,Mohit Kumar Jolly,Prakash Kulkarni,Vidyanand Nanjundiah
  • Publisher : Academic Press
  • Release : 10 June 2020
GET THIS BOOK Phenotypic Switching

Phenotypic Switching: Implications in Biology and Medicine provides a comprehensive examination of phenotypic switching across biological systems, including underlying mechanisms, evolutionary significance, and its role in biomedical science. Contributions from international leaders discuss conceptual and theoretical aspects of phenotypic plasticity, its influence over biological development, differentiation, biodiversity, and potential applications in cancer therapy, regenerative medicine and stem cell therapy, among other treatments. Chapters discuss fundamental mechanisms of phenotypic switching, including transition states, cell fate decisions, epigenetic factors, stochasticity, protein-based inheritance,

A Mechanistic and Functional Study of White opaque Phenotypic Switching in Candida Albicans

A Mechanistic and Functional Study of White opaque Phenotypic Switching in Candida Albicans
  • Author : Mathew Gregory Miller
  • Publisher : Unknown
  • Release : 03 December 2021
GET THIS BOOK A Mechanistic and Functional Study of White opaque Phenotypic Switching in Candida Albicans

Candida albicans is a major fungal pathogen of humans. It is a harmless commensal in healthy individuals, but it can cause serious infections in immune-compromised hosts. C. albicans undergoes a meta-stable and reversible switch between two distinct cell types known as white and opaque. The role of white-opaque switching in the biology of C. albicans was originally not well understood. We discovered an unexpected relationship between white-opaque switching and the sexual cycle of C. albicans . The mating type locus of

Interactions Between Phenotypic Switching Gene Network Dynamics and Evolutionary Dynamics in Growing Cell Populations

Interactions Between Phenotypic Switching  Gene Network Dynamics and Evolutionary Dynamics in Growing Cell Populations
  • Author : Merzu Kebede Belete
  • Publisher : Unknown
  • Release : 03 December 2021
GET THIS BOOK Interactions Between Phenotypic Switching Gene Network Dynamics and Evolutionary Dynamics in Growing Cell Populations

Gene expression is a stochastic biological processes that controls the different phenotypes of an organism depending on the environment. High-resolution single cell measurements show that genetically identical cells can be different from each other even in a homogeneous environment, leading a spectrum of phenotypes with different cellular fitnesses that can reversibly switch between phenotypes. How population-level properties emerge from single cell behavior and how mutants emerge and spread in such populations is unclear. In this thesis, we developed mathematical models

Candida Albicans Phenotypic Switching and Functional Plasticity in the Mammalian Host

Candida Albicans Phenotypic Switching and Functional Plasticity in the Mammalian Host
  • Author : Brittany Gianetti
  • Publisher : Unknown
  • Release : 03 December 2021
GET THIS BOOK Candida Albicans Phenotypic Switching and Functional Plasticity in the Mammalian Host

In order to determine the host signals and fungal signaling pathways that control the white-GUT switch and drive commensalism, we developed an in vitro system to induce switching behavior and screened a library of C. albicans signaling mutants. We identified three fungal signaling pathways (Hog1, Rim101, and PKA), previously associated with other morphological transitions, which promote GUT cell formation. Together these studies help to understand how C. albicans' phenotypic plasticity influences its interactions with the mammalian host.

Phenotypic Switching of Bacterial Cells in Extreme Environments

Phenotypic Switching of Bacterial Cells in Extreme Environments
  • Author : Sudip Nepal
  • Publisher : Unknown
  • Release : 03 December 2021
GET THIS BOOK Phenotypic Switching of Bacterial Cells in Extreme Environments

A large number of terrestrial microbial lives thrive in extremes of environmental conditions, including extremes of pressure, temperature, salinity, pH, and a combination of them. For example, all the marine biomass thrive at high hydrostatic pressure depending on depth. The temperature in the ocean can be very high near the hydrothermal vents and salinity and pH depends on the composition of salt in the surrounding areas. On the surface, hot springs, lakes and geysers provide high temperature conditions, while many

Cellular and Phenotypic Plasticity in Cancer

Cellular and Phenotypic Plasticity in Cancer
  • Author : Petranel Theresa Ferrao,Andreas Behren,Robin Anderson, Erik Thompson
  • Publisher : Unknown
  • Release : 17 September 2015
GET THIS BOOK Cellular and Phenotypic Plasticity in Cancer

The process of Epithelial-Mesenchymal-Transition (EMT) is known to result in a phenotype change in cells from a proliferative state to a more invasive state. EMT has been reported to drive the metastatic spread of various cancers and has also been associated with drug resistance to cytotoxics and targeted therapeutics. Recently phenotype switching akin to EMT has been reported in non-epithelial cancers such as metastatic melanoma. This process involves changes in EMT-Transcription Factors (EMT-TFs), suggesting that phenotype-switching may be common to