Pharmaceutical Medicine and Translational Clinical Research

• Author : Divya Vohora,Gursharan Singh
• Publisher : Academic Press
• Release : 14 November 2017

Pharmaceutical Medicine and Translational Clinical Research covers clinical testing of medicines and the translation of pharmaceutical drug research into new medicines, also focusing on the need to understand the safety profile of medicine and the benefit-risk balance. Pharmacoeconomics and the social impact of healthcare on patients and public health are also featured. It is written in a clear and straightforward manner to enable rapid review and assimilation of complex information and contains reader-friendly features. As a greater understanding of these

• Author : Bruce H. Littman,Rajesh Krishna
• Publisher : Cambridge University Press
• Release : 31 January 2011

This book, edited by two innovative leaders in the field, focuses on the new discipline of translational medicine as it pertains to drug development within the pharmaceutical and biotechnology industry. Translational medicine seeks to translate biological and molecular knowledge of disease and how drugs work into innovative development strategies that reduce the cost and increase the speed of delivering new medicines for patients. This book outlines general strategies, biomarker development, imaging tools, translational human models and examples of their application

• Author : James Mittra,Christopher-Paul Milne
• Publisher : CRC Press
• Release : 19 April 2016

This book brings together a range of academic, industry and practitioner perspectives on translational medicine (TM). It enhances conceptual and practical understanding of the emergence and progress of the field and its potential impact on basic research, therapeutic development, and institutional infrastructure. In recognition of the various implications TM has for public health policy and commercial innovation, the book addresses the major systemic aspects of the field. The contributors explore the dynamic interactions and key challenges in translating new science

• Author : Sarwar Beg,Majed Al Robaian,Mahfoozur Rahman,Syed Sarim Imam,Nabil Alruwaili,Sunil Kumar Panda
• Publisher : CRC Press
• Release : 01 May 2020

Pharmaceutical manufacturers are constantly facing quality crises of drug products, leading to an escalating number of product recalls and rejects. Due to the involvement of multiple factors, the goal of achieving consistent product quality is always a great challenge for pharmaceutical scientists. This volume addresses this challenge by using the Quality by Design (QbD) concept, which was instituted to focus on the systematic development of drug products with predefined objectives to provide enhanced product and process understanding. This volume presents

• Author : Fritz Dufour, MBA, DESS
• Publisher : Fritz Dufour
• Release : 19 December 2017

The preliminary idea behind translational medicine, conducting biological research to treat diseases, is not a new concept. But, scientists have been serious about placing the patient at all levels of the research process – right at the basic science level phase and all the way to the bedside – since only the 1990s. Today, translational research is a scientific field, although multidisciplinary. That innovation stemmed from the discoveries of new diseases and new technologies that allow healthcare professionals to have new perspectives

• Author : Shein-Chung Chow,Jen-Pei Liu
• Publisher : John Wiley & Sons
• Release : 18 November 2013

Praise for the Second Edition: “...a grand feast for biostatisticians. It stands ready to satisfy the appetite of any pharmaceutical scientist with a respectable statistical appetite.” —Journal of Clinical Research Best Practices The Third Edition of Design and Analysis of Clinical Trials provides complete, comprehensive, and expanded coverage of recent health treatments and interventions. Featuring a unified presentation, the book provides a well-balanced summary of current regulatory requirements and recently developed statistical methods as well as an overview of the

• Author : Dennis Cosmatos,Shein-Chung Chow
• Publisher : CRC Press
• Release : 17 December 2008

Examines Critical Decisions for Transitioning Lab Science to a Clinical Setting The development of therapeutic pharmaceutical compounds is becoming more expensive, and the success rates for getting such treatments approved for marketing and to the patients is decreasing. As a result, translational medicine (TM) is becoming increasingly important in the healthcare industry – a means of maximizing the consideration and use of information collected as compounds transition from initial lab discovery, through pre-clinical testing, early clinical trials, and late confirmatory studies

• Author : Juan Pou,Antonio Riveiro,Paulo Davim
• Publisher : Elsevier
• Release : 21 May 2021

Additive Manufacturing explains the background theory, working principles, technical specifications, and latest developments in a wide range of additive manufacturing techniques. Topics addressed include treatments of manufactured parts, surface characterization, and the effects of surface treatments on mechanical behavior. Many different perspectives are covered, including design aspects, technologies, materials and sustainability. Experts in both academia and industry contribute to this comprehensive guide, combining theoretical developments with practical improvements from R&D. This unique guide allows readers to compare the characteristics

• Author : Elke Gasthuys,Karel Allegaert,Lien Dossche,Mark Turner
• Publisher : Academic Press
• Release : 17 January 2023

Despite the broad consensus that children merit the same quality of drug treatment as any other age group, children remain frequently neglected during drug research and development. Even with the adoption of multiple legislations addressing this problem, the lack of efficacy and safety data of marketed as well as newly developed drugs still remain in the pediatric population. Essentials of Translational Pediatric Drug Development: From Past needs to Future Opportunities provides integrated up-to-date insights relevant for both translational researchers and

• Author : Honorio Silva,Sandor Kerpel-Fronius,Peter David Stonier,Dominique J. Dubois
• Publisher : Frontiers Media SA
• Release : 08 July 2021

• Author : Tarun Kumar Bhatt,Surendra Nimesh
• Publisher : Academic Press
• Release : 21 January 2021

The Design and Development of Novel Drugs and Vaccines: Principles and Protocols presents both in silico methods and experimental protocols for vaccine and drug design and development, critically reviewing the most current research and emphasizing approaches and technologies that accelerate and lower the cost of product development. Sections review the technologies and approaches used to identify, characterize and establish a protein as a new drug and vaccine target, cover several molecular methods for in vitro studies of the desired target,

• Author : Alexzander A. A. Asea,Punit Kaur
• Publisher : Springer Nature
• Release : 24 February 2022

The book Coronavirus Therapeutics Volume I provides the most comprehensive review on contemporary knowledge on the origin and structural biology and molecular aspects of Coronaviruses. This also describes the etiology and pathogeny and therapeutic targets including vaccine drug candidates against Coronaviruses in the light of current scientific knowledge. Using an integrative approach to the understanding of Coronaviruses structure, function and immunobiology, the contributors provide a synopsis of novel mechanisms by which Coronaviruses can be treated. Key basic and clinical research

• Author : Shein-Chung Chow
• Publisher : CRC Press
• Release : 03 September 2018

Since the publication of the first edition in 2000, there has been an explosive growth of literature in biopharmaceutical research and development of new medicines. This encyclopedia (1) provides a comprehensive and unified presentation of designs and analyses used at different stages of the drug development process, (2) gives a well-balanced summary of current regulatory requirements, and (3) describes recently developed statistical methods in the pharmaceutical sciences. Features of the Fourth Edition: 1. 78 new and revised entries have been added for a total of 308 chapters

• Author : Andrew J. Krentz,Lutz Heinemann,Marcus Hompesch
• Publisher : Springer
• Release : 22 September 2016

The world is beset by a pandemic of obesity and type 2 diabetes and the need for new drugs is startlingly clear; recent years have seen a huge increase in research activity to fill this gap. The development of new drugs for diabetes and obesity must be founded upon a sound appreciation of the pathophysiology of these common disorders. The dual defects of insulin resistance and impaired insulin secretion are fundamental to the pathogenesis and progression of obesity-associated type 2 diabetes. There

• Author : Alexzander A. A. Asea,Punit Kaur
• Publisher : Springer Nature
• Release : 04 November 2019

The book Heat Shock Protein 90 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP90. Using an integrative approach, the contributors provide a synopsis of novel mechanisms, previously unknown signal transduction pathways. To enhance the ease of reading and comprehension, this book has been subdivided into various section including; Section I, reviews current progress on our understanding Oncogenic Aspects of HSP90; Section II, focuses on Bimolecular Aspects of HSP90; Section III, emphasizes