Peptide And Protein Delivery

✏Book Title : Peptide and Protein Delivery
✏Author : Chris Van Der Walle
✏Publisher : Academic Press
✏Release Date : 2011-05-12
✏Pages : 380
✏ISBN : 0123849365
✏Available Language : English, Spanish, And French

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✏Peptide and Protein Delivery Book Summary : The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. A needed reference for entry level researchers and researchers working in interdisciplinary / collaborative projects, Peptide and Protein Delivery addresses the current and emerging routes for delivery of therapeutics. Covering cerebral delivery, pulmonary delivery, transdermal delivery, intestinal delivery, ocular delivery, parenteral delivery, and nasal delivery, this resource offers an overview of the main routes in therapeutics. Researchers across biochemistry, pharmaceutical, molecular biology, cell biology, immunology, chemistry and biotechnology fields will find this publication invaluable for peptide and protein laboratory research. Discusses the most recent data, ideas and concepts Presents case studies and an industrial perspective Details information from the molecular level to bioprocessing Thought provoking, for the novice to the specialist Timely, for today's biopharmaceuticals market

✏Book Title : Peptide and Protein Drug Delivery
✏Author : Vincent Lee
✏Publisher : CRC Press
✏Release Date : 1990-11-19
✏Pages : 912
✏ISBN : 0824778960
✏Available Language : English, Spanish, And French

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✏Peptide and Protein Drug Delivery Book Summary : This reference/text covers fundamentals of peptide and protein drug delivery, including such considerations as synthesis, physical chemistry and biochemistry, analysis, proteolytic and transport constraints, pharmacokinetics, and pharmacodynamics; bioavailability from routes of administration, detai

✏Book Title : Peptide and Protein Drug Delivery
✏Author : Sven Frøkjær
✏Publisher : Munksgaard International Publishers
✏Release Date : 1998
✏Pages : 483
✏ISBN : CORNELL:31924084752058
✏Available Language : English, Spanish, And French

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✏Peptide and Protein Drug Delivery Book Summary :

✏Book Title : Delivery of Protein and Peptide Drugs in Cancer
✏Author : Vladimir P Torchilin
✏Publisher : World Scientific
✏Release Date : 2006-04-05
✏Pages : 392
✏ISBN : 9781783260003
✏Available Language : English, Spanish, And French

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✏Delivery of Protein and Peptide Drugs in Cancer Book Summary : Written by leading scientists in the field of delivery of protein and peptide drugs to tumors for cancer therapy, this important book provides a broad introduction to the field, with discussion by key experts on the physiological barriers for protein and peptide drugs in tumors, and the different approaches to stabilization of these drugs in biological surroundings, as well as their enhanced delivery to tumors and inside cancer cells. This book can be used as an advanced textbook by graduate students and young scientists and clinicians at the early stages of their career. It is also suitable for non-experts from related areas of chemistry, biochemistry, molecular biology, physiology, experimental and clinical oncology and pharmaceutical sciences, who are interested in general problems of drug delivery and drug targeting as well as in a more specialized topics of using protein and peptide drugs for tumor therapy. Prof Torchilin is an expert in Nanomedicine and a recipient of numerous awards including the Lenin Prize in Science & Technology of the former USSR, membership in the European Academy of Sciences, and AAPS Research Achievement Award in Pharmaceutics and Drug Delivery. He served as an Associate Professor of Radiology at Harvard Medical School before joining Northeastern University as the Chairman of the Department of Pharmaceutical Sciences. Contents:Influence of Tumor Physiology on Delivery of Therapeutics (R B Campbell)Enhanced Permeability and Retention (EPR) Effect and Tumor-Selective Delivery of Anticancer Drugs (K Greish et al.)Basic Strategies for PEGylation of Peptide and Protein Drugs (G Pasut et al.)PEGylated Proteins as Cancer Therapeutics (M Morpurgo et al.)PEGylated Proteins in Immunotherapy of Cancer (J F Eliason)Silencing Proteins: Nanotechnological Approaches to Deliver of siRNA for Cancer Therapy (R M Schiffelers et al.)Anti-Cancer Proteins and Peptides in Liposomes (V Torchilin)Folate-Mediated Delivery of Protein and Peptide Drugs into Tumors (J A Reddy et al.)Transferrin Receptor Mediated Delivery of Protein and Peptide Drugs into Tumors (J Fahrmeir & M Ogris)Transmembrane Delivery of Protein and Peptide Drugs into Cancer Cells (C C Saenz & S F Dowdy)Protein and Peptide Drugs to Suppress Tumor Angiogenesis (C Rüegg)Utilizing Lymphatic Transport in Enhancing the Delivery of Drugs, Including Proteins, and Peptides, to Metastatic Tumors (E K Wasan & K M Wasan)Delivery of Protein and Peptide Drugs to Brain Tumors (H B Newton)Protein and Peptide-Based Cancer Gene Therapy (S Chada & R Ramesh) Readership: Graduate students & academics from cancer therapy, protein & peptide drugs, drug delivery, & tumor targeting areas; non-experts interested in drug delivery to tumors. Key Features:Written by leading scientists such as Prof Veronese, Prof Maeda, Prof Dowdy, Prof Torchilin & Prof WasanDetailed explanation of physiological barriers for protein and peptide drugs in tumorsDifferent approaches to the stabilization of proteins and peptides in biological surroundings and their enhanced delivery into tumors and inside cancer cellsKeywords:Cancer;Protein & Peptide Drugs;Delivery;Tumor Physiology;Drug Carriers;Pegylation;Liposomes;Angiogenesis;Lymphatic Transport;Protein Transduction

✏Book Title : Proteins and Peptides
✏Author : Randall J. Mrsny
✏Publisher : CRC Press
✏Release Date : 2009-10-19
✏Pages : 288
✏ISBN : 9781420078077
✏Available Language : English, Spanish, And French

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✏Proteins and Peptides Book Summary : Addressing the increased use of protein and peptide candidates as treatments for previously untreatable diseases, this comprehensive and progressive source provides the reader with a roadmap to an increased understanding of issues critical for successfully developing a protein or peptide therapeutic candidate. Proteins and Peptides is

✏Book Title : Pharmaceutical Formulation Development of Peptides and Proteins
✏Author : Lars Hovgaard
✏Publisher : CRC Press
✏Release Date : 2012-11-14
✏Pages : 392
✏ISBN : 9781439853894
✏Available Language : English, Spanish, And French

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✏Pharmaceutical Formulation Development of Peptides and Proteins Book Summary : The rapid advances in recombinant DNA technology and the increasing availability of peptides and proteins with therapeutic potential are a challenge for pharmaceutical scientists who have to formulate these compounds as drug products. Pharmaceutical Formulation Development of Peptides and Proteins, Second Edition discusses the development of therap

✏Book Title : Trends and Future Perspectives in Peptide and Protein Drug Delivery
✏Author : Vincent Lee
✏Publisher : CRC Press
✏Release Date : 1995-02-01
✏Pages : 392
✏ISBN : 3718656418
✏Available Language : English, Spanish, And French

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✏Trends and Future Perspectives in Peptide and Protein Drug Delivery Book Summary :

✏Book Title : Peptide and Protein Drug Analysis
✏Author : Ronald Reid
✏Publisher : CRC Press
✏Release Date : 1999-11-12
✏Pages : 904
✏ISBN : 1420001337
✏Available Language : English, Spanish, And French

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✏Peptide and Protein Drug Analysis Book Summary : Furthering efforts to simulate the potency and specificity exhibited by peptides and proteins in healthy cells, this remarkable reference supplies pharmaceutical scientists with a wealth of techniques for tapping the enormous therapeutic potential of these molecules-providing a solid basis of knowledge for new drug design. Provides a broad, comprehensive overview of peptides and proteins as mediators of cell movement, proliferation, differentiation, and communication. Written by more than 50 leading international authorities, Peptides and Protein Drug Analysis discusses strategies for dealing with the complexity of peptides and proteins in conformational flexibility and amino acid sequence variability analyzes drug formulations facilitated by solid-phase peptide synthesis and recombinant DNA technology examines chemical purity analysis by high-pressure chromatographic, capillary electrophoretic, gel electrophoretic, and isoelectric focusing methods highlights drug design elements derived from protein folding, bioinformatics, and computational chemistry demonstrates uses of unnatural mutagenesis and combinatorial chemistry explores mass spectrometry, protein sequence, and carbohydrate analysis illustrates bioassays and other new functional analysis methods surveys spectroscopic techniques such as ultraviolet, fluorescence, Fourier transform infrared, and nuclear magnetic resonance (NMR) addresses ways of distinguishing between levels of therapeutic and endogenous agents in cells reviews structural analysis tools such as ultracentrifugation and light, X-ray, and neutron scattering and more! Featuring over 3400 bibliographic citations and more than 500 tables, equations, and illustrations, Peptide and Protein Drug Analysis is a must-read resource for pharmacists; pharmacologists; analytical, organic, and pharmaceutical chemists; cell and molecular biologists; biochemists; and upper-level undergraduate and graduate students in these disciplines.

✏Book Title : Protein Formulation and Delivery Second Edition
✏Author : Eugene J. McNally
✏Publisher : CRC Press
✏Release Date : 2007-10-26
✏Pages : 376
✏ISBN : 0849379520
✏Available Language : English, Spanish, And French

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✏Protein Formulation and Delivery Second Edition Book Summary : This title is intended to assist pharmaceutical scientists in the development of stable protein formulations during the early stages of the product development process, providing a comprehensive review of mechanisms and causes of protein instability in formulation development, coverage of accelerated stability testing methods and relevant analytical methods, and an overview of the drug substance manufacturing process. Preformulation and the development of traditional solutions and lyophilized formulations frequently used for intravenous delivery and non-traditional formulations are also addressed. Because many developments in the field have emerged since the publication of the First Edition, this Second Edition addresses important new patient-friendly developments in the field, such as formulation for implantable devices, needle-free formulation and delivery approaches, and oral delivery of proteins.

✏Book Title : Biological Barriers to Protein Delivery
✏Author : Kenneth L. Audus
✏Publisher : Springer Science & Business Media
✏Release Date : 1993
✏Pages : 495
✏ISBN : 0306443686
✏Available Language : English, Spanish, And French

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✏Biological Barriers to Protein Delivery Book Summary : In response to the tremendous increase in the number of protein and peptide drugs, this treatise critically reviews transport and metabolism mechanisms relating to the delivery of endogenous and recombinant proteins to mammalian organs, tissues, and cells. It will promote fruitful collaboration among academic and industrial scientists in the fields of pharmacology, cell biology, biochemistry, physiology, and immunology.

✏Book Title : Delivery Technologies for Biopharmaceuticals
✏Author : Lene Jorgensen
✏Publisher : John Wiley & Sons
✏Release Date : 2009-10-23
✏Pages : 442
✏ISBN : 9780470688403
✏Available Language : English, Spanish, And French

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✏Delivery Technologies for Biopharmaceuticals Book Summary : Advances in biotechnology have provided scientists with an increasing number of biopharmaceuticals such as novel peptide and protein drugs as well as nucleic acid based drugs for gene therapy. However, successful delivery of these biopharmaceuticals is a major challenge because their molecular properties lead to poor physical and chemical stability in the body and limited membrane permeability. Therefore researchers are developing a range of new delivery technologies and materials to enable these new drugs to be delivered intact to their target sites. Delivery Technologies for Biopharmaceuticals describes strategies to overcome the main barriers for successful delivery of therapeutic peptides, proteins, and nucleic acid-based drugs or vaccines related to the site of administration and the target site. Many of the approaches described are reported in formulations in current clinical trials as well as in marketed products. Contents include: challenges in delivery of biopharmaceuticals novel formulation approaches for peptide and protein injectables non-viral chemical vectors and viral technology for delivery of nucleic acid based drugs immune response, adjuvants and delivery systems for vaccines several examples of delivery systems for different biopharmaceuticals a critical assessment of delivery technologies for biopharmaceuticals Delivery Technologies for Biopharmaceuticals is an essential single-volume introduction to the technologies used by researchers to ensure efficient delivery of this exciting new class of drugs. It will be of value to researchers and students working in drug delivery, formulation, biopharmaceuticals, medicinal chemistry, and new materials development.

✏Book Title : Peptide and Protein Interaction with Membrane Systems
✏Author : Sara Bobone
✏Publisher : Springer
✏Release Date : 2014-05-31
✏Pages : 140
✏ISBN : 9783319064345
✏Available Language : English, Spanish, And French

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✏Peptide and Protein Interaction with Membrane Systems Book Summary : In her thesis, Sara Bobone outlines spectroscopic studies of antimicrobial peptides (AMPs) which are promising lead compounds for drugs used to fight multidrug resistant bacteria. Bobone shows that AMPs interact with liposomes and she clarifies the structure of pores formed by one of these molecules. These results help us to understand how AMPs are selective for bacterial membranes and how their activity can be finely tuned by modifying their sequence. Findings which solve several conundrums debated in the literature for years. In addition, Bobone uses liposomes as nanotemplates for the photopolymerization of hydrogels - exploiting the self- assembly properties of phospholipids. Bobone was able to trap an enzyme using nanometeric particles, while still allowing its activity by the diffusion of substrates and products through the network of the polymer. The innovative nano devices described in this thesis could solve many of the hurdles still hampering the therapeutic application of protein-based drugs.

✏Book Title : Therapeutic Protein and Peptide Formulation and Delivery
✏Author : Zahra Shahrokh
✏Publisher : Amer Chemical Society
✏Release Date : 1997
✏Pages : 228
✏ISBN : UOM:39015041771521
✏Available Language : English, Spanish, And French

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✏Therapeutic Protein and Peptide Formulation and Delivery Book Summary : This volume reviews protein stability and the analytical and biophysical characterization of proteins. It emphasizes drug delivery approaches, especially local delivery through the skin. Including both academic and industrial perspectives from such companies as Genentech, Amgen, and Merck, the book also discusses novel drug delivery polymers and the development of pharmaceutical protein formulations.

✏Book Title : Inhalation Delivery of Therapeutic Peptides and Proteins
✏Author : Akwete Adjei
✏Publisher : CRC Press
✏Release Date : 1997-07-08
✏Pages : 952
✏ISBN : 0824797809
✏Available Language : English, Spanish, And French

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✏Inhalation Delivery of Therapeutic Peptides and Proteins Book Summary : This exhaustive reference-the first book of its kind to describe in detail the functionality of the human respiratory tract and its impact on both local and systemic delivery of biotherapeutic and macromolecular drug systems-offers comprehensive analyses of peptide and protein drug delivery through the lung. Summarizes over 130 patents granted worldwide on alternative systems for pulmonary delivery of therapeutic drugs-especially peptides and proteins! Examining macromolecular drug delivery as an efficient, patient-friendly, and cost-effective method of treatment, Inhalation Delivery of Therapeutic Peptides and Proteins discusses airway physiology and biomechanics the pharmaceutical concerns associated with the respiratory tract as a viable port of drug entry to the body key peptide drugs under development and in use to treat local lung disease, including cyclosporines, interferons, antitrypsins, protease inhibitors, and deoxyribonucleases the systemic delivery of peptide and protein drugs using fine-particle technology gene therapy employing gene delivery through the airways new developments in pulmonary delivery technologies emphasizing inhaled peptide and protein drugs guidelines for the successful introduction of peptide inhalation aerosol products into the marketplace and much more!

✏Book Title : Handbook of Cell Penetrating Peptides
✏Author : Ulo Langel
✏Publisher : CRC Press
✏Release Date : 2006-08-15
✏Pages : 600
✏ISBN : 1420006088
✏Available Language : English, Spanish, And French

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✏Handbook of Cell Penetrating Peptides Book Summary : Since the first Handbook of Cell-Penetrating Peptides was prepared in 2001, the wealth of new information on the use of these peptides as transport systems has in fact served to confound the field. The constant internal change in the field of cell-penetrating peptides (CPPs) is due to recent research uncovering apparent ambiguities in cellular upta

✏Book Title : Challenges in Delivery of Therapeutic Genomics and Proteomics
✏Author : Ambikanandan Misra
✏Publisher : Elsevier
✏Release Date : 2010-09-09
✏Pages : 686
✏ISBN : 0123849659
✏Available Language : English, Spanish, And French

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✏Challenges in Delivery of Therapeutic Genomics and Proteomics Book Summary : Delivery of therapeutic proteomics and genomics represent an important area of drug delivery research. Genomics and proteomics approaches could be used to direct drug development processes by unearthing pathways involved in disease pathogenesis where intervention may be most successful. This book describes the basics of genomics and proteomics and highlights the various chemical, physical and biological approaches to protein and gene delivery. Covers a diverse array of topics from basic sciences to therapeutic applications of proteomics and genomics delivery Of interest to researchers in both academia and industry Highlights what’s currently known and where further research is needed

✏Book Title : Peptide Drug Delivery to the Brain
✏Author : William M. Pardridge
✏Publisher : Raven Press (ID)
✏Release Date : 1991
✏Pages : 357
✏ISBN : UOM:39015022016532
✏Available Language : English, Spanish, And French

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✏Peptide Drug Delivery to the Brain Book Summary : Discusses new and established strategies for delivering peptides and antibodies through the blood-brain barrier. It reviews concepts on blood-brain barrier transport biology, assesses the utility and limitations of traditional brain drug delivery methods and describes new drug delivery techniques.

✏Book Title : Delivery Systems for Peptide Drugs
✏Author : S.S. Davis
✏Publisher : Springer Science & Business Media
✏Release Date : 2013-11-11
✏Pages : 370
✏ISBN : 9781475799606
✏Available Language : English, Spanish, And French

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✏Delivery Systems for Peptide Drugs Book Summary : Recent years have seen enormous advances in the field of protein and peptide engineering and a greater understanding in the way in which biological response modifiers function in the body. It is now possible through the use of recombinant DNA techniques, or by solid phase protein synthesis, to produce significant quantities of a wide variety of regulatory agents that are therapeutically applicable. The list of these response modifiers expands almost daily to include interferons, macrophage activation factors, neuropeptides and agents that may have potential in cardiovascular disease, inflammation, contraception etc. Prospects to use some of these materials in medicine have reached the stage where products have either been approved by regulatory authorities or are the subject of applications as investigatory drugs or as new therapeutic agents. In some uses the pertinent agent will be administered on an acute basis in the form of a simple injection, as, for example, the use of a tissue plasminogen activator for the treatment of coronary infarct. In other cases regulatory proteins and peptides are indicated for chronic therapy and here they will need to be administered by an appropriate delivery system. Unfortunately, the research on delivery systems for peptides and proteins has not kept pace with the rapid progress in biotechnology and, consequently, there are presently few systems that are entirely appropriate for the administration of macromolecular drugs according to complex dosage regimens, (eg intermittent and pulsed therapy). Furthermore essential pharmacokinetic and pharmacodynamic data may be missing.

✏Book Title : Drug Delivery
✏Author : Ashim K. Mitra
✏Publisher : Jones & Bartlett Publishers
✏Release Date : 2014-08-18
✏Pages : 400
✏ISBN : 9781449674267
✏Available Language : English, Spanish, And French

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✏Drug Delivery Book Summary : Drug Delivery is the latest and most up-to-date text on drug delivery and offers an excellent working foundation for students and clinicians in health professions and graduate students including nursing, pharmacy, medicine, dentistry, as well as researchers and scientists. Presenting this complex content in an organized and concise format, Drug Delivery allows students to gain a strong understanding of the key concepts of drug delivery.This text focuses on the basic concepts of drug delivery while thoroughly examining various topics such as: CNS delivery Gene delivery Ocular delivery World-wide research on drug delivery Recent advances in drug deliveryA significant advancement has been made in the field of drug delivery. This text provides a detailed overview of drug delivery systems, routes of drug administration and development of various formulations. The cutting edge research being carried out in this field will be compiled and a focus on worldwide research on drug delivery and targeting at the molecular, cellular, and organ levels will also be summarized.Each new print copy includes access to the Navigate Companion Website including: Chapter Quizzes, Interactive Glossary, Crossword Puzzles , Interactive Flashcards, and Matching Exercises

✏Book Title : Biodrug Delivery Systems
✏Author : Mariko Morishita
✏Publisher : CRC Press
✏Release Date : 2016-04-19
✏Pages : 488
✏ISBN : 9781420086713
✏Available Language : English, Spanish, And French

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✏Biodrug Delivery Systems Book Summary : Biodrug Delivery Systems: Fundamentals, Applications and Clinical Development presents the work of an international group of leading experts in drug development and biopharmaceutical science who discuss the latest advances in biodrug delivery systems and associated techniques. The book discusses components of successful formulation, delivery, and p

✏Book Title : Advances in Drug Delivery Systems 6
✏Author : James M. Anderson
✏Publisher : Elsevier
✏Release Date : 2013-10-22
✏Pages : 372
✏ISBN : 9781483161570
✏Available Language : English, Spanish, And French

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✏Advances in Drug Delivery Systems 6 Book Summary : Advances in Drug Delivery Systems, 6 focuses on the progress in drug delivery systems as manifested in the fields of international pharmaceutics, polymer science, biotechnology, molecular biology, and cell biology. The selection first tackles biologically engineered microstructures and approaches to targeting bioactive compounds. Discussions focus on therapeutic efficiency of fatty acylated antiviral antibodies; effect of artificial fatty acylation on protein binding and uptake; and controlled release of proteins from lipid microcylinders. The text then elaborates on mucosal delivery of macromolecules and targeted delivery of diagnostic agents by surface-modified liposomes. The book examines the factors on in vitro micelle stability of adriamycin-block copolymer conjugates; vaginal and reproductive system treatments using a bioadhesive polymer; and control of the disposition profiles of proteins in the kidney via chemical modification. The publication also takes a look at drug delivery using biodegradable microspheres; approaches to improved antibody- and peptide-mediated targeting for imaging and therapy of cancer; and biodegradable microspheres for the delivery of oral vaccines. The selection is a valuable source material for scientists and readers interested in the advances in the systems of drug delivery.

✏Book Title : Polymeric Peptide Mimics for Protein Delivery
✏Author : Coralie Backlund
✏Publisher :
✏Release Date : 2018
✏Pages :
✏ISBN : OCLC:1055555804
✏Available Language : English, Spanish, And French

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✏Polymeric Peptide Mimics for Protein Delivery Book Summary : The plasma membrane is a major obstacle in the development and use of biomacromolecules for intracellular applications. Consequently, proteins with intracellular targets represent an enormous, yet under studied avenue for therapeutics. Extended research has aimed at facilitating intracellular delivery of exogenous proteins using protein transduction domains (PTDs), which allow transport of bioactive molecules into cells. Synthetic polymers, inspired by PTDs, provide a well-controlled platform to vary molecular architecture for structure activity relationship studies. Specifically, this thesis focuses on the use of ring-opening metathesis, a facile and efficient polymerization technique, through which we can vary structural parameters to optimize delivery of non-covalently encapsulated proteins. The aim was to characterize, optimize, and utilize PTD mimics (PTDMs) for functional protein delivery. Fluorescently labeled cargo were used to elucidate the predominant cellular entry mechanism for the PTDMs and were compared to their ability to deliver protein into cells. A series of polymers was designed around the most membrane active polymers to explore the incorporation of guanidine and hydrophobic moieties, yielding a PTDM capable of high protein delivery into a variety of cell types. The PTDM was then explored for use as a vaccine delivery reagent into immune cells. The ability to have a specific response with the cargo of interest verifies cytosolic delivery using the PTDMs and provides valuable insight into their use to affect intracellular pathways.

✏Book Title : Protein Delivery
✏Author : Lynda M. Sanders
✏Publisher : Springer Science & Business Media
✏Release Date : 1997-04-30
✏Pages : 433
✏ISBN : 9780306453595
✏Available Language : English, Spanish, And French

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✏Protein Delivery Book Summary : Thirteen chapters by industrial and academic authorities in this rapidly evolving field present detailed case histories and reviews of current sophisticated protein-drug delivery technologies. Highlights include a comprehensive overview of insulin delivery and a discussion of the use of biodegradable microspheres.

✏Book Title : Therapeutic Peptides and Proteins
✏Author : Ajay K. Banga
✏Publisher : CRC Press
✏Release Date : 2005-09-14
✏Pages : 376
✏ISBN : 9781420039832
✏Available Language : English, Spanish, And French

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✏Therapeutic Peptides and Proteins Book Summary : Upon publication of the first edition of Therapeutic Peptides and Proteins ten years ago there were only 19 biotechology medicines on the market. Currently there are more than 100, with at least 400 more in various stages of development. That alone would be grounds for a new edition. Add to that the fact that it is still difficult to find up

✏Book Title : Manchester
✏Author : John J. Parkinson-Bailey
✏Publisher : Manchester University Press
✏Release Date : 2000
✏Pages : 366
✏ISBN : 0719056063
✏Available Language : English, Spanish, And French

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✏Manchester Book Summary : Advances in biotechnology have provided scientists with an increasing number of biopharmaceuticals such as novel peptide and protein drugs as well as nucleic acid based drugs for gene therapy. However, successful delivery of these biopharmaceuticals is a major challenge because their molecular properties lead to poor physical and chemical stability in the body and limited membrane permeability. Therefore researchers are developing a range of new delivery technologies and materials to enable these new drugs to be delivered intact to their target sites.Delivery Technologies for Biopharmaceuticals describes strategies to overcome the main barriers for successful delivery of therapeutic peptides, proteins, and nucleic acid-based drugs or vaccines related to the site of administration and the target site. Many of the approaches described are reported in formulations in current clinical trials as well as in marketed products. Contents include:challenges in delivery of biopharmaceuticals novel formulation approaches for peptide and protein injectables novel non-injectable formulation approaches of peptides and proteins chemical vectors for delivery of nucleic acid based drugs viral technology for delivery of nucleic acids the innate immune response, adjuvants and delivery systems solid lipid nanoparticle based systems for delivery of biomacromolecule therapeutics dendrimers in delivery of biopharmaceuticals modification of peptides and proteins nanocarriers for the delivery of peptides and proteins polymer-based delivery systems for oral delivery of peptides and proteins advanced pulmonary delivery of peptide/protein drugs using polymeric particles polymer microparticles for nucleic acid delivery pulmonary delivery of small interfering RNA for novel therapeutics lipid-based formulations for siRNA delivery cellular bioavailability of peptide nucleic acids (PNA) conjugated to cell penetrating peptides DEAE-Dextran-MMA graft copolymer for non-viral delivery of DNA liposomes in adjuvant systems for parenteral delivery of vaccines influenza virosomes as delivery systems for antigens GRAZAX: an oromucosal vaccine for treating immunotheraphy against grass pollen allergy delivery technologies for biopharmaceuticals: a critical assessmentDelivery Technologies for Biopharmaceuticals is an essential single-volume introduction to the technologies used by researchers to ensure efficient delivery of this exciting new class of drugs. It will be of value to researchers and students working in drug delivery, formulation, biopharmaceuticals, medicinal chemistry, and new materials development.

✏Book Title : Physical Methods to Characterize Pharmaceutical Proteins
✏Author : James N. Herron
✏Publisher : Springer Science & Business Media
✏Release Date : 2013-11-21
✏Pages : 362
✏ISBN : 9781489910790
✏Available Language : English, Spanish, And French

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✏Physical Methods to Characterize Pharmaceutical Proteins Book Summary : Proteins are still gaining importance in the pharmaceutical world, where they are used to improve our arsenal of therapeutic drugs and vaccines and as diagnostic tools. Proteins are different from "traditional" low-molecular-weight drugs. As a group, they exhibit a number of biopharmaceutical and formulation problems. These problems have drawn considerable interest from both industrial and aca demic environments, forcing pharmaceutical scientists to explore a domain previ ously examined only by peptide and protein chemists. Biopharmaceutical aspects of proteins, e.g., low oral bioavailability, have been extensively investigated. Although all possible conventional routes of ad ministration have been examined for proteins, no real, generally applicable alter native to parenteral administration in order to achieve systemic effects has yet been discovered. Several of these biopharmaceutical options have been discussed in Volume 4 of this series, Biological Barriers to Protein Delivery. Proteins are composed of many amino acids, several of which are notorious for their chemical instability. Rational design of formulations that optimize the native structure and/or bioactivity of a protein is therefore of great importance when long shelf life is required, as it is for pharmaceutical products. This issue has also been examined in two prior volumes of this series: Volume 2: Stability of Protein Pharmaceuticals (Part A) and Volume 5: Stability and Characterization of Protein and Peptide Drugs.

✏Book Title : Tissue Engineering And Novel Delivery Systems
✏Author : Michael J. Yaszemski
✏Publisher : CRC Press
✏Release Date : 2003-11-04
✏Pages : 620
✏ISBN : 9780824757731
✏Available Language : English, Spanish, And French

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✏Tissue Engineering And Novel Delivery Systems Book Summary : Essential to anyone working in the field, this reference focuses on rencent advancements in tissue construction, repair and regeneration—examining developments in gene and drug therapy, the evolution of tissue-engineered products, and new technologies for the design of functional tissues and organ systems.

✏Book Title : Peptide Transport and Delivery Into the Central Nervous System
✏Author : Laszlo Prokai
✏Publisher : Springer Science & Business Media
✏Release Date : 2003
✏Pages : 245
✏ISBN : 3764367164
✏Available Language : English, Spanish, And French

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✏Peptide Transport and Delivery Into the Central Nervous System Book Summary : Various peptides native to the brain and the spinal cord, as well as various synthetic peptides, peptide analogues and peptidomimetics could be useful in the treatment of diseases of the central nervous system. This book provides an overview of the role and neuropharmaceutical potential of these peptides, and discusses the state of the art and future trends in the use of peptide pharmacotherapy involving the brain.

✏Book Title : Microparticulate Systems for the Delivery of Proteins and Vaccines
✏Author : Smadar Cohen
✏Publisher : CRC Press
✏Release Date : 1996-08-23
✏Pages : 552
✏ISBN : 0824797531
✏Available Language : English, Spanish, And French

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✏Microparticulate Systems for the Delivery of Proteins and Vaccines Book Summary : This practical guide offers concise coverage of the scientific and pharmaceutical aspects of protein delivery from controlled release microparticulate systems-emphasizing protein stability during encapsulation and release.

✏Book Title : Transdermal and Intradermal Delivery of Therapeutic Agents
✏Author : Ajay K Banga
✏Publisher : CRC Press
✏Release Date : 2011-05-16
✏Pages : 309
✏ISBN : 9781439805107
✏Available Language : English, Spanish, And French

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✏Transdermal and Intradermal Delivery of Therapeutic Agents Book Summary : Skin, once thought to be an impenetrable barrier, is an extremely active organ capable of interacting with its environment. Advancements in science combined with the need for diverse drug delivery modalities have introduced a variety of transdermal and intradermal products for existing drugs at a fraction of the cost of new drug development. Commercialization of transdermal drug delivery requires technology from many disciplines beyond pharmaceutical sciences, such as polymer chemistry, adhesion sciences, mass transport, web film coating, printing, and medical technology. A comprehensive discussion of these technologies and practices, Transdermal and Intradermal Delivery of Therapeutic Agents: Application of Physical Technologies covers: Commercial development of devices and products based on transdermal physical enhancement technologies Selecting optimal enhancement technology for a specific drug molecule using case studies Physicochemical properties and practical commercial considerations related to cost, unmet clinical needs, marketing, or intellectual property protection Technologies such as microneedles, iontophoresis, electroporation, and sonophoresis, with examples for delivery of small molecules, cosmeceuticals, proteins, and vaccines Practical information on experimental procedures and challenges related to skin irritation and safety issues Up-to-date and accessible to researchers and industry experts, this book provides a comprehensive discussion of the physical approaches and practical considerations for the laboratory and marketplace.