Organ on a Chip

• Author : Julia Hoeng,David Bovard,Manuel Peitsch
• Publisher : Academic Press
• Release : 01 November 2019

Organ on a Chip: Convergence of Advanced Materials, Cells, and Microscale Technologies contains chapters from world-leading researchers in the field of organ on a chip development and applications, with perspectives from life sciences, medicine, physiology and engineering. The book contains an overview of the field, with sections covering the major organ systems and currently available technologies, platforms and methods. As readers may also be interested in creating biochips, materials and engineering best practice, these topics are also described. Users will

• Author : Dr.Hakim Saboowala
• Publisher : Dr.Hakim Saboowala
• Release : 07 January 2020

The capability of traditional platforms, such as well plate, does not match researchers’ demands for precise and creative experiments any more. Direct detection and analysis of biomolecules and cells in physiological microenvironment is urgently needed for fast evaluation of biology and pharmacy. The past several years have witnessed remarkable development opportunities in vitro organs and tissues models with multiple functions based on microfluidic devices, termed as “organ-on-a-chip”. It is a promising technology in rebuilding physiological functions of tissues and organs,

• Author : Qasem Ramadan,Massimo Alberti,Martin Dufva,Yi-Chung Tung
• Publisher : Frontiers Media SA
• Release : 16 October 2019

Recent developments in microfluidics have demonstrated enormous potential of microscale cell culture for biology studies and recognized as instrumental in performing rapid and efficient experiments on small-sample volumes. Microfluidic-based cell culture is an area of research that keeps growing and gaining importance as a prominent technology, able to link scientific disciplines with industrial and clinical applications. In particular, organotypic cell culture and its integration in microfluidic devices would enable the realization of “in vivo-like” cell microenvironment within systems that are

• Author : Han Liang Lim
• Publisher : Unknown
• Release : 14 June 2021

Cancer ranks amongst the most lethal diseases worldwide, partly due to there being more than 120 different types of cancer, each one different from the other. Even for cancers from the same organ, different mutations in different cells within the same tissue can give rise to different types of cancer, which may require completely different treatments. Due to advancements in medical and pharmacological sciences, different drug regiments for different types of cancer exist, which has contributed to improving the survival rates

• Author : Julia Hoeng,David Bovard,Manuel C. Peitsch
• Publisher : Academic Press
• Release : 09 November 2019

Organ-on-a-Chip: Engineered Microenvironments for Safety and Efficacy Testing contains chapters from world-leading researchers in the field of organ on a chip development and applications, with perspectives from life sciences, medicine, physiology and engineering. The book contains an overview of the field, with sections covering the major organ systems and currently available technologies, platforms and methods. As readers may also be interested in creating biochips, materials and engineering best practice, these topics are also described. Users will learn about the limitations

• Author : Gaurav Agrawal
• Publisher : Unknown
• Release : 14 June 2021

Patients around the world who suffer from a host of debilitating conditions rely on medications for treatment. However, pharmaceutical researchers and drug developers face immense challenges to new drug discovery. Drug companies currently spend 10-15 years and upwards of $1 billion (USD) developing and testing a single new drug, and despite this, up to 90% of drug candidates ultimately fail to pass clinical trials and obtain FDA approval. A significant reason for this failure is the inability of traditional pre-clinical testing systems,

• Author : Jonas Christoffersson
• Publisher : Linköping University Electronic Press
• Release : 22 January 2019

Organs-on-chips are dynamic cell culture devices created with the intention to mimic organ function in vitro. Their purpose is to assess the toxicity and efficacy of drugs and, as early as possible in the pharmaceutical development process, predict the outcome of clinical trials. The aim of this thesis is to explain and discuss these cell culture devices from a design perspective and to experimentally exemplify some of the specific functions that characterize organs-on-chips. The cells in our body reside in

• Author : Yu-suke Torisawa,Yi-Chung Tung
• Publisher : MDPI
• Release : 27 May 2020

Recent advances in microsystems technology and cell culture techniques have led to the development of organ-on-chip microdevices that produce tissue-level functionality, not possible with conventional culture models, by recapitulating natural tissue architecture and microenvironmental cues within microfluidic devices. Since the physiological microenvironments in living systems are mostly microfluidic in nature, the use of microfluidic devices facilitates engineering cellular microenvironments; the microfluidic devices allow for control of local chemical gradients and dynamic mechanical forces, which play important roles in cellular viability

• Author : Sean V. Murphy,Anthony Atala
• Publisher : CRC Press
• Release : 30 November 2016

Miniaturization in the fields of chemistry and molecular biology has resulted in the "lab-on-a-chip." Such systems are micro-fabricated devices capable of handling extremely small fluid volumes facilitating the scaling of single or multiple lab processes down to a microchip-sized format. The convergence of lab-on-a-chip technology with the field of cell biology facilitated the development of "organ-on-a-chip" systems. Such systems simulate the function of tissues and organs, having the potential to bypass some cell and animal testing methods. These technologies have

• Author : Anonim
• Publisher : Unknown
• Release : 14 June 2021

• Author : Anonim
• Publisher : Unknown
• Release : 14 June 2021

• Author : Marco Rasponi
• Publisher : Humana
• Release : 08 August 2021

This book provides a collection of microphysiological systems employed for chemical/drug screening and strategies to mimic various physiological conditions. Chapters guide readers through Organ-on-a-Chip( OoC) platforms such as liver, intestine, blood-brain barrier, kidney, vessels, cardiac and skeletal muscles, articular joint, human fat. Additional chapters detail microfabrication technologies used to fabricate OoC devices such as, standard photo- and soft-lithography, techniques to fabricate membranes, and industrial-oriented fabrication methods.Written in the format of the highly successful Methods in Molecular Biology series,

• Author : Bianka Großhäuser
• Publisher : Unknown
• Release : 28 March 2017

• Author : Ana Moya Lara
• Publisher : Unknown
• Release : 14 June 2021

Los dispositivos ‘Organ-On-a-Chip' han revolucionado la forma de conocer la biología que hasta el momento se ha venido realizando con los cultivos celulares. Estos sistemas, que contemplan el co-cultivo en tres dimensiones y tecnología microfluídica, tienen como propósito mimetizar la fisiología humana con sistemas de cultivo in-vitro. Su finalidad es la de incrementar el conocimiento de los procesos biológicos, así como también de disponer de una herramienta de diagnóstico efectiva para el

• Author : Anonim
• Publisher : Unknown
• Release : 14 June 1971