Ocular Transporters and Receptors

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  • Author : Ashim K Mitra
  • Publisher : Elsevier
  • Pages : 276 pages
  • ISBN : 190881831X
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Ocular Transporters and Receptors

Download or Read online Ocular Transporters and Receptors full in PDF, ePub and kindle. this book written by Ashim K Mitra and published by Elsevier which was released on 31 October 2013 with total page 276 pages. We cannot guarantee that Ocular Transporters and Receptors book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Ocular transporters and receptors contains detailed descriptions of major transporters and receptors expressed in the eye, with special emphasis on their role in drug delivery. The complex anatomy and the existence of multiple barriers in the eye pose a considerable challenge to successful drug delivery to the eye. Hence ocular transporters and receptors are important targets for drug delivery. A significant advancement has been made in the field of ocular transport research and their role in drug delivery. In this book the cutting edge research being carried out in this field is compiled and summarized. The book focuses on key areas, including the anatomy and physiology of the eye, biology of ocular transporters and receptors, techniques in characterization of transporters and receptors, transporters and receptors in the anterior and posterior segment in the eye, the role of ocular transporters and receptors in drug delivery, and transporter-metabolism interplay in the eye. Highly focused on ocular transporters Most up-to-date research compilation Detailed description of role of transporters and receptors in ocular drug discovery and delivery

Ocular Transporters and Receptors

Ocular Transporters and Receptors
  • Author : Ashim K Mitra
  • Publisher : Elsevier
  • Release : 31 October 2013
GET THIS BOOK Ocular Transporters and Receptors

Ocular transporters and receptors contains detailed descriptions of major transporters and receptors expressed in the eye, with special emphasis on their role in drug delivery. The complex anatomy and the existence of multiple barriers in the eye pose a considerable challenge to successful drug delivery to the eye. Hence ocular transporters and receptors are important targets for drug delivery. A significant advancement has been made in the field of ocular transport research and their role in drug delivery. In this

Ocular Transporters in Ophthalmic Diseases and Drug Delivery

Ocular Transporters in Ophthalmic Diseases and Drug Delivery
  • Author : Joyce Tombran-Tink,Colin J. Barnstable
  • Publisher : Springer Science & Business Media
  • Release : 09 April 2008
GET THIS BOOK Ocular Transporters in Ophthalmic Diseases and Drug Delivery

In this exceptionally important new work, a panel of distinguished authors discusses all the latest developments in the study of ocular transporters. Focusing on the molecular characteristics, localization, and substrate specificities in various compartments of the eye, this volume discusses how transporters regulate the clarity of the cornea and lens, the movements of fluids across the ciliary epithelium and nutrients across the retinal pigment epithelium.

The Biology of the Eye

The Biology of the Eye
  • Author : Jorge Fischbarg
  • Publisher : Elsevier
  • Release : 09 December 2005
GET THIS BOOK The Biology of the Eye

Acknowledgement This book is the result of a collective effort. Due to an oversight, mention of three of the contributors who played an especially decisive role in bringing the work to fruition was omitted from the book. They should share fully in the intellectual credits accruing from this publication. I would therefore like to acknowledge and thank the following for their outstanding contributions to editing the work: Dr. Morten Dornonville la Cour (MD, Dr. Med. Sci.) solicited and edited the

Mechanisms of Water and Solute Transport at the Ocular Surface

Mechanisms of Water and Solute Transport at the Ocular Surface
  • Author : Marc Harris Levin
  • Publisher : Unknown
  • Release : 18 June 2021
GET THIS BOOK Mechanisms of Water and Solute Transport at the Ocular Surface

Actions of and interactions among AQPs, CFTR, and ENaC are also of central importance to airway surface liquid (ASL) function and dysfunction, and have been considered with regard to both the etiology and possible treatment of cystic fibrosis (CF) lung disease. Recent data indicated clinical benefit of nebulized hypertonic saline in CF. The proposed mechanism of increased ASL volume relies on purported inhibition of lung AQPs by the ENaC inhibitor amiloride. Sensitive fluorescence methods indicated that amiloride does not inhibit

Lacrimal Gland Tear Film and Dry Eye Syndromes 3

Lacrimal Gland  Tear Film  and Dry Eye Syndromes 3
  • Author : David A. Sullivan,Michael E. Stern,Kazuo Tsubota,Darlene A. Dartt,Rose M. Sullivan,B. Britt Bromberg
  • Publisher : Springer
  • Release : 31 January 2003
GET THIS BOOK Lacrimal Gland Tear Film and Dry Eye Syndromes 3

During the past several decades, a significant international research effort has been directed towards understanding the composition and regulation of the preocular tear film. This effort has been motivated by the recognition that the tear film plays a critical role in maintaining corneal and conjunctival integrity, protecting against microbial challenge and preserving visual acuity. In addition, research has been stimulated by the knowledge that alteration or deficiency of the tear film, which occurs in numerous individuals throughout the world, may

Adler s Physiology of the Eye

Adler s Physiology of the Eye
  • Author : Francis Heed Adler
  • Publisher : Mosby Incorporated
  • Release : 18 June 2021
GET THIS BOOK Adler s Physiology of the Eye

Revised and updated, this tenth edition covers the full range of topics needed to understand all of the complex functions of the eye, including optics, electrophysiology of the retinal system, visual acuity, colour vision, ocular circulation and more.

Pharmacology of Ocular Therapeutics

Pharmacology of Ocular Therapeutics
  • Author : Thirumurthy Velpandian
  • Publisher : Springer
  • Release : 29 February 2016
GET THIS BOOK Pharmacology of Ocular Therapeutics

This book comprises an integrated review of ocular therapeutics across all relevant fields. It addresses the real-world requirements of ophthalmologists, pharmacists and optometrists, as observed through working alongside these practitioners for two decades. Knowledge surrounding agents used in ophthalmic practice has, historically, been scattered. The book facilitates understanding of ocular drug therapy by compiling all key aspects of the pharmacology, toxicology, pharmaceutical science, ocular biochemistry and cell biology of these agents. Chapters detail drug transfer across barriers, systemic toxicity of

Design of Prodrugs of Acyclovir for Ocular Oral and Genital Herpes Virus Infections Targeting the Oligopeptide and Amino Acid Transporter on the Cornea and Intestine for Improved Bioavailability Safety and Therapeutic Activity

Design of Prodrugs of Acyclovir for Ocular  Oral and Genital Herpes Virus Infections  Targeting the Oligopeptide and Amino Acid Transporter on the Cornea and Intestine for Improved Bioavailability  Safety and Therapeutic Activity
  • Author : Banmeet Singh Anand
  • Publisher : Unknown
  • Release : 18 June 2021
GET THIS BOOK Design of Prodrugs of Acyclovir for Ocular Oral and Genital Herpes Virus Infections Targeting the Oligopeptide and Amino Acid Transporter on the Cornea and Intestine for Improved Bioavailability Safety and Therapeutic Activity

Recently significant amount of work has been reported on substrate specificities of membrane transporters and receptors leading to successful design of prodrugs targeted to them for improved efficacy and absorption. VACV is such a prodrug that is recognized by the peptide transporter, hPEPT1 resulting in enhancement of oral bioavailability of acyclovir by three to five fold in humans. Utilizing transporters present on the corneal epithelium may enhance corneal permeability of polar compounds. The presence of an oligopeptide and amino acid