Non Canonical Autophagy

📒Non Canonical Autophagy ✍ Lorenzo Galluzzi

Non Canonical Autophagy Book PDF
✏Book Title : Non Canonical Autophagy
✏Author : Lorenzo Galluzzi
✏Publisher : Academic Press
✏Release Date : 2021-05-01
✏Pages : 250
✏ISBN : 9780128209110
✏Available Language : English, Spanish, And French

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✏Non Canonical Autophagy Book Summary : Non-canonical Autophagy: Mechanisms and Pathophysiological Implications outlines the differences between ‘canonical’ and ‘non-canonical’ forms of autophagy, highlighting the discoveries concerning the molecular mechanisms underlying these unconventional forms of autophagy and the advancements in pathophysiological features of ‘non-canonical’ autophagy. Non-canonical Autophagy: Mechanisms and Pathophysiological Implications also discusses all the forms ‘non-canonical’ autophagy and the complexity of autophagy-dependent cell death as the challenges and pitfalls in the development of clinically viable modulators of autophagy. This book aims to give readers a better understanding of mechanisms underlying ‘non-canonical’ autophagy so that they can interpret biological effects of autophagy correctly and identify reliable novel and effective treatment strategies. Presents the most advanced information regarding the molecular mechanism underlying non-canonical autophagy Outlines the increasing evidence regarding the involvement of non-canonical autophagy in multiple physiological and pathological processes Discusses the therapeutic potential of autophagy modulators and the obstacles that have limited their development

Regulation Of B Cell Responses By Non Canonical Autophagy Book PDF
✏Book Title : Regulation of B Cell Responses by Non canonical Autophagy
✏Author : Paula Maldonado Villavicencio
✏Publisher :
✏Release Date : 2019
✏Pages :
✏ISBN : OCLC:1197752180
✏Available Language : English, Spanish, And French

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✏Regulation of B Cell Responses by Non canonical Autophagy Book Summary :

📒Autophagy In Health And Disease ✍ Roberta A. Gottlieb

Autophagy In Health And Disease Book PDF
✏Book Title : Autophagy in Health and Disease
✏Author : Roberta A. Gottlieb
✏Publisher : Academic Press
✏Release Date : 2012-10-16
✏Pages : 227
✏ISBN : 9780123851017
✏Available Language : English, Spanish, And French

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✏Autophagy in Health and Disease Book Summary : Autophagy in Health and Disease offers an overview of the latest research in autophagy with a translational emphasis. This publication takes scientific research in autophagy a step further and offers integrated content with advancements in autophagy from cell biology and biochemical research to clinical treatments. A necessary reference for the bookshelf of medical and scientific researchers and students, Autophagy in Health and Disease presents high quality, reputable information on autophagy, allowing the reader quick access to the most applicable information. Discusses current understanding of the roles of autophagy in health and disease Covers the background of autophagy, the development of tools and therapeutics to measure and modulate autophagy, and autophagy in tissues and disease processes Features an accompanying website with figures and tables

Autophagy In Autoimmunity Book PDF
✏Book Title : Autophagy in Autoimmunity
✏Author : Xu-jie Zhou
✏Publisher : Frontiers Media SA
✏Release Date : 2019-05-15
✏Pages : 161
✏ISBN : 9782889458127
✏Available Language : English, Spanish, And French

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✏Autophagy in Autoimmunity Book Summary :

Autophagy Of The Nervous System Book PDF
✏Book Title : Autophagy of the Nervous System
✏Author : Zhenyu Yue
✏Publisher : World Scientific
✏Release Date : 2012
✏Pages : 426
✏ISBN : 9789814350440
✏Available Language : English, Spanish, And French

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✏Autophagy of the Nervous System Book Summary : What is autophagy? Why would neurons or other brain cells digest parts of themselves through autophagy? How can autophagy save the lives of cells under some conditions, but act as a culprit or accomplice to cell death in others? How does dysfunction of autophagy contribute to neurological diseases and can it be repaired or restored? This book addresses these questions and provide an expert view of the emerging concepts in autophagy research, focusing on autophagic processes and regulation in neurons. Current experimental evidence for both evolutionarily conserved and specialized regulatory mechanisms for autophagy in the mammalian nervous system will be presented. Advances in our understanding of the complex interplay of autophagy induction and downregulation will be discussed in relation to the critical balance needed to modulate neuroprotection versus neurodegeneration in the context of neurological diseases including Alzheimer's, Parkinson's, Huntington's, ischemic-hypoxic and lysosomal diseases.

Non Canonical Cyclic Nucleotides Book PDF
✏Book Title : Non canonical Cyclic Nucleotides
✏Author : Roland Seifert
✏Publisher : Springer
✏Release Date : 2017-04-28
✏Pages : 387
✏ISBN : 9783319526737
✏Available Language : English, Spanish, And French

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✏Non canonical Cyclic Nucleotides Book Summary : The cyclic purine nucleotides 3’,5’-cAMP and 3’,5’-cGMP are well-established second messengers. cGMP has recently been covered in a volume of the Handbook of Experimental Pharmacology (volume 191). In addition to 3’,5’-cAMP and 3’,5’-cGMP, so-called non-canonical cyclic nucleotides exist. These comprise the cyclic pyrimidine nucleotides 3’,5’-cCMP and 3’,5’-cUMP, the purine nucleotide 3’,5’-cIMP, the 2’,3’-nucleoside monophosphates and cyclic dinucleotides. In this volume of the Handbook of Pharmacology, word-leading experts in the field summarize our current knowledge on these non-canonical cyclic nucleotides, discuss open questions, future research directions and the pharmacotherapeutic implications. Special emphasis will be given to the emerging roles of 3’,5’-cCMP and 3’,5’-cUMP as second messengers with regard to generators, effectors, biological functions, inactivation and bacterial toxins. The role of 3’,5’-cIMP as potential second messenger will also be critically discussed. Furthermore, we will consider transport of cyclic nucleotides and their potential role as first messengers. The role of the cyclic dinucleotide cGAMP in the immune system will covered, too. Lastly, the book will present important methodological aspects ranging from mass-spectrometric methods for cyclic nucleotide detection to the synthesis of nucleotide analogs as experimental tools and holistic methods for analysis of cyclic nucleotide effects.

Autophagic Degradation Of Organelles In The Yeast Saccharomyces Cerevisiae Book PDF
✏Book Title : Autophagic Degradation of Organelles in the Yeast Saccharomyces Cerevisiae
✏Author :
✏Publisher :
✏Release Date : 2008
✏Pages : 696
✏ISBN : OCLC:794749498
✏Available Language : English, Spanish, And French

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✏Autophagic Degradation of Organelles in the Yeast Saccharomyces Cerevisiae Book Summary : For some of the studies a fluorescent biosensor expressed in the cytosol, or targeted to mitochondria or the nucleus, was used in order to monitor autophagic degradation of the respective compartment/organelle. Here the assay was based upon a genetically encoded dual colour-emission biosensor. Rosella, the fusion of a relatively pH-insensitive fast-maturing variant of the red fluorescent protein DsRed, with a pH-sensitive variant of GFP. By virtue of being targeted to different compartments/organelles the dual colour nature of Rosella biosensor, allows unambiguous distinction between material delivered to the vacuole (red fluorescence, but pH-based loss of green fluorescence) and that localised in cytosol, mitochondria and the nucleus (red and green fluorescence retained). This novel assay allows not only fast and simple qualitative analysis, but also quantitative analysis of cells in a population undergoing autophagy. The autophagic degradation of the cytosol was found to be fully dependent on the macroautophagic machinery. On the other hand, autophagic degradation of the nucleus can be observed to occur 24 hours following nitrogen starvation and either independently of some ATG genes (e.g. ATG5 and ATG12), but does rely on others (e.g. ATG3 and ATG4). Other data concerning dependence on components of the NV-junction and complexes previously identified as being involved in microautophagic processes suggest that the process of nucleophagy observed and described in this thesis is different from the PMN.

Novel And Complimentary Approaches To Prostate Cancer Therapy Book PDF
✏Book Title : Novel and Complimentary Approaches to Prostate Cancer Therapy
✏Author : Randie Hee Kim
✏Publisher :
✏Release Date : 2009
✏Pages : 258
✏ISBN : UCAL:X83519
✏Available Language : English, Spanish, And French

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✏Novel and Complimentary Approaches to Prostate Cancer Therapy Book Summary :

📒The Chaperonopathies ✍ Alberto J.L. Macario

The Chaperonopathies Book PDF
✏Book Title : The Chaperonopathies
✏Author : Alberto J.L. Macario
✏Publisher : Springer Science & Business Media
✏Release Date : 2013-04-10
✏Pages : 116
✏ISBN : 9789400746671
✏Available Language : English, Spanish, And French

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✏The Chaperonopathies Book Summary : This Brief provides a concise review of chaperonopathies, i.e., diseases in which molecular chaperones play an etiologic-pathogenic role. Introductory chapters deal with the chaperoning system and chaperoning teams and networks, HSP-chaperone subpopulations, the locations and functions of chaperones, and chaperone genes in humans. Other chapters present the chaperonopathies in general, including their molecular features and mechanistic classification into by defect, excess, or mistake. Subsequent chapters discuss the chaperonopathies in more detail, focusing on their distinctive characteristics: primary or secondary; quantitative and/or qualitative; structural and hereditary or acquired; genetic polymorphisms; gene dysregulation; age-related; associated with cancer, chronic inflammatory conditions, and autoimmune diseases. The interconnections between the chaperoning and the immune systems in cancer development, chronic inflammation, autoimmunity, and ageing are outlined, which leads to a discussion on the future prospects of chaperonotherapy. The latter may consist of chaperone gene and protein replacement/supplementation in cases of deficiency and of gene or protein blocking when the chaperone actively promotes disease. The last chapter presents the extracellular chaperones and details on how the chaperone Hsp60 is secreted into the extracellular space and, thus, appears in the blood of cancer patients with potential to participate in carcinogenesis and chronic inflammation and autoimmunity. Chaperones as clinically useful biomarkers are mentioned when pertinent. Likewise, guidelines for clinical evaluation of chaperonopathies and for their histopathological and molecular identification are provided throughout. The book also provides extensive bibliography organized by chapter and topic with comments.

Medical Biochemistry E Book Book PDF
✏Book Title : Medical Biochemistry E Book
✏Author : John W Baynes
✏Publisher : Elsevier Health Sciences
✏Release Date : 2014-01-24
✏Pages : 658
✏ISBN : 9781455745814
✏Available Language : English, Spanish, And French

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✏Medical Biochemistry E Book Book Summary : Brought to you in a thorough yet accessible manner, the new edition of Medical Biochemistry gives access to all of the latest information on basic and clinically focused genetic and molecular biology. Featuring a team of contributors that includes investigators involved in cutting-edge research as well as experienced clinicians, this updated medical textbook offers a unique combination of both research and practice that's ideal for today's problem-based integrated courses. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Relate biochemistry to everyday practice with the help of Clinical Boxes integrated into the text, and access in-depth coverage of important topics - including recent research in biochemistry - through Advanced Concept Boxes. Test your knowledge and improve retention with Active Learning Boxes at the conclusion of each chapter, and quickly review the most common lab tests performed with convenient Clinical Test Boxes. Effectively study the most updated information in biochemistry with the help of a dynamic, full-color design. Better understand the relationship between science and clinical practice with material organized by organ rather than system. Gain a thorough understanding of biomarkers and their uses with brand-new information on the subject. Access today's most recent research regarding Gene Therapy, Proteomics and Recombinant DNA Techniques, Role of Kidney in Metabolism, and Neurochemistry.

Immunity To Human Fungal Pathogens Mechanisms Of Host Recognition Protection Pathology And Fungal Interference Book PDF
✏Book Title : Immunity to Human Fungal Pathogens Mechanisms of Host Recognition Protection Pathology and Fungal Interference
✏Author : Steven P. Templeton
✏Publisher : Frontiers Media SA
✏Release Date : 2019-01-24
✏Pages :
✏ISBN : 9782889456826
✏Available Language : English, Spanish, And French

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✏Immunity to Human Fungal Pathogens Mechanisms of Host Recognition Protection Pathology and Fungal Interference Book Summary : Fungi are found in virtually every environment, and comprise a significant portion of the normal microflora of healthy individuals. Some species of fungi are aeroallergen sources capable of inducing sensitization and causing exacerbation of asthma and respiratory allergy. Others are transmissible between hosts and may cause no symptoms in healthy individuals. However, immune suppressed individuals may develop invasive disease marked by tissue invasion with a potential for widespread dissemination. Existing therapies for patients consist of antifungal drugs, yet these require prolonged administration with the possibility of adverse side effects, and may be rendered ineffective by the emergence of antifungal-resistant strains. It is therefore of interest to increase our understanding of host-pathogen interactions in order to facilitate the development of new therapies for individuals suffering from fungal infection and disease. These early interactions are shaped by an array of constituent and secreted factors that stimulate or inhibit host immune responses toward protective or detrimental immunity. Likewise, an array of preformed factors and tissue-resident cells provide early protection from fungal infection and provide extracellular signals that result in localized recruitment of inflammatory cells and determine the character of subsequent adaptive antifungal immunity. This Research Topic explores the host and fungal pathways that program innate and adaptive immunity and the immune cells, molecules, and regulatory pathways that comprise protective or detrimental responses to fungal exposure or infection. Over 200 authors contributed reviews, opinions, or original research focusing on antifungal immunity in humans and in experimental models. We believe that the results of these efforts provide a benchmark for further advances and improved antifungal therapies.

📒Handbook Of Cell Signaling ✍ Ralph A. Bradshaw

Handbook Of Cell Signaling Book PDF
✏Book Title : Handbook of Cell Signaling
✏Author : Ralph A. Bradshaw
✏Publisher : Academic Press
✏Release Date : 2010
✏Pages : 3047
✏ISBN : STANFORD:36105215320636
✏Available Language : English, Spanish, And French

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✏Handbook of Cell Signaling Book Summary : KEY FEATURES: * Contains over 350 chapters of comprehensive coverage on cell signaling * Includes discussion on topics from ligand/receptor interactions to organ/organism responses * Provides user-friendly, well-illustrated, reputable content by experts in the field DESCRIPTION: Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors.

Recent Progress In Melioidosis And Glanders Book PDF
✏Book Title : Recent progress in Melioidosis and Glanders
✏Author : Alfredo G. Torres
✏Publisher : Frontiers E-books
✏Release Date :
✏Pages :
✏ISBN : 9782889190812
✏Available Language : English, Spanish, And French

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✏Recent progress in Melioidosis and Glanders Book Summary : Burkholderia pseudomallei and B. mallei, causes melioidosis and glanders, respectively, which are two endemic infectious diseases in many parts of the world. The recent reports of glanders outbreaks in horses in Pakistan and Bahrain and the increasing incidence of human melioidosis in Thailand and other tropical regions have resulted in increased research efforts to prevent these diseases. Moreover, both B. mallei and B. pseudomallei exhibit an intriguing intracellular life cycle including the induction of actin tail formation and cell fusion and thereby have developed as model organisms in infection biology. This Research Topic summarizes recent progress to understand these pathogens at the molecular level, with emphasis in their virulence traits, host pathogen interactions, population structure and potential targets for therapeutic intervention and vaccine development.

Emerging Functions Of Septins Book PDF
✏Book Title : Emerging Functions of Septins
✏Author : Manoj B. Menon
✏Publisher : Frontiers Media SA
✏Release Date : 2017-10-10
✏Pages :
✏ISBN : 9782889452873
✏Available Language : English, Spanish, And French

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✏Emerging Functions of Septins Book Summary : Together with the microfilament, microtubule and intermediate-filament networks, septins constitute an integral part of the eukaryotic cytoskeleton. Historically identified as proteins critical for septum formation in the budding yeast Saccharomyces cerevisiae, septin family GTPases are expressed and participate in the process of cytokinesis in most eukaryotes except higher plants. More than a dozen septin genes in mammals, together with various splice variants displaying tissue-specific expression patterns and flexible hetero-polymeric higher-order assembly achieve an unfathomable complexity superior to the other cytoskeletal components. Even though the initial studies in the septin field was restricted to their evolutionarily conserved role in cell division, strong expression of septins in the non-dividing cells of the brain generated great interest in understanding their role in neuronal morphogenesis and other aspects of cellular function. On one hand, recent developments indicate complex non-canonical roles for septins in diverse processes ranging from neuronal development to immune response and calcium signaling. On the other hand several lines of data including those from knockout models question the universal role for septins in animal cell cytokinesis. Mammalian hematopoietic cells seem to proliferate and efficiently undergo cytokinesis in the absence of pivotal septin proteins in a context-dependent manner. The lack of septin-dependence of hematopoiesis also opens the possibility of safely targeting septin-dependent cytokinesis for solid-tumor therapy. Thus the septin field is perfectly poised with novel roles for septins being discovered and the basic understanding on septin assembly and its canonical functions constantly revisited. The objective of this research topic was to provide an exclusive platform for discussing these rapid advances in the septin field. With a mixture of reviews and research articles encompassing diverse areas of septin research, ranging from the humble yeast model to human cancer, this ebook will be an interesting reading material for both experts as well as new comers to the septin field.

Protein Kinases In Development And Disease Book PDF
✏Book Title : Protein Kinases in Development and Disease
✏Author :
✏Publisher : Academic Press
✏Release Date : 2017-02-22
✏Pages : 498
✏ISBN : 9780128016244
✏Available Language : English, Spanish, And French

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✏Protein Kinases in Development and Disease Book Summary : Protein Kinases in Development and Disease discusses and reviews important, but often neglected, kinases. A good representation of current model organisms from plants and C. elegans to mice are used as the basis to illustrate how we can use our understanding of normal development to learn about disease. Reviews kinases, the fundamental regulators of most biological processes that have key roles in the development of all organisms Includes a broad scope of topics that are addressed Allows researchers and newcomers to this research area to gain a thorough picture of the current knowledge

Dissertation Abstracts International Book PDF
✏Book Title : Dissertation Abstracts International
✏Author :
✏Publisher :
✏Release Date : 2008
✏Pages :
✏ISBN : STANFORD:36105131549649
✏Available Language : English, Spanish, And French

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✏Dissertation Abstracts International Book Summary :

Effects Of Kringle 5 Of Plasminogen And Endostatin On Angiogenesis Book PDF
✏Book Title : Effects of Kringle 5 of Plasminogen and Endostatin on Angiogenesis
✏Author : Tri Minh Bui Nguyen
✏Publisher :
✏Release Date : 2007
✏Pages : 196
✏ISBN : MINN:31951P010570022
✏Available Language : English, Spanish, And French

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✏Effects of Kringle 5 of Plasminogen and Endostatin on Angiogenesis Book Summary :

Genetic Screens To Understand The C9orf72 Repeat Expansion In Amyotrophic Lateral Sclerosis Book PDF
✏Book Title : Genetic Screens to Understand the C9ORF72 Repeat Expansion in Amyotrophic Lateral Sclerosis
✏Author : Noo Ri Chai
✏Publisher :
✏Release Date : 2020
✏Pages :
✏ISBN : OCLC:1190715949
✏Available Language : English, Spanish, And French

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✏Genetic Screens to Understand the C9ORF72 Repeat Expansion in Amyotrophic Lateral Sclerosis Book Summary : Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative movement disorder. The most common known genetic cause of ALS to date is a GGGGCC hexanucleotide repeat expansion in the C9ORF72 gene. There are currently three hypotheses as to how this mutation can cause neurodegeneration in ALS. First, the repeat expansion leads to reduced gene expression and therefore, C9ORF72 haploinsufficiency could contribute to the disease. The remaining two hypotheses focus on gain-of-function consequences arising from the bidirectional transcription and translation of the repeat. Both the sense and anti-sense repeat RNA form foci that may sequester RNA binding proteins, preventing them from performing their normal functions. Finally, the non-canonical translation of both the GGGGCC and GGCCCC transcripts produces six distinct species of dipeptide repeat proteins (DPRs): glycine-arginine, glycine-alanine, glycine-proline, proline-arginine, proline-alanine, and proline-glycine. The arginine-rich DPRs cause overt toxicity in various model systems, suggesting an obvious link to neurodegeneration, but many questions remain about all three hypotheses and their relative roles in driving ALS pathogenesis. This dissertation is an attempt at addressing some of these questions. Chapter 2 examines the glycine-arginine and proline-arginine DPRs to see whether the two species have a shared mechanism of toxicity. Yeast genetic screens identified numerous genes that block glycine-arginine toxicity when deleted. After comparing our findings to previously identified modifiers of proline-arginine toxicity, we discovered that only half the proline-arginine hits were identified in the glycine-arginine screens. This incomplete overlap suggests that glycine-arginine and proline-arginine may act on distinct pathways within the cell. Chapter 3 shifts to address the question of endogenous C9ORF72 function. In hopes of gaining additional insight into C9ORF72 function, we performed a genome-wide synthetic lethal CRISPR screen in human myeloid cells to identify genetic interactors of C9ORF72. We discovered that loss of FIS1, a gene encoding a mitochondrial membrane protein, is synthetic lethal with loss of C9ORF72. FIS1's role in mitophagy suggested an obvious parallel to C9ORF72's role in autophagy, but surprisingly, follow-up experiments moved the genetic interaction away from mitochondria and pointed instead to a role for FIS1 and C9ORF72 in immune regulation.

Yonsei Medical Journal Book PDF
✏Book Title : Yonsei Medical Journal
✏Author :
✏Publisher :
✏Release Date : 2010
✏Pages :
✏ISBN : MINN:31951P01110331Z
✏Available Language : English, Spanish, And French

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✏Yonsei Medical Journal Book Summary :

📒Yeast Vacuole Function ✍ Maria Ula Hutchins

Yeast Vacuole Function Book PDF
✏Book Title : Yeast Vacuole Function
✏Author : Maria Ula Hutchins
✏Publisher :
✏Release Date : 2001
✏Pages : 232
✏ISBN : UCAL:X62066
✏Available Language : English, Spanish, And French

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✏Yeast Vacuole Function Book Summary :

📒Abeloff S Clinical Oncology E Book ✍ John E. Niederhuber

Abeloff S Clinical Oncology E Book Book PDF
✏Book Title : Abeloff s Clinical Oncology E Book
✏Author : John E. Niederhuber
✏Publisher : Elsevier Health Sciences
✏Release Date : 2013-09-12
✏Pages : 2224
✏ISBN : 9781455728817
✏Available Language : English, Spanish, And French

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✏Abeloff s Clinical Oncology E Book Book Summary : Practical and clinically focused, Abeloff’s Clinical Oncology is a trusted medical reference book designed to capture the latest scientific discoveries and their implications for cancer diagnosis and management of cancer in the most accessible manner possible. Abeloff’s equips everyone involved - from radiologists and oncologists to surgeons and nurses - to collaborate effectively and provide the best possible cancer care. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Select the most appropriate tests and imaging studies for cancer diagnosis and staging of each type of cancer, and manage your patients in the most effective way possible by using all of the latest techniques and approaches in oncology. Enhance your understanding of complex concepts with a color art program that highlights key points and illustrates relevant scientific and clinical problems. Stay at the forefront of the latest developments in cancer pharmacology, oncology and healthcare policy, survivorship in cancer, and many other timely topics. See how the most recent cancer research applies to practice through an increased emphasis on the relevance of new scientific discoveries and modalities within disease chapters. Streamline clinical decision making with abundant new treatment and diagnostic algorithms as well as concrete management recommendations. Take advantage of the collective wisdom of preeminent multidisciplinary experts in the field of oncology, including previous Abeloff’s editors John E. Niederhuber, James O. Armitage, and Michael B. Kastan as well as new editors James H. Doroshow from the National Cancer Institute and Joel E. Tepper of Gunderson & Tepper: Clinical Radiation Oncology. Quickly and effortlessly access the key information you need with the help of an even more user-friendly, streamlined format. Access the complete contents anytime, anywhere at Expert Consult, and test your mastery of the latest knowledge with 500 online multiple-choice review questions.

📒Mbc

Mbc Book PDF
✏Book Title : MBC
✏Author :
✏Publisher :
✏Release Date : 2003
✏Pages :
✏ISBN : STANFORD:36105114027167
✏Available Language : English, Spanish, And French

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✏MBC Book Summary :

Anticancer Research Book PDF
✏Book Title : Anticancer Research
✏Author :
✏Publisher :
✏Release Date : 2009
✏Pages :
✏ISBN : UCLA:L0098924012
✏Available Language : English, Spanish, And French

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✏Anticancer Research Book Summary :

Biochemistry And Cell Biology Book PDF
✏Book Title : Biochemistry and Cell Biology
✏Author :
✏Publisher :
✏Release Date : 2005
✏Pages :
✏ISBN : OSU:32435074880337
✏Available Language : English, Spanish, And French

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✏Biochemistry and Cell Biology Book Summary :

Best Practice Research Book PDF
✏Book Title : Best Practice Research
✏Author :
✏Publisher :
✏Release Date : 2008
✏Pages :
✏ISBN : UCLA:L0099036659
✏Available Language : English, Spanish, And French

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✏Best Practice Research Book Summary :

Molecular Biology Of The Cell Book PDF
✏Book Title : Molecular Biology of the Cell
✏Author :
✏Publisher :
✏Release Date : 2006
✏Pages :
✏ISBN : STANFORD:36105122124808
✏Available Language : English, Spanish, And French

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✏Molecular Biology of the Cell Book Summary :

Issues In Biological Biochemical And Evolutionary Sciences Research 2011 Edition Book PDF
✏Book Title : Issues in Biological Biochemical and Evolutionary Sciences Research 2011 Edition
✏Author :
✏Publisher : ScholarlyEditions
✏Release Date : 2012-01-09
✏Pages : 2846
✏ISBN : 9781464963704
✏Available Language : English, Spanish, And French

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✏Issues in Biological Biochemical and Evolutionary Sciences Research 2011 Edition Book Summary : Issues in Biological, Biochemical, and Evolutionary Sciences Research: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Biological, Biochemical, and Evolutionary Sciences Research. The editors have built Issues in Biological, Biochemical, and Evolutionary Sciences Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Biological, Biochemical, and Evolutionary Sciences Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Biological, Biochemical, and Evolutionary Sciences Research: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Index To Theses With Abstracts Accepted For Higher Degrees By The Universities Of Great Britain And Ireland And The Council For National Academic Awards Book PDF
✏Book Title : Index to Theses with Abstracts Accepted for Higher Degrees by the Universities of Great Britain and Ireland and the Council for National Academic Awards
✏Author :
✏Publisher :
✏Release Date : 2006
✏Pages :
✏ISBN : UOM:39015066168694
✏Available Language : English, Spanish, And French

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✏Index to Theses with Abstracts Accepted for Higher Degrees by the Universities of Great Britain and Ireland and the Council for National Academic Awards Book Summary :

The Nutrient Responsive Regulation Of Cell Division And Quiescence In Chlamydomonas Reinhardtii Book PDF
✏Book Title : The Nutrient responsive Regulation of Cell Division and Quiescence in Chlamydomonas Reinhardtii
✏Author : Tomomi Takeuchi
✏Publisher :
✏Release Date : 2019
✏Pages : 263
✏ISBN : 1392701309
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✏The Nutrient responsive Regulation of Cell Division and Quiescence in Chlamydomonas Reinhardtii Book Summary : Faced with adverse conditions, nearly all cells are able to cease energy-costly processes associated with the cell division cycle and enter a reversible alternative state known as quiescence (G0). In the green microalga Chlamydomonas reinhardtii, the entry into and exit from such a non-dividing state is mediated in response to the availability of nutrients, such as nitrogen (N). Following N starvation, a whole-sale reprogramming of intracellular processes takes place in order to maximize the chances of survival, including the repression of cell cycle-related genes, the multi-level downregulation of photosynthesis, the induction of autophagy, and the diversion of carbon (C) towards triacylglycerols (TAG).One protein implicated in the regulation of nutrient-responsive quiescence-associated transcriptomic programs in Chlamydomonas is Compromised Hydrolysis of TAG 7 (CHT7). The CHT7 protein contains cysteine-rich motifs that are often collectively referred to as the CXC domain, which is widely known for its ability to bind DNA in a sequence-specific manner in animals. A number of CXC domain-containing proteins in both animals and plants have been identified as core constituents of transcriptional regulatory complexes termed DREAM (DP, RB, E2F and Myb-MuvB) complexes, which act to coordinate cell cycle-related gene expression in response to various signals present during quiescence, cell proliferation and differentiation, and development. Through the generation of newly introgressed cell-walled lines and the detailed examination of the cht7 mutant at cellular levels, my dissertation work identified novel quiescence-related transcriptional defects in cht7 during N starvation, including derepression of DNAmetabolism and cell cycle-related genes and downregulation of oxidoreductase- and nutrient transporter-encoding genes. Largely due to their inability to repress S/M (DNA synthesis/mitosis) phase-specific gene expression, the cht7 cells were unable to properly arrest nuclear replication and cell division following N removal. The loss of viability during N starvation and the abortive divisions during N refeeding were identified as causal for the observed delay in resuming growth and the reduction in colony formation in cht7 following N resupply.The homolog of the retinoblastoma tumor suppressor (RB) protein in Chlamydomonas, MAT3, and CHT7 were shown to coimmunoprecipitated together during N-replete synchronized growth and following N deprivation, and several phosphorylated isoforms of CHT7 were identified under these conditions. Despite the presence of the presumed DNA-binding function of the CXC domain in CHT7, the largely disordered C-terminal half of CHT7 with predicted protein-binding domains, and not the proposed CXC DNA-binding domain, was essential for the ability of CHT7 to form stable complexes, and to restore the cellular phenotypes and transcript levels back to wild-type levels in the cht7 mutant. Taken together, while the mechanism of CHT7 function likely differs from that of canonical CXC domain proteins, CHT7 is necessary for the establishment of an effective quiescent state and thus, the nutrient-mediated life-cycle transitions in Chlamydomonas. A better understanding of how the cell division cycle is regulated in response to nutrient scarcity may improve the prospects of biofuels and biomass production in microalgae.