NK Cell Based Cancer Immunotherapy

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  • Author : Francisco Borrego
  • Publisher : Frontiers Media SA
  • Pages : null pages
  • ISBN : 2889199347
  • Rating : /5 from reviews
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Download or Read online NK Cell Based Cancer Immunotherapy full in PDF, ePub and kindle. this book written by Francisco Borrego and published by Frontiers Media SA which was released on 08 September 2016 with total page null pages. We cannot guarantee that NK Cell Based Cancer Immunotherapy book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Natural killer (NK) cells are innate lymphoid cells that have a significant role in regulating the defenses against cancer development and certain viral infections. They are equipped with an array of activating and inhibitory receptors that stimulate or diminish NK cell activity, respectively. Inhibitory receptors include, among others, the MHC class I ligands killer cell immunoglobulin-like receptors (KIR) in humans, and members of the Ly49 family of receptors in mice, and CD94/NKG2A. Activating receptors include cytokine and chemokine receptors, and those that interact with ligands expressed on target cells, such as the natural cytotoxicity receptors or NCRs (NKp30, NKp44 and NKp46), NKG2D, CD244 and DNAM-1. In addition, NK cells express Fc?RIIIA or CD16, the receptor that exerts antibody-dependent cell mediated cytotoxicity (ADCC). NK cells also express the death ligands FasL and TRAIL. The killing or sparing of target cells depends on the integration of distinct signals that originate from NK cell receptors. NK cells spare healthy cells that express normal levels of MHC class I molecules and low amounts of stress-induced self-molecules, whereas they kill target cells that down-regulate MHC class I molecules and/or up-regulate stress-induced self-molecules. The latter are common signatures of virus-infected cells and tumors. All the accumulated knowledge on NK cell biology, along with many clinical observations, is driving multiple efforts to improve the arsenal of NK cell-based therapeutic tools in the fight against malignant diseases. Indeed, NK cell-based immunotherapy is becoming a promising approach for the treatment of many cancers. It is well known that NK cells have a significant role in the anti-tumor effect of therapeutic antibodies that use ADCC as a mechanism of action. In addition to this, administration of autologous and allogeneic NK cells after activation and expansion ex vivo is used in the treatment of cancer. Moreover, adoptive transfer of NK cell lines has been tested in humans, and genetically modified NK cells expressing chimeric antigen receptors are being studied in preclinical models for potential use in the clinic.

NK Cell Based Cancer Immunotherapy

NK Cell Based Cancer Immunotherapy
  • Author : Francisco Borrego,Susana Larrucea,Rafael Solana,Raquel Tarazona
  • Publisher : Frontiers Media SA
  • Release : 08 September 2016
GET THIS BOOK NK Cell Based Cancer Immunotherapy

Natural killer (NK) cells are innate lymphoid cells that have a significant role in regulating the defenses against cancer development and certain viral infections. They are equipped with an array of activating and inhibitory receptors that stimulate or diminish NK cell activity, respectively. Inhibitory receptors include, among others, the MHC class I ligands killer cell immunoglobulin-like receptors (KIR) in humans, and members of the Ly49 family of receptors in mice, and CD94/NKG2A. Activating receptors include cytokine and chemokine

NK Cells in Cancer Immunotherapy

NK Cells in Cancer Immunotherapy
  • Author : Lynda Addou-Klouche
  • Publisher : Unknown
  • Release : 24 January 2022
GET THIS BOOK NK Cells in Cancer Immunotherapy

Natural killer (NK) cells are crucial components of the innate immune system and play critical roles in host immunity against viral infections and cancer. NK cells' activity is controlled by the interaction of a wide range of receptors expressed on their surfaces with cell surface ligands. Opposite signals delivered by inhibitory and activating receptors tightly regulate NK cells' cytotoxicity. Natural killer cells can discriminate between normal and cancer cells. NK cells are known to directly recognize and kill malignant cells

Natural Killer Cells

Natural Killer Cells
  • Author : Jacques Zimmer
  • Publisher : Springer Science & Business Media
  • Release : 12 January 2010
GET THIS BOOK Natural Killer Cells

Natural killer (NK) cells have been at the forefront of immunology for two decades. During that time, a great amount of information about these cells has been obtained. They are important in antiinfectious and antitumoral defense and shape the adaptive immune response. In addition, they can act as immunoregulatory cells. In recent years, the therapeutic potential of NK cells in cancer immunotherapy has become increasingly evident. This book describes in detail current knowledge about NK cells and covers a broad

Cancer Immunotherapy

Cancer Immunotherapy
  • Author : Sarah S. Donatelli,Julie Y. Djeu
  • Publisher : Elsevier Inc. Chapters
  • Release : 04 June 2013
GET THIS BOOK Cancer Immunotherapy

Natural Killer (NK) cells are a unique subset of lymphocytes genetically programmed to locate and destroy cellular malignancies. They accomplish this through unique cell surface receptors that, upon contacting a target cell, transmit either inhibitory or activating intracellular signals, ultimately determining whether the target cell will be killed or spared. Acquisition of the capacity to kill comes only after the NK cell is rendered tolerant to healthy self cells through interaction with naturally expressed MHC I molecules. The resulting functional

Molecular Strategies Aimed to Boost NK Cell based Immunotherapy of Cancer

Molecular Strategies Aimed to Boost NK Cell based Immunotherapy of Cancer
  • Author : Loredana Cifaldi,Daniel Olive,James Di Santo
  • Publisher : Frontiers Media SA
  • Release : 31 July 2020
GET THIS BOOK Molecular Strategies Aimed to Boost NK Cell based Immunotherapy of Cancer

In this Research Topic, we would like to honor the memory of Prof. Vito Pistoia and pay tribute to his scientific contributions to the field of Cancer Immunity and Immunotherapy. Topic Editor Daniel Olive is the co-founder and shareholder of company Imcheck Therapeutics. All other topic editors declare no competing interests with regards to the Research Topic subject.

NK Cells in Cancer Immunotherapy Successes and Challenges

NK Cells in Cancer Immunotherapy  Successes and Challenges
  • Author : Anahid Jewett
  • Publisher : Academic Press
  • Release : 15 March 2021
GET THIS BOOK NK Cells in Cancer Immunotherapy Successes and Challenges

NK cells in cancer immunotherapy: Successes and Challenges explains the latest immunotherapeutic strategies focusing on NK cells to allow the best and precise combination treatment to be offered to cancer patients. It provides existing background knowledge in the field of immunotherapy and discusses the future areas of research required to carry out cutting edge validated therapies for patients. Immunotherapy is fast becoming the method of choice for cancer therapy. Although remarkable advances have been made in the field of immunotherapy,

Successes and Challenges of NK Immunotherapy

Successes and Challenges of NK Immunotherapy
  • Author : Benjamin Bonavida,Anahid Jewett
  • Publisher : Academic Press
  • Release : 23 June 2021
GET THIS BOOK Successes and Challenges of NK Immunotherapy

Successes and Challenges of NK Immunotherapy: Increasing Anti-tumor Efficacy describes the unique therapeutic applications of NK cells to fight cancers and eliminate the bulk and subset of cancer stem cells responsible for metastasis, relapse and recurrences. The book provides information on the development, engineering, mechanisms of action, response to various preclinical models, and applications in various clinical trials. Sections cover the development of highly engineered cytotoxic NK cells, their mechanisms of action, preclinical and clinical applications, the development and application

Expansion of Highly Cytotoxic Human Natural Killer Cells by Osteoclast for Cancer Immunotherapy

Expansion of Highly Cytotoxic Human Natural Killer Cells by Osteoclast for Cancer Immunotherapy
  • Author : So-Hyun Park
  • Publisher : Unknown
  • Release : 24 January 2022
GET THIS BOOK Expansion of Highly Cytotoxic Human Natural Killer Cells by Osteoclast for Cancer Immunotherapy

Natural Killer (NK) cells have a crucial role in immune surveillance against a variety of infectious microorganisms and tumors. NK cells are known to mediate direct cytotoxicity as well as antibody dependent cellular cytotoxicity (ADCC) against a variety of tumor cells. Also, they are known to regulate the functions of other cells by producing key cytokines and chemokines. In the tumor microenvironment, cytotoxic function of NK cells is suppressed by a number of distinct effectors and their secreted factors. It

The Added Value of Natural Killer Cells in Immunotherapy for Leukemia

The Added Value of Natural Killer Cells in Immunotherapy for Leukemia
  • Author : Eva Lion,Evelien Smits,Viggo Van Tendeloo
  • Publisher : LAP Lambert Academic Publishing
  • Release : 01 July 2012
GET THIS BOOK The Added Value of Natural Killer Cells in Immunotherapy for Leukemia

The ultimate goal of tumor immunotherapy is the eradication of tumor cells by the immune system. Both innate and adaptive immune responses can contribute to the elimination of tumor cells, with natural killer (NK) cells and T lymphocytes as pivotal players, respectively. Dendritic cells (DC) are the most professional antigen-presenting cells of the immune system, bridging innate and adaptive immune responses through interaction with NK cells and presenting tumor-associated antigens to T cells. A major hurdle in anti-tumor immunity, however,

Lymphocytes in Immunotherapy of Cancer

Lymphocytes in Immunotherapy of Cancer
  • Author : Paul Koldovsky,Ursula Koldovsky,Lutwin Beck,Karl-Heinz Vosteen
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOK Lymphocytes in Immunotherapy of Cancer

In the past, research in cancer immunology has produced informa tion important for other medical disciplines. It helped, for example, in formulating the laws of immunogenetics and in achieving a better understanding of the mechanism governing the fate of allotrans planted tissue. Cancer has often been considered a foreign body, and therefore many attempts have been made to cure it on the basis of the immunological principles applicable to parasitic, bacterial, or viral diseases. Vaccination has been investigated clinically for

Natural Killer Cells the Future of Cancer Immunotherapy

Natural Killer Cells  the Future of Cancer Immunotherapy
  • Author : Priyanka Senthil
  • Publisher : Unknown
  • Release : 20 April 2020
GET THIS BOOK Natural Killer Cells the Future of Cancer Immunotherapy

Cellular therapeutics is an emerging field with significant advances in the engineering of immune effector cells that play a revolutionary role in treatment for cancer. Up until now, most immunomodulatory strategies focus on enhancing T cells, which are lymphocyte immune cells that are important for cell-mediated immunity to fight pathogens and cancer. T cells have proven their ability in successful cellular therapies against leukemia, but may soon face competition. Through several preclinical studies, researchers have discovered new guardian immune cells

Clinical Applications of Natural Killer Cells

Clinical Applications of Natural Killer Cells
  • Author : Yui Harada
  • Publisher : Unknown
  • Release : 24 January 2022
GET THIS BOOK Clinical Applications of Natural Killer Cells

Natural killer (NK) cells are an essential component of the innate immune system, and they play a crucial role in immunity against malignancies. Recent advances in our understanding of NK cell biology have paved the way for new therapeutic strategies based on NK cells for the treatment of various cancers. In this section, we will focus on NK cell immunotherapy, including the enhancement of antibody-dependent cellular cytotoxicity, the manipulation of receptor-mediated activation, inclusion criteria based on killer cell immunoglobulin-like receptor (

Natural Killer Cells

Natural Killer Cells
  • Author : Mourad Aribi
  • Publisher : BoD – Books on Demand
  • Release : 13 December 2017
GET THIS BOOK Natural Killer Cells

The book Natural Killer Cells is the result of a collective work that addresses in a clear and comprehensive way for readers and through as many sensuous details as possible, the most and various fundamental aspects of natural killer cells, as well as their clinical applications in cancer immunotherapy. This book will serve as an invaluable resource and pedagogical support for clinicians, researchers, basic scientists, immunology and immunopathology lecturers, as well as for students in biology and medicine, especially the