New Targeting In The Reversal Of Resistant Glioblastomas

New Targeting In The Reversal Of Resistant Glioblastomas Book PDF
✏Book Title : New Targeting in The Reversal of Resistant Glioblastomas
✏Author : Ali Syed Arbab
✏Publisher : Academic Press
✏Release Date : 2021-01-15
✏Pages : 309
✏ISBN : 0128225270
✏Available Language : English, Spanish, And French

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✏New Targeting in The Reversal of Resistant Glioblastomas Book Summary : New Targeting in The Reversal of Resistant Glioblastomas discusses the possible alternative treatment strategies by targeting not only the tumor cells but also by targeting tumor microenvironment, metabolic pathways and interaction of cytokines to tumor cells. Some of the treatments discussed can be easily translated to clinics due to FDA approval status of the drugs for different purposes. The current treatment for primary as well as recurrent glioblastomas is failing because clinicians are not considering the effect of bone marrow derived cells to the development of resistance to clinically practiced therapies. Bone marrow derived cells are shown to cause therapy resistance by releasing different immunosuppressive and proangiogenic factors that revive cancer stem cells, causing altered metabolisms. This book helps the reader rethink the treatment strategies to successfully fight glioblastomas.The book is a valuable resource for cancer researchers, clinicians, graduate students and several members of biomedical field who are interested in learning about the novel treatments to fight resistance to chemotherapy drugs from glioblastomas. Explains the effect of bone marrow derived cells to the development of resistance to clinically practiced therapies Provides information on the availability of alternate therapies for recurrent glioblastoma when standard practice failed Discusses targeting tumor microenvironment using available FDA approved drugs as an alternative treatment strategy for glioblastoma

Drug Resistance In Colorectal Cancer Molecular Mechanisms And Therapeutic Strategies Book PDF
✏Book Title : Drug Resistance in Colorectal Cancer Molecular Mechanisms and Therapeutic Strategies
✏Author : Chi Hin Cho
✏Publisher : Academic Press
✏Release Date : 2020-05-24
✏Pages : 240
✏ISBN : 9780128199381
✏Available Language : English, Spanish, And French

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✏Drug Resistance in Colorectal Cancer Molecular Mechanisms and Therapeutic Strategies Book Summary : Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies, Volume Eight, summarizes the molecular mechanisms of drug resistance in colorectal cancer, along with the most up-to-date therapeutic strategies available. The book discusses reasons why colorectal tumors become refractory during the progression of the disease, but also explains how drug resistance occurs during chemotherapy. In addition, users will find the current therapeutic strategies used by clinicians in their practice in treating colorectal cancer. The combination of conventional anticancer drugs with chemotherapy-sensitizing agents plays a pivotal role in improving the outcome of colorectal cancer patients, in particular those with drug-resistant cancer cells. From a clinical point-of-view, the content of this book provides clinicians with updated therapeutic strategies for a better choice of drugs for drug-resistant colorectal cancer patients. It will be a valuable source for cancer researchers, oncologists and several members of biomedical field who are dedicated to better treat patients with colorectal cancer. Presents a systemic summary of molecular mechanisms for a quick and in-depth understanding Updates current trends in the field with pioneering information on drug resistance Encompasses both basic and clinical approaches for a better understanding of unsolved problems from a holistic point-of-view

Biological Mechanisms And The Advancing Approaches To Overcoming Cancer Drug Resistance Book PDF
✏Book Title : Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance
✏Author : Andrew Freywald
✏Publisher : Academic Press
✏Release Date : 2020-12-04
✏Pages : 308
✏ISBN : 9780128213117
✏Available Language : English, Spanish, And French

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✏Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance Book Summary : Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance, Volume 12, discusses new approaches that are being undertaken to counteract tumor plasticity, understand and tackle the interactions with the microenvironment, and disrupt the rewiring of malignant cells or bypass biological mechanism of resistance by using targeted radionuclide therapies. This book provides a unique opportunity to the reader to understand the fundamental causes of drug resistance and how different approaches are applied. It is a one-stop-shop to understand why it is so difficult to treat cancer, and why only a very few patients respond to therapy and a significant portion develop resistance. Despite a rapid development of more effective anti-cancer drugs and combination therapies, cancer remains the leading cause of lethality in the developed world. The main reason for this is the ability of heterogeneous subpopulations of tumor cells interacting with constantly evolving tumor microenvironment to resist elimination and eventually, trigger cancer relapse. In this book, experts review current concepts explaining molecular and biological mechanisms of cancer drug resistance and discussing advancing approaches for overcoming these therapeutic challenges. Provides the most updated knowledge on the mechanisms of cancer drug resistance and the emerging therapeutic approaches reviewed by experts in the field Brings detailed analyses of most important recently reported developments related to drug resistance and their relevance to overcoming it in cancer patients Discusses in-depth molecular mechanisms and novel concepts of cancer resistance to conventional and advanced therapies

Drug Efflux Pumps In Cancer Resistance Pathways From Molecular Recognition And Characterization To Possible Inhibition Strategies In Chemotherapy Book PDF
✏Book Title : Drug Efflux Pumps in Cancer Resistance Pathways From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy
✏Author :
✏Publisher : Academic Press
✏Release Date : 2019-11-07
✏Pages : 394
✏ISBN : 9780128141410
✏Available Language : English, Spanish, And French

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✏Drug Efflux Pumps in Cancer Resistance Pathways From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy Book Summary : Drug Efflux Pumps in Cancer Resistance Pathways: From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy, Volume Seven, describes the fundamental aspects of efflux pumps of the ATP-binding cassette superfamily in cancer resistance pathways, along with strategies to target and improve chemotherapy efficacy. Pumps of the ATP-binding cassette superfamily (ABCs) regulate the access of drugs to the intracellular space. In this context, the overexpression of ABCs is a well-known mechanism of multidrug resistance in cancer and is associated with therapeutic failure. Cancer types discussed include breast, endocrine, hematologic, gastrointestinal, musculoskeletal, lung, skin and central nervous system cancers. The book is a valuable source for researchers and advanced students in cancer, biology, pharmacology, pharmaceutical sciences, biomaterials and medical/clinical sciences that are interested in accessing a comprehensive compendium on efflux pumps in mechanisms of cancer resistance. Offers comprehensive and detailed descriptions of the basic aspects of efflux pumps in a very schematic and didactic manner Describes the involvement of efflux pumps in cancer resistance in different cancer types Encompasses an updated overview on state-of-the-art approaches that capitalize on their inhibition to improve chemotherapy and overcome resistance

Novel Therapies In Head And Neck Cancer Beyond The Horizon Book PDF
✏Book Title : Novel Therapies in Head and Neck Cancer Beyond the Horizon
✏Author : Maie A. St. John
✏Publisher : Academic Press
✏Release Date : 2020-06-29
✏Pages : 266
✏ISBN : 9780128209295
✏Available Language : English, Spanish, And French

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✏Novel Therapies in Head and Neck Cancer Beyond the Horizon Book Summary : Novel Therapies in Head and Neck Cancer: Beyond the Horizon, Volume Twelve, provides a high-level synthesis of the latest treatments and outcomes relating to head and neck cancer. Chemotherapy and immunotherapy for those cancer types are rapidly evolving, and an updated source based on the expertise of internationally renowned researchers is necessary. This book discusses the outcome of recent trials using chemotherapy, novel approaches for HPV+ SCCA, cases in which immunotherapy is more likely to be successful, and precision medicine based on target therapies. Additionally, new approaches for rare diseases in head and neck and novel drug delivery platforms are presented. This book will be a very useful source so that students, scientists and clinicians who can be facile with the data, build on what is known, and continue to offer cutting-edge, validated therapies to all patients. Covers new chemotherapy trials, specifically on HPV and non-HPV related cancer types Discusses the application of immunotherapy to treat rare types of head and neck cancer Presents updated information on targeted therapies, specifically focusing on skin cancer in the region

Overcoming Ovarian Cancer Chemoresistance Book PDF
✏Book Title : Overcoming Ovarian Cancer Chemoresistance
✏Author : Goli Samimi
✏Publisher : Academic Press
✏Release Date : 2020-11-19
✏Pages : 188
✏ISBN : 9780128198414
✏Available Language : English, Spanish, And French

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✏Overcoming Ovarian Cancer Chemoresistance Book Summary : Overcoming Ovarian Cancer Chemoresistance presents non-overlapping review chapters that discuss the state of the field in overcoming chemoresistance of ovarian cancer and treatment options before and following recurrence, considering the genetic makeup of the ovarian cancer patient and her tumor. With the uptake of both germline and somatic gene testing, clinicians can obtain a more comprehensive understanding of ovarian tumors and this book provides information to link the genetic makeup of a tumor (or patient) with the best available treatment. The book discusses topics such as strategies to fight chemo-resistance in ovarian cancer, circulating DNA as a monitor of response, BRCA mutations, ovarian cancer stem cells, immunotherapy and vaccines. Additionally, it brings a list of promising agents at clinical and pre-clinical stage that will impact the treatment in the near future. This book is a valuable source for cancer researchers, oncologists and several members of biomedical field who need to understand how to battle chemoresistance in ovarian cancer. Provides a comprehensive view of both biological and genetic determinants of resistance, as well as technical approaches to monitor response Discusses genetic reversions as a unique alteration and a new field of study Includes a chapter on upcoming and promising agents that are in the pre-clinical and early clinical space, to set the stage for future directions in the field

Anticancer Research Book PDF
✏Book Title : Anticancer Research
✏Author :
✏Publisher :
✏Release Date : 2009
✏Pages :
✏ISBN : NWU:35558005731662
✏Available Language : English, Spanish, And French

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✏Anticancer Research Book Summary :

Oncology Of Infancy And Childhood E Book Book PDF
✏Book Title : Oncology of Infancy and Childhood E Book
✏Author : Stuart H. Orkin
✏Publisher : Elsevier Health Sciences
✏Release Date : 2009-06-09
✏Pages : 1392
✏ISBN : 9781437721386
✏Available Language : English, Spanish, And French

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✏Oncology of Infancy and Childhood E Book Book Summary : To address the growing complexities of childhood cancer, Nathan and Oski’s Hematology and Oncology of Infancy and Childhood has now been separated into two distinct volumes. With this volume devoted strictly to pediatric oncology, and another to pediatric hematology, you will be on the cutting edge of these two fields. This exciting new, full-color reference provides you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children with cancer. It brings together the pathophysiology of disease with detailed clinical guidance on diagnosis and management for the full range of childhood cancers, including aspects important in optimal supportive care. Written by the leading names in pediatric oncology, this resource is an essential tool for all who care for pediatric cancer patients. Offers comprehensive coverage of all pediatric cancers, including less common tumors, making this the most complete guide to pediatric cancer. Covers emerging research developments in cancer biology and therapeutics, both globally and in specific pediatric tumors. Includes a section on supportive care in pediatric oncology, written by authors who represent the critical subdisciplines involved in this important aspect of pediatric oncology. Uses many boxes, graphs, and tables to highlight complex clinical diagnostic and management guidelines. Presents a full-color design that includes clear illustrative examples of the relevant pathology and clinical issues, for quick access to the answers you need. Incorporates the codified WHO classification for all lymphomas and leukemias.

📒Clinical Radiation Oncology E Book ✍ Leonard L. Gunderson

Clinical Radiation Oncology E Book Book PDF
✏Book Title : Clinical Radiation Oncology E Book
✏Author : Leonard L. Gunderson
✏Publisher : Elsevier Health Sciences
✏Release Date : 2011-09-16
✏Pages : 1660
✏ISBN : 9781455726035
✏Available Language : English, Spanish, And French

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✏Clinical Radiation Oncology E Book Book Summary : With thorough updates throughout, Clinical Radiation Oncology provides the most comprehensive, authoritative, and up-to-date information available for treating patients with cancer. From a multidisciplinary perspective, this new edition, edited by Drs. Leonard L. Gunderson and Joel E. Tepper, examines the therapeutic management of specific disease sites based on both single-modality and combined-modality approaches - providing you with the well-rounded, cutting-edge guidance you need to offer the most effective treatments. A consistent chapter format, full-color design, and access to the full text at www.expertconsult.com make reference fast and easy. It is an ideal resource for mastering the latest, most effective techniques and modalities! Deepen your knowledge with a comprehensive, clinical approach to the scientific foundations of radiation oncology and general oncology as well as state-of-the-art techniques and modalities. Implement a multidisciplinary, "team care" approach to providing intricate treatment plans for patients, often in conjunction with medical oncologists, and surgeons. Broaden your understanding of the basic biology of the disease processes. Examine the therapeutic management of specific disease sites based on single-modality and combined-modality approaches. Quickly and easily find critical information thanks to an easily accessible, full-color design with over 800 color figures that clearly depict treatment techniques. Get broad multimodality perspectives and unique insights from a diverse team of respected editors and contributors –many of whom are new to this edition – affiliated with institutions across North America and internationally Access the fully searchable text anywhere, anytime at www.expertconsult.com, along with references, additional images and tables, video clips and more! Stay current with comprehensive updates throughout that include a new chapter on survivorship issues, and additional video clips on treatments such as prostate and penile cancer brachytherapy. Improve outcomes by providing the most effective treatment for each patient with expanded coverage of new modalities and treatment regimens. Understand and comply with the latest staging guidelines.

Pharmacotherapy Book PDF
✏Book Title : Pharmacotherapy
✏Author :
✏Publisher :
✏Release Date : 1996
✏Pages :
✏ISBN : UCLA:L0075680066
✏Available Language : English, Spanish, And French

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✏Pharmacotherapy Book Summary :

Modern Management Of High Grade Glioma Part Ii An Issue Of Neurosurgery Clinics E Book Book PDF
✏Book Title : Modern Management of High Grade Glioma Part II An Issue of Neurosurgery Clinics E Book
✏Author : Isaac Yang
✏Publisher : Elsevier Health Sciences
✏Release Date : 2012-07-15
✏Pages : 240
✏ISBN : 9781455747689
✏Available Language : English, Spanish, And French

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✏Modern Management of High Grade Glioma Part II An Issue of Neurosurgery Clinics E Book Book Summary : Standard therapy for high grade glioma is a topic that is evolving, timely, and relevant. Guest Editors Isaac Yang, MD and Seunggu Han, MD have assembled a group of experts on management of high grade glioma. Some of the articles in this issue include: Use of language mapping to aid resection of eloquent gliomas; Clinical trials with immunotherapy; Clinical trials for small molecule inhibitors; Nanotechnology potential applications for GBM therapy; High Grade Gliomas in children; Modern Advances in Brain Tumor Treatments; Molecular pathways of Avastin interactions for the treatment of glioblastoma; and Quality of Life and Outcomes in Glioblastoma management.

Castration Resistant Prostate Cancer An Issue Of Urologic Clinics E Book Book PDF
✏Book Title : Castration Resistant Prostate Cancer An Issue of Urologic Clinics E Book
✏Author : Adam S. Kibel
✏Publisher : Elsevier Health Sciences
✏Release Date : 2012-11-01
✏Pages : 240
✏ISBN : 9781455747238
✏Available Language : English, Spanish, And French

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✏Castration Resistant Prostate Cancer An Issue of Urologic Clinics E Book Book Summary : Castrate Resistant Prostate Cancer is advanced disease that has stopped responding to hormone therapy. This issue of the Urologic Clinics focuses on the various forms of therapy including immunotherapy, first line chemotherapy, and novel targeted agents. Articles on defining the diseae and palliative care are also included.

Microrna Targeted Cancer Therapy Book PDF
✏Book Title : MicroRNA Targeted Cancer Therapy
✏Author : Fazlul H. Sarkar
✏Publisher : Springer Science & Business
✏Release Date : 2014-04-22
✏Pages : 351
✏ISBN : 9783319051345
✏Available Language : English, Spanish, And French

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✏MicroRNA Targeted Cancer Therapy Book Summary : Since the discovery of microRNAs (miRNAs) some twenty years ago by Victor Ambros, David Baulcombe and Gary Ruvkun, these three scientists worked to uncover the mystery of miRNA, the small segments of nucleotides that silence genes. While studying the development of the nematode worm, Ambros and Ruvkun discovered miRNA in animals, while Baulcombe discovered it in plants. Since their discovery, it took more than two decade to fully appreciate the value of miRNA in human health and diseases. Emerging evidence suggest that the activation of oncogenes and/or the inactivation of tumor suppressor genes contribute to the development and progression of tumors. The regulation of genes is by far controlled by many transcription factors which are often deregulated during the development and progression of cancer. In addition, emerging evidence clearly suggests that the deregulation of miRNAs or small non-coding RNAs could also regulate the expression of genes and likewise, miRNA genes are also regulated by transcription factors. The most attractive feature of miRNAs is that one miRNA can regulate many target genes (mRNAs) and thus miRNA targeted therapy is highly promising because multiple genes could be regulated by targeting a single miRNA, which becomes very important for the killing of highly heterogeneous populations of cancer cells within a tumor mass. Therefore, miRNA targeted therapy is an attractive attribute of miRNA research, which is covered through eighteen chapters complied in this book “MicroRNA targeted Cancer therapy” and it is hoped that the field of miRNA research will be appreciated through critical reading of these chapters on the cutting-edge research on miRNAs.

Cancer Research Book PDF
✏Book Title : Cancer Research
✏Author :
✏Publisher :
✏Release Date : 2006-07
✏Pages :
✏ISBN : CORNELL:31924101069973
✏Available Language : English, Spanish, And French

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✏Cancer Research Book Summary :

Protein Kinase C In Cancer Signaling And Therapy Book PDF
✏Book Title : Protein Kinase C in Cancer Signaling and Therapy
✏Author : Marcelo G. Kazanietz
✏Publisher : Springer Science & Business Media
✏Release Date : 2010-06-10
✏Pages : 494
✏ISBN : 9781607615439
✏Available Language : English, Spanish, And French

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✏Protein Kinase C in Cancer Signaling and Therapy Book Summary : Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980’s with its identification as an effector of phorbol esters, natural products with tumor promoting activity. Phorbol esters had long been of interest to the cancer research field due to early studies in the mouse skin carcinogenesis model, which showed that prolonged topical application of phorbol esters promoted the formation of skin tumors on mice previously treated with mutagenic agents. Research in the last years has established key roles for PKC isozymes in the control of cell proliferation, migration, adhesion, and malignant transformation. In addition, there is a large body of evidence linking PKC to invasion and cancer cell metastasis. Moreover, it is now well established that the expression of PKC isozymes is altered in various types of cancers. More importantly, small molecule inhibitors have been developed with significant anti-cancer activity. The relevance of PKC isozymes in cancer signaling is therefore remarkable. This book will have 4 sections. There will be 23 chapters. Each section will have a brief introduction by an expert in the field (~ 1-2 pages).

The Journal Of Neuroscience Book PDF
✏Book Title : The Journal of Neuroscience
✏Author :
✏Publisher :
✏Release Date : 2008
✏Pages :
✏ISBN : NWU:35558005687088
✏Available Language : English, Spanish, And French

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✏The Journal of Neuroscience Book Summary :

Journal Of The National Cancer Institute Book PDF
✏Book Title : Journal of the National Cancer Institute
✏Author :
✏Publisher :
✏Release Date : 1998
✏Pages :
✏ISBN : COLUMBIA:HR01790560
✏Available Language : English, Spanish, And French

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✏Journal of the National Cancer Institute Book Summary :

📒Breast Cancer Management ✍ Lynda R. Wiseman

Breast Cancer Management Book PDF
✏Book Title : Breast Cancer Management
✏Author : Lynda R. Wiseman
✏Publisher : Lippincott Williams & Wilkins
✏Release Date : 2000
✏Pages : 133
✏ISBN : UCSD:31822028487379
✏Available Language : English, Spanish, And French

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✏Breast Cancer Management Book Summary :

📒The Chemotherapy Source Book ✍ Michael Clinton Perry

The Chemotherapy Source Book Book PDF
✏Book Title : The Chemotherapy Source Book
✏Author : Michael Clinton Perry
✏Publisher : Lippincott Williams & Wilkins
✏Release Date : 1996
✏Pages : 1518
✏ISBN : UOM:39015038143650
✏Available Language : English, Spanish, And French

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✏The Chemotherapy Source Book Book Summary : The updated Third Edition of The Chemotherapy Source Book is the most current and comprehensive reference on cancer chemotherapy. It brings together pharmacologic and patient management information in one source that practitioners can consult for any question encountered in the delivery of chemotherapy. This edition features increased information on the expanding use of high-dose therapy for various cancers, including breast cancer, leukemias, multiple myeloma, Hodgkin's disease, non-Hodgkin's lymphoma, lung cancer, and ovarian cancer. Coverage also includes new material on monoclonal antibodies, monoclonal antibody therapy, and breast, colon, and lung cancers, and information on five new drugs approved since the Second Edition. A Brandon-Hill recommended title.

Delineation Of Molecular Targets For Malignant Brain Tumors Book PDF
✏Book Title : Delineation of Molecular Targets for Malignant Brain Tumors
✏Author : Shane G. Smith
✏Publisher :
✏Release Date : 2003
✏Pages : 282
✏ISBN : UCLA:L0087446829
✏Available Language : English, Spanish, And French

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✏Delineation of Molecular Targets for Malignant Brain Tumors Book Summary :

📒Abeloff S Clinical Oncology E Book ✍ John E. Niederhuber

Abeloff S Clinical Oncology E Book Book PDF
✏Book Title : Abeloff s Clinical Oncology E Book
✏Author : John E. Niederhuber
✏Publisher : Elsevier Health Sciences
✏Release Date : 2013-09-12
✏Pages : 2224
✏ISBN : 9781455728817
✏Available Language : English, Spanish, And French

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✏Abeloff s Clinical Oncology E Book Book Summary : Practical and clinically focused, Abeloff’s Clinical Oncology is a trusted medical reference book designed to capture the latest scientific discoveries and their implications for cancer diagnosis and management of cancer in the most accessible manner possible. Abeloff’s equips everyone involved - from radiologists and oncologists to surgeons and nurses - to collaborate effectively and provide the best possible cancer care. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Select the most appropriate tests and imaging studies for cancer diagnosis and staging of each type of cancer, and manage your patients in the most effective way possible by using all of the latest techniques and approaches in oncology. Enhance your understanding of complex concepts with a color art program that highlights key points and illustrates relevant scientific and clinical problems. Stay at the forefront of the latest developments in cancer pharmacology, oncology and healthcare policy, survivorship in cancer, and many other timely topics. See how the most recent cancer research applies to practice through an increased emphasis on the relevance of new scientific discoveries and modalities within disease chapters. Streamline clinical decision making with abundant new treatment and diagnostic algorithms as well as concrete management recommendations. Take advantage of the collective wisdom of preeminent multidisciplinary experts in the field of oncology, including previous Abeloff’s editors John E. Niederhuber, James O. Armitage, and Michael B. Kastan as well as new editors James H. Doroshow from the National Cancer Institute and Joel E. Tepper of Gunderson & Tepper: Clinical Radiation Oncology. Quickly and effortlessly access the key information you need with the help of an even more user-friendly, streamlined format. Access the complete contents anytime, anywhere at Expert Consult, and test your mastery of the latest knowledge with 500 online multiple-choice review questions.

Mechanism Of Nanogp8 In Glioblastoma Multiforme Book PDF
✏Book Title : Mechanism of NANOGP8 in Glioblastoma Multiforme
✏Author : Jonhoi Carl Smith
✏Publisher :
✏Release Date : 2019
✏Pages : 41
✏ISBN : OCLC:1182026068
✏Available Language : English, Spanish, And French

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✏Mechanism of NANOGP8 in Glioblastoma Multiforme Book Summary : Glioblastoma multiforme (GBM) is an incurable brain tumor, with patients only expecting to live 15 to 16 months post-diagnosis with the most current treatments options including surgery, chemotherapy, and radiation. How GBM resist treatment is still not very well known. However, cancer stem cells (CSCs), a subset of cells in GBM tissue considered responsible for therapeutic resistance and the poor patient prognosis. NANOG, a homeobox gene, is responsible for maintaining pluripotency of embryonic stem cells and is observed in CSCs. NANOGP8, a retrogene in the NANOG family is expressed in CSCs and provides cells with stem-like characteristics previously observed in stem cells. Thus, we hypothesize that NANOGP8 is not only useful as diagnostic and/or prognostic marker, but a target to improve the efficacy of current GBM treatments since it regulates signaling pathways responsible for cell proliferation. I will investigate the mechanisms in which NANOGP8 expression starts in CSCs and increase TMZ efficacy by silencing embryonic stem cell genes in Glioblastoma. As a retrogene, NANOGP8 derive from reverse transcription of the parent gene NANOG and lacks the promoters for expression in cells. We expect to detect some modifications to the upstream sequence of NANOGP8 that may serve as initiators of expression, such as an insertion of a promotor. Although NANOGP8 has similar function to original NANOG parent gene, NANOGP8 may also have additional oncogenic functions making CSCs more resistant to therapy.

Acetates Advances In Research And Application 2011 Edition Book PDF
✏Book Title : Acetates Advances in Research and Application 2011 Edition
✏Author :
✏Publisher : ScholarlyEditions
✏Release Date : 2012-01-09
✏Pages : 33
✏ISBN : 9781464944079
✏Available Language : English, Spanish, And French

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✏Acetates Advances in Research and Application 2011 Edition Book Summary : Acetates: Advances in Research and Application: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Acetates in a compact format. The editors have built Acetates: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Acetates in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Acetates: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

📒Brain Tumors E Book ✍ Andrew H. Kaye

Brain Tumors E Book Book PDF
✏Book Title : Brain Tumors E Book
✏Author : Andrew H. Kaye
✏Publisher : Elsevier Health Sciences
✏Release Date : 2011-12-06
✏Pages : 1088
✏ISBN : 9780702048180
✏Available Language : English, Spanish, And French

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✏Brain Tumors E Book Book Summary : Meet the increasing need for effective brain tumor management with the highly anticipated revision of Brain Tumors by Drs. Andrew H. Kaye and Edward R. Laws. Over the past decade, enormous advances have been made in both the diagnosis and the surgical and radiotherapeutic management of brain tumors. This new edition guides you through the latest developments in the field, including hot topics like malignant gliomas, functional brain mapping, neurogenetics and the molecular biology of brain tumors, and biologic and gene therapy. Benefit from the knowledge and experience of Drs. Andrew H. Kaye and Edward R. Laws, globally recognized experts in the field of neurosurgery, as well as many other world authorities.

Modern Management Of High Grade Glioma Part I An Issue Of Neurosurgery Clinics E Book Book PDF
✏Book Title : Modern Management of High Grade Glioma Part I An Issue of Neurosurgery Clinics E Book
✏Author : Isaac Yang
✏Publisher : Elsevier Health Sciences
✏Release Date : 2012-04-28
✏Pages : 174
✏ISBN : 9781455744183
✏Available Language : English, Spanish, And French

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✏Modern Management of High Grade Glioma Part I An Issue of Neurosurgery Clinics E Book Book Summary : Standard therapy for high grade glioma is a topic that is evolving, timely, and relevant. Guest Editors Isaac Yang, MD and Seunggu Han, MD have assembled a group of experts to highlight the latest updates on various forms of management of high grade glioma. Some of the articles included in this issue focus on Extent of Resection for Glioblastoma; Role of adjuvant radiation therapy; Survival benefit of the Temozolomide protocol; Alternative chemotherapeutic agents; The role of avastin; Radiology; Pseuodprogression and Treatment effect; Pathology; Medical Management; Management of insular gliomas; Use of motor mapping; GBM treatment with clinical trials for surgical resection; Clinical trials with immunotherapy; Clinical trials for small molecule inhibitors; Future role of CED for GBM treatment; Application of a vault nanoparticle therapy for GBM therapy; Management of high grade gliomas in pediatric populations; Targeting Glioma Stem Like Cells with a focus on CD 133; and Potential Role for STAT3 inhibitors in glioblastoma.

📒Glucocorticoids And Mood ✍ Lewis L. Judd

Glucocorticoids And Mood Book PDF
✏Book Title : Glucocorticoids and Mood
✏Author : Lewis L. Judd
✏Publisher : Wiley-Blackwell
✏Release Date : 2009-11-23
✏Pages : 352
✏ISBN : STANFORD:36105213128080
✏Available Language : English, Spanish, And French

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✏Glucocorticoids and Mood Book Summary : "This volume presents papers stemming from the conference "Glucocorticoids and Mood: Clinical Manifestations, Risk Factors and Molecular Mechanisms" held on July 20-21, 2008 in San Diego, California"--P. v.

Principles Of Neuro Oncology Book PDF
✏Book Title : Principles of Neuro Oncology
✏Author : David Schiff
✏Publisher : McGraw-Hill Professional
✏Release Date : 2005-06-23
✏Pages : 750
✏ISBN : UOM:39015061018613
✏Available Language : English, Spanish, And French

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✏Principles of Neuro Oncology Book Summary : Provides comprehensive coverage of diagnosis and treatment of all and metastic tumors of the nervous system. Offering streamlined access to sophisticated imaging studies that aid in diagnosis, and to management guidelines for treatment, the text assists those physicians who care for the growing numnbers of patients with nervous system malignancies.

Current Opinion In Oncology Book PDF
✏Book Title : Current Opinion in Oncology
✏Author :
✏Publisher :
✏Release Date : 1998
✏Pages :
✏ISBN : UCLA:L0078439312
✏Available Language : English, Spanish, And French

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✏Current Opinion in Oncology Book Summary :

Yonsei Medical Journal Book PDF
✏Book Title : Yonsei Medical Journal
✏Author :
✏Publisher :
✏Release Date : 2010
✏Pages :
✏ISBN : MINN:31951P01110331Z
✏Available Language : English, Spanish, And French

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✏Yonsei Medical Journal Book Summary :

Thomas Hematopoietic Cell Transplantation Book PDF
✏Book Title : Thomas Hematopoietic Cell Transplantation
✏Author : E. Donnall Thomas
✏Publisher : Wiley-Blackwell
✏Release Date : 2009-04-13
✏Pages : 1718
✏ISBN : NWU:35558005721242
✏Available Language : English, Spanish, And French

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✏Thomas Hematopoietic Cell Transplantation Book Summary : Accompanying CD-ROM contains ... "full content of the book, database of figures, search function."--CD-ROM label.