Neural Stem Cells And Adult Neurogenesis

Neural Stem Cells And Adult Neurogenesis Book PDF
✏Book Title : Neural Stem Cells and Adult Neurogenesis
✏Author : Arie S. Mobley
✏Publisher : Academic Press
✏Release Date : 2019-03-15
✏Pages : 375
✏ISBN : 9780128110140
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Neural Stem Cells and Adult Neurogenesis Book Summary : Neural Stem Cells and Adult Neurogenesis provides graduate students and neuroscientists with a basic understanding of what neural stem cells are and the cell types they produce. This early graduate level reference describes their physiology and potential for medicine and provides students with fundamental stem cell information. An overview of stem cell sources in the human body and a brief mention of relevant diseases provide context for the value of this knowledge. The book also includes chapters on induced pluripotent stem cells (iPSCs), the methods used to obtain them, and a review of the ethical challenges associated with stem cell research. For each region, the book provides a description of its neurogenic niche, cellular and molecular biology, and information on the neurons' contribution to normal and diseased brain function. The level of information is appropriate for early graduate students, introducing technology and molecular biology in an accessible format. Provides a basic understanding of what a stem cell is, the different types, and their potential in health and research Details adult neurogenesis and its role in behavior, stroke and disease Includes walkthrough and technology boxes that illustrate experimental concepts, new approaches and techniques

Adult Neurogenesis And Neural Stem Cells In Mammals Book PDF
✏Book Title : Adult Neurogenesis and Neural Stem Cells in Mammals
✏Author : Philippe Taupin
✏Publisher : Nova Publishers
✏Release Date : 2006
✏Pages : 208
✏ISBN : 1594548560
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Adult Neurogenesis and Neural Stem Cells in Mammals Book Summary : This title contains a book and CD. The brain has a number of nerve cells estimated at a magnitude of 10 to 100 billion, and 1014 to 1015 synapses, and therefore is the most complex organ of the human body. During fetal development the foundations of the brain are laid as billions of neurons form appropriate connections and patterns. In the adult mammalian brain, most neurons are post-mitotic, and therefore at risk for irreversible damage. As we age, atrophy of the brain occurs. As brain weight declines the volume of the brain in the 8th decade is reduced by 6 per cent -10 per cent versus the third decade, and neuronal loss occurs, up to 10,000 to 100,000 neurons are lost per day, though this estimation is being revised downward with the advance of more sophisticated measurements.

📒Adult Neurogenesis ✍ Gerd Kempermann

Adult Neurogenesis Book PDF
✏Book Title : Adult Neurogenesis
✏Author : Gerd Kempermann
✏Publisher : Oxford University Press, USA
✏Release Date : 2006
✏Pages : 426
✏ISBN : 0195179714
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Adult Neurogenesis Book Summary : The discovery of adult neurogenesis and of stem cells in the brain has changed our view of the mature brain. Though we now know that the adult brain can make new neurons, it normally does so only in two privileged regions, the olfactory bulb and the hippocampus. Yet stem cells, which have the potential to produce new neurons, can be found throughout the adult brain. So why does the brain not make wider use of its potential for neurogenesis? And what is the function of new neurons and of neural stem cells in areas where they occur? After all, the brain regenerates poorly and many neurological and psychiatric disorders are chronic because cell replacement has not taken place. This is the first comprehensive, integrated account of one of the most exciting areas of neuroscience. It begins with the historical background and discusses theories of adult neurogenesis and neural stem cell biology in the context of learning and memory processes as well as structural plasticity. It describes in detail neurogenesis in the adult hippocampus and olfactory system and then surveys the regulatory, functional, and comparative aspects, concluding with a chapter on the provocative hypotheses that link failing adult neurogenesis with such diseases as temporal lobe epilepsy, major depression, brain tumors, and dementias. For graduate students, investigators, and clinicians in the neurosciences, developmental biology, and stem cell research, this book is a unique resource that sifts through the evidence for exciting scientific ideas and fosters a realistic view of the therapeutic possibilities for the use of stem cells in the adult brain.

Stem Cells And Regenerative Medicine Book PDF
✏Book Title : Stem Cells and Regenerative Medicine
✏Author : Philippe Taupin
✏Publisher : Nova Publishers
✏Release Date : 2008
✏Pages : 164
✏ISBN : 1604564725
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Stem Cells and Regenerative Medicine Book Summary : The subject of this book is stem cell research and regenerative medicine. Stem cells are undifferentiated cells that have the ability to differentiate into different lineages of the body. Stem cells carry tremendous potential for the treatment of a broad range of disease and injuries. Stem cells exist in embryonic, fetal, and adult tissues, including the adult central nervous system. This book aims at, in depth, the recent developments in stem cell research and regenerative medicine. Though this book encompasses all the fields of stem cell research and regenerative medicine, it emphasises adult neurogenesis and neural stem cell research and therapy.

Neural Stem Cells In Development Adulthood And Disease Book PDF
✏Book Title : Neural Stem Cells in Development Adulthood and Disease
✏Author : H. Georg Kuhn
✏Publisher : Springer
✏Release Date : 2014-11-22
✏Pages : 202
✏ISBN : 9781493919086
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Neural Stem Cells in Development Adulthood and Disease Book Summary : This comprehensive volume is the first to specifically target developing, adult and diseased neural stem cells. It explores recent advances in the understanding of neural stem cell biology along with strategies that use these cells to tackle neurological diseases and brain aging. Ten inclusive chapters discuss a wide range of topics including neurogenesis, neurodegeneration, demyelinating disease, mood regulation, and spinal cord regeneration, among others. Written by world-renowned scientists in the field, Neural Stem Cells in Development, Adulthood and Disease presents cutting-edge studies of interest to both established neurogenesis researchers and readers with general interests in nervous system science. It is an authoritative addition to the Stem Cell Biology and Regenerative Medicine series.

Exam Prep For Neural Stem Cells And Adult Neurogenesis Book PDF
✏Book Title : Exam Prep for Neural Stem Cells and Adult Neurogenesis
✏Author :
✏Publisher :
✏Release Date :
✏Pages :
✏ISBN :
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Exam Prep for Neural Stem Cells and Adult Neurogenesis Book Summary :

Adult Neurogenesis Twenty Years Later Physiological Function Versus Brain Repair Book PDF
✏Book Title : Adult neurogenesis twenty years later physiological function versus brain repair
✏Author : Paolo Peretto
✏Publisher : Frontiers Media SA
✏Release Date : 2015-05-01
✏Pages :
✏ISBN : 9782889194940
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Adult neurogenesis twenty years later physiological function versus brain repair Book Summary : The discovery that mammalian brains contain neural stem cells which perform adult neurogenesis - the production and integration of new neurons into mature neural circuits - has provided a fully new vision of neural plasticity. On a theoretical basis, this achievement opened new perspectives for therapeutic approaches in restorative and regenerative neurology. Nevertheless, in spite of striking advancement concerning the molecular and cellular mechanisms which allow and regulate the neurogenic process, its exploitation in mammals for brain repair strategies remains unsolved. In non-mammalian vertebrates, adult neurogenesis also contributes to brain repair/regeneration. In mammals, neural stem cells do respond to pathological conditions in the so called "reactive neurogenesis", yet without substantial regenerative outcome. Why, even in the presence of stem cells in the brain, we lack an effective reparative outcome in terms of regenerative neurology, and which factors hamper the attainment of this goal? Essentially, what remains unanswered is the question whether (and how) physiological functions of adult neurogenesis in mammals can be exploited for brain repair purposes.

📒Neural Stem Cells ✍ Luca Bonfanti

Neural Stem Cells Book PDF
✏Book Title : Neural Stem Cells
✏Author : Luca Bonfanti
✏Publisher : BoD – Books on Demand
✏Release Date : 2013-04-24
✏Pages : 430
✏ISBN : 9789535110699
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Neural Stem Cells Book Summary : Twenty years after the discovery of neural stem cells, the question whether the central nervous system can be considered among regenerative tissues is still open. On one side, deep characterization of neural stem and progenitor cells, their niches, and their progeny in brain neurogenic sites overtly showed that new neurons can be generated in the brain of adult mammals, including humans. On the other side, many problems arise when stem cells encounter the mature brain parenchyma, still hampering the development of efficacious therapeutic approaches with endogenous or exogenously-delivered neural stem cells. This book tries to make the point on these extremely promising, yet unresolved, issues.

Neurogenesis In The Adult Brain Ii Book PDF
✏Book Title : Neurogenesis in the Adult Brain II
✏Author : Tatsunori Seki
✏Publisher : Springer Science & Business Media
✏Release Date : 2011-06-15
✏Pages : 211
✏ISBN : 443153945X
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Neurogenesis in the Adult Brain II Book Summary : The discovery of adult neurogenesis caused a paradigm shift in the neurosciences. For more than 100 years, it was believed that adult neurons do not regenerate. Joseph Altman and Fernando Nottebohm found proof to the contrary and changed the course of history. Their research, included here, provides the foundations of the field. Today, adult neurogenesis is a rapidly expanding discipline applicable to the study of brain development and diseases, learning and memory, aging, and neuropsychiatric disorders. With multiple authors, the 27 chapters of this book contain the latest work in two volumes. The first presents the basic biology of adult neurogenesis in non-mammalian vertebrates and in the mammalian hippocampus and olfactory bulb, and the second discusses clinical implications and delves into adult neurogenesis and brain injury as well as neurodegenerative and neuropsychiatric pathologies. With details of the anatomy, physiology, and molecular biology of the two neurogenic brain regions, this book provides indispensable knowledge for many areas of neuroscience and for experimental and clinical applications of adult neurogenesis to brain therapy.

Stem Cells And Regenerative Medicine Pharmacology And Therapy Book PDF
✏Book Title : Stem Cells and Regenerative Medicine Pharmacology and therapy
✏Author : Philippe Taupin
✏Publisher : Nova Publishers
✏Release Date : 2008
✏Pages : 133
✏ISBN : 1604564741
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Stem Cells and Regenerative Medicine Pharmacology and therapy Book Summary : Annotation. Stem Cells and Regenerative Medicine, Volumes I, II, and III, present an overview and in-depth analysis of recent developments in stem cell research and therapy in a compilation of recently-published, peer-reviewed articles.

Identification And Characterization Of Neural Progenitor Cells In The Adult Mammalian Brain Book PDF
✏Book Title : Identification and Characterization of Neural Progenitor Cells in the Adult Mammalian Brain
✏Author : Sara Gil-Perotín
✏Publisher : Springer Science & Business Media
✏Release Date : 2009-04-21
✏Pages : 104
✏ISBN : 3540887199
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Identification and Characterization of Neural Progenitor Cells in the Adult Mammalian Brain Book Summary : Adult neurogenesis has been questioned for many years. In the early 1900s, a dogma was established that denied new neuron formation in the adult brain. In the last century however, new discoveries have demonstrated the real existence of proliferation in the adult brain, and in the last decade, these studies led to the identification of neural stem cells in mammals. Adult neural stem cells are undifferentiated cells that are present in the adult brain and are capable of dividing and differentiating into glia and new neurons. Newly formed neurons terminally differentiate into mature neurons in the olfactory bulb and the dentate gyrus of the hippocampus. Since then, a number of new research lines have emerged whose common objective is the phenotypical and molecular characterization of brain stem cells. As a result, new therapies are successfully being applied to animal models for certain neurodegenerative diseases or stroke. At present, and in years to come, this finding extends to the adult human brain, and gives reason and hope to all the previous studies.

Neural Stem Cells And Cellular Therapy Book PDF
✏Book Title : Neural Stem Cells and Cellular Therapy
✏Author : Philippe Taupin
✏Publisher : Nova Biomedical
✏Release Date : 2010
✏Pages : 210
✏ISBN : 1608760170
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Neural Stem Cells and Cellular Therapy Book Summary : Over the past-decade or so, studies have revealed and confirmed that new nerve cells are generated in the adult brain of mammals, including humans. These new nerve cells originate from cells, referred as neural stem cells. Neural stem cells have the capacity to generate nerve cells and repair the brain. Hence, contrary to a long-held dogma, neural stem cells reside in the adult brain and therefore the adult brain has the capacity of, and may be amenable to, repair. Adult neurogenesis and neural stem cells offer new avenues and opportunities for the treatment and cure of a broad range of neurological diseases, disorders and injuries. Neural stem cells and cellular therapy aims at providing an overview and in depth analysis of recent developments in neuralstem cell research and therapy. This book is composed of recently published review articles that went through the peer-review process.

Neural Stem Cells And Therapy Book PDF
✏Book Title : Neural Stem Cells and Therapy
✏Author : Tao Sun
✏Publisher : BoD – Books on Demand
✏Release Date : 2012-02-15
✏Pages : 454
✏ISBN : 9789533079585
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Neural Stem Cells and Therapy Book Summary : This book is a collective work of international experts in the neural stem cell field. The book incorporates the characterization of embryonic and adult neural stem cells in both invertebrates and vertebrates. It highlights the history and the most advanced discoveries in neural stem cells, and summarizes the mechanisms of neural stem cell development. In particular, this book provides strategies and discusses the challenges of utilizing neural stem cells for therapy of neurological disorders and brain and spinal cord injuries. It is suitable for general readers, students, doctors and researchers who are interested in understanding the principles of and new discoveries in neural stem cells and therapy.

50th Anniversary Of Adult Neurogenesis Olfaction Hippocampus And Beyond Book PDF
✏Book Title : 50th Anniversary of Adult Neurogenesis Olfaction Hippocampus and beyond
✏Author : Alino Martinez-Marcos
✏Publisher : Frontiers Media SA
✏Release Date : 2016-09-21
✏Pages :
✏ISBN : 9782889199631
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏50th Anniversary of Adult Neurogenesis Olfaction Hippocampus and beyond Book Summary : In the mid-sixties, the discovery by Altman and co-workers of neurogenesis in the adult brain changed the previous conception of the immutability of this organ during adulthood sustained among others by Cajal. This discovery was ignored up to eighty’s when Nottebohm demonstrated neurogenesis in birds. Subsequently, two main neurogenic zones were characterized: the subventricular zone of the lateral ventricle and the subgranular layer of the dentate gyrus. Half century later, the exact role of new neurons in the adult brain is not completely understand. This book is composed by a number of articles by leaders in the filed covering from an historic perspective to potential therapeutic opportunities.

📒Neural Stem Cells ✍ Jane E. Bottenstein

Neural Stem Cells Book PDF
✏Book Title : Neural Stem Cells
✏Author : Jane E. Bottenstein
✏Publisher : Springer Science & Business Media
✏Release Date : 2003-11-30
✏Pages : 473
✏ISBN : 9781402075889
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Neural Stem Cells Book Summary : Neural Stem Cells: Development and Transplantation provides comprehensive, critical and insightful reviews by leading experts in this exciting field of research. This volume will provide the latest data on neural stem cell properties and their therapeutic applications. This volume will be particularly useful for students, basic scientists, and clinicians in the academic or industrial sectors who have an interest in understanding neural development and its application to repairing the nervous system.

📒Perspectives Of Stem Cells ✍ Henning Ulrich

Perspectives Of Stem Cells Book PDF
✏Book Title : Perspectives of Stem Cells
✏Author : Henning Ulrich
✏Publisher : Springer Science & Business Media
✏Release Date : 2010-01-14
✏Pages : 290
✏ISBN : 9048133750
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Perspectives of Stem Cells Book Summary : Stem cells are fascinating cell types. They can replicate themselves forever while retaining the potential to generate progeny with speci?c functions. Because of these special properties, stem cells have been subjects of intensive investigation, from understanding basic mechanisms underlying tissue generation, to modeling human diseases, to application for cell replacement therapy. Stem cells come in different forms. For example, mouse embryonic stem cells can general all cell types in a body, either in a dish or when put back into mouse embryos. On the other hand, neural stem cells in the adult brain generate neurons and glia cells that contribute to the brain’s plasticity. Rapid progress has been made in the stem cell ?eld with discov- ies published in a record speed. A quick Pubmed search has returned 2789 hits for “embryonic stem cells” and 815 hits for “adult neural stem cells/neurogenesis” in the year 2008 alone. It remains a taunting task for all who are interested in stem cells to keep up with rapidly accumulating literatures. The “Perspectives of Stem Cells” by a truly international team of experts provides a timely and invaluable highlight of the stem cell ?eld gearing toward future therapeutic applications in the nervous system. Stem cells with neural potentials have attracted a lot of attention because of their promise for cell replacement therapy, ranging from degenerative neurological dis- ders to spinal cord injuries.

📒Neural Stem Cells ✍ Alfredo Quiñones-Hinojosa

Neural Stem Cells Book PDF
✏Book Title : Neural Stem Cells
✏Author : Alfredo Quiñones-Hinojosa
✏Publisher : Saunders
✏Release Date : 2007
✏Pages : 198
✏ISBN : 141604339X
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Neural Stem Cells Book Summary : "Neural stem cells have the capacity to generate all of the multiple cell types found in the brain and spinal cord, thus, they have the potential to repair tissue injured by trauma or disease. The Guest Editors are researchers and clinicians who have done extensive work on human neural stem cells and the regeneration of neural cells in the brain. This issue of the Neurosurgery Clinics discusses embryonic and adult neural stem cells and their role in brain tumors, neurorestoration, trauma, and stroke. Contents: 1. Embryonic human stem cells: Present and Future; Germinal Regions in the Adult Human Brain; Astrocytes as Adult Neural Stem Cells; Identification of Human Brain Tumor Initiating Cells; BMP-Mediated Therapeutic Targeting of Brain Tumor Stem Cells; Neural Precursors and Their Role in Medulloblastomas; PDGF-Mediated Gliomagenesis and Brain Tumor Recruitment; Stem Cells as Vehicles for the Treatment of Brain Cancer; Gene Chip Analysis of Epigenetic Stem Cell Remodeling; Glial Progenitors and Demyelinating Lesions; Adult Neurogenesis and Hippocampal Memory Function; Radiation Response of Neural Precursors; Injury following trauma or stroke; Regeneration of the Injured Spinal Cord; TBI-Related Effects on Neurogenesis; Neurogenesis after stroke: effects of growth factors. "

Neural Development And Stem Cells Book PDF
✏Book Title : Neural Development and Stem Cells
✏Author : Mahendra S. Rao
✏Publisher : Springer Science & Business Media
✏Release Date : 2007-10-28
✏Pages : 468
✏ISBN : 9781592599141
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Neural Development and Stem Cells Book Summary : Developing the second edition of Neural Development and Stem Cells was neces- tated by the rapid increase in our knowledge of the development of the nervous system. It has become increasingly clear that stem cells are a heterogeneous population that changes extensively during development. Perhaps the most important advance in our understanding of stem cell behavior has been the realization that regionalization of stem cells occurs early in development and this bias toward differentiation in phe- types of neurons or cells characteristic of a particular part of the brain appears to persist even after prolonged culture. We have therefore included additional chapters on olf- tory epithelial stem cells and retinal stem cells, both of which differ in their properties from ventricular zone and subventricular zone–derived neural stem cells. It is also now clear from an analysis of mutants and transgenics where the death or self-renewal pa- way is altered that cell death regulates stem cell number. As a consequence, this second edition includes a separate chapter on cell death that summarizes the important changes in the death pathway that occur as stem cells mature. The existing chapters in the book have also been extensively revised and updated by experts who have generously c- tributed their time and expertise. The chapters have been organized along the lines of our understanding of how the nervous system develops (Fig. 1, on p. vi).

Glial And Neural Stem Cells As New Therapeutic Targets For Neurodegenerative Disorders Book PDF
✏Book Title : Glial and Neural Stem Cells as New Therapeutic Targets for Neurodegenerative Disorders
✏Author : Sara Xapelli
✏Publisher : Frontiers Media SA
✏Release Date : 2020-06-08
✏Pages :
✏ISBN : 9782889637416
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Glial and Neural Stem Cells as New Therapeutic Targets for Neurodegenerative Disorders Book Summary :

Neural Stem Cells For Brain And Spinal Cord Repair Book PDF
✏Book Title : Neural Stem Cells for Brain and Spinal Cord Repair
✏Author : Tanja Zigova
✏Publisher : Springer Science & Business Media
✏Release Date : 2002-11-05
✏Pages : 434
✏ISBN : 9781592592982
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Neural Stem Cells for Brain and Spinal Cord Repair Book Summary : Active neuroscientists survey NSCs as potential tools for central nervous system and spinal cord repair by explaining their clinically significant fundamental properties, manipulations, and potential therapeutic paradigms. Their discussion of the fundamental biology of NSCs illustrates the signaling pathways that regulate stem cell division and differentiation, and defines the methods of NSC expansion and propagation, neuromorphogenesis, the factors determining cell fate both in vitro and in situ, and the induction of self-reparative processes within the brain. They also present strategies that may lead to fruitful clinical applications in the near future. These range from the replacement of degenerated, dysfunctional, or maldeveloped cells to the provision of factors that may protect, correct, recruit, promote self-repair, or mediate the connectivity of host cells.

Examining The Role Of Fxr1p In Adult Neurogenesis Book PDF
✏Book Title : Examining the Role of FXR1P in Adult Neurogenesis
✏Author : Natalie Patzlaff
✏Publisher :
✏Release Date : 2017
✏Pages : 131
✏ISBN : OCLC:1164161491
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Examining the Role of FXR1P in Adult Neurogenesis Book Summary : Fragile X related protein 1 (FXR1P) is part of the fragile X family of RNA binding proteins (FXRs), which includes the fragile X mental retardation protein (FMRP) and fragile X related protein 2 (FXR2P). Both FMRP and FXR2P regulate adult neural stem cells (aNSCs) and neurogenesis, a process linked to neurological disorders, such as Fragile X syndrome. Although FXR1P has been implicated in diverse developmental processes and neurological diseases, its role in neurodevelopment is not well-understood. The goal of this study was to elucidate the function of FXR1P in aNSCs and hippocampal neurogenesis. We used a Tamoxifen-inducible triple transgenic mouse model to investigate how Fxr1 deletion affects aNSC proliferation and fate specification. Deletion of Fxr1 resulted in significantly decreased populations of radial glia-like cells, neuroblasts, immature neurons, neurons, and astrocytes. We hypothesized that this reduction in new cell numbers resulted from impaired proliferation, which was confirmed both in vivo and in vitro. We discovered that FXR1P-deficient aNSCs have altered expression of a select number of cell-cycle genes, and identified the mRNA of cyclin-dependent kinase inhibitor 1A (Cdkn1a, p21) as a direct target of FXR1P. Restoration of p21 mRNA to wildtype levels rescued the proliferation deficit in aNSCs lacking FXR1P, demonstrating that p21 is a mediator of FXR1P in aNSCs. Since Fxr1 deletion in aNSCs results in a reduction of new neurons, we also performed behavioral tests for locomotion, anxiety, and hippocampal learning and memory. Although these results are preliminary, it is likely that the loss of FXR1P in aNSCs results in impaired hippocampal-dependent learning and memory.

Neural Stem Cells In Health And Disease Book PDF
✏Book Title : Neural Stem Cells in Health and Disease
✏Author : Ashok K Shetty
✏Publisher : World Scientific Publishing Company
✏Release Date : 2015-08-28
✏Pages : 572
✏ISBN : 9789814623193
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Neural Stem Cells in Health and Disease Book Summary : This book is a comprehensive guide on neural stem cell behavior in health and disease. The book confers the altered behavior of endogenous neural stem cells in neurodegenerative disease conditions and the prospects of neural stem cell therapy for alleviating brain dysfunction in a variety of neurodegenerative disorders. Neural stem cell activity and neurogenesis in the adult brain is now confirmed in virtually all mammalian species including humans. Hence, a series of chapters in the first half of the book discusses the current knowledge on mechanisms of neural stem cell activity, the extent and functional significance of neurogenesis in the adult brain under normal, aged and disease environments, the susceptibility of neural stem cells and the plasticity of neurogenesis to alcohol, drugs of abuse and anesthetic agents, and advanced techniques that trigger neurogenesis in non-neurogenic regions. A second series of chapters in this book are focused on discussing the promise and efficacy of grafting of neural stem cells and/or other stem cells for treating neurological disorders such as Parkinson's disease, stroke, temporal lobe epilepsy, Alzheimer's disease and spinal cord injury. The final chapter confers on advances that are made in manufacturing a variety of neural cell types from human pluripotent stem cells that can be used as donor cells for cell transplantation.

Stem Cells And Regenerative Medicine Book PDF
✏Book Title : Stem Cells and Regenerative Medicine
✏Author : Philippe Taupin
✏Publisher : Nova Publishers
✏Release Date : 2008
✏Pages : 164
✏ISBN : 1604564725
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Stem Cells and Regenerative Medicine Book Summary : The subject of this book is stem cell research and regenerative medicine. Stem cells are undifferentiated cells that have the ability to differentiate into different lineages of the body. Stem cells carry tremendous potential for the treatment of a broad range of disease and injuries. Stem cells exist in embryonic, fetal, and adult tissues, including the adult central nervous system. This book aims at, in depth, the recent developments in stem cell research and regenerative medicine. Though this book encompasses all the fields of stem cell research and regenerative medicine, it emphasises adult neurogenesis and neural stem cell research and therapy.

Stem Cell Applications In Diseases Book PDF
✏Book Title : Stem Cell Applications in Diseases
✏Author : Mikkel L. Sorensen
✏Publisher : Nova Publishers
✏Release Date : 2008
✏Pages : 325
✏ISBN : 1604562412
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Stem Cell Applications in Diseases Book Summary : Stem cells are the foundation cells for every organ, tissue and cell in the body. They are like a blank microchip that can ultimately be programmed to perform any number of specialised tasks. Stem cells are undifferentiated, "blank" cells that do not yet have a specific function. Under proper conditions, stem cells begin to develop into specialised tissues and organs. Additionally, stem cells are self-sustaining and can replicate themselves for long periods of time. These unique characteristics make stem cells very promising for supplying cells to treat debilitating diseases like Alzheimer's disease, cancer, Parkinson's disease, type-1 diabetes, spinal cord injury, stroke, burns, heart disease, osteoarthritis and rheumatoid arthritis. This new book presents the latest research in the field from around the world.

Emerging Roles For Hippocampal Adult Neural Stem Cells In Memory Book PDF
✏Book Title : Emerging Roles for Hippocampal Adult Neural Stem Cells in Memory
✏Author : Aaron R. Friedman
✏Publisher : Biota Publishing
✏Release Date : 2013-12-01
✏Pages : 39
✏ISBN : 9781615044771
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Emerging Roles for Hippocampal Adult Neural Stem Cells in Memory Book Summary : Approximately 50 years ago, newly generated neurons were discovered in the adult hippocampus of the rat brain. This discovery contradicted a key principle in mammalian developmental neurobiology—that all the neurons of the brain are made during early development—and led to intensive study to find out how new neurons are generated and how the process of neurogenesis is regulated. Since then, a unique population of adult neural stem cells has been identified, and many of the molecular pathways that control their self-renewal, proliferation, and cell fate have been elucidated. However, the presence of new neurons in the adult brain also poses intriguing functional questions that have, as yet, gone largely unanswered. Why is adult neurogenesis restricted to select brain regions? What functional benefit do these new cells confer? Indeed, the field of adult neurogenesis offers a unique opportunity to study naïve neurons as they mature, form connections with existing neural networks, and begin to participate in information processing. We review the basics of adult NSC biology and the maturation of newborn neurons. In particular, we focus on new neurons in the hippocampus, and how they contribute to function in this key memory-forming structure of the brain.

📒Human Neural Stem Cells ✍ Leonora Buzanska

Human Neural Stem Cells Book PDF
✏Book Title : Human Neural Stem Cells
✏Author : Leonora Buzanska
✏Publisher : Springer
✏Release Date : 2018-09-12
✏Pages : 329
✏ISBN : 9783319934853
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Human Neural Stem Cells Book Summary : This book summarizes early pioneering achievements in the field of human neural stem cell (hNSC) research and combines them with the latest advances in stem cell technology, including reprogramming and gene editing. The powerful potential of hNSC to generate and repair the developing and adult CNS has been confirmed by numerous experimental in vitro and in vivo studies. The book presents methods for hNSC derivation and discusses the mechanisms underlying NSC in vitro fate decisions and their in vivo therapeutic mode of action. The long-standing dogma that the human central nervous system (CNS) lacks the ability to regenerate was refuted at the end of the 20th century, when evidence of the presence of neurogenic zones in the adult human brain was found. These neurogenic zones are home to human neural stem cells (hNSCs), which are capable of self-renewing and differentiating into neurons, astrocytes and oligodendrocytes. NSCs isolated from human CNS have a number of clinical advantages, especially the innate potential to differentiate into functional neural cells. Nevertheless, their full clinical exploitation has been hindered by limited access to the tissue and low expansion potential. The search for an alternative to CNS sources of autologous, therapeutically competent hNSCs was the driving force for the many studies proving the in vitro plasticity of different somatic stem cells to generate NSCs and their functional progeny. Now the era of induced pluripotent stem cells has opened entirely new opportunities to achieve research and therapeutic goals with the aid of hNSCs.

Textbook Of Neural Repair And Rehabilitation Volume 1 Neural Repair And Plasticity Book PDF
✏Book Title : Textbook of Neural Repair and Rehabilitation Volume 1 Neural Repair and Plasticity
✏Author : Michael E. Selzer
✏Publisher : Cambridge University Press
✏Release Date : 2006-02-16
✏Pages : 724
✏ISBN : 0521856418
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Textbook of Neural Repair and Rehabilitation Volume 1 Neural Repair and Plasticity Book Summary : Covers the basic sciences relevant to recovery of function following injury to the nervous system.

The Cell Cycle In The Central Nervous System Book PDF
✏Book Title : The Cell Cycle in the Central Nervous System
✏Author : Damir Janigro
✏Publisher : Springer Science & Business Media
✏Release Date : 2008-01-23
✏Pages : 563
✏ISBN : 1597450219
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏The Cell Cycle in the Central Nervous System Book Summary : Cell Cycle in the Central Nervous System overviews the changes in cell cycle as they relate to prenatal and post natal brain development, progression to neurological disease or tumor formation.Topics covered range from the cell cycle during the prenatal development of the mammalian central nervous system to future directions in postnatal neurogenesis through gene transfer, electrical stimulation, and stem cell introduction. Additional chapters examine the postnatal development of neurons and glia, the regulation of cell cycle in glia, and how that regulation may fail in pretumor conditions or following a nonneoplastic CNS response to injury. Highlights include treatments of the effects of deep brain stimulation on brain development and repair; the connection between the electrophysiological properties of neuroglia, cell cycle, and tumor progression; and the varied immunological responses and their regulation by cell cycle.

Stem Cells And Regenerative Medicine Embryonic And Adult Stem Cells Book PDF
✏Book Title : Stem Cells and Regenerative Medicine Embryonic and adult stem cells
✏Author : Philippe Taupin
✏Publisher : Nova Publishers
✏Release Date : 2008
✏Pages : 86
✏ISBN : 1604564733
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Stem Cells and Regenerative Medicine Embryonic and adult stem cells Book Summary : The subject of this book is stem cell research and regenerative medicine. Stem cells are undifferentiated cells that have the ability to differentiate into different lineages of the body. Stem cells carry tremendous potential for the treatment of a broad range of disease and injuries. Stem cells exist in embryonic, foetal, and adult tissues, including the adult central nervous system. This book aims at, in depth, the recent developments in stem cell research and regenerative medicine. Though this book encompasses all the fields of stem cell research and regenerative medicine, it emphasises embryonic and adult stem cells.

Neural Stem Cells In Health And Diseases Book PDF
✏Book Title : Neural Stem Cells in Health and Diseases
✏Author : Ashok K. Shetty
✏Publisher : World Scientific Publishing Company Incorporated
✏Release Date : 2015
✏Pages : 548
✏ISBN : 9814623172
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Neural Stem Cells in Health and Diseases Book Summary : This book is a comprehensive guide on neural stem cell behavior in health and disease. It will cover the altered behavior of endogenous neural stem cells in neurodegenerative conditions and the prospects of neural stem cell therapy for alleviating brain dysfunction in a variety of neurodegenerative disorders. First set of chapters will focus on neural stem cell proliferation, neuronal differentiation and maturation of progeny of cells derived from neural stem cells in brain regions, such as the hippocampus and the subventricular zone of the forebrain. Neural stem cell behavior in young and aged brains and functional implications of altered neural stem cell behavior will be discussed as well. The second set of chapters will cover altered behavior of endogenous neural stem cells and their functional implications in disorders, such as temporal lobe epilepsy, cancer, traumatic brain injury, stroke, Alzheimer's disease, addiction and alcohol use. The third set of chapters will discuss prospects of stem cell therapy for various neurological disorders, which will comprise of their behavior after grafting and functional recovery mediated by them. Additional chapters will discuss how to generate the right neural cell types from induced pluripotent stem cells for screening and cell therapy of central nervous system disorders.