Drug Delivery to the Central Nervous System

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  • Author : Kewal K. Jain
  • Publisher : Humana
  • Pages : 321 pages
  • ISBN : 9781493961597
  • Rating : /5 from reviews
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Download or Read online Drug Delivery to the Central Nervous System full in PDF, ePub and kindle. this book written by Kewal K. Jain and published by Humana which was released on 23 August 2016 with total page 321 pages. We cannot guarantee that Drug Delivery to the Central Nervous System book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Playing an important role in the treatment of neurological disorders, the delivery of drugs to central nervous system (CNS), both administered directly and administered systematically for targeted action, encounters a major challenge in the form of the blood-brain barrier (BBB), which limits the access of drugs to the brain substance. In Drug Delivery to the Central Nervous System, experts in the field present essential methods used to deliver therapeutics across the BBB, both in experimental animals and in humans. In addition to those methods, several overviews of innovative methods and their applications are presented in order to give a glimpse of the future of this research. As a volume in the successful Neuromethods series, this book presents its protocols with the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and cutting-edge, Drug Delivery to the Central Nervous System serves as an ideal guide to scientists continuing to pursue knowledge of the delicate interactions between pharmaceuticals and the brain.

Drug Delivery to the Central Nervous System

Drug Delivery to the Central Nervous System
  • Author : Kewal K. Jain
  • Publisher : Humana
  • Release : 23 August 2016
GET THIS BOOK Drug Delivery to the Central Nervous System

Playing an important role in the treatment of neurological disorders, the delivery of drugs to central nervous system (CNS), both administered directly and administered systematically for targeted action, encounters a major challenge in the form of the blood-brain barrier (BBB), which limits the access of drugs to the brain substance. In Drug Delivery to the Central Nervous System, experts in the field present essential methods used to deliver therapeutics across the BBB, both in experimental animals and in humans. In

Nanomedicines for Brain Drug Delivery

Nanomedicines for Brain Drug Delivery
  • Author : Javier O. Morales,Pieter J. Gaillard
  • Publisher : Humana
  • Release : 20 November 2020
GET THIS BOOK Nanomedicines for Brain Drug Delivery

This volume explores the latest research in central nervous system (CNS) targeted nanocarriers, methods for their synthesis, and its characterization process. Chapters in this book cover topics such as polymeric nanoparticles and liposomes; self-assembled peptide-based scaffolds for lesions of the nervous system; use of peptides as CNS drugs and as potential carriers to optimize brain-targeted delivery; ways to model and assess blood brain barrier absorption of drugs; and the role of neurodegeneration progress of nanomaterials and their potential toxicity concerns.

Nervous System Drug Delivery

Nervous System Drug Delivery
  • Author : Russell R. Lonser,Malisa Sarntinoranont,Kristof Bankiewicz
  • Publisher : Academic Press
  • Release : 25 June 2019
GET THIS BOOK Nervous System Drug Delivery

Nervous System Drug Delivery: Principles and Practice helps users understand the nervous system physiology affecting drug delivery, the principles that underlie various drug delivery methods, and the appropriate application of drug delivery methods for drug- and disease-specific treatments. Researchers developing nervous system putative therapeutic agents will use this book to optimize drug delivery during preclinical assessment and to prepare for regulatory advancement of new agents. Clinicians will gain direct insights into pathophysiologic alterations that impact drug delivery and students and

Drug Delivery to the Brain

Drug Delivery to the Brain
  • Author : Margareta Hammarlund-Udenaes,Elizabeth C.M. de Lange,Robert G. Thorne
  • Publisher : Springer Science & Business Media
  • Release : 03 December 2013
GET THIS BOOK Drug Delivery to the Brain

The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood –brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics

Peptide Transport and Delivery into the Central Nervous System

Peptide Transport and Delivery into the Central Nervous System
  • Author : Laszlo Prokai,Katalin Prokai-Tatrai
  • Publisher : Birkhäuser
  • Release : 06 December 2012
GET THIS BOOK Peptide Transport and Delivery into the Central Nervous System

Hypo- or hypersecretion, alteration in storage, release, catabolism, and post-translational processing of neuropeptides are associated with the etiology of many diseases affecting the central nervous system (CNS). Various peptides native to the brain and the spinal cord, as well as various synthetic peptides, peptide analogues and peptidomimetics developed as their agonists or antagonists could be useful in the treatment of these CNS maladies. However, peptides face a formidable obstacle in reaching the intended site of action due to the existence

Drug and Gene Delivery to the Central Nervous System for Neuroprotection

Drug and Gene Delivery to the Central Nervous System for Neuroprotection
  • Author : Hari S. Sharma,Dafin F. Muresanu,Aruna Sharma
  • Publisher : Springer
  • Release : 05 June 2017
GET THIS BOOK Drug and Gene Delivery to the Central Nervous System for Neuroprotection

This book summarizes the latest research on drug and gene delivery to the central nervous system (CNS). The chapters address safety concerns regarding the nanotechnology that is needed to develop nanomedicine for clinical practice. Particular focus is given to new technologies that have emerged in recent years to deliver therapeutic materials, such as genes, drugs, and other agents using nanotechnologies of diverse origin. This is an ideal book for students, teachers, researchers, and clinicians interested in a deeper understanding of

Nanoparticles for Brain Drug Delivery

Nanoparticles for Brain Drug Delivery
  • Author : Carla Vitorino,Andreia Jorge,Alberto A.C.C. Pais
  • Publisher : CRC Press
  • Release : 16 March 2021
GET THIS BOOK Nanoparticles for Brain Drug Delivery

In an era wherein nanotechnology has sparked a huge research interest, brain drug delivery is not an exception. Aiming at fighting several central nervous system (CNS) conditions, tailored nanoparticles open new avenues to address several challenges in the fields of drug delivery and brain targeting. This book gathers contributions from experts in different, complementary fields, having in common their interest in developing new strategies for brain delivery based on nanotechnologies. The book encompasses general aspects pertaining to fundamental development, including

The Blood brain Barrier and Drug Delivery to the Cns

The Blood brain Barrier and Drug Delivery to the Cns
  • Author : Michael Bradbury,Jorg Kreuter,David Begley
  • Publisher : CRC Press
  • Release : 30 August 2019
GET THIS BOOK The Blood brain Barrier and Drug Delivery to the Cns

This timely and compact monograph addresses how to determine drug permeability across the blood-brain barrier more effectively. Focusing on the physiological mechanisms that influence the passage of agents into the brain, the book covers the latest research on the blood-brain barrier, the current problems of and solutions to drug delivery to the central nervous system (CNS), existing strategies, and prospects for future research. Avoid excessive in vivo experimentation and utilize timesaving in vitro techniques. A concise reference with reviews from

Liposomal Drug Delivery to the Central Nervous System

Liposomal Drug Delivery to the Central Nervous System
  • Author : Rita Nieto Montesinos
  • Publisher : Unknown
  • Release : 23 May 2022
GET THIS BOOK Liposomal Drug Delivery to the Central Nervous System

Central nervous system diseases represent a huge world of burden of human suffering with negative economic results. Most therapeutic compounds cannot attain the brain because of the blood-brain barrier and its expression of efflux transporters. Among them, the P-glycoprotein plays a significant role leading to failure of various clinical treatments. A non-invasive strategy to circumvent the blood-brain barrier and P-glycoprotein emphasizes on the encapsulation and therefore masking of therapeutic compounds in drug delivery systems. Up to now, liposomes are the

Blood Brain Barrier in Drug Discovery

Blood Brain Barrier in Drug Discovery
  • Author : Li Di,Edward H. Kerns
  • Publisher : John Wiley & Sons
  • Release : 02 February 2015
GET THIS BOOK Blood Brain Barrier in Drug Discovery

Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery. • Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects • Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies • Covers BBB physiology, medicinal chemistry design

Brain Targeted Drug Delivery Systems

Brain Targeted Drug Delivery Systems
  • Author : Huile Gao,Xiaoling Gao
  • Publisher : Academic Press
  • Release : 20 September 2018
GET THIS BOOK Brain Targeted Drug Delivery Systems

Brain Targeted Drug Delivery Systems: A Focus on Nanotechnology and Nanoparticulates provides a guide on nanoparticulates to both academic and industry researchers. The book discusses key points in the development of brain targeted drug delivery, summarizes available strategies, and considers the main problems and pitfalls evidenced in current studies on brain targeted drug delivery systems. As the brain is the most important organ in the human body, and disorders of the central nervous system (CNS) are the most serious threat