Molecular Mechanisms of Dementia

• Author : Akhlaq A. Farooqui
• Publisher : Academic Press
• Release : 15 April 2019

Considerable progress has been made in neurochemical and therapeutic aspects of dementia research in recent years. Molecular and Therapeutic Aspects of Dementia presents readers with comprehensive and cutting-edge information on the neurochemical mechanisms of various types of dementias. It provides a clearly written and logically organized and comprehensive overview of molecular aspects of risk factors, symptoms, pathogenesis, biomarkers, and therapeutic strategies for various types of dementia. This book is written for the international audience of neurochemists, neuroscientists, neurologists, neuropharmacologists, and

• Author : Wilma Wasco,Rudolph Tanzi
• Publisher : Springer Science & Business Media
• Release : 01 November 1996

The past decade has witnessed a revolution in the attempts of scientists to under stand the molecular basis of dementia. Although dementia, as defined by global cogni tive decline involving gradual loss of memory, reasoning, judgment, and orientation, presents most commonly in the form of Alzheimer's disease (AD), an assortment of other less common disorders, such as prion and Pick's disease, can also lead to symp toms that are similar to those observed in patients with AD. The primary goal

• Author : Wilma Wasco,Rudolph Tanzi
• Publisher : Humana Press
• Release : 03 October 2013

The past decade has witnessed a revolution in the attempts of scientists to under stand the molecular basis of dementia. Although dementia, as defined by global cogni tive decline involving gradual loss of memory, reasoning, judgment, and orientation, presents most commonly in the form of Alzheimer's disease (AD), an assortment of other less common disorders, such as prion and Pick's disease, can also lead to symp toms that are similar to those observed in patients with AD. The primary goal

• Author : Ian Macreadie
• Publisher : MDPI
• Release : 25 October 2019

Alzheimer’s disease (AD) is an age-related neurological disease that affects tens of millions of people, in addition to their carers. Hallmark features of AD include plaques composed of amyloid beta, as well as neurofibrillary tangles of tau protein. However, despite more than a century of study, the cause of Alzheimer’s disease remains unresolved. The roles of amyloid beta and tau are being questioned and other causes of AD are now under consideration. The contributions of researchers, model organisms,

• Author : Konrad Beyreuther,Gotthard Schettler
• Publisher : Springer Science & Business Media
• Release : 06 December 2012

• Author : Marie-Francoise Chesselet
• Publisher : Springer Science & Business Media
• Release : 19 October 2000

With the unprecedented identification of new mutation mechanisms in neurodegenerative diseases and the emergence of common mechanisms among diseases that were once considered unrelated, neurobiologists are poised for the development of new therapies based on high throughput screenings and a better understanding of the molecular and cellular mechanisms leading to neurodegeneration. In Molecular Mechanisms of Neurodegenerative Diseases, Marie-Francoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from

• Author : Nicolae-Daniel Pirici
• Publisher : Unknown
• Release : 21 June 2021

• Author : Louise Ann Pemberton
• Publisher : Unknown
• Release : 21 June 2021

• Author : Nicolae-Daniel Pirici
• Publisher : Unknown
• Release : 21 June 2021

• Author : Dennis Dickson
• Publisher : John Wiley & Sons
• Release : 07 November 2011

Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within

• Author : Kōji Abe
• Publisher : Elsevier Science Health Science Division
• Release : 21 June 2021

The International Symposium on Molecular Mechanism and Epochal Therapeutics of Ischemic Stroke and Dementia was held in Okayama on October 18-20, 2002. This proceeding covers topics relating to the molecular mechanism and therapeutics of these diseases, including: the role of intracellular signaling in cerebral ischemia; genes and genetic models of cerebral ischemia; neuroprotection with hypothermia and against inflammation; molecular mechanisms and therapy for ischemic brain damage; neurotrophic factors and gene therapy for stroke; imaging of brain function; molecular mechanisms of Alzheimer's

• Author : S. Tariq Ahmad,Jin-A. Lee
• Publisher : Elsevier Inc. Chapters
• Release : 29 July 2013

Autophagy is a highly regulated process that promotes vital cellular homeostasis by allowing bulk non-specific degradation of the cytoplasmic contents, mainly damaged and/or surplus organelles and proteins. Autophagy is ubiquitous in eukaryotes, highly conserved from yeast to mammals, and occurs in all mammalian tissues. Historically, autophagy was characterized as the coping response to limited energy resources (starvation), to generate additional biomolecular raw materials. However, research in the past two decades has demonstrated the indispensible roles of autophagy in eukaryotic

• Author : Nagehan Ersoy Tunalı
• Publisher : BoD – Books on Demand
• Release : 20 January 2021

Neurodegenerative diseases represent a very large group of heterogeneous disorders affecting specific subtypes of neurons in the brain. This book contributes insight both to the awareness of the brain and its neurodegenerative states. The chapters present current knowledge regarding genetics, molecular mechanisms, and new therapeutic strategies against neurodegenerative disorders. The book is intended to serve as a source to aid clinicians and researchers in the field, and also life science readers to increase their understanding and awareness of the clinical

• Author : Robert Crichton,Roberta Ward
• Publisher : John Wiley & Sons
• Release : 04 September 2013

Neurodegenerative diseases of the human brain appear in variousforms, resulting in disorders of movement and coordination,cognitive deterioration and psychiatric disturbances. Many of thekey factors leading to neurodegenerative diseases are similar,including the dysfunction of metal ion homeostasis, redox-activemetal ions generating oxidative stress, and intracellular inclusionbodies. Metal-based Neurodegeneration presents a detailed surveyof the molecular origins of neurodegenerative diseases. Eachchapter is dedicated to a specific disease, presenting the latestscientific findings, including details of their biochemicalactors (proteins or peptides), their normal and

• Author : Sangram S. Sisodia,Rudolph E. Tanzi
• Publisher : Springer Science & Business Media
• Release : 16 February 2007

This book examines every major aspect of Alzheimer disease at a time when there has been no scholarly research volume on the subject published in the last 3-5 years. This edition includes expanded coverage of the cellular-level exploration of related dementing disorders, with in-depth presentation of prion diseases, Pick's disease, fronto-temporal disorders, transgenic models, and biochemistry of presenilins.