Molecular Mechanisms of Dementia

• Author : Wilma Wasco,Rudolph Tanzi
• Publisher : Springer Science & Business Media
• Release : 01 November 1996

The past decade has witnessed a revolution in the attempts of scientists to under stand the molecular basis of dementia. Although dementia, as defined by global cogni tive decline involving gradual loss of memory, reasoning, judgment, and orientation, presents most commonly in the form of Alzheimer's disease (AD), an assortment of other less common disorders, such as prion and Pick's disease, can also lead to symp toms that are similar to those observed in patients with AD. The primary goal

• Author : Akhlaq A. Farooqui
• Publisher : Academic Press
• Release : 15 April 2019

Considerable progress has been made in neurochemical and therapeutic aspects of dementia research in recent years. Molecular and Therapeutic Aspects of Dementia presents readers with comprehensive and cutting-edge information on the neurochemical mechanisms of various types of dementias. It provides a clearly written and logically organized and comprehensive overview of molecular aspects of risk factors, symptoms, pathogenesis, biomarkers, and therapeutic strategies for various types of dementia. This book is written for the international audience of neurochemists, neuroscientists, neurologists, neuropharmacologists, and

• Author : Ian Macreadie
• Publisher : MDPI
• Release : 25 October 2019

Alzheimer’s disease (AD) is an age-related neurological disease that affects tens of millions of people, in addition to their carers. Hallmark features of AD include plaques composed of amyloid beta, as well as neurofibrillary tangles of tau protein. However, despite more than a century of study, the cause of Alzheimer’s disease remains unresolved. The roles of amyloid beta and tau are being questioned and other causes of AD are now under consideration. The contributions of researchers, model organisms,

• Author : Nicolae-Daniel Pirici
• Publisher : Unknown
• Release : 16 May 2022

• Author : Marie-Francoise Chesselet
• Publisher : Springer Science & Business Media
• Release : 19 October 2000

With the unprecedented identification of new mutation mechanisms in neurodegenerative diseases and the emergence of common mechanisms among diseases that were once considered unrelated, neurobiologists are poised for the development of new therapies based on high throughput screenings and a better understanding of the molecular and cellular mechanisms leading to neurodegeneration. In Molecular Mechanisms of Neurodegenerative Diseases, Marie-Francoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from

• Author : Konrad Beyreuther,Gotthard Schettler
• Publisher : Springer Science & Business Media
• Release : 06 December 2012

• Author : Dennis Dickson,Roy O. Weller
• Publisher : John Wiley & Sons
• Release : 09 September 2011

Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within

• Author : Nicolae-Daniel Pirici
• Publisher : Unknown
• Release : 16 May 2022

• Author : S. Tariq Ahmad,Jin-A. Lee
• Publisher : Elsevier Inc. Chapters
• Release : 29 July 2013

Autophagy is a highly regulated process that promotes vital cellular homeostasis by allowing bulk non-specific degradation of the cytoplasmic contents, mainly damaged and/or surplus organelles and proteins. Autophagy is ubiquitous in eukaryotes, highly conserved from yeast to mammals, and occurs in all mammalian tissues. Historically, autophagy was characterized as the coping response to limited energy resources (starvation), to generate additional biomolecular raw materials. However, research in the past two decades has demonstrated the indispensible roles of autophagy in eukaryotic

• Author : Robert Crichton,Roberta Ward
• Publisher : John Wiley & Sons
• Release : 04 September 2013

Neurodegenerative diseases of the human brain appear in variousforms, resulting in disorders of movement and coordination,cognitive deterioration and psychiatric disturbances. Many of thekey factors leading to neurodegenerative diseases are similar,including the dysfunction of metal ion homeostasis, redox-activemetal ions generating oxidative stress, and intracellular inclusionbodies. Metal-based Neurodegeneration presents a detailed surveyof the molecular origins of neurodegenerative diseases. Eachchapter is dedicated to a specific disease, presenting the latestscientific findings, including details of their biochemicalactors (proteins or peptides), their normal and

• Author : Vladimir N. Uversky,Anthony Fink
• Publisher : Springer Science & Business Media
• Release : 26 May 2007

The second volume continues to fill the gap in protein review and protocol literature. It does this while summarizing recent achievements in the understanding of the relationships between protein misfoldings, aggregation, and development of protein deposition disorders. The focus of Part B is the molecular basis of differential disorders.

• Author : Yusaku Nakabeppu,Toshiharu Ninomiya
• Publisher : Springer
• Release : 06 May 2019

This book describes the precise mechanisms by which insulin resistance and diabetes mellitus (DM) act as risk factors for Alzheimer’s disease (AD). It opens by discussing the de novo synthesis of insulin in the brain and its functional significance with regard to glucose metabolism and maintenance of neuronal function in the brain. The epidemiological evidence that DM is a risk factor for the development of dementia, including AD as well as vascular dementia, is then examined. Subsequent chapters explore

• Author : Nagehan Ersoy Tunalı
• Publisher : BoD – Books on Demand
• Release : 20 January 2021

Neurodegenerative diseases represent a very large group of heterogeneous disorders affecting specific subtypes of neurons in the brain. This book contributes insight both to the awareness of the brain and its neurodegenerative states. The chapters present current knowledge regarding genetics, molecular mechanisms, and new therapeutic strategies against neurodegenerative disorders. The book is intended to serve as a source to aid clinicians and researchers in the field, and also life science readers to increase their understanding and awareness of the clinical

• Author : Louise Ann Pemberton
• Publisher : Unknown
• Release : 16 May 2022

• Author : Naofumi Shiomi
• Publisher : BoD – Books on Demand
• Release : 31 August 2016

Numerous studies had been performed to elucidate the mechanisms of aging and to achieve rejuvenation, with some success reported in recent years. However, at present, the findings from those studies are not sufficient to resolve the issue of aging. This book presents an overview of recent topics on cellular aging and rejuvenation. In the early chapters, the molecular mechanisms of aging via the activities of clock and ion channel proteins, in addition to overall aspects, are discussed. In the latter